Lista de obras - Jorg Tatzelt - Dominio Público Uruguay

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

artículo científico publicado en 1997

A protein quality control pathway regulated by linear ubiquitination

scientific article published on 18 March 2019

A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds

artículo científico publicado en 2001

Aberrant Folding of Pathogenic Parkin Mutants

artículo científico publicado en 2008

Abnormalities in stress proteins in prion diseases

artículo científico publicado en 1998

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

artículo científico publicado en 2018

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)

artículo científico publicado en 2013

Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.

artículo científico publicado en 2006

Cationic Lipopolyamines Induce Degradation of PrPSc in Scrapie-Infected Mouse Neuroblastoma Cells

article published in 2000

Cellular prion protein mediates toxic signaling of amyloid beta

artículo científico publicado en 2011

Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.

artículo científico publicado en 2010

Conserved stress-protective activity between prion protein and Shadoo

artículo científico publicado en 2011

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

artículo científico publicado en 2015

Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation

artículo científico publicado en 2003

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

artículo científico publicado en 2012

Dimerization of the cellular prion protein inhibits propagation of scrapie prions

artículo científico publicado en 2018

Folding and misfolding of the prion protein in the secretory pathway

artículo científico publicado en 2004

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

artículo científico publicado en 2019

Geldanamycin restores a defective heat shock response in vivo

artículo científico publicado en 2001

Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.

artículo científico publicado en 2008

Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseases

artículo científico publicado en 2018

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

artículo científico publicado en 2003

Inhibition of complex glycosylation increases the formation of PrPsc

artículo científico publicado en 2003

Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

artículo científico publicado en 2001

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

artículo científico publicado en 2009

Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation

artículo científico publicado en 2004

Molecular basis of cerebral neurodegeneration in prion diseases.

artículo científico publicado en 2007

Neuroprotective and neurotoxic signaling by the prion protein

artículo científico publicado en 2011

Observing fibrillar assemblies on scrapie-infected cells

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration

artículo científico publicado en 2015

Parkin is protective against proteotoxic stress in a transgenic zebrafish model

artículo científico publicado en 2010

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

artículo científico publicado en 2011

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

artículo científico publicado en 2007

Pathogenic mutations inactivate parkin by distinct mechanisms.

artículo científico publicado en 2005

Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.

artículo científico publicado en 2004

Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain

artículo científico publicado en 2003

Prion disease: a tale of folds and strains

artículo científico

Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system

artículo científico publicado en 1997

Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor

artículo científico publicado en 2006

Prion proteins

artículo científico publicado el 1 de enero de 2011

Propagation of prion strains through specific conformers of the prion protein

artículo científico publicado en 1997

Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing

scientific article published on 01 October 2010

Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein

artículo científico publicado en 1996

SecY-mediated quality control prevents the translocation of non-gated porins

scientific article published on 01 October 2020

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

artículo científico publicado en 2016

Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes

artículo científico publicado en 2007

Stress-protective signalling of prion protein is corrupted by scrapie prions

artículo científico publicado en 2008

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

artículo científico publicado en 2018

Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

artículo científico publicado en 2013

Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations

artículo científico publicado en 2006

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

artículo científico publicado en 2017

Synthesis of a GPI anchor module suitable for protein post-translational modification

artículo científico publicado en 2010

The C-terminal Globular Domain of the Prion Protein Is Necessary and Sufficient for Import into the Endoplasmic Reticulum

artículo científico publicado en 2003

The Cellular Prion Protein: A Player in Immunological Quiescence

artículo científico publicado en 2015

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

artículo científico publicado en 2013

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.

artículo científico publicado en 2017

The RAB GTPase RAB18 modulates macroautophagy and proteostasis

artículo científico publicado en 2017

The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins

artículo científico publicado en 2017

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

artículo científico publicado en 2011

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.

artículo científico publicado en 2012

The mechanism of adenovirus DNA integration: studies in a cell-free system.

artículo científico publicado en 1995

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein

artículo científico publicado en 2010

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

artículo científico publicado en 2020

The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose

artículo científico publicado en 2005

The prion protein in neuroimmune crosstalk

scientific article published on 15 November 2018

The prion protein: friend and foe

artículo científico publicado en 2009

The role of chaperones in Parkinson's disease and prion diseases.

artículo científico publicado en 2006

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

scientific article published on 05 March 2019

The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites

artículo científico publicado en 2004

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

artículo científico publicado en 2008

The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum

artículo científico publicado en 2013

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

scientific article published on 04 May 2020

alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum

artículo científico publicado en 2009

Lista de obras de Jorg Tatzelt

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

A protein quality control pathway regulated by linear ubiquitination

A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds

Aberrant Folding of Pathogenic Parkin Mutants

Abnormalities in stress proteins in prion diseases

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)

Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.

Cationic Lipopolyamines Induce Degradation of PrPSc in Scrapie-Infected Mouse Neuroblastoma Cells

Cellular prion protein mediates toxic signaling of amyloid beta

Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.

Conserved stress-protective activity between prion protein and Shadoo

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

Dimerization of the cellular prion protein inhibits propagation of scrapie prions

Folding and misfolding of the prion protein in the secretory pathway

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

Geldanamycin restores a defective heat shock response in vivo

Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.

Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseases

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

Inhibition of complex glycosylation increases the formation of PrPsc

Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation

Molecular basis of cerebral neurodegeneration in prion diseases.

Neuroprotective and neurotoxic signaling by the prion protein

Observing fibrillar assemblies on scrapie-infected cells

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration

Parkin is protective against proteotoxic stress in a transgenic zebrafish model

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

Pathogenic mutations inactivate parkin by distinct mechanisms.

Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.

Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain

Prion disease: a tale of folds and strains

Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system

Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor

Prion proteins

Propagation of prion strains through specific conformers of the prion protein

Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing

Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein

SecY-mediated quality control prevents the translocation of non-gated porins

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes

Stress-protective signalling of prion protein is corrupted by scrapie prions

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

Synthesis of a GPI anchor module suitable for protein post-translational modification

The C-terminal Globular Domain of the Prion Protein Is Necessary and Sufficient for Import into the Endoplasmic Reticulum

The Cellular Prion Protein: A Player in Immunological Quiescence

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.

The RAB GTPase RAB18 modulates macroautophagy and proteostasis

The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.

The mechanism of adenovirus DNA integration: studies in a cell-free system.

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose

The prion protein in neuroimmune crosstalk

The prion protein: friend and foe

The role of chaperones in Parkinson's disease and prion diseases.

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum