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Lista de obras de Felix Sahm

A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas

artículo científico publicado en 2018

A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma-like features and Nuclear Clusters (DGONC)

artículo científico publicado en 2020

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

artículo científico publicado en 2024

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

scientific article published on 01 November 2020

A vaccine targeting mutant IDH1 induces antitumour immunity

artículo científico publicado en 2014

ACTR-61. LONG-TERM ANALYSES OF THE NOA-08 RANDOMIZED PHASE III TRIAL

AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry

artículo científico publicado en 2013

ANGI-08RADIOGENOMIC rCBV-IMAGING VISUALIZES THE DISTINCT ANGIOGENESIS TRANSCRIPTOME SIGNATURES OF IDH MUTANT AND WILD-TYPE GLIOMAS.

artículo científico publicado en 2015

ATIM-33. NOA-16: A FIRST-IN-MAN MULTICENTER PHASE I CLINICAL TRIAL OF THE GERMAN NEUROONCOLOGY WORKING GROUP EVALUATING A MUTATION-SPECIFIC PEPTIDE VACCINE TARGETING IDH1R132H IN PATIENTS WITH NEWLY DIAGNOSED MALIGNANT ASTROCYTOMAS

ATIM-35. VXM01 PHASE I STUDY IN PATIENTS WITH PROGRESSIVE GLIOBLASTOMA – FINAL RESULTS

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

artículo científico publicado en 2014

Abstract 4736: N-myc downstream regulated gene 1: A novel mediator of hypoxia-driven chemoresistance in glioblastoma

article

Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data

artículo científico publicado en 2020

Addressing diffuse glioma as a systemic brain disease with single-cell analysis

artículo científico publicado en 2011

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

artículo científico publicado en 2015

Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

artículo científico publicado en 2023

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

artículo científico publicado en 2011

An integrative histopathological and epigenetic characterization of primary intracranial mesenchymal tumors, FET:CREB-fused broadening the spectrum of tumor entities in comparison with their soft tissue counterparts

artículo científico publicado en 2021

An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data

artículo científico publicado en 2020

Analysis of CIC-associated CpG island methylation in oligoastrocytoma.

artículo científico publicado en 2013

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

artículo científico publicado en 2018

Application of mutant IDH1 antibody to differentiate diffuse glioma from nonneoplastic central nervous system lesions and therapy-induced changes

artículo científico publicado en 2010

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

artículo científico publicado en 2018

Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multi-pool CEST MRI at 7.0 Tesla.

artículo científico publicado en 2018

Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody

artículo científico publicado en 2011

Automated quantitative tumour response assessment of MRI in neuro-oncology with artificial neural networks: a multicentre, retrospective study

artículo científico publicado en 2019

Automatic Analysis of Cellularity in Glioblastoma and Correlation with ADC Using Trajectory Analysis and Automatic Nuclei Counting

artículo científico publicado en 2016

BRAF V600E expression and distribution in desmoplastic infantile astrocytoma/ganglioglioma.

artículo científico publicado en 2014

BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression

artículo científico publicado en 2014

BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis.

artículo científico publicado en 2012

Brain tumour cells interconnect to a functional and resistant network

artículo científico publicado en 2015

CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

scientific article published on 08 July 2020

CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas

artículo científico publicado en 2012

Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated <i>ROS1/NTRK</i>-Fusion Positive Pediatric High-Grade Glioma

artículo científico publicado en 2020

Cerebrospinal Fluid cfDNA Sequencing for Classification of Central Nervous System Glioma

artículo científico publicado en 2024

Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength

artículo científico publicado en 2020

Chemical exchange saturation transfer (CEST) signal intensity at 7T MRI of WHO IV° gliomas is dependent on the anatomic location

artículo científico publicado en 2018

Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p

artículo científico publicado en 2018

Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1

artículo científico publicado en 2020

Clinical Significance of Molecular Diagnosis of Pilocytic Astrocytoma: A Case Report

scientific article published on 05 June 2019

Clinical characteristics and prognostic factors of adult patients with pilocytic astrocytoma

scientific article published on 27 April 2020

Comparative evaluation of T-cell receptors in experimental glioma-draining lymph nodes

artículo científico publicado en 2021

Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ

artículo científico publicado en 2020

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.

