Lista de obras - Norman Saunders - Dominio Público Uruguay

A bipedal mammalian model for spinal cord injury research: The tammar wallaby

artículo científico publicado en 2017

A developmentally regulated blood-cerebrospinal fluid transfer mechanism for albumin in immature rats

artículo científico publicado en 1992

A fetuin-related glycoprotein (?2HS) in human embryonic and fetal development

article

Acetaminophen in Pregnancy and Adverse Childhood Neurodevelopment

artículo científico publicado en 2017

Acute-phase α2-macroglobulin in csf during development of the fetal rat.

artículo científico publicado en 1983

Age-dependent changes in the proteome following complete spinal cord transection in a postnatal South American opossum (Monodelphis domestica)

artículo científico publicado en 2011

Age-dependent transcriptome and proteome following transection of neonatal spinal cord of Monodelphis domestica (South American grey short-tailed opossum)

artículo científico publicado en 2014

Age-related differences in the local cellular and molecular responses to injury in developing spinal cord of the opossum, Monodelphis domestica

article

An immunocytochemical demonstration of alpha 2HS-glycoprotein in the developing neocortex of the rat

scientific journal article

An outflow of acetylcholine from normal and regenerating ventral roots of the cat.

artículo científico publicado en 1974

Aquaporin-1 in the choroid plexuses of developing mammalian brain

artículo científico publicado en 2005

Arrested development of the dorsal column following neonatal spinal cord injury in the opossum, Monodelphis domestica

artículo científico publicado en 2014

Assessment of upwind dinghy sailing performance using a Virtual Reality Dinghy Sailing Simulator.

artículo científico publicado en 1998

Axonal transport and acetylcholine in rat preganglionic neurones

artículo científico publicado en 1973

Barrier mechanisms in the brain, I. Adult brain.

artículo científico publicado en 1999

Barrier mechanisms in the developing brain.

artículo científico publicado en 2012

Barriers in the brain: a renaissance?

artículo científico publicado en 2008

Barriers in the developing brain and Neurotoxicology

artículo científico

Blood-CSF barrier function in the rat embryo.

artículo científico publicado en 2006

Blood-brain, blood-cerebrospinal fluid and cerebrospinal fluid-brain barriers in a marsupial (Macropus eugenii) during development

article

Blood-cerebrospinal fluid transfer of plasma proteins during fetal development in the sheep.

artículo científico publicado en 1980

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development.

artículo científico publicado en 2017

Breakdown of the blood-brain barrier to proteins in white matter of the developing brain following systemic inflammation.

artículo científico publicado en 2005

Cell junctions and membrane specializations in the ventricular zone (germinal matrix) of the developing sheep brain: a CSF-brain barrier

artículo científico publicado en 1987

Cellular distribution of transferrin immunoreactivity in the developing rat brain

artículo científico publicado en 1987

Cellular specificity of the blood-CSF barrier for albumin transfer across the choroid plexus epithelium

artículo científico publicado en 2014

Cellular transfer of macromolecules across the developing choroid plexus of Monodelphis domestica.

artículo científico publicado en 2009

Cerebrospinal fluid secretion

artículo científico publicado en 2010

Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice.

artículo científico publicado en 2007

Comparative aspects of subplate zone studied with gene expression in sauropsids and mammals

artículo científico publicado en 2011

Comparison of proteins in CSF of lateral and IVth ventricles during early development of fetal sheep

artículo científico publicado en 1983

Complex tight junctions of epithelial and of endothelial cells in early foetal brain

artículo científico publicado en 1975

Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.

artículo científico publicado en 2012

Correction: Molecular Characterisation of Transport Mechanisms at the Developing Mouse Blood–CSF Interface: A Transcriptome Approach.

artículo científico publicado en 2012

Determinants of drug entry into the developing brain

scientific article published on 07 August 2019

Development of motoneurons and primary sensory afferents in the thoracic and lumbar spinal cord of the South American opossum Monodelphis domestica

article

Development of spinal cord in the isolated CNS of a neonatal mammal (the opossum Monodelphis domestica) maintained in longterm culture

artículo científico publicado en 1994

Development of thalamocortical projections in the South American gray short-tailed opossum (Monodelphis domestica).

artículo científico publicado en 1998

Development of the lateral ventricular choroid plexus in a marsupial, Monodelphis domestica

artículo científico publicado en 2010

Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection ⬇️

artículo científico publicado el 1 de agosto de 2013

Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide

scientific article published on 12 April 2019

Developmental neurotoxicity of industrial chemicals

artículo científico publicado en 2007

Developmental profile of a fetuin-like glycoprotein in neocortex, cerebrospinal fluid and plasma of post-natal tammar wallaby (Macropus eugenii).

