Lista de obras - Sherwin Sy - Dominio Público Uruguay

A Markov chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation.

scientific article published on 30 August 2013

A mathematical model-based analysis of the time-kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa

artículo científico publicado en 2018

A model-based analysis of pharmacokinetic-pharmacodynamic (PK/PD) indices of avibactam against Pseudomonas aeruginosa

artículo científico publicado en 2018

A perspective on the toxicological mechanisms possibly contributing to the failure of oral glycoprotein IIb/IIIa antagonists in the clinic

artículo científico publicado en 2004

Application of Pharmacometric Analysis in the Design of Clinical Pharmacology Studies for Biosimilar Development.

artículo científico publicado en 2018

Application of Trial Simulation in the Design of a Prospective Study for Concentration-QTc Analysis in Support of a Thorough QT Study Waiver

artículo científico publicado en 2020

Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of <i>Escherichia coli and Klebsiella pneumoniae</i> harbouring serine- and New Delhi metallo-β-lactamases

artículo científico publicado en 2021

Change in topoisomerase 1 (Top1) positive circulating tumor cells impacts overall survival in patients with advanced breast cancer after treatment with etirinotecan pegol.

artículo científico publicado en 2018

Clinical Pharmacokinetics and Pharmacodynamics of Ceftazidime-Avibactam Combination: A Model-Informed Strategy for its Clinical Development

scientific article published on 01 May 2019

Dermal pharmacokinetics of pyrazinamide determined by microdialysis sampling in rats

artículo científico publicado en 2017

Dose Optimization of Moxifloxacin and Linezolid Against Tuberculosis Using Mathematical Modeling and Simulation

artículo científico publicado en 2018

Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model

artículo científico publicado en 2015

Estimation of intracellular concentration of stavudine triphosphate in HIV-infected children given a reduced dose of 0.5 milligrams per kilogram twice daily

artículo científico publicado en 2013

Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration.

artículo científico publicado en 2016

Evaluation of in vitro synergy between vertilmicin and ceftazidime against Pseudomonas aeruginosa using a semi-mechanistic pharmacokinetic/pharmacodynamic model.

artículo científico publicado en 2014

Experimental design and modeling approach to evaluate efficacy of β-lactam/β-lactamase inhibitor combinations

artículo científico publicado en 2017

Fixed-dose combinations: a potential means to boost drug development for selected drugs

artículo científico publicado en 2017

Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model

artículo científico publicado en 2015

In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.

artículo científico publicado en 2012

In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms

artículo científico publicado en 2016

Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients.

artículo científico publicado en 2013

Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors.

artículo científico publicado en 2018

Largazole pharmacokinetics in rats by LC-MS/MS.

artículo científico publicado en 2014

Learning and augmenting natural processes: potential means of combating antimicrobial resistance from a drug R&D perspective

scientific article published on 06 September 2019

Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression

artículo científico publicado en 2002

Mulitvariate cluster analysis of a human hepatic cytochrome P450 database

artículo científico publicado en 2002

N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis

artículo científico publicado en 2015

Pharmacodynamic Attainment of the Synergism of Meropenem and Fosfomycin Combination against Pseudomonas aeruginosa Producing Metallo-β-Lactamase

scientific article published on 24 May 2019

Pharmacodynamic Effects of Sulbactam/Meropenem/Polymyxin-B Combination Against Extremely Drug Resistant Acinetobacter baumannii Using Checkerboard Information

scientific article published on 19 June 2019

Pharmacodynamic Evaluation of Fosfomycin against Escherichia coli and Klebsiella spp. from Urinary Tract Infections and the Influence of pH on Fosfomycin Activities

artículo científico publicado en 2017

Pharmacodynamic Evaluation of the Potential Clinical Utility of Fosfomycin and Meropenem in Combination Therapy against KPC-2-Producing Klebsiella pneumoniae

artículo científico publicado en 2016

Pharmacokinetic evaluation of avicularin using a model-based development approach

artículo científico publicado en 2015

Pharmacokinetics and pharmacodynamics in antibiotic dose optimization.

artículo científico publicado en 2015

Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis

artículo científico publicado en 2014

Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii

scientific article published on 22 January 2020

Physiologically-based pharmacokinetic-pharmacodynamic evaluation of meropenem plus fosfomycin in pediatrics

scientific article published on 07 July 2020

Physiologically-based pharmacokinetics of ziprasidone in pregnant women

artículo científico publicado en 2019

Population Pharmacokinetic and Covariate Analysis of Apatinib, an Oral Tyrosine Kinase Inhibitor, in Healthy Volunteers and Patients with Solid Tumors

artículo científico publicado en 2016

Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

artículo científico publicado en 2011

Potentiation of ceftazidime by avibactam against β-lactam-resistant Pseudomonas aeruginosa in an in vitro infection model

artículo científico publicado en 2017

Predicting pediatric age-matched weight and body mass index

artículo científico publicado en 2014

Prediction of in vivo and in vitro infection model results using a semimechanistic model of avibactam and aztreonam combination against multidrug resistant organisms

artículo científico publicado en 2017

Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.

artículo científico publicado en 2015

Rapid and efficient method for the quantification of lychnopholide in rat plasma by liquid chromatography-tandem mass spectrometry for pharmacokinetic application

artículo científico publicado en 2015

Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers

artículo científico publicado en 2002

Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model

artículo científico publicado en 2015

Simultaneous quantification of seven active metabolites of roxifiban in human plasma by LC/MS/MS in the presence of an interfering displacer at millimolar concentrations

artículo científico publicado en 2003

The use of roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease

artículo científico publicado en 2003

Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk.

artículo científico publicado en 2008

Lista de obras de Sherwin Sy

A Markov chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation.

A mathematical model-based analysis of the time-kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa

A model-based analysis of pharmacokinetic-pharmacodynamic (PK/PD) indices of avibactam against Pseudomonas aeruginosa

A perspective on the toxicological mechanisms possibly contributing to the failure of oral glycoprotein IIb/IIIa antagonists in the clinic

Application of Pharmacometric Analysis in the Design of Clinical Pharmacology Studies for Biosimilar Development.

Application of Trial Simulation in the Design of a Prospective Study for Concentration-QTc Analysis in Support of a Thorough QT Study Waiver

Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of <i>Escherichia coli and Klebsiella pneumoniae</i> harbouring serine- and New Delhi metallo-β-lactamases

Change in topoisomerase 1 (Top1) positive circulating tumor cells impacts overall survival in patients with advanced breast cancer after treatment with etirinotecan pegol.

Clinical Pharmacokinetics and Pharmacodynamics of Ceftazidime-Avibactam Combination: A Model-Informed Strategy for its Clinical Development

Dermal pharmacokinetics of pyrazinamide determined by microdialysis sampling in rats

Dose Optimization of Moxifloxacin and Linezolid Against Tuberculosis Using Mathematical Modeling and Simulation

Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model

Estimation of intracellular concentration of stavudine triphosphate in HIV-infected children given a reduced dose of 0.5 milligrams per kilogram twice daily

Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration.

Evaluation of in vitro synergy between vertilmicin and ceftazidime against Pseudomonas aeruginosa using a semi-mechanistic pharmacokinetic/pharmacodynamic model.

Experimental design and modeling approach to evaluate efficacy of β-lactam/β-lactamase inhibitor combinations

Fixed-dose combinations: a potential means to boost drug development for selected drugs

Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model

In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.

In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms

Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients.

Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors.

Largazole pharmacokinetics in rats by LC-MS/MS.

Learning and augmenting natural processes: potential means of combating antimicrobial resistance from a drug R&D perspective

Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression

Mulitvariate cluster analysis of a human hepatic cytochrome P450 database

N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis

Pharmacodynamic Attainment of the Synergism of Meropenem and Fosfomycin Combination against Pseudomonas aeruginosa Producing Metallo-β-Lactamase

Pharmacodynamic Effects of Sulbactam/Meropenem/Polymyxin-B Combination Against Extremely Drug Resistant Acinetobacter baumannii Using Checkerboard Information

Pharmacodynamic Evaluation of Fosfomycin against Escherichia coli and Klebsiella spp. from Urinary Tract Infections and the Influence of pH on Fosfomycin Activities

Pharmacodynamic Evaluation of the Potential Clinical Utility of Fosfomycin and Meropenem in Combination Therapy against KPC-2-Producing Klebsiella pneumoniae

Pharmacokinetic evaluation of avicularin using a model-based development approach

Pharmacokinetics and pharmacodynamics in antibiotic dose optimization.

Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis

Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii

Physiologically-based pharmacokinetic-pharmacodynamic evaluation of meropenem plus fosfomycin in pediatrics

Physiologically-based pharmacokinetics of ziprasidone in pregnant women

Population Pharmacokinetic and Covariate Analysis of Apatinib, an Oral Tyrosine Kinase Inhibitor, in Healthy Volunteers and Patients with Solid Tumors

Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

Potentiation of ceftazidime by avibactam against β-lactam-resistant Pseudomonas aeruginosa in an in vitro infection model

Predicting pediatric age-matched weight and body mass index

Prediction of in vivo and in vitro infection model results using a semimechanistic model of avibactam and aztreonam combination against multidrug resistant organisms

Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.

Rapid and efficient method for the quantification of lychnopholide in rat plasma by liquid chromatography-tandem mass spectrometry for pharmacokinetic application

Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers

Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model

Simultaneous quantification of seven active metabolites of roxifiban in human plasma by LC/MS/MS in the presence of an interfering displacer at millimolar concentrations

The use of roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease

Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk.