Lista de obras - Ulf Nilsson - Dominio Público Uruguay

1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

artículo científico publicado en 2010

3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3.

artículo científico publicado en 2005

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

scientific article published on 12 December 2019

A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1

scientific article published on 02 August 2019

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

artículo científico publicado en 2016

A study of the donor properties of sialyl phosphites having an auxiliary 3-(S)-phenylseleno group

artículo científico publicado en 2001

Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface

artículo científico

Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors

artículo científico publicado en 2019

An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

scientific article published on 23 January 2019

Arene-anion based arginine-binding motif on a galactose scaffold: structure-activity relationships of interactions with arginine-rich galectins

artículo científico publicado en 2011

Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors

artículo científico publicado en 2008

Arynes in the Monoarylation of Unprotected Carbohydrate Amines

artículo científico publicado en 2018

C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions

artículo científico publicado en 2005

Carbohydrate functionalization using cationic iron carbonyl complexes

artículo científico publicado en 2008

Comparative 1H NMR study of hydroxy protons in galabioside and its S-linked 4-thiodisaccharide analogue in aqueous solution

artículo científico publicado en 1999

Conformational studies on phenyl thioglycosides: a remote effect on disaccharide linkage by phenyl aglycons attenuates recognition of galabiosides by a bacterial adhesin

artículo científico publicado en 2003

Coupling of <i>N</i>-tosylhydrazones with tetrazoles: synthesis of 2-β-D-glycopyranosylmethyl-5-substituted-2<i>H</i>-tetrazole type glycomimetics

artículo científico publicado en 2020

Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.

artículo científico publicado en 2017

Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides

artículo científico publicado en 2008

Efficient O-Functionalization of Carbohydrates with Electrophilic Reagents

artículo científico publicado en 2016

Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: galectin oligosaccharide specificity studies in a fluorescence polarization assay.

artículo científico publicado en 2003

Epimers Switch Galectin-9 Domain Selectivity: 3N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal

scientific article published on 04 December 2019

Extracellular and intracellular small-molecule galectin-3 inhibitors

Flap Dynamics in Aspartic Proteases: A Computational Perspective

artículo científico publicado en 2016

Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions

artículo científico publicado en 2004

Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3.

artículo científico publicado en 2009

Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin

artículo científico publicado en 2004

Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury

artículo científico publicado en 2014

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

artículo científico publicado en 2010

Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice

artículo científico publicado en 2012

Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro

artículo científico publicado en 2013

Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types

artículo científico publicado en 2012

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

artículo científico publicado en 2016

Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells

artículo científico publicado en 2008

Haemophilus influenzae surface fibril (Hsf) is a unique twisted hairpin-like trimeric autotransporter

artículo científico publicado en 2014

Human trophoblast requires galectin-3 for cell migration and invasion

artículo científico publicado en 2019

Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

artículo científico publicado en 2016

Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor

artículo científico publicado en 2011

In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors

scientific article published on 03 January 2020

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor

artículo científico publicado en 2012

Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection

artículo científico publicado en 2010

Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding

scientific article published on 23 January 2019

Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors

artículo científico publicado en 2013

Ligand binding and complex formation of galectin-3 is modulated by pH variations

artículo científico publicado en 2014

Ligand induced galectin-3 protein self-association

artículo científico publicado en 2012

Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans

artículo científico publicado en 2016

Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers

artículo científico publicado en 2005

Monovalent interactions of galectin-1

artículo científico publicado en 2010

Multimeric lactoside "click clusters" as tools to investigate the effect of linker length in specific interactions with peanut lectin, galectin-1, and -3.

artículo científico publicado en 2010

Mutational tuning of galectin-3 specificity and biological function

artículo científico publicado en 2010

Oligosaccharide-receptor interaction of the Gal alpha 1-4Gal binding adhesin of Streptococcus suis. Combining site architecture and characterization of two variant adhesin specificities.

artículo científico publicado en 1994

PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein.

artículo científico publicado en 1996

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.

artículo científico publicado en 2016

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C

artículo científico publicado en 2016

Physical properties of Escherichia coli P pili measured by optical tweezers

artículo científico publicado en 2004

Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

artículo científico publicado en 2011

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

artículo científico publicado en 2010

Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.

artículo científico publicado en 2008

Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides

artículo científico publicado en 2003

Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain

scientific article published on 01 August 2018

Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations.

artículo científico publicado en 2017

Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3

artículo científico publicado en 2012

Solid-phase extraction for combinatorial libraries.

artículo científico publicado en 2000

Spindle pole cohesion requires glycosylation-mediated localization of NuMA.

artículo científico publicado en 2017

Stereo- and regioselective hydroboration of 1-exo-methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors.

