Lista de obras - Paolo Paoli - Dominio Público Uruguay

2-Methoxybenzoyl phosphate: a new substrate for continuous fluorimetric and spectrophotometric acyl phosphatase assays

artículo científico publicado en 1995

5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases

artículo científico publicado en 2007

5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.

artículo científico publicado en 2009

5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

artículo científico publicado en 2015

A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase

artículo científico publicado en 2003

A single amino acid mutation affects elicitor and expansins-like activities of cerato-platanin, a non-catalytic fungal protein

artículo científico publicado en 2017

An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

artículo científico publicado en 2018

Anoikis molecular pathways and its role in cancer progression

artículo científico publicado en 2013

Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches

artículo científico publicado en 2011

Azido-Substituted BODIPY Dyes for the Production of Fluorescent Carbon Nanotubes

artículo científico publicado en 2015

Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth

artículo científico publicado en 2015

Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform

scientific journal article

Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds

scientific article published on 21 September 2018

Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction

artículo científico publicado en 2019

Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory ag

artículo científico publicado en 2016

Does Fermentation Really Increase the Phenolic Content in Cereals? A Study on Millet

scientific article published on 07 March 2020

Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes

artículo científico publicado en 2019

Effect of IR laser on myoblasts: a proteomic study

artículo científico publicado en 2013

Effect of selected strains of lactobacilli on the antioxidant and anti-inflammatory properties of sourdough

scientific article published on 20 July 2018

Enzymatic Inhibitors from Natural Sources: A Huge Collection of New Potential Drugs

artículo científico publicado en 2021

Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells

scientific article published on 27 March 2019

Human Acid β-Glucosidase Inhibition by Carbohydrate Derived Iminosugars: Towards New Pharmacological Chaperones for Gaucher Disease.

artículo científico publicado en 2015

Hydrogen peroxide triggers the formation of a disulfide dimer of muscle acylphosphatase and modifies some functional properties of the enzyme

artículo científico publicado en 2001

In depth study of phenolic profile and PTP-1B inhibitory power of cold-pressed grape seed oils of different varieties

scientific article published on 27 July 2018

In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives

artículo científico publicado en 2016

Insulin inhibits platelet-derived growth factor-induced cell proliferation.

artículo científico publicado en 2004

LMW-PTP modulates glucose metabolism in cancer cells

scientific article published on 04 August 2018

LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy

artículo científico publicado en 2019

Liquid Crystal-Induced Myoblast Alignment

artículo científico publicado en 2019

Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair

artículo científico publicado en 2017

Low molecular weight protein tyrosine phosphatase and caveolin-1: interaction and isoenzyme-dependent regulation.

artículo científico publicado en 2007

Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme.

artículo científico publicado en 2016

Mechanism of acylphosphatase inactivation by Woodward's reagent K.

artículo científico publicado en 1997

Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc-driven model of colon cancer

artículo científico publicado en 2019

Morin: A Promising Natural Drug

artículo científico

Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study

scientific article published on 12 March 2019

Multiwalled carbon nanotubes for drug delivery: Efficiency related to length and incubation time.

artículo científico publicado en 2017

New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells

artículo científico publicado en 2012

Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment

scientific article published on 29 September 2020

Porcine liver low Mr phosphotyrosine protein phosphatase: The amino acid sequence

artículo científico publicado en 1994

PrPc activation induces neurite outgrowth and differentiation in PC12 cells: role for caveolin-1 in the signal transduction pathway

artículo científico publicado en 2009

Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress

artículo científico publicado en 2008

Protein N-homocysteinylation induces the formation of toxic amyloid-like protofibrils.

artículo científico publicado en 2010

Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus

artículo científico publicado en 2018

Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1

artículo científico publicado en 2007

Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease

scientific article published on 08 February 2019

Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.

artículo científico publicado en 2009

Study on a Fermented Whole Wheat: Phenolic Content, Activity on PTP1B Enzyme and In Vitro Prebiotic Properties

artículo científico publicado en 2019

Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study

scientific article published on 29 August 2018

Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition

artículo científico publicado en 2014

Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.

