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Lista de obras de Pádraig D'arcy

A drug screening assay on cancer cells chronically adapted to acidosis

artículo científico publicado en 2018

A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells.

artículo científico publicado en 2013

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

artículo científico publicado en 2014

Activated monocytes augment TRAIL-mediated cytotoxicity by human NK cells through release of IFN-γ

scientific article published on 26 October 2012

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15

artículo científico publicado en 2019

Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

scientific article published on 08 July 2019

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics.

artículo científico publicado en 2016

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

artículo científico publicado en 2009

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

artículo científico publicado en 2012

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties ⬇️

artículo científico publicado el 29 de julio de 2011

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570 ⬇️

artículo científico publicado en 2020

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

artículo científico publicado en 2011

Iron chelators target both proliferating and quiescent cancer cells.

artículo científico publicado en 2016

MYC is downregulated by a mitochondrial checkpoint mechanism.

artículo científico publicado en 2017

Multipotent mesenchymal stromal cells express FoxP3: a marker for the immunosuppressive capacity?

artículo científico publicado en 2011

Oncogenic functions of the cancer-testis antigen SSX on the proliferation, survival, and signaling pathways of cancer cells

artículo científico publicado en 2014

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

scientific article published on 10 June 2019

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

artículo científico publicado en 2011

Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation

artículo científico publicado en 2019

Reactivation of p53 function in synovial sarcoma cells by inhibition of p53-HDM2 interaction.

artículo científico publicado en 2008

Regulation of TRAIL-receptor expression by the ubiquitin-proteasome system.

artículo científico publicado en 2014

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

artículo científico publicado en 2019

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth

artículo científico publicado en 2014

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

artículo científico publicado en 2021

Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling

artículo científico publicado en 2008

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

artículo científico publicado en 2015

The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

artículo científico publicado en 2014

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

scientific article published on 25 August 2018

The oncoprotein SS18-SSX1 promotes p53 ubiquitination and degradation by enhancing HDM2 stability.

artículo científico publicado en 2008

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

artículo científico publicado en 2011

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

artículo científico publicado en 2016

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