Lista de obras - Frank Skorpen - Dominio Público Uruguay

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

artículo científico publicado en 2011

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

artículo científico publicado en 2009

A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2)

artículo científico publicado en 2011

A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

artículo científico publicado en 2004

A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A

artículo científico publicado en 1997

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

artículo científico publicado en 2008

Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway

artículo científico publicado en 2013

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

artículo científico publicado en 2009

Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study

artículo científico publicado en 2017

Base excision repair of DNA in mammalian cells

artículo científico publicado en 2000

Bg/ll polymorphism in the UNG gene in 4 populations

article

COMT genotypes and use of antipsychotic medication: linking population-based prescription database to the HUNT study

artículo científico publicado en 2008

CUBN is a gene locus for albuminuria

artículo científico publicado en 2011

Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling

artículo científico publicado en 2017

Causal associations of tobacco smoking with cardiovascular risk factors: a Mendelian randomization analysis of the HUNT Study in Norway

artículo científico publicado en 2014

Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids

Clinical and genetic factors related to cancer-induced bone pain and bone pain relief

artículo científico publicado en 2014

Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals

artículo científico publicado en 2011

Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT).

artículo científico publicado en 2008

Erratum: Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scholarly article published in Nature Genetics

Erratum: Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

article

Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids

artículo científico publicado en 1997

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene

artículo científico publicado en 2006

Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks

artículo científico publicado en 2017

Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing

artículo científico publicado en 2004

Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids

artículo científico publicado en 2015

Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry

artículo científico publicado en 2011

Genetic findings related to pain and analgesics–why are they so inconsistent?

Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag Health Study

artículo científico publicado en 2009

Genetic variability and clinical efficacy of morphine

artículo científico publicado en 2005

Genetic variability of pain - A patient focused end-point.

artículo científico publicado en 2015

Genetic variation and cognitive dysfunction in opioid-treated patients with cancer

artículo científico publicado en 2016

Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain

artículo científico publicado en 2008

Genetic variation-- important for the clinical effect of opioids?

artículo científico publicado en 2005

Health care providers underestimate symptom intensities of cancer patients: a multicenter European study

artículo científico publicado en 2010

High Systolic Blood Pressure Is Associated With Val/Val Genotype in the Catechol-O-Methyltransferase GeneThe Nord-Trøndelag Health Study (HUNT)

article published in 2007

Human Uracil-DNA Glycosylase

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

artículo científico publicado en 2003

Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1

artículo científico publicado en 1996

Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia

artículo científico publicado en 2015

Identification of possible genetic polymorphisms involved in cancer cachexia: a systematic review

scientific article published on April 2011

Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply

artículo científico publicado en 2002

Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients

artículo científico publicado en 2011

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

artículo científico publicado en 2012

Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium

artículo científico publicado en 2017

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

artículo científico publicado en 2014

Investigation of the fine structure of European populations with applications to disease association studies

artículo científico publicado en 2008

Is there a genetic cause for cancer cachexia? - a clinical validation study in 1797 patients

artículo científico publicado en 2011

Is there a genetic cause of appetite loss?-an explorative study in 1,853 cancer patients

artículo científico publicado en 2012

Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer: the European Pharmacogenetic Opioid Study (EPOS).

artículo científico publicado en 2012

Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner

artículo científico publicado en 2005

Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium

artículo científico publicado en 2012

Lung cancer susceptibility locus at 5p15.33

artículo científico publicado en 2008

Marked over expression of uncoupling protein-2 in beta cells exerts minor effects on mitochondrial metabolism

artículo científico publicado en 2012

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

artículo científico publicado en 2002

Multiple Loci modulate opioid therapy response for cancer pain

artículo científico publicado en 2011

No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study

artículo científico publicado en 2006

No large-effect low-frequency coding variation found for myocardial infarction

artículo científico publicado en 2014

Nociceptive stimuli responses at different levels of general anaesthesia and genetic variability

artículo científico publicado en 2012

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

artículo científico publicado en 1997

OP006. A preeclampsia genome-wide linkage scan in norwegian families

artículo científico publicado en 2013

Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression

artículo científico publicado en 2009

P-selectin genotype is associated with the development of cancer cachexia

artículo científico publicado en 2012

Paracetamol counteracts docosahexaenoic acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro

artículo científico publicado en 1997

Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells

article

Passive smoking in relation to lung cancer incidence and histologic types in Norwegian adults: the HUNT study

artículo científico publicado en 2017

Prediction of opioid dose in cancer pain patients using genetic profiling: not yet an option with support vector machine learning

artículo científico publicado en 2018

Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study

artículo científico publicado en 2015

Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway

artículo científico publicado en 2012

Properties and functions of human uracil-DNA glycosylase from the UNG gene

artículo científico publicado en 2001

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scientific journal article

Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

artículo científico publicado en 1998

Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus

artículo científico publicado en 1998

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

article by Holthe M et al published 1 January 2003 in The Pharmacogenomics Journal

Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway

artículo científico publicado en 2017

Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function

artículo científico publicado en 1994

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

artículo científico publicado en 2014

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

artículo científico publicado en 2004

The N-terminally truncated µ3 and µ3-like opioid receptors are transcribed from a novel promoter upstream of exon 2 in the human OPRM1 gene

artículo científico publicado en 2013

The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

artículo científico publicado en 2005

The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study

artículo científico publicado en 2006

The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study

artículo científico publicado en 2012

The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study

artículo científico publicado en 2016

The impact of the catechol-O-methyltransferase Val158Met polymorphism on survival in the general population--the HUNT study

artículo científico publicado en 2007

The methylation status of the gene for O6-methylguanine-DNA methyltransferase in human Mer+ and Mer- cells

artículo científico publicado en 1995

The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses

artículo científico publicado en 2016

Time dynamics of autoantibodies are coupled to phenotypes and add to the heterogeneity of autoimmune diabetes in adults: the HUNT study, Norway

article

Transepithelial transport of morphine and mannitol in Caco-2 cells: the influence of chitosans of different molecular weights and degrees of acetylation

Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

article

Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain

artículo científico publicado en 2013

Variable response to opioid treatment: any genetic predictors within sight?

artículo científico publicado en 2008

Variation in the COMT gene: implications for pain perception and pain treatment

scientific article published on April 2009

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

artículo científico publicado en 2002

Lista de obras de Frank Skorpen

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2)

A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study

Base excision repair of DNA in mammalian cells

Bg/ll polymorphism in the UNG gene in 4 populations

COMT genotypes and use of antipsychotic medication: linking population-based prescription database to the HUNT study

CUBN is a gene locus for albuminuria

Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling

Causal associations of tobacco smoking with cardiovascular risk factors: a Mendelian randomization analysis of the HUNT Study in Norway

Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids

Clinical and genetic factors related to cancer-induced bone pain and bone pain relief

Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals

Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT).

Erratum: Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Erratum: Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene

Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks

Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing

Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids

Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry

Genetic findings related to pain and analgesics–why are they so inconsistent?

Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag Health Study

Genetic variability and clinical efficacy of morphine

Genetic variability of pain - A patient focused end-point.

Genetic variation and cognitive dysfunction in opioid-treated patients with cancer

Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain

Genetic variation-- important for the clinical effect of opioids?

Health care providers underestimate symptom intensities of cancer patients: a multicenter European study

High Systolic Blood Pressure Is Associated With Val/Val Genotype in the Catechol-O-Methyltransferase GeneThe Nord-Trøndelag Health Study (HUNT)

Human Uracil-DNA Glycosylase

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1

Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia

Identification of possible genetic polymorphisms involved in cancer cachexia: a systematic review

Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply

Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

Investigation of the fine structure of European populations with applications to disease association studies

Is there a genetic cause for cancer cachexia? - a clinical validation study in 1797 patients

Is there a genetic cause of appetite loss?-an explorative study in 1,853 cancer patients

Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer: the European Pharmacogenetic Opioid Study (EPOS).

Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner

Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium

Lung cancer susceptibility locus at 5p15.33

Marked over expression of uncoupling protein-2 in beta cells exerts minor effects on mitochondrial metabolism

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

Multiple Loci modulate opioid therapy response for cancer pain

No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study

No large-effect low-frequency coding variation found for myocardial infarction

Nociceptive stimuli responses at different levels of general anaesthesia and genetic variability

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

OP006. A preeclampsia genome-wide linkage scan in norwegian families

Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression

P-selectin genotype is associated with the development of cancer cachexia

Paracetamol counteracts docosahexaenoic acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro

Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells

Passive smoking in relation to lung cancer incidence and histologic types in Norwegian adults: the HUNT study

Prediction of opioid dose in cancer pain patients using genetic profiling: not yet an option with support vector machine learning

Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study

Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway

Properties and functions of human uracil-DNA glycosylase from the UNG gene

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway

Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

The N-terminally truncated µ3 and µ3-like opioid receptors are transcribed from a novel promoter upstream of exon 2 in the human OPRM1 gene