artículo científico publicado en 1991

Differential immunocytochemical staining for fetuin and transferrin in the developing cortical plate

artículo científico publicado en 1984

Distribution of alpha-fetoprotein in fetal plasma and in amniotic and allantoic fluids of the pig

scientific article published on 01 March 1984

Double replica technique applied to choroid plexus from early foetal sheep: completeness and complexity of tight junctions

artículo científico publicado el 1 de abril de 1979

Early cortical plate specific glycoprotein in a marsupial species belongs to the same family as fetuin and α2 HS glycoprotein

article

Effect of antimitotic drugs on the intraaxonal transport of neurotransmitters in rat adrenergic and cholinergic nerves

artículo científico publicado el 30 de junio de 1975

Effect of minocycline on inflammation-induced damage to the blood-brain barrier and white matter during development

artículo científico publicado en 2007

Effects of amino acids on zinc transport in rat erythrocytes ⬇️

artículo científico publicado el 1 de enero de 1992

Effects of histidine on tissue zinc distribution in rats

artículo científico publicado en 1992

Effects of neonatal systemic inflammation on blood-brain barrier permeability and behaviour in juvenile and adult rats

artículo científico publicado en 2011

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain

scientific article published on 08 June 2020

Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat.

artículo científico publicado en 2010

Electrolytes and water in the brain and cerebrospinal fluid of the foetal sheep and guinea-pig

artículo científico publicado en 1972

Engaging neuroscience to advance translational research in brain barrier biology.

artículo científico publicado en 2011

Expression and cellular distribution of ubiquitin in response to injury in the developing spinal cord of Monodelphis domestica

artículo científico publicado en 2013

Expression and distribution of fetuin in the developing sheep fetus

artículo científico publicado en 1994

Expression and localization of P2 nucleotide receptor subtypes during development of the lateral ventricular choroid plexus of the rat.

artículo científico publicado en 2007

Factors involved in inflammation-induced developmental white matter damage.

artículo científico publicado en 2009

Fetuin as a marker of cortical plate cells in the fetal cow neocortex: a comparison of the distribution of fetuin, alpha 2HS-glycoprotein, alpha-fetoprotein and albumin during early development

artículo científico publicado en 1987

Fetuin expression in the dorsal root ganglia and trigeminal ganglia of perinatal rats

artículo científico publicado en 1997

Fetuin in neurons of the retina and cerebellum during fetal and postnatal development of the rat.

artículo científico publicado en 1999

Fetuin in the developing neocortex of the rat: distribution and origin

artículo científico publicado en 2000

Fetuin--an old friend revisited

artículo científico publicado el 1 de noviembre de 1992

Fetuin: The bovine homologue of human α2 HS glycoprotein

artículo científico publicado en 1987

Fetuin: an acute phase protein in cattle

artículo científico publicado en 1992

Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)

artículo científico publicado en 2006

Growth of axons through a lesion in the intact CNS of fetal rat maintained in long-term culture

article

Hormonal evidence for induced ovulation in Monodelphis domestica

article

Identification of fetuin in human and rat fetuses and in other species

article

Immune responses at brain barriers and implications for brain development and neurological function in later life

artículo científico publicado en 2013

Immunohistochemical evidence for an intracellular localization of plasma proteins in human foetal choroid plexus and brain

artículo científico publicado el 1 de septiembre de 1979

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study

artículo científico publicado en 2015

Intercellular barriers to and transcellular transfer of albumin in the fetal sheep brain

artículo científico publicado en 1997

Intra-axonal transport of neurotransmitters in mammalian neurons.

artículo científico publicado en 1974

Letter: Permeability of blood-cerebrospinal fluid barrier during foetal and perinatal life

artículo científico publicado en 1976

Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat.

artículo científico publicado en 2005

Low levels of Na, K-ATPase and carbonic anhydrase II during choroid plexus development suggest limited involvement in early CSF secretion

artículo científico publicado en 2008

Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

artículo científico publicado en 2015

Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach.

artículo científico publicado en 2013

Medications for pregnant women: A balancing act between the interests of the mother and of the fetus

scientific article published on 26 April 2020

Modification of macrophage response to lipopolysaccharide by fetuin

article

Modification of protein transfer across blood/cerebrospinal fluid barrier in response to altered plasma protein composition during development

artículo científico publicado en 2010

Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach

artículo científico publicado en 2012

Monodelphis domestica (grey short-tailed opossum): an accessible model for studies of early neocortical development

artículo científico publicado en 1989

NEUROBID--an EU-funded project to study the developing brain barriers

artículo científico publicado en 2010

Neuraminic acid specific lectins as markers of early cortical plate neurons

artículo científico publicado en 1993

Nucleotide and deduced amino acid sequence of a gamma subunit of bovine fibrinogen.

artículo científico publicado en 1989

Nucleotide and deduced amino acid sequence of sheep alpha 1 antitrypsin.

artículo científico publicado en 1989

Onset of neocortical synaptogenesis in neonatal Monodelphis domestica (South American grey short-tailed opossum).

artículo científico publicado en 1992

Ontogenetic development of diffusional restriction to protein at the pial surface of the rat brain: an electron microscopical study

artículo científico publicado en 1997

Origin and fate of fetuin-containing neurons in the developing neocortex of the fetal sheep

artículo científico publicado en 1992

Pathological changes in the white matter after spinal contusion injury in the rat ⬇️

artículo científico publicado en 2012

Permeability and route of entry for lipid-insoluble molecules across brain barriers in developing Monodelphis domestica

artículo científico publicado en 2001

Permeability of the developing and mature blood-brain barriers to theophylline in rats.

artículo científico publicado en 1998

Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain

scientific article published on 15 July 2018

Plasma proteins in fetal sheep brain: blood-brain barrier and intracerebral distribution

artículo científico publicado en 1981

Postnatal development of the telencephalon of the tammar wallaby (Macropus eugenii). An accessible model of neocortical differentiation

artículo científico publicado en 1985

Proceedings: An experimental model of perinatal intraventricular haemorrhage.

artículo científico publicado en 1975

Proceedings: Penetration of labelled protein from blood into foetal brain and c.s.f

artículo científico publicado en 1975

Proceedings: Penetration of plasma proteins from blood into c.s.f. in the immature foetal sheep

artículo científico publicado en 1976

Proteins in cerebrospinal fluid and plasma of fetal pigs during development

artículo científico publicado en 1982

Proteins in cerebrospinal fluid and plasma of fetal rats during development

article

Proteins in cerebrospinal fluid and plasma of fetal sheep during development

article

Proteins in cerebrospinal fluid and plasma of the pouch young tammar wallaby (Macropus eugenii) during development

article

Rapid effect of nerve injury upon axonal transport of phospholipids

artículo científico publicado en 1980

Rapid transport of acetylcholine in rat sciatic nerve proximal and distal to a lesion

scientific article published on 01 January 1974

Reduced Levels of Alpha-1-Antitrypsin in Children Exposed to High Levels of Air Pollution

artículo científico publicado en 1993

Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse

artículo científico publicado en 2011

Regeneration of immature mammalian spinal cord after injury.

artículo científico publicado en 1996

Regeneration of supraspinal axons after complete transection of the thoracic spinal cord in neonatal opossums (Monodelphis domestica).

artículo científico publicado en 2003

Regulation of GABAB receptors by histamine and neuronal activity in the isolated spinal cord of neonatal opossum in culture

artículo científico publicado en 1991

Repair of connections in injured neonatal and embryonic spinal cord in vitro.

artículo científico publicado en 1994

SPARC/osteonectin, an endogenous mechanism for targeting albumin to the blood-cerebrospinal fluid interface during brain development

artículo científico publicado en 2011

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury

artículo científico publicado en 2016

Spatio-temporal progression of grey and white matter damage following contusion injury in rat spinal cord

artículo científico publicado en 2010

Species-specific transfer of plasma albumin from blood into different cerebrospinal fluid compartments in the fetal sheep.

artículo científico publicado en 1991

Spontaneous development of full weight-supported stepping after complete spinal cord transection in the neonatal opossum, Monodelphis domestica

artículo científico publicado en 2011

Stimulation of defecation in spinal cord-injured rats by a centrally acting ghrelin receptor agonist.

artículo científico publicado en 2011

Structural characteristics and barrier properties of the choroid plexuses in developing brain of the opossum (Monodelphis Domestica).

artículo científico publicado en 2003

Studies of the development of brain barrier systems to lipid insoluble molecules in fetal sheep ⬇️

artículo científico publicado el 1 de julio de 1979

Synthesis and localization of plasma proteins in the developing human brain

scientific article published on 01 July 1988

Synthesis of plasma proteins by rat fetal brain and choroid plexus

artículo científico publicado en 1984

Synthesis of plasma proteins in fetal, adult, and neoplastic human brain tissue

artículo científico publicado en 1986

Synthesis of the foetal protein fetuin by early developing neurons in the immature neocortex

artículo científico publicado en 1993

TGF-beta receptor type II and fetuin in the developing sheep neocortex.