artículo científico publicado en 2014

Correlated MRI and Ultramicroscopy (MR-UM) of Brain Tumors Reveals Vast Heterogeneity of Tumor Infiltration and Neoangiogenesis in Preclinical Models and Human Disease

Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness.

artículo científico publicado en 2011

Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

artículo científico publicado en 2021

Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

artículo científico publicado en 2019

DNA Methylation Associates With Clinical Courses of Atypical Meningiomas: A Matched Case-Control Study

artículo científico publicado en 2022

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas

artículo científico publicado en 2019

DNA methylation profiling to predict recurrence risk in meningioma: development and validation of a nomogram to optimize clinical management

scientific article published on 01 July 2019

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

artículo científico publicado en 2017

DNA methylation-based classification of central nervous system tumours

artículo científico publicado en 2018

DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment

artículo científico publicado en 2018

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics

scientific article published on 25 November 2019

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles

artículo científico publicado en 2019

Detection of 2-hydroxyglutarate in formalin-fixed paraffin-embedded glioma specimens by gas chromatography/mass spectrometry

artículo científico

Diagnostic Challenges in Meningioma

artículo científico

Differential nuclear ATRX expression in sarcomas

artículo científico publicado en 2015

Differentiation of glioblastoma and primary CNS lymphomas using susceptibility weighted imaging

artículo científico publicado en 2012

Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14

artículo científico publicado en 2019

Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma

scientific article published on 05 September 2018

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

artículo científico publicado en 2013

Durable Control of Metastatic AKT1-Mutant WHO Grade 1 Meningothelial Meningioma by the AKT Inhibitor, AZD5363.

artículo científico publicado en 2017

EPEN-06. YAP1 SUBGROUP SUPRATENTORIAL EPENDYMOMA REQUIRES TEAD AND NUCLEAR FACTOR I-MEDIATED TRANSCRIPTIONAL PROGRAMS FOR TUMORIGENESIS

artículo científico publicado en 2019

Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux.

artículo científico publicado en 2017

Endometrial stromal sarcomas with BCOR-rearrangement harbor MDM2 amplifications

scientific article published on 30 April 2020

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

artículo científico publicado en 2016

Evaluation of microvascular permeability with dynamic contrast-enhanced MRI for the differentiation of primary CNS lymphoma and glioblastoma: radiologic-pathologic correlation.

artículo científico publicado en 2014

Evidence of H3 K27M mutations in posterior fossa ependymomas

artículo científico publicado en 2016

Experimental Cerebral Malaria Spreads along the Rostral Migratory Stream

artículo científico publicado en 2016

FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.

artículo científico publicado en 2018

Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma

artículo científico publicado en 2014

Farewell to oligoastrocytoma: response to letters

artículo científico publicado en 2014

Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter-hypermethylation - the NCT Neuro Master Match (N2M2) pilot study

artículo científico publicado en 2017

Federated learning enables big data for rare cancer boundary detection

Frequent AKT1E17K mutations in skull base meningiomas are associated with mTOR and ERK1/2 activation and reduced time to tumor recurrence

artículo científico publicado en 2017

GE-30OLIGOASTROCYTOMA DOES NOT EXIST: IN-SITU MOLECULAR GENETICS FAVORS CLASSIFICATION AS EITHER OLIGODENDROGLIOMA OR ASTROCYTOMA.

artículo científico publicado en 2014

GENE-06. DISTINCT MOLECULAR SUBGROUPS OF TUMORS OF THE PINEAL REGION CORRELATE WITH CLINICAL PARAMETERS AND GENETIC ALTERATIONS

artículo científico publicado en 2019

GENE-07. MOLECULAR NEUROPATHOLOGY 2.0 - INCREASING DIAGNOSTIC ACCURACY IN PEDIATRIC NEUROONCOLOGY.

