Lista de obras - Angel F. Lopez - Dominio Público Uruguay

14-3-3 protein signaling in development and growth factor responses.

artículo científico publicado en 2005

14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival.

artículo científico publicado en 2009

14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain.

artículo científico publicado en 2014

14-3-3ζ coordinates adipogenesis of visceral fat.

artículo científico publicado en 2015

14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders

artículo científico publicado en 2015

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

artículo científico publicado en 2016

1H and 15N chemical shift assignments for domain 4 of the common beta-chain of the IL-3, IL-5 and GM-CSF receptors

artículo científico publicado en 1999

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis.

artículo científico publicado en 2015

A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia

artículo científico publicado en 2014

A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor.

artículo científico publicado en 1996

A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

artículo científico publicado en 2008

A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis

artículo científico publicado en 2016

A phase I study of the GM-CSF antagonist E21R

artículo científico publicado en 2002

A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr

artículo científico publicado en 1996

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

artículo científico publicado en 2018

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.

artículo científico publicado en 2010

Antibody dependent cell-mediated cytotoxicity of Trypanosoma cruzi: the release of tritium-labelled RNA, DNA and protein ⬇️

artículo científico publicado el 1 de junio de 1978

Antibody-dependent cytotoxicity of Trypanosoma cruzi antigen-coated mouse cell lines by eosinophils and neutrophils

scientific article published on 01 January 1983

Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors

artículo científico publicado en 2010

C-fms protein expression by B-cells, with particular reference to the hairy cells of hairy-cell leukaemia

artículo científico publicado en 1993

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

artículo científico publicado en 2015

Carbohydrate-specific monoclonal antibodies bind to human granulocytes and stimulate antibody-dependent cellular cytotoxicity.

artículo científico

Characterization of a distinct population of circulating human non-adherent endothelial forming cells and their recruitment via intercellular adhesion molecule-3

artículo científico publicado en 2012

Characterization of human leucocytes bearing the IL-3 receptor.

artículo científico publicado en 1996

Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo

artículo científico publicado en 2002

Comment on "KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study".

artículo científico publicado en 2017

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

artículo científico publicado en 2016

Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition

artículo científico publicado en 1997

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

scientific article published on 19 February 2014

Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex

artículo científico publicado en 2008

Cytokine receptor activation at the cell surface

artículo científico

Differential binding of IL-3 and GM-CSF to human monocytes

artículo científico publicado en 1992

Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells.

artículo científico publicado en 2006

Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies

scientific article published on 01 July 1984

Down-modulation of receptors for granulocyte colony-stimulating factor on human neutrophils by granulocyte-activating agents

scientific article published on 01 September 1986

Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity

artículo científico publicado en 2011

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

artículo científico publicado en 2021

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody

artículo científico publicado en 2014

Effect of GM-CSF on HIV-1 replication in monocytes/macrophages in vivo and in vitro: a review

artículo científico publicado en 1998

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

artículo científico publicado en 2015

Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes ⬇️

artículo científico publicado el 28 de julio de 1977

Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state ⬇️

artículo científico publicado el 22 de marzo de 2013

Epitope diversity of monoclonal antibodies revealed by cross-species reactivity

artículo científico publicado en 1984

Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice

artículo científico publicado en 2010

Examination of the role of the proteolytically-activated form of protein kinase C in the differentiation of human haemopoietic cells

artículo científico publicado en 1992

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML.

artículo científico publicado en 2009

Functional neutrophils from long-term murine bone marrow cell cultures

artículo científico publicado en 1987

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells.

artículo científico publicado en 1992

Granulocyte-macrophage colony-stimulating factor augments phagocytosis of Mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo.

