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Lista de obras de Nir Hacohen

1830. Single-cell Transcriptional Profiling Reveals an Immune Cell State Signature of Bacterial Sepsis

artículo científico publicado en 2019

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

artículo científico publicado en 2016

<i>CXCL9:SPP1</i> macrophage polarity identifies a network of cellular programs that control human cancers

artículo científico publicado en 2023

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks ⬇️

artículo científico publicado en 2015

A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation

artículo científico publicado en 2015

A cell-free antibody engineering platform rapidly generates SARS-CoV-2 neutralizing antibodies

artículo científico publicado en 2020

A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens

scientific article published on 27 August 2018

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.

artículo científico publicado en 2016

A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals

artículo científico publicado en 2012

A large peptidome dataset improves HLA class I epitope prediction across most of the human population

scientific article published on 16 December 2019

A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection

artículo científico publicado en 2009

A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein

artículo científico publicado en 2004

A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression

scientific article published on 18 December 2018

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

article published in 2021

A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma

artículo científico publicado en 2021

ATIM-32. PERSONALIZED NEOANTIGEN-TARGETING VACCINE GENERATES ROBUST SYSTEMIC AND INTRATUMORAL T CELL RESPONSES IN GLIOBLASTOMA (GBM) PATIENTS

Accelerating Medicines Partnership: Organizational Structure and Preliminary Data From the Phase 1 Studies of Lupus Nephritis

artículo científico publicado en 2020

An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling

artículo científico publicado en 2017

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

artículo científico publicado en 2014

An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome

scientific article published on 26 July 2018

An immune-cell signature of bacterial sepsis

artículo científico publicado en 2020

An immunogenic personal neoantigen vaccine for patients with melanoma

artículo científico publicado en 2017

An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion

artículo científico publicado en 2011

Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages

artículo científico publicado en 2017

Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

artículo científico publicado en 2019

Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

scientific article published on 27 April 2020

Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy

scientific article published on 20 January 2020

B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity

artículo científico publicado en 2012

B cells and tertiary lymphoid structures promote immunotherapy response

artículo científico publicado en 2020

CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis

artículo científico publicado en 2014

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

artículo científico publicado en 2014

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

artículo científico publicado en 2018

Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells

artículo científico publicado en 2008

Challenges and recommendations for epigenomics in precision health.

artículo científico publicado en 2017

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

artículo científico publicado en 2009

Common genetic variants modulate pathogen-sensing responses in human dendritic cells

artículo científico publicado en 2014

Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

artículo científico publicado en 2015

Correction: Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease

scientific article published on 01 March 2020

Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma

artículo científico publicado en 2018

Corrigendum: Landscape of X chromosome inactivation across human tissues

scientific article published in Nature

Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq

artículo científico publicado en 2020

Damaged DNA marching out of aging nucleus

artículo científico publicado en 2019

Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli

artículo científico publicado en 2013

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 November 2018

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 January 2019

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

artículo científico publicado en 2019

Differentiation of exhausted CD8<sup>+</sup> T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

artículo científico publicado en 2021

Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy

artículo científico publicado en 2014

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19

artículo científico publicado en 2021

Editorial overview: Cancer immunology: genomics & biomarkers: Cancer immunity through the prism of genomics and proteomics

artículo científico publicado en 2016

Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans

artículo científico publicado en 2011

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

artículo científico publicado en 2013

Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

artículo científico publicado en 2009

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

scientific article published on 31 January 2019

Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade

scientific article published on 09 September 2020

Forward RNAi screens in primary human hematopoietic stem/progenitor cells

artículo científico publicado en 2009

Full-length transcriptome assembly from RNA-Seq data without a reference genome

artículo científico publicado en 2011

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

artículo científico publicado en 2017

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

artículo científico publicado en 2018

GeNets: a unified web platform for network-based genomic analyses.