artículo científico publicado en 2017

GENE-08. THE MNP 2.0 STUDY: PROSPECTIVE INTEGRATION OF DNA METHYLATION PROFILING IN CNS TUMOR DIAGNOSTICS

GENE-12. ANAPLASTIC NEUROEPITHELIAL TUMOR WITH CONDENSED NUCLEI (ANTCON): A NOVEL BRAIN TUMOR ENTITY WITH RECURRENT NTRK FUSION

GENE-13. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

artículo científico publicado en 2019

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

artículo científico publicado en 2016

Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma

artículo científico publicado en 2019

Glioblastoma hijacks neuronal mechanisms for brain invasion

artículo científico publicado en 2022

Glioma IDH1 mutation patterns off the beaten track.

artículo científico publicado en 2011

Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma

artículo científico publicado en 2015

Glutamatergic synaptic input to glioma cells drives brain tumour progression

scientific article published on 18 September 2019

HG-68COMBINED ALTERATIONS IN MAPK PATHWAY GENES, CDKN2A/B AND ATRX CHARACTERIZE ANAPLASTIC PILOCYTIC ASTROCYTOMA.

artículo científico publicado en 2016

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

scientific article published on 18 February 2020

High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses.

artículo científico publicado en 2012

Highlights of the inaugural ten - the launch of Neuro-Oncology Advances

artículo científico publicado en 2019

Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases

artículo científico publicado en 2017

ID(H)entifying checkpoint inhibitor candidates among diffuse glioma

artículo científico publicado en 2017

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.

artículo científico publicado en 2015

IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma

artículo científico publicado en 2015

IMMU-49. CYTOTOXIC T CELLS AND THEIR ACTIVATION STATUS ARE INDEPENDENT PROGNOSTIC MARKERS IN MENINGIOMAS

article published in 2018

IMPS-14PROGNOSTIC ROLE OF REGULATORY T-CELLS IN PRIMARY AND RECURRENT MENINGIOMA.

artículo científico publicado en 2015

Identification of KIF11 As a Novel Target in Meningioma

scientific article published on 15 April 2019

Identification of T cell target antigens in glioblastoma stem-like cells using an integrated proteomics-based approach in patient specimens

artículo científico publicado en 2017

Identification of distinctive features in human intracranial tumors by label-free nonlinear multimodal microscopy

scientific article published on 09 July 2019

Imaging necrosis during treatment is associated with worse survival in EORTC 26101 study

scientific article published on 10 May 2019

Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma

artículo científico publicado en 2013

Immunohistochemical analysis of 1844 human epithelial and haematopoietic tumours and sarcomas for IDH1R132H mutation.

artículo científico publicado en 2011

Impaired remission from autoimmune neuroinflammation upon T cell-specific knockout of the stress kinase GCN2

scholarly article by Jana Sonner et al published October 2014 in Journal of Neuroimmunology

In situ proximity ligation assay to evaluate presentation of a mutated CD4 epitope in human glioma tissue

scholarly article by Lukas Bunse et al published October 2014 in Journal of Neuroimmunology

Incidence, mortality and outcome of meningiomas: A population-based study from Germany

artículo científico publicado en 2019

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Infratentorial IDH-mutant astrocytoma is a distinct subtype

artículo científico publicado en 2020

Inhibition of CD95/CD95L Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma

artículo científico publicado en 2018

Integrated molecular analysis of adult sonic hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator

artículo científico publicado en 2021

Integrated molecular characterization of IDH-mutant glioblastomas

artículo científico publicado en 2018

Intracranial tumour haemorrhage following intravenous thrombolysis

artículo científico publicado en 2015

Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT

artículo científico publicado en 2019

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

artículo científico publicado en 2019

K27M-mutant histone-3 as a novel target for glioma immunotherapy

artículo científico publicado en 2017

LG-27DKFZ-BT66 - A NOVEL PILOCYTIC ASTROCYTOMA MODEL FOR PRECLINICAL DRUG TESTING.

artículo científico publicado en 2016

LGG-04. CHARACTERIZATION OF ONCOGENE-INDUCED SENESCENCE AND THE ROLE OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA.

artículo científico publicado en 2017

LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA.

artículo científico publicado en 2018

LGG-13. PAPILLARY GLIONEURONAL TUMOR (PGNT) EXHIBITS A CHARACTERISTIC METHYLATION PROFILE AND MANDATORY FUSIONS INVOLVING PRKCA

LGG-20. MOLECULARLY-DEFINED DIFFUSE LEPTOMENINGEAL GLIONEURONAL TUMOR (DLGNT) COMPRISES TWO SUBGROUPS WITH DISTINCT CLINICAL AND GENETIC FEATURES

LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration

artículo científico publicado en 2024

La fréquence des mutations de BRAF est élevée dans les histiocytoses de Langerhans et d’Erdheim-Chester, mais nulle dans les autres histiocytoses

Lomustine and Bevacizumab in Progressive Glioblastoma

artículo científico publicado en 2017

Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity.

artículo científico publicado en 2014

Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice.

artículo científico publicado en 2017

Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence

artículo científico publicado en 2018

MB-26SHH DESMOPLASTIC/NODULAR MEDULLOBLASTOMA AND GORLIN SYNDROME IN THE SETTING OF DOWN SYNDROME: CASE REPORT WITH MOLECULAR PROFILING.

artículo científico publicado en 2016

MNGI-02. PREOPERATIVE EMBOLIZATION OF MENINGIOMA: INFERIOR NEUROLOGICAL OUTCOME, INCREASED RISK OF CARDIOVASCULAR COMPLICATIONS AND SHORTER TIME TO RECURRENCE?

MNGI-05. DEVELOPMENT AND VALIDATION OF A DNA METHYLOME-BASED PREDICTOR OF MENINGIOMA RECURRENCE AND MENINGIOMA RECURRENCE SCORE

artículo científico publicado en 2018

MNGI-13. A DNA METHYLATION-BASED CLASSIFIER FOR ASSESSMENT OF RISK OF RECURRENCE IN MENINGIOMA

MNGI-14. LOSS OF HISTONE H3K27me3 IDENTIFIES A SUBSET OF MENINGIOMAS WITH INCREASED RISK OF RECURRENCE

MNGI-28. CORRELATION OF METHYLATION CLASS AND GENETIC ALTERATIONS WITH PROGRESSION FREE SURVIVAL IN MENINGIOMA

artículo científico publicado en 2018

MYCN amplification drives an aggressive form of spinal ependymoma

scientific article published on 14 August 2019

Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles

artículo científico publicado en 2014

Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein

artículo científico publicado en 2013

Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

artículo científico publicado en 2017

Methylation-based classification of benign and malignant peripheral nerve sheath tumors

artículo científico publicado en 2016

Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes ⬇️

artículo científico publicado en 2020

Molecular Diagnostics in Pediatric Brain Tumors: Impact on Diagnosis and Clinical Decision-Making - A Selected Case Series

scientific article published on 11 July 2018

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

artículo científico publicado en 2021

Molecular and translational advances in meningiomas

scientific article published on 01 January 2019

Molecular characterization of medulloblastomas with extensive nodularity (MBEN).

artículo científico publicado en 2018

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

artículo científico publicado en 2017

Molecular profiling-based decision for targeted therapies in IDH wild-type glioblastoma

artículo científico publicado en 2020

Molecular progression of SHH-activated medulloblastomas

scientific article published on 27 April 2019

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

scientific article published on 25 November 2019

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features.

artículo científico publicado en 2018

Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay

scientific article published on 26 September 2020

Mutant IDH1R132H bears a mutation-specific CD4 T cell epitope suitable for vaccination of human CNS tumors

scholarly article by Theresa Schumacher et al published October 2014 in Journal of Neuroimmunology

Mutation specific antibodies: tool or dinosaur?

artículo científico publicado en 2012

Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology.

