Lista de obras - Patrick J. Hrdlicka - Dominio Público Uruguay

25 years and still going strong: 2'-O-(pyren-1-yl)methylribonucleotides - versatile building blocks for applications in molecular biology, diagnostics and materials science

artículo científico publicado en 2017

2′-N-(Pyren-1-yl)acetyl-2′-Amino-α-L-LNA: Synthesis and Detection of Single Nucleotide Mismatches in DNA and RNA Targets

artículo científico publicado en 2007

Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles

artículo científico publicado en 2015

C2'-pyrene-functionalized triazole-linked DNA: universal DNA/RNA hybridization probes.

artículo científico publicado en 2011

C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability

artículo científico publicado en 2014

C5-amino acid functionalized LNA: positively poised for antisense applications

artículo científico

C5-functionalized DNA, LNA, and α-L-LNA: positional control of polarity-sensitive fluorophores leads to improved SNP-typing

artículo científico publicado en 2011

C5-functionalized LNA: unparalleled hybridization properties and enzymatic stability

artículo científico publicado en 2009

Carbohydrate-functionalized locked nucleic acids: oligonucleotides with extraordinary binding affinity, target specificity, and enzymatic stability.

artículo científico publicado en 2014

Characterization of nerolidol biotransformation based on indirect on-line estimation of biomass concentration and physiological state in batch cultures of Aspergillus niger

artículo científico publicado en 2004

DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles.

artículo científico publicado en 2012

DNA strands with alternating incorporations of LNA and 2'-O-(pyren-1-yl)methyluridine: SNP-discriminating RNA detection probes.

artículo científico publicado en 2013

Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection

artículo científico publicado en 2007

Efficient Discrimination of Single Nucleotide Polymorphisms (SNPs) Using Oligonucleotides Modified with C5-Pyrene-Functionalized DNA and Flanking Locked Nucleic Acid (LNA) Monomers.

artículo científico publicado en 2016

Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAs

artículo científico publicado en 2012

Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

artículo científico publicado en 2009

Glowing locked nucleic acids: brightly fluorescent probes for detection of nucleic acids in cells.

artículo científico publicado en 2010

Gold-peptide nanoconjugate cellular uptake is modulated by serum proteins.

artículo científico publicado en 2011

High-Affinity DNA Targeting Using Readily Accessible Mimics of N2′-Functionalized 2′-Amino-α-L-LNA ⬇️

artículo científico publicado el 9 de agosto de 2011

Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

artículo científico publicado en 2013

Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes

artículo científico publicado en 2020

Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling

artículo científico

Invader LNA: efficient targeting of short double stranded DNA.

artículo científico publicado en 2010

Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications.

artículo científico publicado en 2015

Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides

artículo científico publicado en 2013

Locked nucleic acid (LNA) induced effect on the hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers.

artículo científico

Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes

artículo científico publicado en 2016

Mixed-Sequence Recognition of Double-Stranded DNA Using Enzymatically Stable Phosphorothioate Invader Probes

artículo científico publicado en 2015

Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays

artículo científico publicado en 2005

N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.

artículo científico publicado en 2007

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

artículo científico publicado en 2016

Nicked Invader probes: multistranded and sequence-unrestricted recognition of double-stranded DNA

artículo científico publicado en 2022

Novel insights into the use of Glowing LNA as nucleic acid detection probes--influence of labeling density and nucleobases

artículo científico publicado en 2010

Nucleic acid structural engineering using pyrene-functionalized 2'-amino-alpha-L-LNA monomers and abasic sites

artículo científico publicado en 2008

Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-beta-alanyl 2'-amino-LNA.

artículo científico publicado en 2005

Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.

artículo científico publicado en 2009

Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.

artículo científico publicado en 2009

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids.

artículo científico publicado en 2010

Preparation of C5-functionalized locked nucleic acids (LNAs)

artículo científico publicado en 2011

Pyrene-functionalized 2'-amino-alpha-L-LNA as potential diagnostic probes

artículo científico publicado en 2007

Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.

artículo científico publicado en 2011

Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).

artículo científico publicado en 2010

Recognition of Double-Stranded DNA Using Energetically Activated Duplexes Modified with N2'-Pyrene-, Perylene-, or Coronene-Functionalized 2'-N-Methyl-2'-amino-DNA Monomers.

artículo científico publicado en 2015

Recognition of double-stranded DNA using LNA-modified toehold Invader probes

artículo científico publicado en 2021

Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers

artículo científico publicado en 2014

Recognition of mixed-sequence DNA duplexes: design guidelines for invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers.

artículo científico publicado en 2013

Recognition of mixed-sequence DNA targets using spermine-modified Invader probes

artículo científico publicado en 2019

Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2'-triphenylene- and coronene-functionalized RNA monomers

artículo científico publicado en 2017

SYNTHESIS OF A 2′-AMINO-α-L-LNA-T PHOSPHORAMIDITE

artículo científico publicado en 2005

Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens

artículo científico publicado en 2013

Self-assembled monolayers of thiols adsorbed on Au/ZnO-functionalized silica nanosprings: photoelectron spectroscopy-analysis and detection of vaporized explosives

artículo científico publicado en 2014

Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: lessons to be learned

artículo científico publicado en 2007

Synthesis and Hybridization Studies of 2‘-Amino-α-L-LNA and Tetracyclic “Locked LNA”†

scientific article published on 01 May 2006

Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd).

