Lista de obras - William J. Martin - Dominio Público Uruguay

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

artículo científico publicado en 2005

3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity

article

A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model

artículo científico publicado en 2004

A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships

artículo científico publicado en 2012

A role for the melanocortin 4 receptor in sexual function

artículo científico publicado en 2002

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula

artículo científico publicado en 2002

An analgesia circuit activated by cannabinoids

artículo científico publicado en 1998

An examination of the central sites of action of cannabinoid-induced antinociception in the rat

artículo científico publicado en 1995

Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections

artículo científico publicado en 1999

Antinociceptive actions of cannabinoids following intraventricular administration in rats

artículo científico publicado en 1993

Application of the classical Einthoven model of bronchoconstriction to the study of inhaled bronchodilators in rodents

artículo científico publicado en 2010

Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

article

Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.

artículo científico publicado en 2005

Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla

artículo científico publicado en 1998

Characterization of Wide Dynamic Range Neurons in the Deep Dorsal Horn of the Spinal Cord in Preprotachykinin-A Null Mice In Vivo

artículo científico publicado en 2004

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior

artículo científico publicado en 2005

Currying favor with central inhibitory circuits. Focus on: "effects of TRPA1 agonists mustard oil and cinnamaldehyde on lumbar wide-dynamic range neuronal responses to innocuous and noxious cutaneous stimuli in rats".

artículo científico publicado en 2007

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

artículo científico publicado en 2002

Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing.

artículo científico publicado en 1999

Differential modulation of ventral tegmental area circuits by the nociceptin/orphanin FQ system

artículo científico publicado en 2020

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocorti

artículo científico publicado en 2005

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

artículo científico publicado en 2005

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

article

Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

artículo científico publicado en 2010

Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

artículo científico publicado en 2009

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

artículo científico publicado en 2011

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

artículo científico publicado en 2010

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

artículo científico publicado en 2009

Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists

artículo científico publicado en 2010

Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain

article

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists

artículo científico publicado en 2010

Effects of σ ligands on rat cerebellar purkinje neuron firing: An iontophoretic study

scientific article published on 01 January 1994

Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose

artículo científico publicado en 2009

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography

article

Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception

scientific journal article

Imidazopyridines: A novel class of hNav1.7 channel blockers

article

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

scientific journal article

In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models.

artículo científico publicado en 2013

Inflammation-induced up-regulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing.

artículo científico publicado en 1999

Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters

artículo científico publicado en 2009

Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2

artículo científico publicado en 1995

Melanocortin receptors and erectile function

artículo científico publicado en 2004

Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain

artículo científico publicado en 2005

Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

artículo científico publicado en 2010

Pain Processing: Paradoxes and Predictions

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

artículo científico publicado en 2014

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

article

Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.

artículo científico publicado en 2014

Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats

artículo científico publicado en 2005

Relationship between the firing frequency of injured peripheral neurons and inhibition of firing by sodium channel blockers

artículo científico publicado en 2006

Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model

artículo científico publicado en 2013

Reversal of neuropathic pain by alpha-hydroxyphenylamide: a novel sodium channel antagonist

artículo científico publicado en 2006

Sodium channel blockade may contribute to the analgesic efficacy of antidepressants

artículo científico publicado en 2006

Spinal cannabinoids are anti-allodynic in rats with persistent inflammation.

artículo científico publicado en 1999

Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers

article

Substituted biaryl pyrazoles as sodium channel blockers

article

Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers

artículo científico publicado en 2005

The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. ⬇️

artículo científico publicado en 2002

The behavioral and neuroanatomical effects of IB4-saporin treatment in rat models of nociceptive and neuropathic pain

artículo científico publicado en 2004

The rodent amygdala contributes to the production of cannabinoid-induced antinociception

artículo científico publicado en 2003

The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction

artículo científico publicado en 2009

Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs

artículo científico publicado en 2005

Lista de obras de William J. Martin

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity

A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model

A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships

A role for the melanocortin 4 receptor in sexual function

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula

An analgesia circuit activated by cannabinoids

An examination of the central sites of action of cannabinoid-induced antinociception in the rat

Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections

Antinociceptive actions of cannabinoids following intraventricular administration in rats

Application of the classical Einthoven model of bronchoconstriction to the study of inhaled bronchodilators in rodents

Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.

Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla

Characterization of Wide Dynamic Range Neurons in the Deep Dorsal Horn of the Spinal Cord in Preprotachykinin-A Null Mice In Vivo

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior

Currying favor with central inhibitory circuits. Focus on: "effects of TRPA1 agonists mustard oil and cinnamaldehyde on lumbar wide-dynamic range neuronal responses to innocuous and noxious cutaneous stimuli in rats".

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing.

Differential modulation of ventral tegmental area circuits by the nociceptin/orphanin FQ system

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocorti

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists

Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists

Effects of σ ligands on rat cerebellar purkinje neuron firing: An iontophoretic study

Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography

Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception

Imidazopyridines: A novel class of hNav1.7 channel blockers

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models.

Inflammation-induced up-regulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing.

Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters

Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2

Melanocortin receptors and erectile function

Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain

Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

Pain Processing: Paradoxes and Predictions

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.

Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats

Relationship between the firing frequency of injured peripheral neurons and inhibition of firing by sodium channel blockers

Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model

Reversal of neuropathic pain by alpha-hydroxyphenylamide: a novel sodium channel antagonist

Sodium channel blockade may contribute to the analgesic efficacy of antidepressants

Spinal cannabinoids are anti-allodynic in rats with persistent inflammation.

Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers

Substituted biaryl pyrazoles as sodium channel blockers

Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers

The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. ⬇️

The behavioral and neuroanatomical effects of IB4-saporin treatment in rat models of nociceptive and neuropathic pain

The rodent amygdala contributes to the production of cannabinoid-induced antinociception

The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction

Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs