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Lista de obras de Chantal Guillemette

A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity.

artículo científico publicado en 2016

A chromatography/tandem mass spectrometry method for the simultaneous profiling of ten endogenous steroids, including progesterone, adrenal precursors, androgens and estrogens, using low serum volume.

artículo científico publicado en 2015

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for monitoring drug exposure in hematopoietic stem cell transplant recipients

artículo científico publicado en 2012

A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients

artículo científico publicado en 2015

A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

artículo científico publicado en 2004

A pharmacogenetics study of the human glucuronosyltransferase UGT1A4.

artículo científico publicado en 2009

A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3.

artículo científico publicado en 2007

ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients.

artículo científico publicado en 2015

Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines.

artículo científico publicado en 2009

An LC-MS/MS method for quantification of abiraterone, its active metabolites D(4)-abiraterone (D4A) and 5α-abiraterone, and their inactive glucuronide derivatives

artículo científico publicado en 2018

Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population

artículo científico publicado en 2009

Assay reproducibility of serum androgen measurements using liquid chromatography-tandem mass spectrometry.

artículo científico publicado en 2015

Association between circulating levels of sex steroid hormones and Barrett's esophagus in men: a case-control analysis.

artículo científico publicado en 2014

BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.

artículo científico publicado en 2015

Bioavailability of testosterone enanthate dependent on genetic variation in the phosphodiesterase 7B but not on the uridine 5'-diphospho-glucuronosyltransferase (UGT2B17) gene

artículo científico publicado en 2011

Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues

artículo científico publicado en 1998

Characterization of UDP-glucuronosyltransferases active on steroid hormones

artículo científico publicado en 1999

Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.

artículo científico publicado en 2006

Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success

artículo científico publicado en 2011

Circulating estrogens in endometrial cancer cases and their relationship with tissular expression of key estrogen biosynthesis and metabolic pathways.

artículo científico publicado en 2010

Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

artículo científico publicado en 2002

Copy-number variations (CNVs) of the human sex steroid metabolizing genesUGT2B17andUGT2B28and their associations with aUGT2B15functional polymorphism

article

Correlation between circulatory, local prostatic, and intra-prostatic androgen levels

artículo científico publicado en 2010

Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway

artículo científico publicado en 2016

Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism

artículo científico publicado en 2017

DNA repair gene polymorphisms, tumor control, and treatment toxicity in prostate cancer patients treated with permanent implant prostate brachytherapy

scientific article published on 23 March 2020

Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants

artículo científico publicado en 2008

Deletions of the Androgen-MetabolizingUGT2BGenes Have an Effect on Circulating Steroid Levels and Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer

scientific article published on 06 July 2011

Direct haplotyping of kilobase-size DNA using carbon nanotube probes

artículo científico publicado en 2000

Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing

artículo científico publicado en 2016

Downregulation of hepatic acetylation of drugs in chronic renal failure.

artículo científico publicado en 2008

Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism.

artículo científico publicado en 2013

Effect of fibroblastic growth factors (FGF) on steroid UDP-glucuronosyltransferase expression and activity in the LNCaP cell line

artículo científico publicado en 1998

Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics.

artículo científico publicado en 2017

Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.

artículo científico publicado en 2015

Evidence for a role of glucuronosyltransferase in the regulation of androgen action in the human prostatic cancer cell line LNCaP.

artículo científico publicado en 1996

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers

artículo científico publicado en 2013

Evidences of Biological Functions of Biliverdin Reductase A in the Bovine Epididymis.

artículo científico publicado en 2015

Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues: changes from prenatal life to adulthood and in kidney cancer

artículo científico publicado en 2013

Expression of transcripts encoding steroid UDP-glucuronosyltransferases in human prostate hyperplastic tissue and the LNCaP cell line

artículo científico publicado en 1995

Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation

artículo científico publicado en 2010

Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit

artículo científico publicado en 2016

Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer

scientific article published on 22 April 2014

Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk

artículo científico publicado en 2009

Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients

artículo científico publicado en 2019

Glucuronidation and the UDP-glucuronosyltransferases in health and disease.

artículo científico publicado en 2004

Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation

artículo científico publicado en 2019

Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine

artículo científico publicado en 2009

Glucuronosyltransferase activity in human cancer cell line LNCaP.

artículo científico publicado en 1995

Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha

artículo científico publicado en 2004

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

artículo científico publicado en 2004

Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans

artículo científico publicado en 2010

Importance of 5α-reductase gene polymorphisms on circulating and intraprostatic androgens in prostate cancer.

artículo científico publicado en 2013

In Vitro Investigation of Human UDP-Glucuronosyltransferase Isoforms Responsible for Tacrolimus Glucuronidation: Predominant Contribution of UGT1A4

artículo científico publicado en 2011

In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes

artículo científico publicado en 2002

In vitro glucuronidation of fenofibric acid by human UDP-glucuronosyltransferases and liver microsomes.