artículo científico publicado en 2018

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection

Genome-scale loss-of-function screening with a lentiviral RNAi library

artículo científico publicado en 2006

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

artículo científico publicado en 2020

Genome-wide enhancer maps link risk variants to disease genes

scientific article published on 07 April 2021

Getting personal with neoantigen-based therapeutic cancer vaccines

artículo científico publicado en 2013

HLA-binding properties of tumor neoepitopes in humans

artículo científico

Heavy Metal Enlightens Tumor Immunity.

artículo científico publicado en 2017

High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies

artículo científico publicado en 2014

Highly parallel identification of essential genes in cancer cells

scholarly article

How T cells spot tumour cells

artículo científico publicado en 2017

Human STING is a proton channel

artículo científico publicado en 2023

Human systems immunology: hypothesis-based modeling and unbiased data-driven approaches

artículo científico publicado en 2013

IAP inhibitors enhance co-stimulation to promote tumor immunity ⬇️

artículo científico publicado el 13 de septiembre de 2010

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach

artículo científico publicado en 2012

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation

artículo científico

Immune receptor repertoires in pediatric and adult acute myeloid leukemia

scientific article published on 26 November 2019

Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens

artículo científico publicado en 2015

Immunology. Flow cytometry, amped up

artículo científico publicado en 2011

Impact of autoimmune risk alleles on the immune system

artículo científico publicado en 2015

In vivo discovery of immunotherapy targets in the tumour microenvironment

artículo científico publicado en 2014

Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19

scientific article published on 02 September 2020

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

artículo científico publicado en 2014

Integrated urine proteomics and renal single-cell genomics identify an interferon-γ response gradient in lupus nephritis

scientific article published on 12 May 2020

Intersection of population variation and autoimmunity genetics in human T cell activation

artículo científico publicado en 2014

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

artículo científico publicado en 2020

Landscape of B cell immunity and related immune evasion in human cancers

artículo científico publicado en 2019

Landscape of X chromosome inactivation across human tissues

artículo científico publicado en 2017

Landscape of X chromosome inactivation across human tissues

Landscape of tumor-infiltrating T cell repertoire of human cancers

artículo científico publicado en 2016

Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer

scientific article published on 18 August 2020

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

artículo científico publicado en 2019

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

artículo científico publicado en 2016

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia

artículo científico publicado en 2014

Loss of the nuclear protein RTF2 enhances influenza replication

artículo científico publicado en 2020

Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b

artículo científico publicado en 2011

MAUDE: Inferring expression changes in sorting-based CRISPR screens

artículo científico publicado en 2019

MAUDE: inferring expression changes in sorting-based CRISPR screens

artículo científico publicado en 2020

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction

artículo científico publicado en 2017

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling

scientific article published on 12 August 2020

Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.

artículo científico publicado en 2015

Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells

artículo científico publicado en 2011

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue

artículo científico publicado en 2018

Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. ⬇️

artículo científico publicado en 2012

Minimizing the risk of reporting false positives in large-scale RNAi screens

article

Molecular and genetic properties of tumors associated with local immune cytolytic activity

artículo científico publicado en 2015

Monitoring T cell-dendritic cell interactions in vivo by intercellular enzymatic labelling

artículo científico publicado en 2018

Multiplexed enrichment and genomic profiling of peripheral blood cells reveal subset-specific immune signatures

scientific article published on 23 January 2019

Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs

artículo científico publicado en 2014

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program

artículo científico publicado en 2015

MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties

artículo científico publicado en 2011

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

artículo científico publicado en 2010

Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia

artículo científico publicado en 2012

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

scientific article published on 19 December 2018

Neoantigens encoded in the cancer genome

artículo científico publicado en 2016

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells

artículo científico publicado en 2010

OR.80. Identifying Regulators of Cytokine Production in Primary Human T-Cells Using a Lentiviral RNAi Library

