Lista de obras - Mary E. Abood - Dominio Público Uruguay

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor

artículo científico publicado en 2005

3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor

artículo científico publicado en 1999

A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition

artículo científico publicado en 2002

AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2006

Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.

artículo científico publicado en 2014

Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity

artículo científico publicado en 2001

Allosteric Modulators: A Side Door

scientific article published on 08 December 2015

Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling

scientific article published on 23 December 2013

Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity.

scientific article published on February 2008

Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid

artículo científico publicado en 2004

An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region ⬇️

artículo científico publicado el 20 de noviembre de 2003

Analysis of the antinociceptive actions of the kappa-opioid agonist enadoline (CI-977) in neonatal and adult rats: comparison to kappa-opioid receptor mRNA ontogeny

artículo científico publicado en 1995

Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic

artículo científico publicado en 2006

Antisense oligodeoxynucleotides to the kappa-1 receptor block the antinociceptive effects of delta 9-THC in the spinal cord

artículo científico publicado en 1995

Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators

scientific article published on 03 January 2020

Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands

artículo científico publicado en 2009

Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.

artículo científico publicado en 2006

CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.

artículo científico publicado en 2012

CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury.

artículo científico publicado en 2009

CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

artículo científico publicado en 2014

Cannabinoid receptor activation reduces TNFalpha-induced surface localization of AMPAR-type glutamate receptors and excitotoxicity.

artículo científico publicado en 2009

Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice

artículo científico publicado en 1996

Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Cannabinoid receptors in developing rats: detection of mRNA and receptor binding

artículo científico publicado en 1994

Cannabinoid receptors: nomenclature and pharmacological principles

artículo científico publicado en 2012

Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells

artículo científico publicado en 2005

Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.

artículo científico publicado en 2010

Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors

artículo científico publicado en 2015

Crucial positively charged residues for ligand activation of the GPR35 receptor

artículo científico publicado en 2013

Development of behavioral tolerance to delta 9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain

artículo científico publicado en 1993

Developmental expression of cannabinoid receptor mRNA.

artículo científico publicado en 1993

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55.

artículo científico publicado en 2013

Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors.

artículo científico publicado en 2014

Expression of a cannabinoid receptor in baculovirus-infected insect cells.

artículo científico publicado en 1994

Functional interaction between HIV-gp120 and opioid system in the preoptic anterior hypothalamus

scientific article published on 26 September 2013

G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells.

artículo científico publicado en 2015

HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions.

artículo científico publicado en 2011

HIV-gp120 and physical dependence to buprenorphine

artículo científico publicado en 2015

Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms

artículo científico publicado en 2007

High-level expression of the human CB2 cannabinoid receptor using a baculovirus system.

artículo científico publicado en 1998

Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor

artículo científico publicado en 2016

Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.

artículo científico publicado en 2013

Importance of the C-1 Substituent in Classical Cannabinoids to CB2Receptor Selectivity: Synthesis and Characterization of a Series ofO,2-Propano-Δ8-tetrahydrocannabinol Analogs

artículo científico publicado en 1997

Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide

artículo científico publicado en 2011

Isolation and developmental expression of a rat cDNA encoding a cysteine-rich zinc finger protein

scientific journal article

Isolation and expression of a mouse CB1 cannabinoid receptor gene. Comparison of binding properties with those of native CB1 receptors in mouse brain and N18TG2 neuroblastoma cells.

artículo científico publicado en 1997

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55

artículo científico publicado en 2010

Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways

artículo científico publicado en 2015

Membrane fluidity and fatty acid composition of phospholipids in erythrocyte membranes of patients with huntington disease ⬇️

artículo científico publicado en 1979

Modification of opioid agonist binding by pertussis toxin

artículo científico publicado en 1987

Molecular cloning and expression of a delta-opioid receptor from rat brain

scientific journal article

Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.

artículo científico publicado en 2007

Neurobiology of marijuana abuse.

