Lista de obras - Laura H Jacobson - Dominio Público Uruguay

A genetic upper limit to whole-body protein deposition in a strain of growing pigs.

artículo científico publicado en 2006

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

artículo científico publicado en 2015

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

article

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system

artículo científico publicado en 2012

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

artículo científico publicado en 2006

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

artículo científico publicado en 2017

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

artículo científico publicado en 2011

Correlation of cellular changes and spatial memory during aging in rats

artículo científico publicado en 2008

Differential compartmentalization and distinct functions of GABAB receptor variants

artículo científico publicado en 2006

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine

artículo científico publicado en 2015

Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains

artículo científico publicado en 2005

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).

artículo científico publicado en 2015

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

scientific article published on 03 May 2018

Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

artículo científico publicado en 2012

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides

artículo científico publicado en 2013

Distinct effects of IPSU and suvorexant on mouse sleep architecture

artículo científico publicado en 2013

Effect of feeding pasture-finished cattle different conserved forages on Escherichia coli in the rumen and faeces

artículo científico publicado en 2002

Electrical head-only stunning of fallow deer (Dama dama)

artículo científico publicado en 1994

Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.

artículo científico publicado en 2013

Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents

artículo científico publicado en 2008

Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats

artículo científico publicado en 2010

Feeling strained? Influence of genetic background on depression-related behavior in mice: a review.

artículo científico publicado en 2006

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

artículo científico publicado en 2006

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

artículo científico publicado en 2006

Heart rate as a measure of adaptation to stress in cattle

scientific article published on 01 December 1996

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia

artículo científico publicado en 2013

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

scholarly article

Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors

artículo científico publicado en 2013

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice

artículo científico publicado en 2016

Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status

artículo científico publicado en 2016

Orexin OX2 Receptor Antagonists as Sleep Aids

artículo científico publicado en 2016

Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?

artículo científico publicado en 2013

Partitioning psychological and physical sources of transport-related stress in young cattle

artículo científico publicado en 1998

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.

artículo científico publicado en 2016

Salivary cortisol as an indicator of stress in sheep (Ovis ovis)

scientific article published on 01 November 1995

Sex differences in mouse models of fear inhibition: Fear extinction, safety learning, and fear–safety discrimination

artículo científico publicado en 2019

Specific roles of GABA(B(1)) receptor isoforms in cognition.

artículo científico publicado en 2007

Suvorexant for the treatment of insomnia

artículo científico publicado en 2014

The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease

artículo científico publicado en 2018

The Gamma-Aminobutyric Acid B Receptor in Depression and Reward

artículo científico publicado en 2018

The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.

artículo científico publicado en 2011

The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours

scholarly article by Ryan J Keenan published in November 2018

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.

artículo científico publicado en 2007

Lista de obras de Laura H Jacobson

A genetic upper limit to whole-body protein deposition in a strain of growing pigs.

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

Correlation of cellular changes and spatial memory during aging in rats

Differential compartmentalization and distinct functions of GABAB receptor variants

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine

Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides

Distinct effects of IPSU and suvorexant on mouse sleep architecture

Effect of feeding pasture-finished cattle different conserved forages on Escherichia coli in the rumen and faeces

Electrical head-only stunning of fallow deer (Dama dama)

Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.

Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents

Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats

Feeling strained? Influence of genetic background on depression-related behavior in mice: a review.

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

Heart rate as a measure of adaptation to stress in cattle

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice

Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status

Orexin OX2 Receptor Antagonists as Sleep Aids

Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?

Partitioning psychological and physical sources of transport-related stress in young cattle

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.

Salivary cortisol as an indicator of stress in sheep (Ovis ovis)

Sex differences in mouse models of fear inhibition: Fear extinction, safety learning, and fear–safety discrimination

Specific roles of GABA(B(1)) receptor isoforms in cognition.

Suvorexant for the treatment of insomnia

The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease

The Gamma-Aminobutyric Acid B Receptor in Depression and Reward

The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.

The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.