Lista de obras - James Barrow - Dominio Público Uruguay

Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice

artículo científico publicado en 2009

Challenges and opportunities in neuroscience research

artículo científico publicado en 2012

Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates ⬇️

artículo científico publicado el 14 de noviembre de 2011

Classics in chemical neuroscience: diazepam (valium).

artículo científico publicado en 2014

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1

artículo científico publicado en 2007

Design and synthesis of potent and selective macrocyclic thrombin inhibitors

artículo científico publicado en 2003

Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist

artículo científico publicado en 2008

Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors

artículo científico publicado en 2014

Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis

artículo científico publicado en 2015

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation

artículo científico publicado en 2007

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase

artículo científico publicado en 2008

Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors

artículo científico publicado en 2004

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists

artículo científico publicado en 2010

Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels

artículo científico publicado en 2008

Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists.

artículo científico publicado en 2010

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

artículo científico publicado en 2002

Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing

artículo científico publicado en 2009

High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors.

artículo científico publicado en 2010

Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group

artículo científico publicado en 2004

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

artículo científico publicado en 2000

In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.

artículo científico publicado en 2010

Inhibitors of Catechol-O-Methyltransferase ⬇️

artículo científico publicado el 1 de mayo de 2012

Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2

artículo científico publicado en 2014

Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1

artículo científico publicado en 2015

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

artículo científico publicado en 2003

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

artículo científico publicado en 2015

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

artículo científico publicado en 2018

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

artículo científico publicado en 2009

Positive allosteric interaction of structurally diverse T-type calcium channel antagonists.

artículo científico publicado en 2009

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists

artículo científico publicado en 2000

Pyridyl amides as potent inhibitors of T-type calcium channels

artículo científico publicado en 2011

Recent advances in medicinal chemistry for treatment of sleep and wake disorders

artículo científico publicado en 2008

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition

artículo científico publicado en 2010

Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones

scientific article published on 01 August 2000

Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.

artículo científico publicado en 2010

Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328.

artículo científico publicado en 2011

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).

artículo científico publicado en 2015

Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics

artículo científico publicado en 2003

T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats

artículo científico publicado en 2010

T-type calcium channels regulate cortical plasticity in-vivo. [corrected]

artículo científico publicado en 2009

Total Syntheses of Vancomycin and Eremomycin Aglycons

artículo científico publicado en 1998

Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position

artículo científico publicado en 2003

[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey.

artículo científico publicado en 2011

Lista de obras de James Barrow

Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice

Challenges and opportunities in neuroscience research

Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates ⬇️

Classics in chemical neuroscience: diazepam (valium).

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1

Design and synthesis of potent and selective macrocyclic thrombin inhibitors

Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist

Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors

Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase

Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists

Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels

Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists.

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing

High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors.

Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.

Inhibitors of Catechol-O-Methyltransferase ⬇️

Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2

Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

Positive allosteric interaction of structurally diverse T-type calcium channel antagonists.

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists

Pyridyl amides as potent inhibitors of T-type calcium channels

Recent advances in medicinal chemistry for treatment of sleep and wake disorders

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition

Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones

Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.

Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328.

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).

Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics

T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats

T-type calcium channels regulate cortical plasticity in-vivo. [corrected]

Total Syntheses of Vancomycin and Eremomycin Aglycons

Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position

[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey.