Lista de obras - Vladimír Wsól - Dominio Público Uruguay

11Beta-hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics

artículo científico publicado en 2005

3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs.

artículo científico publicado en 2001

A comparison between stereospecificity of oracin reduction and stereoselectivity of oxidation of 11-dihydrooracin enantiomersin vitro in rat and guinea pig

artículo científico publicado en 1999

A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK.

artículo científico publicado en 2012

Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment

artículo científico publicado en 2016

Activity, stereospecificity, and stereoselectivity of microsomal enzymes in dependence on storage and freezing of rat liver samples

scientific article published on 01 October 2000

Albendazole repeated administration induces cytochromes P4501A and accelerates albendazole deactivation in mouflon (Ovis musimon).

artículo científico publicado en 2005

Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile

scientific article published on 10 July 2018

Aldo-keto reductases (AKR) from the AKR1C subfamily catalyze the carbonyl reduction of the novel anticancer drug oracin in man

scientific article published on 26 May 2007

Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3.

artículo científico publicado en 2014

Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase

artículo científico publicado en 2011

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

artículo científico publicado en 2013

Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions

artículo científico publicado en 2001

Bruton's Tyrosine Kinase Inhibitors Ibrutinib and Acalabrutinib Counteract Anthracycline Resistance in Cancer Cells Expressing AKR1C3

artículo científico publicado en 2020

Carbonyl reduction of warfarin: Identification and characterization of human warfarin reductases

artículo científico publicado en 2016

Carbonyl reduction pathways in drug metabolism.

artículo científico

Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier.

artículo científico publicado en 2015

Central composite design as a powerful optimisation technique for enantioresolution of the rac-11-dihydrooracin--the principal metabolite of the potential cytostatic drug oracin

artículo científico publicado en 2002

Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes

artículo científico publicado en 2004

Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes

artículo científico publicado en 2003

Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep.

artículo científico publicado en 2004

Coordination compounds based on 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

scientific article published on 21 May 2007

Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters

scientific article published on 28 February 2019

Deeper insight into the reducing biotransformation of bupropion in the human liver

artículo científico publicado en 2013

Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity

artículo científico publicado en 2017

Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama).

artículo científico publicado en 2001

Effect of substituents on microsomal reduction of benzo(c)fluorene N-oxides

artículo científico publicado en 2000

Efficient isolation of carbonyl-reducing enzymes using affinity approach with anticancer drug oracin as a specific ligand.

artículo científico publicado en 2013

Enzyme stereospecificity as a powerful tool in searching for new enzymes

artículo científico publicado en 2010

Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli.

artículo científico publicado en 2012

Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment

artículo científico publicado en 2015

HPLC-radiometric determination of quinlukast in biological fluids

artículo científico publicado en 2004

High-performance liquid chromatographic assay for the separation and characterization of metabolites of the potential cytostatic drug oracine

scientific article published on 01 May 1996

High-performance liquid chromatography study of stereospecific microsomal enzymes catalysing the reduction of a potential cytostatic drug, oracin. Interspecies comparison

artículo científico publicado en 1998

Human Carbonyl Reductases ⬇️

artículo científico publicado el 1 de octubre de 2010

Human DHRS7, promising enzyme in metabolism of steroids and retinoids?

artículo científico publicado en 2016

Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a description and evaluation of its biochemical properties.

artículo científico publicado en 2015

Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily ⬇️

artículo científico publicado el 19 de diciembre de 2011

In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

artículo científico publicado en 2014

Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3

artículo científico publicado en 2008

Inhibition of human anthracycline reductases by emodin - A possible remedy for anthracycline resistance.

artículo científico publicado en 2016

Inhibition of nitric oxide synthase prevents muscarinic and purinergic functional changes and development of cyclophosphamide-induced cystitis in the rat.

artículo científico publicado en 2014

Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?

artículo científico publicado en 2020

In vitro metabolism of fenofibric acid by carbonyl reducing enzymes.

artículo científico publicado en 2016

Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors

artículo científico publicado en 2014

Liquid chromatographic-electrospray mass spectrometric determination (LC-ESI-MS) of phase II metabolites of flobufen in rat liver microsomes-Chiral discrimination

artículo científico publicado en 2007

Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes

scientific article published on 02 June 2006

Liver microsomal biotransformation of albendazole in deer, cattle, sheep and pig and some related wild breeds.

artículo científico publicado en 2005

Metabolite profile of sibutramine in human urine: a liquid chromatography-electrospray ionization mass spectrometric study

artículo científico publicado en 2006

Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3).

artículo científico publicado en 2014

Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3

artículo científico publicado en 2020

Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin.

artículo científico publicado en 2009

Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases.

artículo científico publicado en 2015

Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.

artículo científico publicado en 2011

Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics

artículo científico publicado en 2005

Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells

artículo científico publicado en 2013

Reduction of flobufen in pig hepatocytes: effect of pig breed (domestic, wild) and castration.

artículo científico publicado en 2003

Reduction of the Potential Anticancer Drug Oracin in the Rat Liver In-vitro

artículo científico publicado en 2000

Reductive metabolism of tiaprofenic acid by the human liver and recombinant carbonyl reducing enzymes

artículo científico publicado en 2017

Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetonein vitro

artículo científico publicado en 2012

S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity

artículo científico publicado en 2013

Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase

artículo científico publicado en 2012

Selective inhibition of aldo-keto reductase 1C3: a novel mechanism involved in midostaurin and daunorubicin synergism

scientific article published on 06 October 2020

Sex differences in stereospecificity of oracin reductases in ratin vitro andin vivo

artículo científico publicado en 1999

Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2003

Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs.

