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Lista de obras de Timothy O'Brien

A Role for MRP8 in in stent restenosis in diabetes

artículo científico publicado en 2012

A comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells on outcome after acute myocardial infarction

artículo científico publicado en 2012

A matrix reservoir for improved control of non-viral gene delivery

artículo científico publicado en 2009

A shape-controlled tuneable microgel platform to modulate angiogenic paracrine responses in stem cells.

artículo científico publicado en 2014

A temporal gene delivery system based on fibrin microspheres.

artículo científico publicado en 2011

Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1

artículo científico publicado en 2009

Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation

artículo científico publicado en 2012

Advances in mesenchymal stem cell-mediated gene therapy for cancer.

artículo científico publicado en 2010

Aerosol-mediated delivery of AAV2/6-IκBα attenuates lipopolysaccharide-induced acute lung injury in rats.

artículo científico publicado en 2015

An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia

artículo científico publicado en 2015

Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models

artículo científico publicado en 2014

Assessment of wound healing in the alloxan-induced diabetic rabbit ear model

artículo científico publicado en 2008

Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model

artículo científico publicado en 2013

Beta cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery.

artículo científico publicado en 2007

Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction-based detection of human DNA in murine organs

artículo científico publicado en 2017

Bone Marrow-Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction Following Intracoronary Delivery: Amelioration by Antithrombin Therapy.

artículo científico publicado en 2015

Bone marrow-derived mesenchymal stem cells promote angiogenic processes in a time- and dose-dependent manner in vitro

artículo científico publicado en 2009

Cardiovascular gene therapy: current status and therapeutic potential.

artículo científico publicado en 2007

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129

scientific article published on 29 March 2019

Characterization of patients with diabetic foot disease presenting to an Irish Podiatry Centre: profiling suitability for entry to a clinical trial of advanced wound therapeutics.

artículo científico publicado en 2016

Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data

artículo científico publicado en 2021

Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture

artículo científico publicado en 2016

Common definition for categories of clinical research: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN)

artículo científico publicado en 2009

Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells.

artículo científico publicado en 2008

Comparison of viral and nonviral vectors for gene transfer to human endothelial progenitor cells

artículo científico publicado en 2009

Compassionate use of interventions: results of a European Clinical Research Infrastructures Network (ECRIN) survey of ten European countries

artículo científico publicado en 2010

Conditions of vector delivery improve efficiency of adenoviral-mediated gene transfer to the transplanted heart

article

Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.

artículo científico publicado en 2007

Developing cell-specific antibodies to endothelial progenitor cells using avian immune phage display technology.

artículo científico publicado en 2011

Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone

artículo científico publicado en 2011

Dietary antioxidants preserve endothelium dependent vasorelaxation in overfed rats

artículo científico publicado en 2002

Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers

artículo científico publicado en 2011

Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque

artículo científico publicado en 2016

Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins.

artículo científico publicado en 2006

Distribution and function of recombinant endothelial nitric oxide synthase in transplanted hearts

scientific article published on 01 June 1999

ER stress contributes to ischemia-induced cardiomyocyte apoptosis

scientific journal article

Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury.

artículo científico publicado en 2009

Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury

artículo científico publicado en 2006

Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries.

artículo científico publicado en 1997

Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury

artículo científico publicado en 2013

Efficacy of adenoviral gene transfer with manganese superoxide dismutase and endothelial nitric oxide synthase in reducing ischemia and reperfusion injury

article

Elevation of cAMP in mesenchymal stem cells transiently upregulates neural markers rather than inducing neural differentiation.

artículo científico publicado en 2009

Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B') in human arterial smooth muscle cells

scientific article published on 01 December 2015

Endothelial progenitor cells for the treatment of diabetic vasculopathy: panacea or Pandora's box?

artículo científico publicado en 2007

Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury.

artículo científico publicado en 2010

Enhanced lipoplex-mediated gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides.