artículo científico publicado en 2000

Granulocyte-macrophage colony-stimulating factor inhibits HIV-1 replication in monocyte-derived macrophages

artículo científico publicado en 2000

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch

artículo científico publicado en 2006

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

artículo científico publicado en 2013

Human interleukin 4 regulates the phenotype of lymphocytes generated during mixed lymphocyte culture and inhibits the IL-2-induced development of LAK function in normal and leukaemic cells

artículo científico publicado en 1989

Human interleukin-3 inhibits the binding of granulocyte-macrophage colony-stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity

artículo científico publicado en 1990

IL-3, IL-5, granulocyte-macrophage colony-stimulating factor receptor alpha-subunit, and common beta-subunit expression by peripheral leukocytes and blood dendritic cells

scientific article published on 01 May 1998

Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three recepto

artículo científico publicado en 1998

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

scientific article published on 13 March 2012

In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3ζ KO mouse model of schizophrenia-like disorders.

artículo científico publicado en 2015

Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation.

artículo científico publicado en 1996

Interleukin 4 is at 5q31 and interleukin 6 is at 7p15

scientific article published on 01 August 1988

Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties.

artículo científico publicado en 2015

Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia

artículo científico publicado en 2014

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling

artículo científico publicado en 2015

Locomotor hyperactivity in 14-3-3ζ KO mice is associated with dopamine transporter dysfunction.

artículo científico publicado en 2013

Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation

artículo científico publicado en 2014

Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex.

artículo científico publicado en 2002

Molecular basis of cytokine receptor activation

artículo científico publicado en 2010

Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly

artículo científico publicado en 1999

Molecular targets of FTY720 (fingolimod).

artículo científico

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

artículo científico publicado en 2013

Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells

artículo científico publicado en 2009

Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells

artículo científico publicado en 1986

Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency

artículo científico publicado en 2011

New approaches in the treatment of asthma.

artículo científico publicado en 2001

New frontiers for IL-5

scientific article published on 01 June 1997

Perverted responses of the human granulocyte-macrophage colony-stimulating factor receptor in mouse cell lines due to cross-species beta-subunit association.

artículo científico publicado en 2001

Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?

artículo científico publicado en 2007

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

artículo científico publicado en 2013

Proteome Analysis of Drosophila Mutants Identifies a Regulatory Role for 14-3-3ε in Metabolic Pathways

artículo científico publicado en 2017

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

artículo científico publicado en 2008

Receptors of the cytokine superfamily: mechanisms of activation and involvement in disease.

artículo científico publicado en 1997

Regulation of haematopoiesis by growth factors - emerging insights and therapies

artículo científico publicado en 2004

Regulatory roles of IL-10-producing human follicular T cells

artículo científico publicado en 2019

Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity

artículo científico publicado en 2017

Signalling by the βc family of cytokines

artículo científico

Specific human granulocyte-macrophage colony-stimulating factor antagonists.

artículo científico publicado en 1994

Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism.

artículo científico publicado en 2005

Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.

artículo científico publicado en 2010

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

artículo científico publicado en 2008

TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy

artículo científico publicado en 2016

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription.

artículo científico publicado en 2013

Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor.

artículo científico publicado en 2013

Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC.

artículo científico publicado en 2014

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

artículo científico publicado en 2016

The Apoptosis-inducing Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Analog E21R Functions through Specific Regions of the Heterodimeric GM-CSF Receptor and Requires Interleukin-1β-converting Enzyme-like Proteases

artículo científico publicado en 1997

The GM-CSF receptor family: mechanism of activation and implications for disease

artículo científico publicado en 2012

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

artículo científico publicado en 2012

The IIb-IIIa glycoprotein complex that mediates platelet aggregation is directly implicated in leukocyte adhesion

artículo científico publicado en 1986

The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation

scientific article published on 27 October 2016

The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis

artículo científico publicado en 2007

The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface

artículo científico publicado en 2003

The functional basis of granulocyte-macrophage colony stimulating factor, interleukin-3 and interleukin-5 receptor activation, basic and clinical implications.

artículo científico publicado en 1999

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

artículo científico publicado en 2009

The lysis of Trypanosoma cruzi epimastigotes by eosinophils and neutrophils

artículo científico publicado el 1 de diciembre de 1978

The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappaB and induction of bcl-2.