artículo científico publicado en 2019

Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction

artículo científico publicado en 2005

Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose

artículo científico

Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

artículo científico publicado en 2015

Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli

artículo científico

Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions

artículo científico publicado en 2019

Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins

artículo científico publicado en 2005

Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters

artículo científico

Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects

scientific article published on 01 January 2019

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.

artículo científico publicado en 2018

Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists

artículo científico publicado en 2014

Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.

artículo científico publicado en 2009

Synthesis of 3-azido-3-deoxy-beta-D-galactopyranosides.

artículo científico publicado en 2009

Synthesis of GD3-lactam: a potential ligand for the development of an anti-melanoma vaccine

artículo científico publicado en 2002

Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors

artículo científico publicado en 2005

Synthesis of a 3'-naphthamido-LacNAc fluorescein conjugate with high selectivity and affinity for galectin-3

scientific article published on 15 May 2006

Synthesis of a globotetraose trimer

artículo científico publicado en 2002

Synthesis of a phenyl thio-beta-D-galactopyranoside library from 1,5-difluoro-2,4-dinitrobenzene: discovery of efficient and selective monosaccharide inhibitors of galectin-7.

artículo científico publicado en 2005

Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors

scientific article published on 14 March 2007

Synthesis of multivalent lactose derivatives by 1,3-dipolar cycloadditions: selective galectin-1 inhibition

scientific article published on 15 May 2006

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity

artículo científico publicado en 2017

Taloside inhibitors of galectin-1 and galectin-3

artículo científico publicado en 2012

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

artículo científico publicado en 2012

The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins

artículo científico publicado en 2011

The role of Galectin-3 in α-synuclein-induced microglial activation

artículo científico publicado en 2014

Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors

artículo científico publicado en 2005

Tri-isopropylsilyl thioglycosides as masked glycosyl thiol nucleophiles for the synthesis of S-linked glycosides and glyco-conjugates

artículo científico publicado en 2014

Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1

scientific article published on 23 January 2013

Lista de obras de Ulf Nilsson

1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3.

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

A study of the donor properties of sialyl phosphites having an auxiliary 3-(S)-phenylseleno group

Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface

Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors

An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

Arene-anion based arginine-binding motif on a galactose scaffold: structure-activity relationships of interactions with arginine-rich galectins

Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors

Arynes in the Monoarylation of Unprotected Carbohydrate Amines

C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions

Carbohydrate functionalization using cationic iron carbonyl complexes

Comparative 1H NMR study of hydroxy protons in galabioside and its S-linked 4-thiodisaccharide analogue in aqueous solution

Conformational studies on phenyl thioglycosides: a remote effect on disaccharide linkage by phenyl aglycons attenuates recognition of galabiosides by a bacterial adhesin

Coupling of <i>N</i>-tosylhydrazones with tetrazoles: synthesis of 2-β-D-glycopyranosylmethyl-5-substituted-2<i>H</i>-tetrazole type glycomimetics

Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.

Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides

Efficient O-Functionalization of Carbohydrates with Electrophilic Reagents

Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: galectin oligosaccharide specificity studies in a fluorescence polarization assay.

Epimers Switch Galectin-9 Domain Selectivity: 3N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal

Extracellular and intracellular small-molecule galectin-3 inhibitors

Flap Dynamics in Aspartic Proteases: A Computational Perspective

Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions

Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3.

Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin

Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice

Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro

Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells

Haemophilus influenzae surface fibril (Hsf) is a unique twisted hairpin-like trimeric autotransporter

Human trophoblast requires galectin-3 for cell migration and invasion

Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release

Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor

In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor

Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection

Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding

Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors

Ligand binding and complex formation of galectin-3 is modulated by pH variations

Ligand induced galectin-3 protein self-association

Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans

Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers

Monovalent interactions of galectin-1

Multimeric lactoside "click clusters" as tools to investigate the effect of linker length in specific interactions with peanut lectin, galectin-1, and -3.

Mutational tuning of galectin-3 specificity and biological function

Oligosaccharide-receptor interaction of the Gal alpha 1-4Gal binding adhesin of Streptococcus suis. Combining site architecture and characterization of two variant adhesin specificities.

PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein.

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C

Physical properties of Escherichia coli P pili measured by optical tweezers

Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.

Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides

Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain

Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations.

Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3

Solid-phase extraction for combinatorial libraries.

Spindle pole cohesion requires glycosylation-mediated localization of NuMA.

Stereo- and regioselective hydroboration of 1-exo-methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors.

Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction

Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose

Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli

Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions

Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins

Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters

Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.

Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists

Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.

Synthesis of 3-azido-3-deoxy-beta-D-galactopyranosides.

Synthesis of GD3-lactam: a potential ligand for the development of an anti-melanoma vaccine

Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors