Lista de obras - Nick Plant - Dominio Público Uruguay

A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile ⬇️

artículo científico publicado el 2 de febrero de 2011

Acrylamide-mediated subacute testicular and genotoxicity, is it reversible?

article

Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential ⬇️

artículo científico publicado en 2015

Can a systems approach produce a better understanding of mood disorders? ⬇️

artículo científico publicado en 2016

Can systems toxicology identify common biomarkers of non-genotoxic carcinogenesis?

artículo científico publicado en 2008

Chapter 2. Enabling Dynamic Response to Chemical Challenge: Nuclear Receptor-mediated Control of Transporter Expression

article

Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays

artículo científico publicado en 2012

Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile

artículo científico publicado en 2012

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

artículo científico publicado en 2011

Control and statistical analysis of in vitro reporter gene assays.

artículo científico publicado en 2000

Design principles of nuclear receptor signaling: how complex networking improves signal transduction.

artículo científico publicado en 2010

Developmental modulation of cysteine conjugate beta-lyase/glutamine transaminase K/kynurenine aminotransferase mRNA in rat brain

artículo científico publicado en 1997

Differential gene expression in rats following subacute exposure to the anticonvulsant sodium valproate

scientific journal article

Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices

artículo científico publicado en 2008

Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.

artículo científico publicado en 2008

EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques

article

Editorial overview

article

Emergence of the silicon human and network targeting drugs

article

Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities

artículo científico publicado en 2006

Evaluation of the toxicological relevance of CYP3A4 induction.

artículo científico publicado en 2003

Fatty acid binding proteins: tissue-specific functions in health and disease

artículo científico

Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth

artículo científico publicado en 2004

Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production ⬇️

artículo científico publicado en 2016

Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

artículo científico publicado en 2002

Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression

artículo científico publicado en 2004

In silico and in vitro modeling of hepatocyte drug transport processes: importance of ABCC2 expression levels in the disposition of carboxydichlorofluroscein

artículo científico publicado en 2008

Inhibition of prenyltransferase activity by statins in both liver and muscle cell lines is not causative of cytotoxicity ⬇️

artículo científico publicado en 2015

Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics ⬇️

artículo científico publicado en 2017

Interaction networks: coordinating responses to xenobiotic exposure

article

Langaside, a novel secoiridolactone glycoside derivative from Tachiadenus longiflorus Griseb. (Gentianaceae) formed by a [2+2] cycloaddition reaction

article

Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis

artículo científico publicado en 2003

Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology ⬇️

artículo científico publicado en 2017

MUFINS: multi-formalism interaction network simulator. ⬇️

artículo científico publicado en 2016

Mixed chelate copper complex, Casiopeina IIgly®, binds and degrades nucleic acids: A mechanism of cytotoxicity

article

Modeling Transport Processes and Their Implications for Chemical Disposition and Action

article

Molecular Biology and Biotechnology ⬇️

artículo científico publicado el 1 de diciembre de 2001

Molecular biology I: transcriptional regulation

scholarly article by Nick Plant published in March 2015

Molecular biology I: transcriptional regulation

scholarly article by Nick Plant published in April 2012

Molecular biology I: transcriptional regulation

scholarly article by Nick Plant published in April 2009

Molecular biology II: protein function ⬇️

scholarly article by Nick Plant published in March 2015

Molecular biology II: protein function

scholarly article by Nick Plant published in April 2012

Molecular biology II: protein function

scholarly article by Nick Plant published in April 2009

Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease ⬇️

article

Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner

artículo científico publicado en 2012

Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae). ⬇️

artículo científico publicado en 2013

Nuclear receptors: the controlling force in drug metabolism of the liver?

artículo científico publicado en 2009

Optimization of stress response through the nuclear receptor-mediated cortisol signalling network

artículo científico publicado en 2013

Peroxisome Proliferators Induce High Levels of DNA Synthesis in Primary Cultures of Rat Hepatocytes

article

Peroxisome Proliferators: Species Differences in Response of Primary Hepatocyte Cultures

article

Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor ⬇️

artículo científico publicado el 16 de diciembre de 2011

Primary liver cells cultured on carbon nanotube substrates for liver tissue engineering and drug discovery applications

artículo científico publicado en 2014

Probabilistic orthology analysis of the ATP-binding cassette transporters: implications for the development of multiple drug resistance phenotype

artículo científico publicado en 2012

QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells ⬇️

artículo científico publicado en 2013

Receptor-dependent regulation of the CYP3A4 gene

artículo científico publicado en 2002

Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors.

artículo científico publicado en 2000

Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells

artículo científico publicado en 2003

Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene

artículo científico publicado en 2004

Seizure control by ketogenic diet-associated medium chain fatty acids

artículo científico publicado en 2013

Site-specific, covalent incorporation of Tus, a DNA-binding protein, on ionic-complementary self-assembling peptide hydrogels using transpeptidase Sortase A as a conjugation tool†Dedicated to the memory of Joachim H. G. Steinke.‡Electronic supplemen

artículo científico publicado en 2013

Sodium valproate induces apoptosis in the rat hepatoma cell line, FaO.

artículo científico publicado en 2003

Strategies for using in vitro screens in drug metabolism

artículo científico publicado en 2004

Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices ⬇️

artículo científico publicado en 2016

Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease

artículo científico publicado en 2014

The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate

artículo científico publicado en 1998

The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks

artículo científico publicado en 2006

The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor ⬇️

artículo científico publicado el 30 de mayo de 2012

The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1.

artículo científico publicado en 2008

The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis

artículo científico publicado en 1998

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes

artículo científico publicado en 2011

Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5′-flanking region, 33, pp. 1085–1095

Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.

artículo científico publicado en 2005

Transcriptional regulation of the human pregnane-X receptor

artículo científico publicado en 2006

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth

artículo científico publicado en 2006

Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

artículo científico publicado en 2007

Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung

artículo científico publicado en 2008

Use of Reporter Genes to Measure Xenobiotic-Mediated Activation of CYP Gene Transcription

artículo científico publicado en 2006

Lista de obras de Nick Plant

A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile ⬇️

Acrylamide-mediated subacute testicular and genotoxicity, is it reversible?

Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential ⬇️

Can a systems approach produce a better understanding of mood disorders? ⬇️

Can systems toxicology identify common biomarkers of non-genotoxic carcinogenesis?

Chapter 2. Enabling Dynamic Response to Chemical Challenge: Nuclear Receptor-mediated Control of Transporter Expression

Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays

Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

Control and statistical analysis of in vitro reporter gene assays.

Design principles of nuclear receptor signaling: how complex networking improves signal transduction.

Developmental modulation of cysteine conjugate beta-lyase/glutamine transaminase K/kynurenine aminotransferase mRNA in rat brain

Differential gene expression in rats following subacute exposure to the anticonvulsant sodium valproate

Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices

Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.

EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques

Editorial overview

Emergence of the silicon human and network targeting drugs

Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities

Evaluation of the toxicological relevance of CYP3A4 induction.

Fatty acid binding proteins: tissue-specific functions in health and disease

Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth

Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production ⬇️

Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression

In silico and in vitro modeling of hepatocyte drug transport processes: importance of ABCC2 expression levels in the disposition of carboxydichlorofluroscein

Inhibition of prenyltransferase activity by statins in both liver and muscle cell lines is not causative of cytotoxicity ⬇️

Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics ⬇️

Interaction networks: coordinating responses to xenobiotic exposure

Langaside, a novel secoiridolactone glycoside derivative from Tachiadenus longiflorus Griseb. (Gentianaceae) formed by a [2+2] cycloaddition reaction

Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis

Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology ⬇️

MUFINS: multi-formalism interaction network simulator. ⬇️

Mixed chelate copper complex, Casiopeina IIgly®, binds and degrades nucleic acids: A mechanism of cytotoxicity

Modeling Transport Processes and Their Implications for Chemical Disposition and Action

Molecular Biology and Biotechnology ⬇️

Molecular biology I: transcriptional regulation

Molecular biology I: transcriptional regulation

Molecular biology I: transcriptional regulation

Molecular biology II: protein function ⬇️

Molecular biology II: protein function

Molecular biology II: protein function

Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease ⬇️

Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner

Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae). ⬇️

Nuclear receptors: the controlling force in drug metabolism of the liver?

Optimization of stress response through the nuclear receptor-mediated cortisol signalling network

Peroxisome Proliferators Induce High Levels of DNA Synthesis in Primary Cultures of Rat Hepatocytes

Peroxisome Proliferators: Species Differences in Response of Primary Hepatocyte Cultures

Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor ⬇️

Primary liver cells cultured on carbon nanotube substrates for liver tissue engineering and drug discovery applications

Probabilistic orthology analysis of the ATP-binding cassette transporters: implications for the development of multiple drug resistance phenotype

QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells ⬇️

Receptor-dependent regulation of the CYP3A4 gene

Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors.

Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells

Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene

Seizure control by ketogenic diet-associated medium chain fatty acids

Site-specific, covalent incorporation of Tus, a DNA-binding protein, on ionic-complementary self-assembling peptide hydrogels using transpeptidase Sortase A as a conjugation tool†Dedicated to the memory of Joachim H. G. Steinke.‡Electronic supplemen

Sodium valproate induces apoptosis in the rat hepatoma cell line, FaO.

Strategies for using in vitro screens in drug metabolism

Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices ⬇️

Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease

The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate

The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks

The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor ⬇️

The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1.

The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes

Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5′-flanking region, 33, pp. 1085–1095

Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.

Transcriptional regulation of the human pregnane-X receptor

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth

Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung

Use of Reporter Genes to Measure Xenobiotic-Mediated Activation of CYP Gene Transcription