Lista de obras - Concepción González Bello

2-substituted-3-dehydroquinic acids as potent competitive inhibitors of type II dehydroquinase

artículo científico publicado en 2009

6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens

scientific article published on 31 March 2020

A New Pathway for Protein Haptenation by β-Lactams.

artículo científico publicado en 2017

A combined photophysical and computational study on the binding of mycophenolate mofetil and its major metabolite to transport proteins

artículo científico publicado en 2018

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors

artículo científico publicado en 2011

Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii

artículo científico publicado en 2017

Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics

artículo científico publicado en 2017

Challenging Antimicrobial Susceptibility and Evolution of Resistance (OXA-681) during Treatment of a Long-Term Nosocomial Infection Caused by a Pseudomonas aeruginosa ST175 Clone

artículo científico publicado en 2019

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

artículo científico publicado en 2015

Comparative binding energy COMBINE analysis for understanding the binding determinants of type II dehydroquinase inhibitors.

artículo científico publicado en 2013

Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies.

artículo científico publicado en 2008

Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase.

artículo científico publicado en 2003

Designing Irreversible Inhibitors--Worth the Effort?

artículo científico publicado en 2015

Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy

artículo científico publicado en 2006

Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors

artículo científico publicado en 2014

Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme.

artículo científico publicado en 2016

Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies.

artículo científico

Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods

scientific article published on 12 October 2019

LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.

artículo científico publicado en 2016

Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamics simulation studies

artículo científico publicado en 2017

Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids

artículo científico publicado en 2013

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases

artículo científico publicado en 2014

Mechanistic studies on type I and type II dehydroquinase with (6 R )- and (6 S )-6-fluoro-3-dehydroquinic acids

artículo científico publicado en 2000

Metal-Assisted Ring-Closing/Opening Process of a Chiral Tetrahydroquinazoline

scientific article published on 23 January 2012

Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas aeruginosa infections

scientific article published on 21 October 2020

Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover

artículo científico publicado en 2013

Nanomolar Competitive Inhibitors ofMycobacterium tuberculosis andStreptomyces coelicolor Type II Dehydroquinase

scientific article published on 01 February 2007

Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase

artículo científico publicado en 2003

Photobinding of Triflusal to Human Serum Albumin Investigated by Fluorescence, Proteomic Analysis, and Computational Studies

artículo científico publicado en 2019

QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes

artículo científico publicado en 2018

Recently developed synthetic compounds with anti-infective activity

artículo científico publicado en 2019

Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.

artículo científico publicado en 2017

Specific chemical modification of bacterial type I dehydroquinase--opportunities for drug discovery

artículo científico publicado en 2015

Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy.

artículo científico publicado en 2016

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues

artículo científico publicado en 2010

Synthesis of Polyhydroxycyclohexanes and Relatives from (−)-Quinic Acid†

scientific article published on 01 March 2003

Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme

artículo científico publicado en 2016

Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase

artículo científico publicado en 2011

Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii

artículo científico publicado en 2019

Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids

artículo científico publicado en 2010

Using surface enhanced Raman scattering to analyze the interactions of protein receptors with bacterial quorum sensing modulators.

artículo científico publicado en 2015

β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs

scientific article published on 13 November 2019

Lista de obras de Concepción González Bello

2-substituted-3-dehydroquinic acids as potent competitive inhibitors of type II dehydroquinase

6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens

A New Pathway for Protein Haptenation by β-Lactams.

A combined photophysical and computational study on the binding of mycophenolate mofetil and its major metabolite to transport proteins

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors

Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii

Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics

Challenging Antimicrobial Susceptibility and Evolution of Resistance (OXA-681) during Treatment of a Long-Term Nosocomial Infection Caused by a Pseudomonas aeruginosa ST175 Clone

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

Comparative binding energy COMBINE analysis for understanding the binding determinants of type II dehydroquinase inhibitors.

Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies.

Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase.

Designing Irreversible Inhibitors--Worth the Effort?

Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy

Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors

Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme.

Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies.

Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods

LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.

Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamics simulation studies

Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases

Mechanistic studies on type I and type II dehydroquinase with (6 R )- and (6 S )-6-fluoro-3-dehydroquinic acids

Metal-Assisted Ring-Closing/Opening Process of a Chiral Tetrahydroquinazoline

Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas aeruginosa infections

Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover

Nanomolar Competitive Inhibitors ofMycobacterium tuberculosis andStreptomyces coelicolor Type II Dehydroquinase

Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase

Photobinding of Triflusal to Human Serum Albumin Investigated by Fluorescence, Proteomic Analysis, and Computational Studies

QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes

Recently developed synthetic compounds with anti-infective activity

Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.

Specific chemical modification of bacterial type I dehydroquinase--opportunities for drug discovery

Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy.

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues

Synthesis of Polyhydroxycyclohexanes and Relatives from (−)-Quinic Acid†

Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme

Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase

Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii

Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids

Using surface enhanced Raman scattering to analyze the interactions of protein receptors with bacterial quorum sensing modulators.

β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs