Lista de obras - Ulf Diczfalusy - Dominio Público Uruguay

24(S),25-epoxycholesterol--a potential friend.

artículo científico publicado en 2004

4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians

artículo científico publicado en 2008

4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.

artículo científico publicado en 2009

4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin

artículo científico publicado en 2008

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

artículo científico publicado en 2011

A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction

artículo científico publicado en 2013

A study of plasmalogen as an index of oxidative stress in patients with chronic renal failure. Evidence of increased oxidative stress in malnourished patients

artículo científico publicado en 1998

Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism

artículo científico publicado en 2000

Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria

artículo científico publicado en 2011

An animal model to study local oxidation of LDL and its biological effects in the arterial wall

artículo científico publicado en 1998

Analysis of cholesterol oxidation products in biological samples.

artículo científico publicado en 2004

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

artículo científico publicado en 2001

Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products

artículo científico publicado en 2001

CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels

artículo científico publicado en 2008

Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells

scientific article published on 01 October 1997

Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis

artículo científico publicado en 2002

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

artículo científico publicado en 2003

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

artículo científico publicado en 1998

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

artículo científico publicado en 2007

Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver

artículo científico publicado en 1995

Cloning and regulation of peroxisome proliferator-induced acyl-CoA thioesterases from mouse liver

artículo científico publicado en 1999

Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin

artículo científico publicado en 2013

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans

artículo científico publicado en 2005

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.

artículo científico publicado en 2005

Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol.

artículo científico publicado en 2011

Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol

artículo científico publicado en 2008

Detecting oxysterols in the human circulation

article

Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry

article

Diagnostic use of cerebral and extracerebral oxysterols

artículo científico publicado en 2004

Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study.

artículo científico publicado en 2005

Effect of the oxidation state of LDL on the modulation of arterial vasomotor response in vitro

artículo científico publicado en 1997

Effects of high-dose itraconazole treatment on lipoproteins in men.

artículo científico publicado en 2007

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin.

artículo científico publicado en 1999

Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport

scientific article published in Journal of Biological Chemistry

FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.

artículo científico publicado en 2010

Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice

artículo científico publicado en 2000

From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans

artículo científico publicado en 2001

High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?

artículo científico publicado en 2010

High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation

artículo científico publicado en 2005

Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones.

artículo científico publicado en 2009

Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans

scientific article published on 01 February 1996

In vivo interconversion of 7β-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress

artículo científico publicado en 2007

Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease.

artículo científico publicado en 1999

Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: Reduction during atorvastatin and fenofibrate therapy

artículo científico publicado en 2006

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients.

artículo científico publicado en 2018

Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases

artículo científico publicado en 2000

Lipoprotein oxidation and progression of carotid atherosclerosis

artículo científico publicado en 1997

Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2'-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men.

artículo científico publicado en 2000

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

artículo científico publicado en 2009

Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status.

artículo científico publicado en 2003

Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)

artículo científico publicado en 2002

Metabolism of 4 beta -hydroxycholesterol in humans.

artículo científico publicado en 2002

Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation

artículo científico publicado en 2011

Microvascular Reactivity in Response to Smoking and Oral Antioxidants in Humans

scientific article published on 01 January 2012

Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism

artículo científico publicado en 2007

Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols.

artículo científico publicado en 1996

Novel pathways of bile acid metabolism involving CYP3A4.

artículo científico publicado en 2005

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid.

artículo científico publicado en 2007

On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions

artículo científico publicado en 2001

On the formation and possible biological role of 25-hydroxycholesterol.

artículo científico

On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO.

artículo científico publicado en 2014

On the origin of the cholestenoic acids in human circulation

artículo científico publicado en 2003

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.

artículo científico publicado en 2002

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

artículo científico publicado en 2001

Oxysterols and Alzheimer's disease.

artículo científico publicado en 2006

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol.

artículo científico publicado en 2001

Oxysterols: friends, foes, or just fellow passengers?

artículo científico publicado en 2002

Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid

artículo científico publicado en 2005

Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients

artículo científico publicado en 2012

Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment

artículo científico publicado en 2014

Phospholipid plasmalogen, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy

artículo científico publicado en 2004

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases.

artículo científico publicado en 2000

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

article

Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study

artículo científico publicado en 2016

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

artículo científico publicado en 2009

Quantitation of receptor ligands by mass spectrometry

artículo científico publicado en 2003

Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin

artículo científico publicado en 2014

Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.

artículo científico publicado en 2014

Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.

artículo científico publicado en 2003

Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study

artículo científico publicado en 2013

Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians

article by E Gebeyehu et al published 16 March 2010 in The Pharmacogenomics Journal

Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers.

artículo científico publicado en 2003

Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms

article

Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.

artículo científico publicado en 2011

Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure

artículo científico publicado en 1999

Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol

scientific journal article

Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes

scientific journal article

The oxysterols cholest-5-ene-3 beta,4 alpha-diol, cholest-5-ene-3 beta,4 beta-diol and cholestane-3 beta,5 alpha,6 alpha-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaques

artículo científico publicado en 1996

Time course of oxysterol formation during in vitro oxidation of low density lipoprotein

artículo científico publicado en 1995

Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy

artículo científico publicado en 2008

Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages

artículo científico publicado en 2004

Transport of side-chain oxidized oxysterols in the human circulation

artículo científico publicado en 1998

Vitamin C reduces cholesterol-induced microcirculatory changes in rabbits

artículo científico publicado en 1997

Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque

artículo científico publicado en 2003

miRNA-27b levels are associated with CYP3A activity in vitro and in vivo

artículo científico publicado en 2015

Lista de obras de Ulf Diczfalusy

24(S),25-epoxycholesterol--a potential friend.

4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians

4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.

4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction

A study of plasmalogen as an index of oxidative stress in patients with chronic renal failure. Evidence of increased oxidative stress in malnourished patients

Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism

Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria

An animal model to study local oxidation of LDL and its biological effects in the arterial wall

Analysis of cholesterol oxidation products in biological samples.

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products

CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels

Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells

Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver

Cloning and regulation of peroxisome proliferator-induced acyl-CoA thioesterases from mouse liver

Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.

Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol.

Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol

Detecting oxysterols in the human circulation

Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry

Diagnostic use of cerebral and extracerebral oxysterols

Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study.

Effect of the oxidation state of LDL on the modulation of arterial vasomotor response in vitro

Effects of high-dose itraconazole treatment on lipoproteins in men.

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin.

Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport

FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.

Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice

From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans

High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?

High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation

Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones.

Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans

In vivo interconversion of 7β-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress

Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease.

Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: Reduction during atorvastatin and fenofibrate therapy

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients.

Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases

Lipoprotein oxidation and progression of carotid atherosclerosis

Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2'-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men.

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status.

Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)

Metabolism of 4 beta -hydroxycholesterol in humans.

Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation

Microvascular Reactivity in Response to Smoking and Oral Antioxidants in Humans

Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism

Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols.

Novel pathways of bile acid metabolism involving CYP3A4.

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid.

On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions

On the formation and possible biological role of 25-hydroxycholesterol.

On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO.

On the origin of the cholestenoic acids in human circulation

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Oxysterols and Alzheimer's disease.

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol.

Oxysterols: friends, foes, or just fellow passengers?

Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid

Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients

Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment

Phospholipid plasmalogen, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases.

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

Quantitation of receptor ligands by mass spectrometry

Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin

Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.

Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.