Lista de obras - Philip Hogg - Dominio Público Uruguay

A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

artículo científico publicado en 2013

A substrate-driven allosteric switch that enhances PDI catalytic activity

artículo científico publicado en 2016

Allosteric control of βII-tryptase by a redox active disulfide bond

artículo científico publicado en 2013

Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation

scientific article published on 10 January 2019

Alterations in the mitochondrial responses to PENAO as a mechanism of resistance in ovarian cancer cells.

artículo científico publicado en 2015

An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function

artículo científico publicado en 2021

Analysis of disulfide bonds in protein structures

artículo científico publicado en 2010

Autoregulation of von Willebrand factor function by a disulfide bond switch.

artículo científico publicado en 2018

Biodistribution and imaging of an hsp90 ligand labelled with 111In and 67Ga for imaging of cell death

artículo científico publicado en 2020

Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation

artículo científico publicado en 2013

Classification of Protein Disulphide Bonds

artículo científico publicado en 2019

Contribution of allosteric disulfide bonds to regulation of hemostasis.

artículo científico publicado en 2009

Control of blood proteins by functional disulfide bonds.

artículo científico publicado en 2014

Disulfide bond acquisition through eukaryotic protein evolution.

artículo científico publicado en 2010

Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma

artículo científico publicado en 2018

Dual-targeting of aberrant glucose metabolism in glioblastoma

artículo científico publicado en 2015

Elimination of the antimicrobial action of the organoarsenical cancer therapeutic, 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid, before finished product sterility testing

artículo científico publicado en 2013

Employing pancreatic tumor γ-glutamyltransferase for therapeutic delivery

artículo científico publicado en 2014

Encryption and decryption of tissue factor.

artículo científico

Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis

artículo científico publicado en 2012

Fibrinogen function achieved through multiple covalent states

artículo científico publicado en 2020

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

scientific article published on 02 December 2019

Hypoxia regulates the production and activity of glucose transporter-1 and indoleamine 2,3-dioxygenase in monocyte-derived endothelial-like cells: possible relevance to infantile haemangioma pathogenesis

artículo científico publicado en 2011

Identification of allosteric disulfides from labile bonds in X-ray structures.

artículo científico publicado en 2018

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

artículo científico publicado en 2019

Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain

Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C

artículo científico publicado en 2013

Mechano-redox control of integrin de-adhesion

artículo científico publicado en 2018

Mitochondrial metabolism inhibitors for cancer therapy.

artículo científico publicado en 2011

Multiple Disulfide-Bonded States of Native Proteins: Estimate of Number Using Probabilities of Disulfide Bond Formation

artículo científico publicado en 2020

Necrotic platelets provide a procoagulant surface during thrombosis

artículo científico publicado en 2015

Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response.

artículo científico publicado en 2018

One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor.

artículo científico publicado en 2017

Optical Imaging of Treatment-Related Tumor Cell Death Using a Heat Shock Protein-90 Alkylator ⬇️

artículo científico publicado el 10 de septiembre de 2013

Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator

artículo científico publicado en 2013

Organic arsenicals as efficient and highly specific linkers for protein/peptide-polymer conjugation.

artículo científico publicado en 2015

Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial

artículo científico publicado en 2012

Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein

artículo científico publicado en 2004

Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα-Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

scientific article published on 01 March 2019

Post-translational control of protein function by disulfide bond cleavage.

artículo científico

Preparation of a Dithiol-Reactive Probe for PET Imaging of Cell Death

scientific article published on 01 January 2019

Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis

artículo científico publicado en 2024

Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation

scientific article published on 12 October 2018

Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes.

artículo científico publicado en 2011

Redox properties of the tissue factor Cys186-Cys209 disulfide bond

scientific article published on 01 August 2011

Redox regulation of methionine aminopeptidase 2 activity

artículo científico publicado en 2014

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

scientific article published on 11 September 2020

Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7

scientific article published on 06 January 2020

TMX1: a new vascular thiol isomerase

scientific article published on 01 January 2019

Targeting allosteric disulphide bonds in cancer ⬇️

artículo científico publicado el 10 de mayo de 2013

Targeting of two aspects of metabolism in breast cancer treatment

artículo científico publicado en 2014

The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas

artículo científico publicado en 2020

The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase.

artículo científico publicado en 2012

Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation

artículo científico publicado en 2019

Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2.

artículo científico publicado en 2013

Zinc is a potent and specific inhibitor of IFN-λ3 signalling.

artículo científico publicado en 2017

γ-Crystallin redox-detox in the lens

artículo científico publicado en 2018

Lista de obras de Philip Hogg

A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

A substrate-driven allosteric switch that enhances PDI catalytic activity

Allosteric control of βII-tryptase by a redox active disulfide bond

Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation

Alterations in the mitochondrial responses to PENAO as a mechanism of resistance in ovarian cancer cells.

An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function

Analysis of disulfide bonds in protein structures

Autoregulation of von Willebrand factor function by a disulfide bond switch.

Biodistribution and imaging of an hsp90 ligand labelled with 111In and 67Ga for imaging of cell death

Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation

Classification of Protein Disulphide Bonds

Contribution of allosteric disulfide bonds to regulation of hemostasis.

Control of blood proteins by functional disulfide bonds.

Disulfide bond acquisition through eukaryotic protein evolution.

Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma

Dual-targeting of aberrant glucose metabolism in glioblastoma

Elimination of the antimicrobial action of the organoarsenical cancer therapeutic, 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid, before finished product sterility testing

Employing pancreatic tumor γ-glutamyltransferase for therapeutic delivery

Encryption and decryption of tissue factor.

Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis

Fibrinogen function achieved through multiple covalent states

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

Hypoxia regulates the production and activity of glucose transporter-1 and indoleamine 2,3-dioxygenase in monocyte-derived endothelial-like cells: possible relevance to infantile haemangioma pathogenesis

Identification of allosteric disulfides from labile bonds in X-ray structures.

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain

Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C

Mechano-redox control of integrin de-adhesion

Mitochondrial metabolism inhibitors for cancer therapy.

Multiple Disulfide-Bonded States of Native Proteins: Estimate of Number Using Probabilities of Disulfide Bond Formation

Necrotic platelets provide a procoagulant surface during thrombosis

Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response.

One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor.

Optical Imaging of Treatment-Related Tumor Cell Death Using a Heat Shock Protein-90 Alkylator ⬇️

Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator

Organic arsenicals as efficient and highly specific linkers for protein/peptide-polymer conjugation.

Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial

Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein

Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα-Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

Post-translational control of protein function by disulfide bond cleavage.

Preparation of a Dithiol-Reactive Probe for PET Imaging of Cell Death

Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis

Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation

Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes.

Redox properties of the tissue factor Cys186-Cys209 disulfide bond

Redox regulation of methionine aminopeptidase 2 activity

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7

TMX1: a new vascular thiol isomerase

Targeting allosteric disulphide bonds in cancer ⬇️

Targeting of two aspects of metabolism in breast cancer treatment

The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas

The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase.

Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation

Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2.

Zinc is a potent and specific inhibitor of IFN-λ3 signalling.

γ-Crystallin redox-detox in the lens