Lista de obras - Olaf Heidenreich - Dominio Público Uruguay

A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin

artículo científico publicado en 2008

AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia

artículo científico publicado en 2011

AML1/ETO inhibits AML1/CCAAT-enhancer binding protein-alpha mediated activation of the CD11c promoter and represses CD11c expression in HL60 cells

scientific article published on 01 August 2003

AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia

artículo científico publicado en 2010

AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

artículo científico publicado en 2002

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia.

artículo científico publicado en 2017

Analysis of the nuclear distribution of the translocation t(8;21)-derived fusion protein AML1/ETO by confocal laser scanning microscopy

artículo científico publicado en 2002

BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance.

artículo científico publicado en 2016

Cleavage of AML1/MTG8 by asymmetric hammerhead ribozymes.

artículo científico publicado en 2001

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

artículo científico publicado en 2012

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2009

Detection and quantification of CBFB/MYH11 fusion transcripts in patients with inv(16)-positive acute myeloblastic leukemia by real-time RT-PCR.

artículo científico publicado en 2001

Determination of key structure-activity relationships in siRNA delivery with a mixed micelle system.

artículo científico publicado en 2013

Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging

artículo científico publicado en 2014

EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation

artículo científico publicado en 2009

Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target

artículo científico publicado en 2000

Exposure of patient-derived mesenchymal stromal cells to TGFB1 supports fibrosis induction in a pediatric acute megakaryoblastic leukemia model

scientific article published on 08 July 2020

Gene silencing by RNAi in mammalian cells

artículo científico publicado en 2003

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

artículo científico publicado en 2020

Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection

artículo científico publicado en 2006

Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection.

artículo científico publicado en 2007

Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression.

artículo científico publicado en 2012

Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.

artículo científico publicado en 2010

Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression.

artículo científico publicado en 2013

Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia.

artículo científico publicado en 2016

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

scientific journal article

Malignant stem cells in childhood ALL: the debate continues!

artículo científico publicado en 2009

Molecular parameters of siRNA--cell penetrating peptide nanocomplexes for efficient cellular delivery.

artículo científico publicado en 2013

New insights to the MLL recombinome of acute leukemias

artículo científico publicado en 2009

Oncogene suppression by small interfering RNAs

artículo científico publicado en 2004

Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia

scientific article published on 13 December 2018

Proliferation of human primary vascular smooth muscle cells depends on serum response factor

artículo científico publicado en 2010

RNA interference as a potential tool in the treatment of leukaemia

artículo científico publicado en 2004

RNase H-independent antisense activity of oligonucleotide N3 '--> P5 ' phosphoramidates.

artículo científico publicado en 1997

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

artículo científico publicado en 2021

Real-time RT-PCR for the detection and quantification of AML1/MTG8 fusion transcripts in t(8;21)-positive AML patients

artículo científico publicado en 1999

Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells

artículo científico publicado en 2002

Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

artículo científico publicado en 2022

Specific inhibition of bcr-abl gene expression by small interfering RNA.

artículo científico publicado en 2002

Suppression of ICAM-1 in human venous endothelial cells by small interfering RNAs

artículo científico publicado en 2005

Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems

scientific article published on 22 February 2010

Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.

artículo científico publicado en 2005

Targeting oncogenes with siRNAs

artículo científico publicado en 2009

The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO

artículo científico publicado en 2011

The MLL recombinome of acute leukemias in 2013.

artículo científico publicado en 2013

The MLL recombinome of acute leukemias in 2017.

artículo científico

The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

artículo científico publicado en 2004

Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo

artículo científico publicado en 2008

UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.

artículo científico publicado en 2015

Understanding the cancer stem cell.

artículo científico publicado en 2010

siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts.

artículo científico publicado en 2006

Lista de obras de Olaf Heidenreich

A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin

AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia

AML1/ETO inhibits AML1/CCAAT-enhancer binding protein-alpha mediated activation of the CD11c promoter and represses CD11c expression in HL60 cells

AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia

AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia.

Analysis of the nuclear distribution of the translocation t(8;21)-derived fusion protein AML1/ETO by confocal laser scanning microscopy

BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance.

Cleavage of AML1/MTG8 by asymmetric hammerhead ribozymes.

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

Detection and quantification of CBFB/MYH11 fusion transcripts in patients with inv(16)-positive acute myeloblastic leukemia by real-time RT-PCR.

Determination of key structure-activity relationships in siRNA delivery with a mixed micelle system.

Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging

EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation

Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target

Exposure of patient-derived mesenchymal stromal cells to TGFB1 supports fibrosis induction in a pediatric acute megakaryoblastic leukemia model

Gene silencing by RNAi in mammalian cells

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection

Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection.

Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression.

Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.

Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression.

Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia.

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

Malignant stem cells in childhood ALL: the debate continues!

Molecular parameters of siRNA--cell penetrating peptide nanocomplexes for efficient cellular delivery.

New insights to the MLL recombinome of acute leukemias

Oncogene suppression by small interfering RNAs

Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia

Proliferation of human primary vascular smooth muscle cells depends on serum response factor

RNA interference as a potential tool in the treatment of leukaemia

RNase H-independent antisense activity of oligonucleotide N3 '--> P5 ' phosphoramidates.

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

Real-time RT-PCR for the detection and quantification of AML1/MTG8 fusion transcripts in t(8;21)-positive AML patients

Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells

Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

Specific inhibition of bcr-abl gene expression by small interfering RNA.

Suppression of ICAM-1 in human venous endothelial cells by small interfering RNAs

Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems

Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.

Targeting oncogenes with siRNAs

The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO

The MLL recombinome of acute leukemias in 2013.

The MLL recombinome of acute leukemias in 2017.

The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo

UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.

Understanding the cancer stem cell.

siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts.