Lista de obras - Lakshmi Wijeyewickrema - Dominio Público Uruguay

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

artículo científico publicado en 2013

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

artículo científico publicado en 2009

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

artículo científico publicado en 2013

Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS

artículo científico publicado en 2013

Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite Sarcoptes scabiei

artículo científico publicado en 2009

Determination of the crystal structure and substrate specificity of ananain

scientific article published on 12 July 2019

Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate

artículo científico publicado en 2011

Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin

article

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

artículo científico publicado en 2007

Fractionation of snake venom metalloproteinases by metal ion affinity: A purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose

article

Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets

artículo científico publicado en 2005

High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism

artículo científico publicado en 2008

Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.

artículo científico publicado en 2012

Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4.

artículo científico publicado en 2015

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?

artículo científico publicado en 2011

Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.

artículo científico publicado en 2013

Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4.

artículo científico publicado en 2011

Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI

artículo científico publicado en 2010

Novel scabies mite serpins inhibit the three pathways of the human complement system

artículo científico publicado en 2012

Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions.

artículo científico publicado en 2004

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

artículo científico publicado en 2016

Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display.

artículo científico publicado en 2000

Protease-associated import systems are widespread in Gram-negative bacteria

scientific article published on 15 October 2019

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

artículo científico publicado en 2015

Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites

artículo científico publicado en 2017

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

artículo científico publicado en 2005

S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction

artículo científico publicado en 2011

Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway

artículo científico publicado en 2014

Serpins and the Complement System

article

Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI.

artículo científico publicado en 2007

Snake venom probes of platelet adhesion receptors and their ligands

artículo científico publicado en 2005

Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase

artículo científico publicado en 2016

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

artículo científico publicado en 2017

The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome

artículo científico publicado en 2013

The effects of exosite occupancy on the substrate specificity of thrombin

artículo científico publicado en 2009

The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis

scientific article published on May 2009

The initiating proteases of the complement system: controlling the cleavage

artículo científico publicado en 2007

The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition

artículo científico publicado en 2011

The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates

artículo científico

The role of the lys628 (192) residue of the complement protease, c1s, in interacting with Peptide and protein substrates

artículo científico publicado en 2014

The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.

artículo científico publicado en 2013

Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism.

artículo científico publicado en 2013

Total synthesis of homogeneous variants of hirudin P6: a post-translationally modified anti-thrombotic leech-derived protein.

artículo científico publicado en 2014

Lista de obras de Lakshmi Wijeyewickrema

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS

Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite Sarcoptes scabiei

Determination of the crystal structure and substrate specificity of ananain

Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate

Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

Fractionation of snake venom metalloproteinases by metal ion affinity: A purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose

Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets

High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism

Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.

Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4.

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?

Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.

Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4.

Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI

Novel scabies mite serpins inhibit the three pathways of the human complement system

Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions.

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display.

Protease-associated import systems are widespread in Gram-negative bacteria

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction

Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway

Serpins and the Complement System

Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI.

Snake venom probes of platelet adhesion receptors and their ligands

Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome

The effects of exosite occupancy on the substrate specificity of thrombin

The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis

The initiating proteases of the complement system: controlling the cleavage

The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition

The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates

The role of the lys628 (192) residue of the complement protease, c1s, in interacting with Peptide and protein substrates

The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.

Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism.

Total synthesis of homogeneous variants of hirudin P6: a post-translationally modified anti-thrombotic leech-derived protein.