Lista de obras - Kaisa Lehti - Dominio Público Uruguay

A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion

artículo científico publicado en 2015

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

artículo científico publicado en 2018

A novel mutation in the matrix metallopeptidase 2 coding gene associated with intrafamilial variability of multicentric osteolysis, nodulosis, and arthropathy

scientific article published on 03 July 2019

Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton

artículo científico publicado en 2014

Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer

artículo científico publicado en 2020

Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality

artículo científico publicado en 2021

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

scientific article published on 25 January 2019

An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature

artículo científico publicado en 2005

An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis

artículo científico publicado en 2012

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy

artículo científico publicado en 2012

Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance

artículo científico publicado en 2021

Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics

artículo científico

EphA2 bears plasticity to tumor invasion

artículo científico publicado en 2013

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

artículo científico publicado en 2013

Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells

artículo científico publicado en 2006

Expression and purification of soluble and inactive mutant forms of membrane type 1 matrix metalloproteinase.

artículo científico publicado en 2000

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex

artículo científico publicado en 2010

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

artículo científico publicado en 2019

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation

artículo científico publicado en 2010

Fibroblasts in the Tumor Microenvironment: Shield or Spear?

artículo científico publicado en 2018

Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma

artículo científico publicado en 2017

High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1

artículo científico publicado en 2019

Identification of 33 candidate oncogenes by screening for base-specific mutations.

artículo científico publicado en 2014

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment.

artículo científico publicado en 2013

Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy.

artículo científico publicado en 2015

Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes

artículo científico publicado en 2019

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

artículo científico publicado en 2011

Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery

artículo científico publicado en 2016

Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.

artículo científico publicado en 2018

Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy ⬇️

scientific article published on 13 December 2018

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.

artículo científico publicado en 2018

MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues

scientific article published on 28 August 2019

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

artículo científico publicado en 2015

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis

artículo científico publicado en 2012

MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.

artículo científico publicado en 2008

MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.

artículo científico publicado en 2008

Membrane-type matrix metalloproteases as diverse effectors of cancer progression

artículo científico publicado en 2017

Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion

artículo científico publicado en 2011

Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

artículo científico publicado en 2021

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.

artículo científico publicado en 2011

Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase

artículo científico publicado en 2002

PROX1 is a transcriptional regulator of MMP14.

artículo científico publicado en 2018

Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism

artículo científico publicado en 2002

Proactive for invasion: Reuse of matrix metalloproteinase for structural memory

artículo científico publicado en 2016

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.

artículo científico publicado en 2015

Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.

artículo científico publicado en 1996

Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain

artículo científico publicado en 2000

RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo

artículo científico publicado en 2017

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

artículo científico publicado en 2008

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

artículo científico publicado en 2019

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

artículo científico publicado en 2017

Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene.

artículo científico publicado en 2000

Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP.

artículo científico publicado en 2011

The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization.

artículo científico publicado en 2018

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

artículo científico publicado en 2020

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.

artículo científico publicado en 2019

Lista de obras de Kaisa Lehti

A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

A novel mutation in the matrix metallopeptidase 2 coding gene associated with intrafamilial variability of multicentric osteolysis, nodulosis, and arthropathy

Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton

Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer

Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature

An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy

Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance

Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics

EphA2 bears plasticity to tumor invasion

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells

Expression and purification of soluble and inactive mutant forms of membrane type 1 matrix metalloproteinase.

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation

Fibroblasts in the Tumor Microenvironment: Shield or Spear?

Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma

High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1

Identification of 33 candidate oncogenes by screening for base-specific mutations.

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment.

Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy.

Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery

Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.

Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy ⬇️

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.

MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis

MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.

MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.

Membrane-type matrix metalloproteases as diverse effectors of cancer progression

Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion

Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.

Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase

PROX1 is a transcriptional regulator of MMP14.

Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism

Proactive for invasion: Reuse of matrix metalloproteinase for structural memory

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.

Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.

Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain

RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene.

Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP.

The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization.

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.