Lista de obras - Dmitriy Minond - Dominio Público Uruguay

AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α.

artículo científico publicado en 2014

An improved fluorescent substrate for assaying soluble and membrane-associated ADAM family member activities.

artículo científico publicado en 2016

Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors

artículo científico publicado en 2007

COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.

artículo científico publicado en 2013

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

artículo científico publicado en 2014

Clinical implications of compounds designed to inhibit ECM-modifying metalloproteinases.

artículo científico

Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).

artículo científico publicado en 2008

Development of an AlphaScreen assay for discovery of inhibitors of low-affinity glycan-lectin interactions

artículo científico publicado en 2013

Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.

artículo científico publicado en 2004

Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences

artículo científico publicado en 2007

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

artículo científico publicado en 2016

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

artículo científico publicado en 2012

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition

artículo científico publicado en 2013

HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

artículo científico publicado en 2008

Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.

scientific article published on 15 August 2013

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

artículo científico

Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

artículo científico publicado en 2009

Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries

artículo científico publicado en 2009

ML302, a Novel Beta-lactamase (BLA) Inhibitor

Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability

scientific article published on 01 September 2004

Multicomponent assembly of 4-aza-podophyllotoxins: A fast entry to highly selective and potent anti-leukemic agents

artículo científico publicado en 2015

NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies

artículo científico publicado en 2010

Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis

artículo científico publicado en 2014

Probe Report for P97/cdc48 Inhibitors

Production of soluble Neprilysin by endothelial cells

artículo científico publicado en 2014

RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain.

artículo científico publicado en 2014

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

artículo científico publicado en 2011

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

artículo científico publicado en 2015

Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

artículo científico publicado en 2006

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

artículo científico publicado en 2006

Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides.

artículo científico publicado en 2015

Lista de obras de Dmitriy Minond

AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α.

An improved fluorescent substrate for assaying soluble and membrane-associated ADAM family member activities.

Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors

COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

Clinical implications of compounds designed to inhibit ECM-modifying metalloproteinases.

Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).

Development of an AlphaScreen assay for discovery of inhibitors of low-affinity glycan-lectin interactions

Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.

Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition

HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries

ML302, a Novel Beta-lactamase (BLA) Inhibitor

Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability

Multicomponent assembly of 4-aza-podophyllotoxins: A fast entry to highly selective and potent anti-leukemic agents

NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies

Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis

Probe Report for P97/cdc48 Inhibitors

Production of soluble Neprilysin by endothelial cells

RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain.

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides.