Lista de obras - Efstratios Stratikos - Dominio Público Uruguay

3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties

artículo científico publicado en 2015

A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk.

artículo científico publicado en 2013

A continuous fluorigenic assay for the measurement of the activity of endoplasmic reticulum aminopeptidase 1: competition kinetics as a tool for enzyme specificity investigation.

artículo científico publicado en 2009

A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction.

scientific article published on January 2009

A novel ERAP2 haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk

artículo científico publicado en 2013

A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy.

artículo científico

A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition

artículo científico publicado en 2014

A simple approach for human recombinant apolipoprotein E4 expression and purification.

artículo científico publicado en 2011

A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1

artículo científico publicado en 2020

Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.

artículo científico publicado en 2012

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein

artículo científico publicado en 2021

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

artículo científico publicado en 2018

Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies ⬇️

artículo científico publicado el 29 de marzo de 2013

ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT ⬇️

artículo científico publicado el 6 de noviembre de 2012

Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.

artículo científico publicado en 2015

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia ⬇️

artículo científico publicado el 1 de enero de 2011

Change in environment of the P1 side chain upon progression from the Michaelis complex to the covalent serpin-proteinase complex

scientific article published on 01 September 1998

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

artículo científico publicado en 2021

Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece

artículo científico publicado en 2018

Correction to "Macromolecular Architecture and Encapsulation of the Anticancer Drug Everolimus Control the Self-Assembly of Amphiphilic Polypeptide-Containing Hybrids"

artículo científico publicado en 2020

Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

artículo científico publicado en 2017

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing

artículo científico publicado en 2015

Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.

artículo científico publicado en 2017

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

scientific article published on 30 December 2019

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

artículo científico publicado en 2021

Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)

artículo científico publicado en 2019

Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.

artículo científico publicado en 2015

Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro

scientific article published on 04 March 2019

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.

artículo científico publicado en 2013

Endoplasmic reticulum aminopeptidases as a double-faced tool to increase or decrease efficiency of antigen presentation in health and disease

scientific article published on 27 March 2019

Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain

artículo científico publicado en 2004

Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases

scientific article published on 01 November 2019

Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system

artículo científico publicado en 2019

Generation of SARS-CoV-2 S1 spike glycoprotein putative antigenic epitopes in vitro by intracellular aminopeptidases

artículo científico publicado en 2020

High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

scientific article published on 13 February 2019

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1

artículo científico publicado en 2011

Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis

artículo científico publicado en 2002

Impaired Antiatherogenic Functions of High-density Lipoprotein in Patients with Ankylosing Spondylitis.

artículo científico publicado en 2015

Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application.

artículo científico publicado en 2018

Intracellular Antigen Processing by ERAP2: Molecular Mechanism and Roles in Health and Disease

article

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

artículo científico publicado en 2017

Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh

artículo científico publicado en 1998

Marcromolecular Architecture and Encapsulation of the Anticancer Drug Everolimus Control the Self-Assembly of Amphiphilic Polypeptide-Containing Hybrids

scientific article published on 18 November 2019

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

scientific article published on 16 December 2019

Modulating antigen processing for cancer immunotherapy.

artículo científico publicado en 2014

Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.

artículo científico publicado en 2014

Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.

artículo científico publicado en 2018

Novel selective inhibitors of aminopeptidases that generate antigenic peptides.

artículo científico publicado en 2013

Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.

artículo científico publicado en 2016

Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1

artículo científico publicado en 2010

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

artículo científico publicado en 2011

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

artículo científico publicado en 2013

Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides

artículo científico publicado en 2014

Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.

artículo científico publicado en 2016

Self-Healing pH- and Enzyme Stimuli-Responsive Hydrogels for Targeted Delivery of Gemcitabine To Treat Pancreatic Cancer

artículo científico publicado en 2018

Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.

artículo científico publicado en 2013

Simultaneous determination of naproxen and its desmethyl metabolite in human serum by second-derivative synchronous fluorescence spectrometry

article by Dimitrios G. Konstantianos et al published May 1994 in Analytica Chimica Acta

Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2

artículo científico publicado en 2015

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

artículo científico publicado en 2011

Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment

artículo científico publicado en 2002

Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation

artículo científico publicado en 2020

The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism

artículo científico publicado en 2017

The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy

scientific article published on 04 January 2021

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

artículo científico publicado en 2017

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific.

artículo científico publicado en 2016

The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing

artículo científico publicado en 2012

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

artículo científico publicado en 2008

The role of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in modulating immune detection of choriocarcinoma

artículo científico publicado en 2018

Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy ⬇️

artículo científico publicado el 30 de octubre de 2012

Thermodynamic destabilization and aggregation propensity as the underlying mechanism behind the genetic association of apoE3 mutants and Lipoprotein Glomerulopathy

scientific article published on 11 October 2018

Lista de obras de Efstratios Stratikos

3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties

A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk.

A continuous fluorigenic assay for the measurement of the activity of endoplasmic reticulum aminopeptidase 1: competition kinetics as a tool for enzyme specificity investigation.

A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction.

A novel ERAP2 haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk

A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy.

A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition

A simple approach for human recombinant apolipoprotein E4 expression and purification.

A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1

Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies ⬇️

ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT ⬇️

Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia ⬇️

Change in environment of the P1 side chain upon progression from the Michaelis complex to the covalent serpin-proteinase complex

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece

Correction to "Macromolecular Architecture and Encapsulation of the Anticancer Drug Everolimus Control the Self-Assembly of Amphiphilic Polypeptide-Containing Hybrids"

Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing

Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)

Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.

Endoplasmic reticulum aminopeptidases as a double-faced tool to increase or decrease efficiency of antigen presentation in health and disease

Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain

Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases

Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system

Generation of SARS-CoV-2 S1 spike glycoprotein putative antigenic epitopes in vitro by intracellular aminopeptidases

High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1

Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis

Impaired Antiatherogenic Functions of High-density Lipoprotein in Patients with Ankylosing Spondylitis.

Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application.

Intracellular Antigen Processing by ERAP2: Molecular Mechanism and Roles in Health and Disease

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh

Marcromolecular Architecture and Encapsulation of the Anticancer Drug Everolimus Control the Self-Assembly of Amphiphilic Polypeptide-Containing Hybrids

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

Modulating antigen processing for cancer immunotherapy.

Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.

Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.

Novel selective inhibitors of aminopeptidases that generate antigenic peptides.

Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.

Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides

Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.

Self-Healing pH- and Enzyme Stimuli-Responsive Hydrogels for Targeted Delivery of Gemcitabine To Treat Pancreatic Cancer

Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.

Simultaneous determination of naproxen and its desmethyl metabolite in human serum by second-derivative synchronous fluorescence spectrometry

Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment

Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation

The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism

The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific.

The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

The role of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in modulating immune detection of choriocarcinoma

Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy ⬇️

Thermodynamic destabilization and aggregation propensity as the underlying mechanism behind the genetic association of apoE3 mutants and Lipoprotein Glomerulopathy