Lista de obras - Jim Iley - Dominio Público Uruguay

4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

artículo científico publicado en 2010

A carbamate-based approach to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation

artículo científico publicado en 2011

Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: chemical hydrolysis and anti-bacterial activity.

artículo científico publicado en 1996

Acyloxymethyl as a drug protecting group. Part 6

scientific article published on 01 April 2000

Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents

scientific article published on 01 November 1997

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media

scientific article published on 01 January 2007

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

artículo científico publicado en 2008

Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates

artículo científico publicado en 1999

Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

artículo científico publicado en 2007

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

artículo científico publicado en 2001

Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase

artículo científico publicado en 2005

Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates

artículo científico publicado en 1999

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

artículo científico publicado en 2006

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

artículo científico publicado en 2009

Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

artículo científico publicado en 2005

Imidazolium ylides from a conjugate addition–proton transfer route and their cycloaddition reactions

artículo científico publicado en 2011

Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide

artículo científico publicado en 2001

Intramolecular 1,3-dipolar cycloadditions of dihydroimidazolium ylides: synthesis of pyrrolo[1,2,3-de]quinoxalines and imidazo[1,2-a]indoles

scientific article published on 18 July 2006

Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one

artículo científico publicado en 2004

Mechanism of the microsomal demethylation of 1-aryl-3,3-dimethyltriazenes

artículo científico publicado en 1990

Microsomal metabolism of N,N-diethyl-m-toluamide (DEET, DET): the extended network of metabolites

artículo científico publicado en 1999

Monofluorinated di- and tetrahydropyrans via Prins-type cyclisations

artículo científico publicado en 2006

N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases

artículo científico publicado en 2012

Oxidation of tertiary benzamides by 5,10,15,20-tetraphenylporphyrinatoironIII chloride-tert-butylhydroperoxide

artículo científico publicado en 2004

Phthalimidomethyl as a drug pro-moiety. Probing its reactivity

scientific article published on 01 April 1998

Pyrrolo[1,2,3-de]quinoxalines: unexpected products from 1,3-dipolar cycloaddition of dihydroimidazolium ylides

Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties.

artículo científico publicado en 2010

Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.

artículo científico publicado en 2009

Synthesis of the pyoverdin chromophore by a biomimetic oxidative cyclization.

artículo científico publicado en 2009

Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.

artículo científico publicado en 2002

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

artículo científico publicado en 2010

Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold

scientific article published on 09 February 2007

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors

artículo científico publicado en 2007

The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases

artículo científico publicado en 2006

The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion

artículo científico publicado en 2007

The microsomal demethylation of N,N-dimethylbenzamides. Substituent and kinetic deuterium isotope effects

artículo científico publicado en 1992

Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: synthesis and stability of N-acylamino acid derivatives of triazenes.

artículo científico publicado en 2008

Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes

artículo científico publicado en 2000

Triazene drug metabolites: part 15. Synthesis and plasma hydrolysis of anticancer triazenes containing amino acid carriers

artículo científico publicado en 1998

Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design

artículo científico publicado en 2008

Lista de obras de Jim Iley

4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

A carbamate-based approach to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation

Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: chemical hydrolysis and anti-bacterial activity.

Acyloxymethyl as a drug protecting group. Part 6

Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates

Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase

Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

Imidazolium ylides from a conjugate addition–proton transfer route and their cycloaddition reactions

Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide

Intramolecular 1,3-dipolar cycloadditions of dihydroimidazolium ylides: synthesis of pyrrolo[1,2,3-de]quinoxalines and imidazo[1,2-a]indoles

Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one

Mechanism of the microsomal demethylation of 1-aryl-3,3-dimethyltriazenes

Microsomal metabolism of N,N-diethyl-m-toluamide (DEET, DET): the extended network of metabolites

Monofluorinated di- and tetrahydropyrans via Prins-type cyclisations

N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases

Oxidation of tertiary benzamides by 5,10,15,20-tetraphenylporphyrinatoironIII chloride-tert-butylhydroperoxide

Phthalimidomethyl as a drug pro-moiety. Probing its reactivity

Pyrrolo[1,2,3-de]quinoxalines: unexpected products from 1,3-dipolar cycloaddition of dihydroimidazolium ylides

Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties.

Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.

Synthesis of the pyoverdin chromophore by a biomimetic oxidative cyclization.

Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors

The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases

The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion

The microsomal demethylation of N,N-dimethylbenzamides. Substituent and kinetic deuterium isotope effects

Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: synthesis and stability of N-acylamino acid derivatives of triazenes.

Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes

Triazene drug metabolites: part 15. Synthesis and plasma hydrolysis of anticancer triazenes containing amino acid carriers

Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design