artículo científico publicado en 2003

The role of disulfide-linked dimerization in interleukin-3 receptor signaling and biological activity.

artículo científico publicado en 2000

The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5

artículo científico publicado en 2000

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

artículo científico publicado en 2008

The βc receptor family - Structural insights and their functional implications

artículo científico

Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins

artículo científico publicado en 2003

Vitamin D(3) signalling to mast cells: A new regulatory axis

artículo científico publicado en 2010

Ywhaz/14-3-3ζ Deletion Improves Glucose Tolerance Through a GLP-1-Dependent Mechanism

artículo científico publicado en 2016

Lista de obras de Angel F. Lopez

14-3-3 protein signaling in development and growth factor responses.

14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival.

14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain.

14-3-3ζ coordinates adipogenesis of visceral fat.

14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

1H and 15N chemical shift assignments for domain 4 of the common beta-chain of the IL-3, IL-5 and GM-CSF receptors

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis.

A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia

A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor.

A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis

A phase I study of the GM-CSF antagonist E21R

A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.

Antibody dependent cell-mediated cytotoxicity of Trypanosoma cruzi: the release of tritium-labelled RNA, DNA and protein ⬇️

Antibody-dependent cytotoxicity of Trypanosoma cruzi antigen-coated mouse cell lines by eosinophils and neutrophils

Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors

C-fms protein expression by B-cells, with particular reference to the hairy cells of hairy-cell leukaemia

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

Carbohydrate-specific monoclonal antibodies bind to human granulocytes and stimulate antibody-dependent cellular cytotoxicity.

Characterization of a distinct population of circulating human non-adherent endothelial forming cells and their recruitment via intercellular adhesion molecule-3

Characterization of human leucocytes bearing the IL-3 receptor.

Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo

Comment on "KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study".

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex

Cytokine receptor activation at the cell surface

Differential binding of IL-3 and GM-CSF to human monocytes

Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells.

Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies

Down-modulation of receptors for granulocyte colony-stimulating factor on human neutrophils by granulocyte-activating agents

Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody

Effect of GM-CSF on HIV-1 replication in monocytes/macrophages in vivo and in vitro: a review

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes ⬇️

Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state ⬇️

Epitope diversity of monoclonal antibodies revealed by cross-species reactivity

Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice

Examination of the role of the proteolytically-activated form of protein kinase C in the differentiation of human haemopoietic cells

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML.

Functional neutrophils from long-term murine bone marrow cell cultures

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells.

Granulocyte-macrophage colony-stimulating factor augments phagocytosis of Mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo.

Granulocyte-macrophage colony-stimulating factor inhibits HIV-1 replication in monocyte-derived macrophages

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

Human interleukin 4 regulates the phenotype of lymphocytes generated during mixed lymphocyte culture and inhibits the IL-2-induced development of LAK function in normal and leukaemic cells

Human interleukin-3 inhibits the binding of granulocyte-macrophage colony-stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity

IL-3, IL-5, granulocyte-macrophage colony-stimulating factor receptor alpha-subunit, and common beta-subunit expression by peripheral leukocytes and blood dendritic cells

Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three recepto

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3ζ KO mouse model of schizophrenia-like disorders.

Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation.

Interleukin 4 is at 5q31 and interleukin 6 is at 7p15

Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties.

Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling

Locomotor hyperactivity in 14-3-3ζ KO mice is associated with dopamine transporter dysfunction.

Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation

Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex.

Molecular basis of cytokine receptor activation

Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly

Molecular targets of FTY720 (fingolimod).

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells

Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells

Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency

New approaches in the treatment of asthma.

New frontiers for IL-5

Perverted responses of the human granulocyte-macrophage colony-stimulating factor receptor in mouse cell lines due to cross-species beta-subunit association.

Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

Proteome Analysis of Drosophila Mutants Identifies a Regulatory Role for 14-3-3ε in Metabolic Pathways