artículo científico publicado en 2010

Ex vivo gene transfer of endothelial nitric oxide synthase to atherosclerotic rabbit aortic rings improves relaxations to acetylcholine

article

Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries

article

Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries

artículo científico publicado en 2002

Expression and function of recombinant endothelial nitric oxide synthase in human endothelial cells

artículo científico publicado en 2000

Expression of Concern: Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure

artículo científico publicado en 2015

Fabry's disease: a family study

scientific article published on 01 April 1990

Fibrin as a delivery system for therapeutic drugs and biomolecules

artículo científico publicado en 2009

Fibrin scaffold promotes adenoviral gene transfer and controlled vector delivery

artículo científico publicado en 2009

Fibrin-lipoplex system for controlled topical delivery of multiple genes

artículo científico publicado en 2009

Functionalized scaffold-mediated interleukin 10 gene delivery significantly improves survival rates of stem cells in vivo

artículo científico publicado en 2011

Gene delivery to the vasculature mediated by low-titre adeno-associated virus serotypes 1 and 5.

artículo científico publicado en 2008

Gene therapy in lung transplantation: effective gene transfer via the airways

artículo científico publicado en 1998

Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors.

artículo científico publicado en 2006

Gene transfer of manganese superoxide dismutase reverses vascular dysfunction in the absence but not in the presence of atherosclerotic plaque

artículo científico publicado en 2001

Gene transfer to coronary artery bypass conduits

artículo científico publicado en 2002

Gene-eluting stents: adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis

artículo científico publicado en 2008

Gene-eluting stents: comparison of adenoviral and adeno- associated viral gene delivery to the blood vessel wall in vivo.

artículo científico publicado en 2006

Gene-eluting stents: non-viral, liposome-based gene delivery of eNOS to the blood vessel wall in vivo results in enhanced endothelialization but does not reduce restenosis in a hypercholesterolemic model

artículo científico publicado en 2011

Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate.

artículo científico publicado en 2008

General practitioners' attitudes and preparedness towards Clinical Decision Support in e-Prescribing (CDS-eP) adoption in the West of Ireland: a cross sectional study.

artículo científico publicado en 2010

H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation

artículo científico publicado en 1999

HDL subparticles and coronary artery disease in NIDDM.

artículo científico publicado en 1996

High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix

artículo científico publicado en 2012

Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat.

artículo científico publicado en 2015

Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism

artículo científico publicado en 2009

Immunogenicity of allogeneic mesenchymal stem cells.

artículo científico publicado en 2012

Immunomodulatory effects of natural polysaccharides assessed in human whole blood culture and THP-1 cells show greater sensitivity of whole blood culture.

artículo científico publicado en 2016

Immunosuppression prolongs adenoviral mediated transgene expression in cardiac allograft transplantation

artículo científico publicado en 1997

Impact of Syndecan-2-Selected Mesenchymal Stromal Cells on the Early Onset of Diabetic Cardiomyopathy in Diabetic db/db Mice

artículo científico publicado en 2021

In vitro models for assessing therapeutic angiogenesis.

artículo científico publicado en 2016

In vivo gene transfer of inducible nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits

artículo científico publicado en 2003

Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells.

artículo científico publicado en 2015

Influence of temperature on adenovirus-mediated gene transfer

artículo científico publicado en 1998

Interference: an alteRNAtive therapy following acute myocardial infarction.

artículo científico

Introduction to series on mesenchymal stromal (stem) cells-MSCs

scientific article published on 01 September 2010

Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord

artículo científico publicado en 2012

Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia

artículo científico publicado el 7 de marzo de 2011

Liposomal gene delivery mediated by tissue-engineered scaffolds

artículo científico publicado en 2009

Liposomal surface coatings of metal stents for efficient non-viral gene delivery to the injured vasculature

artículo científico publicado en 2013

Macromolecular crowding meets oxygen tension in human mesenchymal stem cell culture - A step closer to physiologically relevant in vitro organogenesis.

artículo científico publicado en 2016

Measurement of the Postgraduate Educational Environment of Junior Doctors Training in Medicine at an Irish University Teaching Hospital

artículo científico publicado en 2015

Mesenchymal Stem Cell-mediated delivery of the sodium iodide symporter supports radionuclide imaging and treatment of breast cancer.

artículo científico publicado en 2011

Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells.

artículo científico publicado en 2009

Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression

artículo científico publicado en 2013

Mesenchymal stem cell-based treatment for microvascular and secondary complications of diabetes mellitus

artículo científico publicado en 2014

Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat.

artículo científico publicado en 2011

Mesenchymal stem cells overexpressing ephrin-b2 rapidly adopt an early endothelial phenotype with simultaneous reduction of osteogenic potential

artículo científico publicado en 2010

Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment.

artículo científico publicado en 2008

Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells.

