Lista de obras - Julián Gómez-Cambronero

A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration

artículo científico publicado en 2013

A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells

artículo científico publicado en 2016

A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells

scientific article published on 23 December 2016

A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells

artículo científico publicado en 2013

A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism

artículo científico publicado en 2011

A systematic approach to the complete study of a signaling molecule: ribosomal p90rsk as an example

artículo científico publicado en 2001

Binding of GM-CSF to adherent neutrophils activates phospholipase D

artículo científico publicado en 1999

Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).

artículo científico publicado en 2012

Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).

artículo científico publicado en 2011

Characteristics of the binding of platelet-activating factor to platelets of different animal species.

artículo científico publicado en 1984

Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion

artículo científico publicado en 2015

Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.

artículo científico publicado en 2011

How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD.

artículo científico publicado en 2017

Human cell line that differentiates to all myeloid lineages and expresses neutrophil secondary granule genes.

artículo científico publicado en 2000

IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)

artículo científico publicado en 2011

Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity

artículo científico publicado en 2012

Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras

artículo científico publicado en 2012

Intracellular localization of platelet-activating factor synthesis in human neutrophils

artículo científico publicado en 1988

Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression

artículo científico publicado en 2013

Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function.

artículo científico publicado en 2010

Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model

artículo científico publicado en 2014

Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase

artículo científico publicado en 2003

Modulation of lyso-platelet activating factor: acetyl-CoA acetyltransferase from rat splenic microsomes. The role of cyclic AMP-dependent protein kinase

artículo científico publicado en 1985

Modulation of lyso-platelet-activating factor:acetyl-CoA acetyltransferase from rat splenic microsomes. The role of calcium ions

artículo científico publicado en 1985

New concepts in phospholipase D signaling in inflammation and cancer.

artículo científico publicado en 2010

Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF.

artículo científico publicado en 2005

PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases.

artículo científico publicado en 2016

Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.

artículo científico publicado en 2006

Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor

artículo científico publicado en 2015

Phosphatidic acid, phospholipase D and tumorigenesis.

scientific article published on 19 September 2013

Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.

artículo científico publicado en 2014

Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action

artículo científico publicado en 2011

Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR

artículo científico publicado en 2007

Phospholipase D: a novel major player in signal transduction

artículo científico publicado en 1998

Presence of a phospholipase D (PLD) distinct from PLD1 or PLD2 in human neutrophils: immunobiochemical characterization and initial purification.

artículo científico publicado en 2001

Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD

artículo científico publicado en 2004

Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis

artículo científico publicado en 2007

Synthesis of PAF-acether and blood volume changes in gram-negative sepsis

scientific article published on 01 February 1985

The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF

artículo científico publicado en 2007

The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7

artículo científico publicado en 1987

The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis

artículo científico publicado en 2011

The elucidation of novel SH2 binding sites on PLD2

artículo científico publicado en 2006

The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).

artículo científico publicado en 2011

The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D

artículo científico publicado en 2014

The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion

artículo científico publicado en 2015

The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2.

artículo científico publicado en 2005

Thematic minireview series on phospholipase D and cancer

artículo científico publicado en 2014

Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment

article by Sandra Muñoz-Galván et al published 10 October 2018 in Oncogene

Tyrosine phosphorylation in human neutrophil

artículo científico publicado en 1989

Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.

artículo científico publicado en 2009

Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis.

artículo científico publicado en 2007

p42-MAP kinase is activated in EGF-stimulated interphase but not in metaphase-arrested HeLa cells.

artículo científico publicado en 1999

Lista de obras de Julián Gómez-Cambronero

A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration

A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells

A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells

A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells

A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism

A systematic approach to the complete study of a signaling molecule: ribosomal p90rsk as an example

Binding of GM-CSF to adherent neutrophils activates phospholipase D

Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).

Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).

Characteristics of the binding of platelet-activating factor to platelets of different animal species.

Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion

Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.

How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD.

Human cell line that differentiates to all myeloid lineages and expresses neutrophil secondary granule genes.

IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)

Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity

Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras

Intracellular localization of platelet-activating factor synthesis in human neutrophils

Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression

Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function.

Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model

Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase

Modulation of lyso-platelet activating factor: acetyl-CoA acetyltransferase from rat splenic microsomes. The role of cyclic AMP-dependent protein kinase

Modulation of lyso-platelet-activating factor:acetyl-CoA acetyltransferase from rat splenic microsomes. The role of calcium ions

New concepts in phospholipase D signaling in inflammation and cancer.

Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF.

PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases.

Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.

Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor

Phosphatidic acid, phospholipase D and tumorigenesis.

Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.

Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action

Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR

Phospholipase D: a novel major player in signal transduction

Presence of a phospholipase D (PLD) distinct from PLD1 or PLD2 in human neutrophils: immunobiochemical characterization and initial purification.

Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD

Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis

Synthesis of PAF-acether and blood volume changes in gram-negative sepsis

The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF

The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7

The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis

The elucidation of novel SH2 binding sites on PLD2

The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).

The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D

The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion

The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2.

Thematic minireview series on phospholipase D and cancer

Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment

Tyrosine phosphorylation in human neutrophil

Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.

Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis.

p42-MAP kinase is activated in EGF-stimulated interphase but not in metaphase-arrested HeLa cells.