artículo científico publicado en 1997

Technology for mobility in SCI 10 years from now.

artículo científico

Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials.

artículo científico publicado en 2017

The Effect of Local Application of Vinblastine or Colchicine on Acetylcholine Accumulation in Rat Sciatic Nerve1

artículo científico publicado en 1976

The biological significance of brain barrier mechanisms: help or hindrance in drug delivery to the central nervous system?

artículo científico publicado en 2016

The blood-CSF barrier explained: when development is not immaturity

artículo científico publicado en 2008

The development of a blood-brain barrier mechanism in foetal sheep

artículo científico publicado en 1974

The development of blood-brain barrier and choroid plexus function in immature foetal sheep.

artículo científico publicado en 1972

The distribution of acetylcholine in normal and in regenerating nerves

article

The distribution of plasma proteins during early embryonic development in the sheep

article

The effect of hypercapnia on a blood-brain barrier mechanism in foetal and new-born sheep

artículo científico publicado en 1976

The expression of fetuin in the development and maturation of the hemopoietic and immune systems

artículo científico publicado en 1996

The importance of the blood-brain barrier in fetuses and embryos

artículo científico publicado en 1991

The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions.

artículo científico publicado en 2015

The intact central nervous system of the newborn opossum in long-term culture: fine structure and GABA-mediated inhibition of electrical activity.

artículo científico publicado en 1991

The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.

artículo científico publicado en 1993

The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9.

artículo científico publicado en 2009

The nucleotide and deduced amino acid structures of sheep and pig fetuin. Common structural features of the mammalian fetuin family

artículo científico publicado en 1992

The rat protein encoded by clone pp63 is a fetuinα2-HS glycoprotein-like molecule, but is it the tyrosine kinase inhibitor pp63?

artículo científico publicado en 1992

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

artículo científico publicado en 2014

The subventricular zone is the developmental milestone of a 6-layered neocortex: comparisons in metatherian and eutherian mammals

artículo científico publicado en 2009

Transferrin in fetal rat brain and cerebrospinal fluid

artículo científico publicado en 1983

Transferrin in fetal sheep cerebrospinal fluid and plasma during gestation

artículo científico publicado en 1982

Transporters of the blood-brain and blood-CSF interfaces in development and in the adult.

artículo científico publicado en 2013

Transthyretin distribution in the developing choroid plexus of the South American opossum (Monodelphis domestica).

artículo científico publicado en 1997

Use of a virtual reality physical ride-on sailing simulator as a rehabilitation tool for recreational sports and community reintegration: a pilot study.

artículo científico publicado en 2013

Visual abnormalities in albino wallabies: a brief note

artículo científico publicado en 1999

Weight-bearing locomotion in the developing opossum, Monodelphis domestica following spinal transection: remodeling of neuronal circuits caudal to lesion

artículo científico publicado en 2013

Zn-binding globulin in human fetal brain and liver: a marker for passive blood/CSF transfer of protein

artículo científico publicado en 1993

alpha 2HS-glycoprotein is expressed at high concentration in human fetal plasma and cerebrospinal fluid

artículo científico publicado en 1993

Lista de obras de Norman Saunders

A bipedal mammalian model for spinal cord injury research: The tammar wallaby

A developmentally regulated blood-cerebrospinal fluid transfer mechanism for albumin in immature rats

A fetuin-related glycoprotein (?2HS) in human embryonic and fetal development

Acetaminophen in Pregnancy and Adverse Childhood Neurodevelopment

Acute-phase α2-macroglobulin in csf during development of the fetal rat.

Age-dependent changes in the proteome following complete spinal cord transection in a postnatal South American opossum (Monodelphis domestica)

Age-dependent transcriptome and proteome following transection of neonatal spinal cord of Monodelphis domestica (South American grey short-tailed opossum)

Age-related differences in the local cellular and molecular responses to injury in developing spinal cord of the opossum, Monodelphis domestica

An immunocytochemical demonstration of alpha 2HS-glycoprotein in the developing neocortex of the rat

An outflow of acetylcholine from normal and regenerating ventral roots of the cat.

Aquaporin-1 in the choroid plexuses of developing mammalian brain

Arrested development of the dorsal column following neonatal spinal cord injury in the opossum, Monodelphis domestica

Assessment of upwind dinghy sailing performance using a Virtual Reality Dinghy Sailing Simulator.

Axonal transport and acetylcholine in rat preganglionic neurones

Barrier mechanisms in the brain, I. Adult brain.

Barrier mechanisms in the developing brain.

Barriers in the brain: a renaissance?

Barriers in the developing brain and Neurotoxicology

Blood-CSF barrier function in the rat embryo.