artículo científico publicado en 2009

Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells

artículo científico publicado en 2013

Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.

artículo científico publicado en 2009

Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors

artículo científico publicado en 2012

Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy.

artículo científico publicado en 2018

The contribution of acidic residues to the conformational stability of common-type acylphosphatase.

artículo científico publicado en 1999

The effects of CA IX catalysis products within tumor microenvironment.

artículo científico publicado en 2013

The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1.

artículo científico publicado en 2004

The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment

artículo científico publicado en 2013

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

artículo científico publicado en 2016

Thermodynamics and kinetics of folding of common-type acylphosphatase: comparison to the highly homologous muscle isoenzyme.

artículo científico publicado en 1999

Tumor microenvironment and metabolism in prostate cancer

artículo científico publicado en 2014

Ursolic acid derivatives as potential antidiabetic agents: In vitro, in vivo, and in silico studies.

artículo científico publicado en 2018

miR-210-3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5-fluorouracil

scientific article published on 29 August 2019

Lista de obras de Paolo Paoli

2-Methoxybenzoyl phosphate: a new substrate for continuous fluorimetric and spectrophotometric acyl phosphatase assays

5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases

5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.

5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase

A single amino acid mutation affects elicitor and expansins-like activities of cerato-platanin, a non-catalytic fungal protein

An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

Anoikis molecular pathways and its role in cancer progression

Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches

Azido-Substituted BODIPY Dyes for the Production of Fluorescent Carbon Nanotubes

Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth

Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform

Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds

Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction

Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory ag

Does Fermentation Really Increase the Phenolic Content in Cereals? A Study on Millet

Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes

Effect of IR laser on myoblasts: a proteomic study

Effect of selected strains of lactobacilli on the antioxidant and anti-inflammatory properties of sourdough

Enzymatic Inhibitors from Natural Sources: A Huge Collection of New Potential Drugs

Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells

Human Acid β-Glucosidase Inhibition by Carbohydrate Derived Iminosugars: Towards New Pharmacological Chaperones for Gaucher Disease.

Hydrogen peroxide triggers the formation of a disulfide dimer of muscle acylphosphatase and modifies some functional properties of the enzyme

In depth study of phenolic profile and PTP-1B inhibitory power of cold-pressed grape seed oils of different varieties

In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives

Insulin inhibits platelet-derived growth factor-induced cell proliferation.

LMW-PTP modulates glucose metabolism in cancer cells

LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy

Liquid Crystal-Induced Myoblast Alignment

Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair

Low molecular weight protein tyrosine phosphatase and caveolin-1: interaction and isoenzyme-dependent regulation.

Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme.

Mechanism of acylphosphatase inactivation by Woodward's reagent K.

Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc-driven model of colon cancer

Morin: A Promising Natural Drug

Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study

Multiwalled carbon nanotubes for drug delivery: Efficiency related to length and incubation time.

New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells

Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment

Porcine liver low Mr phosphotyrosine protein phosphatase: The amino acid sequence

PrPc activation induces neurite outgrowth and differentiation in PC12 cells: role for caveolin-1 in the signal transduction pathway

Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress

Protein N-homocysteinylation induces the formation of toxic amyloid-like protofibrils.

Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus

Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1

Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease

Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.

Study on a Fermented Whole Wheat: Phenolic Content, Activity on PTP1B Enzyme and In Vitro Prebiotic Properties

Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study

Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition

Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.

Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells

Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.

Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors

Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy.

The contribution of acidic residues to the conformational stability of common-type acylphosphatase.

The effects of CA IX catalysis products within tumor microenvironment.

The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1.

The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

Thermodynamics and kinetics of folding of common-type acylphosphatase: comparison to the highly homologous muscle isoenzyme.

Tumor microenvironment and metabolism in prostate cancer

Ursolic acid derivatives as potential antidiabetic agents: In vitro, in vivo, and in silico studies.

miR-210-3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5-fluorouracil