artículo científico publicado en 2010

Mutational landscape of primary and recurrent glioblastoma reveals potentially actionable SNVs including WNT pathway variation

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma

artículo científico publicado en 2019

N2M2 (NOA20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma

artículo científico publicado en 2019

NDRG1 prognosticates the natural course of disease in WHO grade II glioma

artículo científico publicado en 2014

NFM-11. PEDIATRIC MENINGIOMAS ARE MOLECULARLY DISTINCT FROM ADULT COUNTERPARTS

article published in 2018

NIMG-75. NECROSIS DURING TREATMENT IS ASSOCIATED WITH WORSE SURVIVAL IN RECURRENT GLIOBLASTOMA PATIENTS – POST HOC IMAGE ANALYSIS OF EORTC 26101

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

artículo científico publicado en 2016

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

artículo científico publicado en 2015

Noninvasive Characterization of Tumor Angiogenesis and Oxygenation in Bevacizumab-treated Recurrent Glioblastoma by Using Dynamic Susceptibility MRI: Secondary Analysis of the European Organization for Research and Treatment of Cancer 26101 Trial

artículo científico publicado en 2020

Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients

scientific article published on 31 July 2018

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort

scientific article published on 24 April 2020

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

artículo científico publicado en 2018

Nuclear Overhauser Enhancement imaging of glioblastoma at 7 Tesla: region specific correlation with apparent diffusion coefficient and histology

artículo científico publicado en 2015

Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour

artículo científico publicado en 2014

PATH-24. MOLECULAR SUBGROUPS OF ADULT EPENDYMAL TUMORS: AN ANALYSIS OF THE GERMAN GLIOMA NETWORK

PDTM-38. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

PDTM-47. CHARACTERIZATION OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA AND ITS ROLE IN ONCOGENE-INDUCED SENESCENCE

Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo

artículo científico publicado en 2017

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA

artículo científico publicado en 2019

Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors

artículo científico publicado en 2015

PerSurge (NOA-30) phase II trial of perampanel treatment around surgery in patients with progressive glioblastoma

scholarly article

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia

artículo científico publicado en 2019

Poor prognosis associated with TERT gene alterations in meningioma is independent of the WHO classification: an individual patient data meta-analysis

artículo científico publicado en 2020

Post-operative cardiovascular complications and time to recurrence in meningioma patients treated with versus without pre-operative embolization: a retrospective cohort study of 741 patients

artículo científico publicado en 2018

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

artículo científico publicado en 2019

Practical Implications of the Updated WHO Classification of Brain Tumors.

artículo científico publicado en 2018

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

artículo científico publicado en 2018

Primary central nervous system lymphoma and atypical glioblastoma: multiparametric differentiation by using diffusion-, perfusion-, and susceptibility-weighted MR imaging

artículo científico publicado en 2014

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.

artículo científico publicado en 2018

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

scientific article published on 20 November 2020

Printed peptide arrays identify prognostic TNC serumantibodies in glioblastoma patients

artículo científico publicado en 2015

Prognostic relevance of miRNA-155 methylation in anaplastic glioma

artículo científico publicado en 2016

Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase

artículo científico publicado en 2012

Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis

artículo científico publicado en 2013

Proximity ligation assay evaluates IDH1R132H presentation in gliomas

artículo científico publicado en 2015

Quantitative susceptibility mapping differentiates between blood depositions and calcifications in patients with glioblastoma

artículo científico publicado en 2013

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

artículo científico publicado en 2021

Radiogenomic rCBV-imaging visualizes the moleculare signature of IDH-mutant and wildtype gliomas

Rare compound heterozygous variants in PNKP identified by whole exome sequencing in a German patient with ataxia-oculomotor apraxia 4 and pilocytic astrocytoma.

artículo científico publicado en 2018

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

artículo científico publicado en 2021

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

artículo científico publicado en 2020

Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology: A risk–benefit analysis

artículo científico publicado en 2024

Report of a Novel Case of Anaplastic Olfactory Groove Meningioma and Its Methylation Subtype

artículo científico publicado en 2017

Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib.