Blood-brain, blood-cerebrospinal fluid and cerebrospinal fluid-brain barriers in a marsupial (Macropus eugenii) during development

Blood-cerebrospinal fluid transfer of plasma proteins during fetal development in the sheep.

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development.

Breakdown of the blood-brain barrier to proteins in white matter of the developing brain following systemic inflammation.

Cell junctions and membrane specializations in the ventricular zone (germinal matrix) of the developing sheep brain: a CSF-brain barrier

Cellular distribution of transferrin immunoreactivity in the developing rat brain

Cellular specificity of the blood-CSF barrier for albumin transfer across the choroid plexus epithelium

Cellular transfer of macromolecules across the developing choroid plexus of Monodelphis domestica.

Cerebrospinal fluid secretion

Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice.

Comparative aspects of subplate zone studied with gene expression in sauropsids and mammals

Comparison of proteins in CSF of lateral and IVth ventricles during early development of fetal sheep

Complex tight junctions of epithelial and of endothelial cells in early foetal brain

Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.

Correction: Molecular Characterisation of Transport Mechanisms at the Developing Mouse Blood–CSF Interface: A Transcriptome Approach.

Determinants of drug entry into the developing brain

Development of motoneurons and primary sensory afferents in the thoracic and lumbar spinal cord of the South American opossum Monodelphis domestica

Development of spinal cord in the isolated CNS of a neonatal mammal (the opossum Monodelphis domestica) maintained in longterm culture

Development of thalamocortical projections in the South American gray short-tailed opossum (Monodelphis domestica).

Development of the lateral ventricular choroid plexus in a marsupial, Monodelphis domestica

Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection ⬇️

Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide

Developmental neurotoxicity of industrial chemicals

Developmental profile of a fetuin-like glycoprotein in neocortex, cerebrospinal fluid and plasma of post-natal tammar wallaby (Macropus eugenii).

Differential immunocytochemical staining for fetuin and transferrin in the developing cortical plate

Distribution of alpha-fetoprotein in fetal plasma and in amniotic and allantoic fluids of the pig

Double replica technique applied to choroid plexus from early foetal sheep: completeness and complexity of tight junctions

Early cortical plate specific glycoprotein in a marsupial species belongs to the same family as fetuin and α2 HS glycoprotein

Effect of antimitotic drugs on the intraaxonal transport of neurotransmitters in rat adrenergic and cholinergic nerves

Effect of minocycline on inflammation-induced damage to the blood-brain barrier and white matter during development

Effects of amino acids on zinc transport in rat erythrocytes ⬇️

Effects of histidine on tissue zinc distribution in rats

Effects of neonatal systemic inflammation on blood-brain barrier permeability and behaviour in juvenile and adult rats

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain

Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat.

Electrolytes and water in the brain and cerebrospinal fluid of the foetal sheep and guinea-pig

Engaging neuroscience to advance translational research in brain barrier biology.

Expression and cellular distribution of ubiquitin in response to injury in the developing spinal cord of Monodelphis domestica

Expression and distribution of fetuin in the developing sheep fetus

Expression and localization of P2 nucleotide receptor subtypes during development of the lateral ventricular choroid plexus of the rat.

Factors involved in inflammation-induced developmental white matter damage.

Fetuin as a marker of cortical plate cells in the fetal cow neocortex: a comparison of the distribution of fetuin, alpha 2HS-glycoprotein, alpha-fetoprotein and albumin during early development

Fetuin expression in the dorsal root ganglia and trigeminal ganglia of perinatal rats

Fetuin in neurons of the retina and cerebellum during fetal and postnatal development of the rat.

Fetuin in the developing neocortex of the rat: distribution and origin

Fetuin--an old friend revisited

Fetuin: The bovine homologue of human α2 HS glycoprotein

Fetuin: an acute phase protein in cattle

Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)

Growth of axons through a lesion in the intact CNS of fetal rat maintained in long-term culture

Hormonal evidence for induced ovulation in Monodelphis domestica

Identification of fetuin in human and rat fetuses and in other species

Immune responses at brain barriers and implications for brain development and neurological function in later life

Immunohistochemical evidence for an intracellular localization of plasma proteins in human foetal choroid plexus and brain

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study

Intercellular barriers to and transcellular transfer of albumin in the fetal sheep brain

Intra-axonal transport of neurotransmitters in mammalian neurons.

Letter: Permeability of blood-cerebrospinal fluid barrier during foetal and perinatal life

Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat.

Low levels of Na, K-ATPase and carbonic anhydrase II during choroid plexus development suggest limited involvement in early CSF secretion