artículo científico publicado en 2003

Stereoselective pharmacokinetics of flobufen in rats

scientific article published on 01 January 1999

Stereospecific biotransformation of albendazole in mouflon and rat-isolated hepatocytes.

artículo científico publicado en 2003

Stereospecific reduction of the original anticancer drug oracin in rat extrahepatic tissues

scientific article published on 01 July 2003

Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: phase I of biotransformation

artículo científico publicado en 2001

Stereospecificity of flobufen metabolism in guinea pigs in vitro and in vivo: phase I of biotransformation

artículo científico publicado en 2004

Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3.

artículo científico publicado en 2011

Synthesis and Biological Activity of Quaternary Ammonium Salt-Type Agents Containing Cholesterol and Terpenes

scientific article published on 24 March 2014

Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles

artículo científico publicado en 2012

Targeting Pharmacokinetic Drug Resistance in Acute Myeloid Leukemia Cells with CDK4/6 Inhibitors

scientific article published on 16 June 2020

The novel anticancer drug oracin: different stereospecificity and cooperativity for carbonyl reduction by purified human liver 11beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2004

The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man.

artículo científico publicado en 2014

The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes

artículo científico publicado en 2005

Use of chiral liquid chromatography for the evaluation of stereospecificity in the carbonyl reduction of potential benzo[c]fluorene antineoplastics benfluron and dimefluron in various species.

artículo científico publicado en 2004

Lista de obras de Vladimír Wsól

11Beta-hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics

3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs.

A comparison between stereospecificity of oracin reduction and stereoselectivity of oxidation of 11-dihydrooracin enantiomersin vitro in rat and guinea pig

A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK.

Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment

Activity, stereospecificity, and stereoselectivity of microsomal enzymes in dependence on storage and freezing of rat liver samples

Albendazole repeated administration induces cytochromes P4501A and accelerates albendazole deactivation in mouflon (Ovis musimon).

Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile

Aldo-keto reductases (AKR) from the AKR1C subfamily catalyze the carbonyl reduction of the novel anticancer drug oracin in man

Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3.

Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions

Bruton's Tyrosine Kinase Inhibitors Ibrutinib and Acalabrutinib Counteract Anthracycline Resistance in Cancer Cells Expressing AKR1C3

Carbonyl reduction of warfarin: Identification and characterization of human warfarin reductases

Carbonyl reduction pathways in drug metabolism.

Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier.

Central composite design as a powerful optimisation technique for enantioresolution of the rac-11-dihydrooracin--the principal metabolite of the potential cytostatic drug oracin

Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes

Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes

Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep.

Coordination compounds based on 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters

Deeper insight into the reducing biotransformation of bupropion in the human liver

Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity

Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama).

Effect of substituents on microsomal reduction of benzo(c)fluorene N-oxides

Efficient isolation of carbonyl-reducing enzymes using affinity approach with anticancer drug oracin as a specific ligand.

Enzyme stereospecificity as a powerful tool in searching for new enzymes

Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli.

Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment

HPLC-radiometric determination of quinlukast in biological fluids

High-performance liquid chromatographic assay for the separation and characterization of metabolites of the potential cytostatic drug oracine

High-performance liquid chromatography study of stereospecific microsomal enzymes catalysing the reduction of a potential cytostatic drug, oracin. Interspecies comparison

Human Carbonyl Reductases ⬇️

Human DHRS7, promising enzyme in metabolism of steroids and retinoids?

Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a description and evaluation of its biochemical properties.

Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily ⬇️

In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3

Inhibition of human anthracycline reductases by emodin - A possible remedy for anthracycline resistance.

Inhibition of nitric oxide synthase prevents muscarinic and purinergic functional changes and development of cyclophosphamide-induced cystitis in the rat.

Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?

In vitro metabolism of fenofibric acid by carbonyl reducing enzymes.

Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors

Liquid chromatographic-electrospray mass spectrometric determination (LC-ESI-MS) of phase II metabolites of flobufen in rat liver microsomes-Chiral discrimination

Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes

Liver microsomal biotransformation of albendazole in deer, cattle, sheep and pig and some related wild breeds.

Metabolite profile of sibutramine in human urine: a liquid chromatography-electrospray ionization mass spectrometric study

Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3).

Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3

Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin.

Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases.

Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.

Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics

Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells

Reduction of flobufen in pig hepatocytes: effect of pig breed (domestic, wild) and castration.

Reduction of the Potential Anticancer Drug Oracin in the Rat Liver In-vitro

Reductive metabolism of tiaprofenic acid by the human liver and recombinant carbonyl reducing enzymes

Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetonein vitro

S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity

Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase

Selective inhibition of aldo-keto reductase 1C3: a novel mechanism involved in midostaurin and daunorubicin synergism

Sex differences in stereospecificity of oracin reductases in ratin vitro andin vivo

Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1.

Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs.

Stereoselective pharmacokinetics of flobufen in rats

Stereospecific biotransformation of albendazole in mouflon and rat-isolated hepatocytes.

Stereospecific reduction of the original anticancer drug oracin in rat extrahepatic tissues

Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: phase I of biotransformation

Stereospecificity of flobufen metabolism in guinea pigs in vitro and in vivo: phase I of biotransformation

Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3.

Synthesis and Biological Activity of Quaternary Ammonium Salt-Type Agents Containing Cholesterol and Terpenes

Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles

Targeting Pharmacokinetic Drug Resistance in Acute Myeloid Leukemia Cells with CDK4/6 Inhibitors

The novel anticancer drug oracin: different stereospecificity and cooperativity for carbonyl reduction by purified human liver 11beta-hydroxysteroid dehydrogenase type 1.

The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man.

The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes

Use of chiral liquid chromatography for the evaluation of stereospecificity in the carbonyl reduction of potential benzo[c]fluorene antineoplastics benfluron and dimefluron in various species.