artículo científico publicado en 2017

Response to trametinib treatment in progressive pediatric low-grade glioma patients

artículo científico publicado en 2020

Retinoblastoma with late metastatic spread-a case report

scientific article published on 05 February 2019

Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1

scientific article published on 27 June 2019

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions

scientific article published on 05 July 2019

SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature

artículo científico publicado en 2016

Sarcoma classification by DNA methylation profiling

artículo científico publicado en 2021

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

artículo científico publicado en 2013

Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02

scientific article published on 08 September 2020

Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy

artículo científico publicado en 2016

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.

artículo científico publicado en 2016

Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter-methylated malignant astrocytoma

scientific article published on 17 February 2020

Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway

artículo científico publicado en 2014

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

scientific article published on 09 July 2018

Sural nerve injury in familial amyloid polyneuropathy: MR neurography vs clinicopathologic tools

artículo científico publicado en 2017

TB-11MOLECULAR NEUROPATHOLOGY 2.0 - INCREASING DIAGNOSTIC ACCURACY IN PEDIATRIC NEUROONCOLOGY.

artículo científico publicado en 2016

TBIO-07. ASSESSING THE UTILITY OF DNA METHYLATION PROFILING IN BRAIN TUMOR DIAGNOSTICS—THE PROSPECTIVE MNP2.0 STUDY

TBIO-10. PEDIATRIC TARGETED THERAPY 2.0: DEVELOPMENT OF PERSONALIZED PEDIATRIC ONCOLOGY

TERT Promoter Mutations and Risk of Recurrence in Meningioma

artículo científico publicado en 2015

TERT and DNMT1 expression predict sensitivity to decitabine in gliomas

artículo científico publicado en 2020

TERT, the target?

scientific article published on 01 November 2018

TRTH-09. PTT2.0: DEVELOPING PERSONALIZED PEDIATRIC ONCOLOGY.

artículo científico publicado en 2017

Targeting resistance against the MDM2 inhibitor RG7388 in glioblastoma cells by the MEK inhibitor trametinib

artículo científico publicado en 2018

The Loss of 1p as a Reliable Marker of Progression in a Child with Aggressive Meningioma: A 16-Year Follow-Up Case Report

scientific article published on 09 December 2020

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

artículo científico publicado en 2018

The dural angioleiomyoma harbors frequent GJA4 mutation and a distinct DNA methylation profile

artículo científico publicado en 2022

The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress

artículo científico publicado en 2013

The genetic landscape of choroid plexus tumors in children and adults

artículo científico publicado en 2020

The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells

artículo científico publicado en 2011

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

artículo científico publicado en 2017

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker

scientific article published on 28 November 2019

Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade

artículo científico publicado en 2016

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma

artículo científico publicado en 2021

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis

artículo científico publicado en 2017

Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.

artículo científico publicado en 2015

Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology

artículo científico publicado en 2017

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

artículo científico publicado en 2021

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

artículo científico publicado en 2019

Tweety-Homolog 1 Drives Brain Colonization of Gliomas.

artículo científico

Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1

artículo científico publicado en 2019

Ultra-high-field sodium MRI as biomarker for tumor extent, grade and IDH mutation status in glioma patients

artículo científico publicado en 2020

VXM01 phase I study in patients with progressive glioblastoma: Final results

Validation of diffusion MRI phenotypes for predicting response to bevacizumab in recurrent glioblastoma: post-hoc analysis of the EORTC-26101 trial

scientific article published on 11 May 2020

WHO 2016 Classification: Changes and Advancements in the Diagnosis of Miscellaneous Primary CNS Tumours

artículo científico publicado en 2017

Whole exome sequencing reveals that the majority of schwannomatosis cases remain unexplained after excluding SMARCB1 and LZTR1 germline variants

article published in 2014

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

scientific article published on 02 September 2019

YAP1-fusions in pediatric NF2-wildtype meningioma

artículo científico publicado en 2019

cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading

artículo científico publicado en 2020

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

artículo científico publicado en 2013

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