artículo científico publicado en 2007

Multigene adenoviral therapy for the attenuation of ischemia-reperfusion injury after preservation for cardiac transplantation

artículo científico publicado en 2003

NRXN1α<sup>+/-</sup> is associated with increased excitability in ASD iPSC-derived neurons

artículo científico publicado en 2021

Nitric oxide synthase gene therapy: progress and prospects.

artículo científico publicado en 2009

Non-viral gene therapy for myocardial engineering

scientific article published on May 2010

Optimization of a fibrin scaffold for sustained release of an adenoviral gene vector

artículo científico publicado en 2006

Optimized aerosol delivery to a mechanically ventilated rodent

artículo científico publicado en 2009

Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury.

artículo científico publicado en 2011

OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas

artículo científico publicado en 2007

Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT).

artículo científico publicado en 2010

Pretreatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease

artículo científico publicado en 2012

Purification of adenoviral vectors by combined anion exchange and gel filtration chromatography.

artículo científico publicado en 2009

Purification of adenovirus and adeno-associated virus: comparison of novel membrane-based technology to conventional techniques.

artículo científico publicado en 2005

ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells

artículo científico publicado en 2015

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.

artículo científico publicado en 2016

Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold

artículo científico publicado en 2011

Relevance of an academic GMP Pan-European vector infra-structure (PEVI).

artículo científico

Remnant lipoproteins induce endothelial plasminogen activator inhibitor-1.

artículo científico publicado en 2001

Restructuring of the Diabetes Day Centre: a pilot lean project in a tertiary referral centre in the West of Ireland.

artículo científico

Results of treatment of pituitary disease in multiple endocrine neoplasia, type I.

artículo científico publicado en 1996

Scaffold and scaffold-free self-assembled systems in regenerative medicine.

artículo científico publicado en 2015

Stem Cell Research & Therapy in 2012.

artículo científico publicado en 2012

Stem cell therapy for cardiac disease.

artículo científico publicado en 2011

Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury

Surgical management of insulinoma associated with multiple endocrine neoplasia type I

artículo científico publicado en 1994

Systematic evaluation of distribution of transgene expression after adenovirus-mediated gene transfer to the transplanted heart

artículo científico publicado en 1998

Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose

scientific article published on 24 July 2020

The Promise of Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease.

artículo científico publicado en 2016

The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats

artículo científico publicado en 2013

The potential of cell-based therapy for diabetes and diabetes-related vascular complications

artículo científico

The rational design of beta cell cytoprotective gene transfer strategies: targeting deleterious iNOS expression.

artículo científico publicado en 2007

The use of therapeutic gene eNOS delivered via a fibrin scaffold enhances wound healing in a compromised wound model

artículo científico publicado en 2008

Therapeutic efficacy of human mesenchymal stromal cells in the repair of established ventilator-induced lung injury in the rat.

artículo científico publicado en 2015

Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia.

artículo científico publicado en 2012

Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro

artículo científico publicado en 2011

Three years of Stem Cell Research & Therapy

artículo científico publicado en 2013

Topical administration of allogeneic mesenchymal stromal cells seeded in a collagen scaffold augments wound healing and increases angiogenesis in the diabetic rabbit ulcer

artículo científico publicado en 2013

Transbronchial gene transfer of endothelial nitric oxide synthase to transplanted lungs

article

Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system

artículo científico publicado en 1998

Translating stem cell research to the clinic: a primer on translational considerations for your first stem cell protocol

artículo científico publicado en 2015

Translation of science to surgery: linking emerging concepts in biological cartilage repair to surgical intervention.

scientific article published on September 2010

Typical investigational medicinal products follow relatively uniform regulations in 10 European Clinical Research Infrastructures Network (ECRIN) countries

artículo científico publicado en 2012

Ulk4 Is Essential for Ciliogenesis and CSF Flow.

artículo científico publicado en 2016

Ulk4 Regulates Neural Stem Cell Pool

artículo científico publicado en 2016

Ulk4 deficiency leads to hypomyelination in mice

artículo científico publicado en 2017

Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds.

artículo científico publicado en 2013

Variability in Endogenous Perfusion Recovery of Immunocompromised Mouse Models of Limb Ischemia

artículo científico publicado en 2016

Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

artículo científico publicado en 2006

When a nephrectomy cures hypoglycaemia

artículo científico publicado el 17 de mayo de 2009

When head rules heart

artículo científico publicado en 2004

eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis

article