artículo científico publicado en 2009

Influence of UDP-glucuronosyltransferase polymorphisms on mycophenolate mofetil-induced side effects in kidney transplant patients.

artículo científico publicado en 2008

Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid

artículo científico publicado en 2006

Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer.

artículo científico publicado en 2006

Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer.

artículo científico publicado en 2005

Liquid Chromatography–Coupled Tandem Mass Spectrometry Based Assay to Evaluate Inosine-5′-monophosphate Dehydrogenase Activity in Peripheral Blood Mononuclear Cells from Stem Cell Transplant Recipients

scientific article published on 02 December 2011

Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.

artículo científico publicado en 2004

Modulation of the UGT2B7 enzyme activity by C-terminally truncated proteins derived from alternative splicing

artículo científico publicado en 2013

Molecular Markers in Key Steroidogenic Pathways, Circulating Steroid Levels, and Prostate Cancer Progression

scientific article published on 27 November 2012

Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.

artículo científico publicado en 2015

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs

artículo científico publicado en 2003

Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia

artículo científico publicado en 2012

Pharmacogenetic impact of UDP-glucuronosyltransferase metabolic pathway and multidrug resistance-associated protein 2 transport pathway on mycophenolic acid in thoracic transplant recipients: an exploratory study.

artículo científico publicado en 2010

Pharmacogenomics of Human Uridine Diphospho-Glucuronosyltransferases and Clinical Implications

artículo científico publicado en 2014

Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers

artículo científico publicado en 2008

Phase II Drug-Metabolizing Polymorphisms and Smoking Predict Recurrence of Non-Muscle-Invasive Bladder Cancer: A Gene-Smoking Interaction

artículo científico publicado en 2015

Polymorphisms in steroid hormone pathway genes and mammographic density

artículo científico publicado en 2003

Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk

artículo científico publicado en 2015

Prediagnostic circulating inflammation markers and endometrial cancer risk in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial

artículo científico publicado en 2016

Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry.

artículo científico publicado en 2009

Profiling of Endogenous Estrogens, Their Precursors, and Metabolites in Endometrial Cancer Patients: Association with Risk and Relationship to Clinical Characteristics

artículo científico publicado en 2010

Protein–protein interactions between the bilirubin-conjugating UDPglucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing

artículo científico publicado en 2013

Quantitative profiling of human renal UDP-glucuronosyltransferases and glucuronidation activity: a comparison of normal and tumoral kidney tissues

artículo científico publicado en 2015

Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens.

scientific article published on 05 February 2013

Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells

artículo científico publicado en 2010

Renal Transplantation

SRD5A Polymorphisms and Biochemical Failure After Radical Prostatectomy

artículo científico publicado en 2011

Sensitive high-performance liquid chromatography–tandem mass spectrometry method for quantitative analysis of mycophenolic acid and its glucuronide metabolites in human plasma and urine

scientific article published on 24 August 2007

Sex steroid hormones in relation to Barrett's esophagus: an analysis of the FINBAR Study

artículo científico publicado en 2017

Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.

artículo científico publicado en 2004

Specificity of glucuronosyltransferase activity in the human cancer cell line LNCaP, evidence for the presence of at least two glucuronosyltransferase enzymes.

artículo científico publicado en 1995

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

artículo científico publicado en 2002

Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.

artículo científico publicado en 2014

Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

artículo científico publicado en 2000

THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER

scientific article published on 04 April 2006

Testosterone challenge and androgen receptor activity in relation to UGT2B17 genotypes

artículo científico publicado en 2013

The Impact of Germline Genetic Variations in Hydroxysteroid (17-Beta) Dehydrogenases on Prostate Cancer Outcomes After Prostatectomy

artículo científico publicado en 2011

The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers

artículo científico publicado en 2007

The R148.3 Gene Modulates Caenorhabditis elegans Lifespan and Fat Metabolism

artículo científico publicado en 2017

The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-

artículo científico publicado en 2013

The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene

artículo científico publicado en 2003

The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy

scientific article published on 01 December 2014

The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression

scientific article published on 26 July 2015

The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk

artículo científico publicado en 2004

The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver.

artículo científico publicado en 2009

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

artículo científico publicado en 2004

The relative protein abundance of UGT1A alternative splice variants as a key determinant of glucuronidation activity in vitro.

artículo científico publicado en 2013

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes.

artículo científico publicado en 2013

Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants

artículo científico publicado en 2011

UGT genomic diversity: beyond gene duplication

artículo científico publicado en 2010

UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans.

artículo científico publicado en 2008

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver

artículo científico publicado en 2005

Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing.

artículo científico publicado en 2015

Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment

artículo científico publicado en 2012