artículo científico publicado en 2005

Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).

artículo científico publicado en 2005

Synthesis and biophysical characterization of oligonucleotides modified with O2'-alkylated RNA monomers featuring substituted pyrene moieties

artículo científico publicado en 2019

Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).

artículo científico publicado en 2014

Synthesis and biophysical studies of N2'-functionalized 2'-amino-alpha-L-LNA.

artículo científico publicado en 2007

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA

artículo científico publicado en 2013

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-thio-2'-deoxy-2'-S-(pyren-1-yl)methyluridine

artículo científico publicado en 2015

Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2'-deoxyuridines.

artículo científico publicado en 2012

Synthesis, hybridization characteristics, and fluorescence properties of oligonucleotides modified with nucleobase-functionalized locked nucleic acid adenosine and cytidine monomers.

artículo científico

Synthesis, nucleic acid hybridization properties and molecular modelling studies of conformationally restricted 3′- O ,4′- C -methylene-linked α- l -ribonucleotides

artículo científico publicado en 2006

Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.

artículo científico publicado en 2005

Lista de obras de Patrick J. Hrdlicka

25 years and still going strong: 2'-O-(pyren-1-yl)methylribonucleotides - versatile building blocks for applications in molecular biology, diagnostics and materials science

2′-N-(Pyren-1-yl)acetyl-2′-Amino-α-L-LNA: Synthesis and Detection of Single Nucleotide Mismatches in DNA and RNA Targets

Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles

C2'-pyrene-functionalized triazole-linked DNA: universal DNA/RNA hybridization probes.

C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability

C5-amino acid functionalized LNA: positively poised for antisense applications

C5-functionalized DNA, LNA, and α-L-LNA: positional control of polarity-sensitive fluorophores leads to improved SNP-typing

C5-functionalized LNA: unparalleled hybridization properties and enzymatic stability

Carbohydrate-functionalized locked nucleic acids: oligonucleotides with extraordinary binding affinity, target specificity, and enzymatic stability.

Characterization of nerolidol biotransformation based on indirect on-line estimation of biomass concentration and physiological state in batch cultures of Aspergillus niger

DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles.

DNA strands with alternating incorporations of LNA and 2'-O-(pyren-1-yl)methyluridine: SNP-discriminating RNA detection probes.

Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection

Efficient Discrimination of Single Nucleotide Polymorphisms (SNPs) Using Oligonucleotides Modified with C5-Pyrene-Functionalized DNA and Flanking Locked Nucleic Acid (LNA) Monomers.

Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAs

Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

Glowing locked nucleic acids: brightly fluorescent probes for detection of nucleic acids in cells.

Gold-peptide nanoconjugate cellular uptake is modulated by serum proteins.

High-Affinity DNA Targeting Using Readily Accessible Mimics of N2′-Functionalized 2′-Amino-α-L-LNA ⬇️

Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes

Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling

Invader LNA: efficient targeting of short double stranded DNA.

Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications.

Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides

Locked nucleic acid (LNA) induced effect on the hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers.

Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes

Mixed-Sequence Recognition of Double-Stranded DNA Using Enzymatically Stable Phosphorothioate Invader Probes

Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays

N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Nicked Invader probes: multistranded and sequence-unrestricted recognition of double-stranded DNA

Novel insights into the use of Glowing LNA as nucleic acid detection probes--influence of labeling density and nucleobases

Nucleic acid structural engineering using pyrene-functionalized 2'-amino-alpha-L-LNA monomers and abasic sites

Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-beta-alanyl 2'-amino-LNA.

Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.

Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids.

Preparation of C5-functionalized locked nucleic acids (LNAs)

Pyrene-functionalized 2'-amino-alpha-L-LNA as potential diagnostic probes

Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.

Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).

Recognition of Double-Stranded DNA Using Energetically Activated Duplexes Modified with N2'-Pyrene-, Perylene-, or Coronene-Functionalized 2'-N-Methyl-2'-amino-DNA Monomers.

Recognition of double-stranded DNA using LNA-modified toehold Invader probes

Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers

Recognition of mixed-sequence DNA duplexes: design guidelines for invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers.

Recognition of mixed-sequence DNA targets using spermine-modified Invader probes

Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2'-triphenylene- and coronene-functionalized RNA monomers

SYNTHESIS OF A 2′-AMINO-α-L-LNA-T PHOSPHORAMIDITE

Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens

Self-assembled monolayers of thiols adsorbed on Au/ZnO-functionalized silica nanosprings: photoelectron spectroscopy-analysis and detection of vaporized explosives

Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: lessons to be learned

Synthesis and Hybridization Studies of 2‘-Amino-α-L-LNA and Tetracyclic “Locked LNA”†

Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd).

Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).

Synthesis and biophysical characterization of oligonucleotides modified with O2'-alkylated RNA monomers featuring substituted pyrene moieties

Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).

Synthesis and biophysical studies of N2'-functionalized 2'-amino-alpha-L-LNA.

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-thio-2'-deoxy-2'-S-(pyren-1-yl)methyluridine

Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2'-deoxyuridines.

Synthesis, hybridization characteristics, and fluorescence properties of oligonucleotides modified with nucleobase-functionalized locked nucleic acid adenosine and cytidine monomers.

Synthesis, nucleic acid hybridization properties and molecular modelling studies of conformationally restricted 3′- O ,4′- C -methylene-linked α- l -ribonucleotides

Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.