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

scientific article published on 29 July 2019

Parsing the Interferon Transcriptional Network and Its Disease Associations

artículo científico publicado en 2016

Peroxisomes are signaling platforms for antiviral innate immunity

artículo científico publicado en 2010

Personal Neoantigen Cancer Vaccines: A Road Not Fully Paved

artículo científico publicado en 2020

Personal neoantigen cancer vaccines: The momentum builds

artículo científico publicado en 2014

Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites

artículo científico publicado en 2014

Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients

artículo científico publicado en 2020

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

artículo científico publicado en 2014

Positional specificity of different transcription factor classes within enhancers

article published in the Proceedings of the National Academy of Sciences of the United States of America

Principles and strategies for developing network models in cancer

artículo científico publicado en 2011

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

artículo científico publicado en 2020

Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers

artículo científico publicado en 2019

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

artículo científico publicado en 2019

RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts

artículo científico publicado en 2006

RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels

artículo científico publicado en 2009

RNAi screen for kinases and phosphatases that play a role in antigen presentation by dendritic cells ⬇️

artículo científico publicado el 12 de junio de 2012

Rab27a and Rab27b control different steps of the exosome secretion pathway

artículo científico publicado en 2010

Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial

artículo científico publicado en 2021

Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL

artículo científico publicado en 2008

Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs

artículo científico publicado en 2002

Resistance to checkpoint blockade therapy through inactivation of antigen presentation.

artículo científico publicado en 2017

Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion

scientific article published on 19 December 2013

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs

artículo científico publicado en 2020

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

artículo científico publicado en 2011

SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

artículo científico publicado en 2020

Semiconductor-based DNA sequencing of histone modification states

artículo científico publicado en 2013

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

artículo científico publicado en 2018

Simultaneous profiling of gene expression and chromatin accessibility in single cells

scientific article published on 28 August 2019

Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker

artículo científico publicado en 2020

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

artículo científico publicado en 2014

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

artículo científico publicado en 2017

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

artículo científico publicado en 2013

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.

artículo científico publicado en 2014

Strategies to discover regulatory circuits of the mammalian immune system

artículo científico publicado en 2011

Streamlined Protocol for Deep Proteomic Profiling of FAC-sorted Cells and Its Application to Freshly Isolated Murine Immune Cells

scientific article published on 21 February 2019

Synaptotagmin-mediated vesicle fusion regulates cell migration

artículo científico publicado en 2010

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

artículo científico publicado en 2020

Systematic discovery of TLR signaling components delineates viral-sensing circuits

artículo científico publicado en 2011

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia

artículo científico publicado en 2014

Systems Immunology: Learning the Rules of the Immune System

artículo científico publicado en 2018

Systems biology approaches to dissect mammalian innate immunity ⬇️

artículo científico publicado el 24 de noviembre de 2010

TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells.

artículo científico publicado en 2011

Targeting individual cells by barcode in pooled sequence libraries

scientific article published on 01 January 2019

Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection

scientific article published on 02 August 2020

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

artículo científico publicado en 2018

The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages

artículo científico publicado en 2020

The Human Cell Atlas

artículo científico publicado en 2017

The Human Cell Atlas

The Human Cell Atlas White Paper ⬇️

artículo científico publicado en 2018

The immune cell landscape in kidneys of patients with lupus nephritis

artículo científico publicado en 2019

The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis

artículo científico publicado en 2020

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection

artículo científico publicado en 2014

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

artículo científico publicado en 2015

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

artículo científico publicado en 2013

The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells

artículo científico publicado en 2009

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

artículo científico publicado en 2020

Transcriptomic Analysis and High-dimensional Phenotypic Mapping of Mononuclear Phagocytes in Mesenteric Lymph Nodes Reveal Differences Between Ulcerative Colitis and Crohn's Disease

scientific article published on 01 March 2020

Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory

artículo científico publicado en 2002

Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease

scientific article published on 22 January 2019

Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses

artículo científico publicado en 2009

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

artículo científico publicado en 2020

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