artículo científico publicado en 1992

Novel Insights into CB1 Cannabinoid Receptor Signaling: A Key Interaction Identified between the Extracellular-3 Loop and Transmembrane Helix 2 ⬇️

artículo científico publicado el 20 de febrero de 2013

Pertussis toxin treatment modifies opiate action in the rat brain striatum

artículo científico publicado en 1985

Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy

artículo científico publicado en 2015

Regulation of both preproenkephalin mRNA and its derived opioids by haloperidol--a method for measurement of peptides and mRNA in the same tissue extract

artículo científico publicado en 1990

Role for C-tail residues in delta opioid receptor downregulation

artículo científico publicado en 2000

Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.

artículo científico publicado en 1999

Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.

artículo científico publicado en 1996

The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55 ⬇️

artículo científico publicado el 28 de marzo de 2012

The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray

artículo científico publicado en 2015

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

artículo científico publicado en 2014

The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.

artículo científico publicado en 1998

The endocannabinoid system as a target for the treatment of neurodegenerative disease

artículo científico publicado en 2010

Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.

artículo científico publicado en 2014

Unique Analogues of Anandamide: Arachidonyl Ethers and Carbamates and Norarachidonyl Carbamates and Ureas

scientific article published on 01 June 1999

Lista de obras de Mary E. Abood

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor

3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor

A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition

AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis

Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.

Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity

Allosteric Modulators: A Side Door

Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling

Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity.

Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid

An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region ⬇️

Analysis of the antinociceptive actions of the kappa-opioid agonist enadoline (CI-977) in neonatal and adult rats: comparison to kappa-opioid receptor mRNA ontogeny

Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic

Antisense oligodeoxynucleotides to the kappa-1 receptor block the antinociceptive effects of delta 9-THC in the spinal cord

Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators

Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands

Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.

CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.

CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury.

CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

Cannabinoid receptor activation reduces TNFalpha-induced surface localization of AMPAR-type glutamate receptors and excitotoxicity.

Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice

Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Cannabinoid receptors in developing rats: detection of mRNA and receptor binding

Cannabinoid receptors: nomenclature and pharmacological principles

Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells

Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.

Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors

Crucial positively charged residues for ligand activation of the GPR35 receptor

Development of behavioral tolerance to delta 9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain

Developmental expression of cannabinoid receptor mRNA.

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55.

Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors.

Expression of a cannabinoid receptor in baculovirus-infected insect cells.

Functional interaction between HIV-gp120 and opioid system in the preoptic anterior hypothalamus

G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells.

HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions.

HIV-gp120 and physical dependence to buprenorphine

Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms

High-level expression of the human CB2 cannabinoid receptor using a baculovirus system.

Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor

Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.

Importance of the C-1 Substituent in Classical Cannabinoids to CB2Receptor Selectivity: Synthesis and Characterization of a Series ofO,2-Propano-Δ8-tetrahydrocannabinol Analogs

Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide

Isolation and developmental expression of a rat cDNA encoding a cysteine-rich zinc finger protein

Isolation and expression of a mouse CB1 cannabinoid receptor gene. Comparison of binding properties with those of native CB1 receptors in mouse brain and N18TG2 neuroblastoma cells.

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55

Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways

Membrane fluidity and fatty acid composition of phospholipids in erythrocyte membranes of patients with huntington disease ⬇️

Modification of opioid agonist binding by pertussis toxin

Molecular cloning and expression of a delta-opioid receptor from rat brain

Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.

Neurobiology of marijuana abuse.

Novel Insights into CB1 Cannabinoid Receptor Signaling: A Key Interaction Identified between the Extracellular-3 Loop and Transmembrane Helix 2 ⬇️

Pertussis toxin treatment modifies opiate action in the rat brain striatum

Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy

Regulation of both preproenkephalin mRNA and its derived opioids by haloperidol--a method for measurement of peptides and mRNA in the same tissue extract

Role for C-tail residues in delta opioid receptor downregulation

Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.

Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.

The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55 ⬇️

The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.

The endocannabinoid system as a target for the treatment of neurodegenerative disease

Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.

Unique Analogues of Anandamide: Arachidonyl Ethers and Carbamates and Norarachidonyl Carbamates and Ureas