Lista de obras - Serge Van Calenbergh - Dominio Público Uruguay

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

scientific article published on 17 June 2020

2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F<sub>420</sub>)-Dependent Nitroreductase (Ddn)

artículo científico publicado en 2020

2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists

artículo científico publicado en 2006

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

artículo científico publicado en 2003

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

artículo científico publicado en 2010

4"-O-Alkylated α-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies

artículo científico publicado en 2018

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists

artículo científico publicado en 2002

6'-derivatised alpha-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

artículo científico publicado en 2008

A "clickable" MTX reagent as a practical tool for profiling small-molecule-intracellular target interactions via MASPIT.

artículo científico publicado en 2013

A Dissociated Glucocorticoid Receptor Modulator Reduces Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma

scientific article published on 05 March 2012

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

artículo científico publicado en 2013

AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ.

artículo científico publicado en 2009

Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents

artículo científico publicado en 2018

Alpha-heteroatom derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials

artículo científico publicado en 2012

Alternative reagents for methotrexate as immobilizing anchor moieties in the optimization of MASPIT: synthesis and biological evaluation

artículo científico publicado en 2015

An immunogen synthesis strategy for the development of specific anti-deoxynivalenol monoclonal antibodies

artículo científico publicado en 2014

An in silico approach for modelling T-helper polarizing iNKT cell agonists

artículo científico publicado en 2014

Antimalarial activity of N(6)-substituted adenosine derivatives. Part 3.

artículo científico publicado en 2004

Antioxidant flavone glycosides from the leaves of Fargesia robusta ⬇️

artículo científico publicado en 2010

Autoreactivity to Sulfatide by Human Invariant NKT Cells

artículo científico publicado en 2017

Broadening the Message: A Nanovaccine Co-loaded with Messenger RNA and α-GalCer Induces Antitumor Immunity through Conventional and Natural Killer T Cells

artículo científico publicado en 2019

Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner

scientific article published on 06 April 2020

Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR.

artículo científico publicado en 2008

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

scientific article published on 05 December 2019

Crystal Structures of Bovine CD1d Reveal Altered αGalCer Presentation and a Restricted A’ Pocket Unable to Bind Long-Chain Glycolipids

artículo científico publicado en 2012

Dancing on Coke: Smuggling Cocaine Dispersed in Polyvinyl Alcohol

artículo científico publicado en 2011

Design, synthesis and biological evaluation of novel bivalent ligands targeting Dopamine D2-like receptors and µ opioid receptor

artículo científico publicado en 2018

Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections

artículo científico publicado en 2016

Determination of paramethoxyamphetamine and other amphetamine-related designer drugs by liquid chromatography/sonic spray ionization mass spectrometry

artículo científico publicado en 2002

Development of a liquid chromatography/tandem mass spectrometry method for the quantification of fumonisin B1, B2 and B3 in cornflakes

artículo científico publicado en 2005

Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

artículo científico publicado en 2009

Discovery of Novel 7-Aryl 7-Deazapurine 3′-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi

Discovery of Pyrrolo[2,3-b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents

scientific article published on 20 September 2019

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

artículo científico publicado en 2004

Divergent strategy for the synthesis of alpha-aryl-substituted fosmidomycin analogues

artículo científico publicado en 2007

Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

scientific article published on 07 March 2019

Efficient Divergent Synthesis of New Immunostimulant 4″-Modified α-Galactosylceramide Analogues.

artículo científico publicado en 2017

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

artículo científico publicado en 2016

Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery

artículo científico publicado en 2011

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

artículo científico publicado en 2003

Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety

artículo científico publicado en 2005

Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics

artículo científico publicado en 2016

Fungicidal activity of truncated analogues of dihydrosphingosine

artículo científico publicado en 2008

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

artículo científico publicado en 2011

Galactosylsphingamides: new α-GalCer analogues to probe the F'-pocket of CD1d

artículo científico publicado en 2017

Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus

artículo científico publicado en 2016

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics

scientific article published on 29 April 2019

Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity

artículo científico publicado en 2009

Kinase Substrate Sensor (KISS), a mammalian in situ protein interaction sensor

artículo científico publicado en 2014

Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation

artículo científico publicado en 2015

Micellar Paclitaxel-Initiated RAFT Polymer Conjugates with Acid-Sensitive Behavior

Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists

artículo científico publicado en 2003

Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position

artículo científico publicado en 2004

Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate

artículo científico publicado en 2007

Mycobacterium tuberculosis Thymidine Monophosphate Kinase Inhibitors: Biological Evaluation and Conformational Analysis of 2′- and 3′-Modified Thymidine Analogues

scholarly article by Philippe Van Rompaey et al published August 2003 in European Journal of Organic Chemistry

New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma

artículo científico publicado en 2019

Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach

artículo científico publicado en 2016

Novel hamamelitannin analogues for the treatment of biofilm related MRSA infections-A scaffold hopping approach.

artículo científico publicado en 2016

Nucleosides with Transposed Base or 4'-Hydroxymethyl Moieties and Their Corresponding Oligonucleotides

artículo científico publicado en 2015

Optimizing the iNKT Cell Dependent Antitumor Effect Using an Altered Glycolipid

scholarly article by Sandrine Aspeslagh et al published January 2010 in Clinical Immunology

Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists

artículo científico publicado en 2006

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

scientific article published in Nature Communications

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

artículo científico publicado en 2007

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

artículo científico publicado en 2009

Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene

scientific article published on 08 January 2020

Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives

artículo científico publicado en 2011

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

article published in 2019

Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity

artículo científico publicado en 2012

Small-molecule potentiators for conventional antibiotics against Staphylococcus aureus

artículo científico publicado en 2017

Structural Basis for the Recognition of C20:2-αGalCer by the Invariant Natural Killer T Cell Receptor-like Antibody L363

artículo científico publicado en 2012

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors

artículo científico publicado en 2018

Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp

artículo científico publicado en 2011

Sydnone Ribosides as a Platform for the Synthesis of Pyrazole C-Nucleosides: A Unified Synthesis of Formycin B and Pyrazofurin

artículo científico publicado en 2020

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

artículo científico publicado en 2008

Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives

artículo científico publicado en 2009

Synthesis and P2Y₂ receptor agonist activities of uridine 5'-phosphonate analogues

artículo científico publicado en 2012

Synthesis and antiviral evaluation of α-L-2'-deoxythreofuranosyl nucleosides

artículo científico publicado en 2011

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase

artículo científico publicado en 2015

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.

artículo científico publicado en 2006

Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors

artículo científico publicado en 2006

Synthesis and biological evaluation of novel PDMP analogues

artículo científico publicado en 2006

Synthesis and conformational analysis of 1-[2,4-dideoxy-4-C-hydroxymethyl-alpha-l-lyxopyranosyl]thymine

artículo científico publicado en 2004

Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

artículo científico publicado en 2012

Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators

artículo científico publicado en 2014

Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors

artículo científico publicado en 2007

Synthesis and evaluation of alpha-halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) as antimalarials

artículo científico publicado en 2010

Synthesis and evaluation of amino-modified alpha-GalCer analogues

artículo científico publicado en 2010

Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones.

artículo científico publicado en 2012

Synthesis and evaluation of thiazolidinedione and dioxazaborocane analogues as inhibitors of AI-2 quorum sensing in Vibrio harveyi.

artículo científico publicado en 2012

Synthesis and in vitro evaluation of alpha-GalCer epimers

artículo científico publicado en 2008

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

artículo científico publicado en 2011

Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists

artículo científico publicado en 2008

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

artículo científico publicado en 2020

Synthesis of 5-substituted 2'-deoxyuridine-5'- phosphonate analogues and evaluation of their antiviral activity

artículo científico publicado en 2012

Synthesis of 6"-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands

artículo científico publicado en 2012

Synthesis of C-5″ and C-6″-modified α-GalCer analogues as iNKT-cell agonists

artículo científico publicado en 2015

Synthesis of C6''-modified α-C-GalCer analogues as mouse and human iNKT cell agonists

artículo científico publicado en 2017

Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides

Synthesis of a Versatile (S)-3-(Hydroxymethyl)butane-1,2,4-triol Building Block and its Application for the Stereoselective Synthesis ofN-Homoceramides

scientific article published on 01 December 2005

Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors

artículo científico publicado en 2006

Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity

artículo científico publicado en 2014

Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human gamma delta T cell activator

artículo científico publicado en 2008

Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

artículo científico publicado en 2007

Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand

artículo científico publicado en 2014

Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons

artículo científico publicado en 2002

Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands

artículo científico publicado en 2005

Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus

artículo científico publicado en 2018

Synthesis of α-Aryl-Substituted and Conformationally Restricted Fosmidomycin Analogues as Promising Antimalarials

Synthesis toward Bivalent Ligands for the Dopamine D2 and Metabotropic Glutamate 5 Receptors

scientific article published on 18 September 2018

Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors

artículo científico publicado en 2010

Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro.

artículo científico publicado en 2014

Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment

scientific article published on 08 January 2020

Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of Fosmidomycin

artículo científico publicado en 2016

The Quorum Sensing Inhibitor Hamamelitannin Increases Antibiotic Susceptibility of Staphylococcus aureus Biofilms by Affecting Peptidoglycan Biosynthesis and eDNA Release

artículo científico publicado en 2016

The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid

artículo científico publicado en 2012

The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides.

artículo científico publicado en 2014

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.

artículo científico publicado en 2009

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

artículo científico publicado en 2003

Transiently Responsive Block Copolymer Micelles Based on N-(2-Hydroxypropyl)methacrylamide Engineered with Hydrolyzable Ethylcarbonate Side Chains

artículo científico publicado en 2015

Triplex formation by pyrene-labelled probes for nucleic acid detection in fluorescence assays

artículo científico publicado en 2008

Unbreakable codes in electrospun fibers: digitally encoded polymers to stop medicine counterfeiting

artículo científico publicado en 2010

Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia

artículo científico publicado en 2008

Zwitterionic-hydrophilic interaction liquid chromatography for l-ascorbic acid 2-phosphate magnesium, a raw material in cell therapy

artículo científico publicado en 2018

pH-Degradable Mannosylated Nanogels for Dendritic Cell Targeting

artículo científico publicado en 2016

Lista de obras de Serge Van Calenbergh

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F<sub>420</sub>)-Dependent Nitroreductase (Ddn)

2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

4"-O-Alkylated α-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists

6'-derivatised alpha-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

A "clickable" MTX reagent as a practical tool for profiling small-molecule-intracellular target interactions via MASPIT.

A Dissociated Glucocorticoid Receptor Modulator Reduces Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ.

Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents

Alpha-heteroatom derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials

Alternative reagents for methotrexate as immobilizing anchor moieties in the optimization of MASPIT: synthesis and biological evaluation

An immunogen synthesis strategy for the development of specific anti-deoxynivalenol monoclonal antibodies

An in silico approach for modelling T-helper polarizing iNKT cell agonists

Antimalarial activity of N(6)-substituted adenosine derivatives. Part 3.

Antioxidant flavone glycosides from the leaves of Fargesia robusta ⬇️

Autoreactivity to Sulfatide by Human Invariant NKT Cells

Broadening the Message: A Nanovaccine Co-loaded with Messenger RNA and α-GalCer Induces Antitumor Immunity through Conventional and Natural Killer T Cells

Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner

Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR.

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Crystal Structures of Bovine CD1d Reveal Altered αGalCer Presentation and a Restricted A’ Pocket Unable to Bind Long-Chain Glycolipids

Dancing on Coke: Smuggling Cocaine Dispersed in Polyvinyl Alcohol

Design, synthesis and biological evaluation of novel bivalent ligands targeting Dopamine D2-like receptors and µ opioid receptor

Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections

Determination of paramethoxyamphetamine and other amphetamine-related designer drugs by liquid chromatography/sonic spray ionization mass spectrometry

Development of a liquid chromatography/tandem mass spectrometry method for the quantification of fumonisin B1, B2 and B3 in cornflakes

Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

Discovery of Novel 7-Aryl 7-Deazapurine 3′-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi

Discovery of Pyrrolo[2,3-b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Divergent strategy for the synthesis of alpha-aryl-substituted fosmidomycin analogues

Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Efficient Divergent Synthesis of New Immunostimulant 4″-Modified α-Galactosylceramide Analogues.

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety

Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics

Fungicidal activity of truncated analogues of dihydrosphingosine

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

Galactosylsphingamides: new α-GalCer analogues to probe the F'-pocket of CD1d

Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics

Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity

Kinase Substrate Sensor (KISS), a mammalian in situ protein interaction sensor

Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation

Micellar Paclitaxel-Initiated RAFT Polymer Conjugates with Acid-Sensitive Behavior

Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists

Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position

Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate

Mycobacterium tuberculosis Thymidine Monophosphate Kinase Inhibitors: Biological Evaluation and Conformational Analysis of 2′- and 3′-Modified Thymidine Analogues

New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma

Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach

Novel hamamelitannin analogues for the treatment of biofilm related MRSA infections-A scaffold hopping approach.

Nucleosides with Transposed Base or 4'-Hydroxymethyl Moieties and Their Corresponding Oligonucleotides

Optimizing the iNKT Cell Dependent Antitumor Effect Using an Altered Glycolipid

Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene

Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity

Small-molecule potentiators for conventional antibiotics against Staphylococcus aureus

Structural Basis for the Recognition of C20:2-αGalCer by the Invariant Natural Killer T Cell Receptor-like Antibody L363

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors

Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp

Sydnone Ribosides as a Platform for the Synthesis of Pyrazole C-Nucleosides: A Unified Synthesis of Formycin B and Pyrazofurin

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives

Synthesis and P2Y₂ receptor agonist activities of uridine 5'-phosphonate analogues

Synthesis and antiviral evaluation of α-L-2'-deoxythreofuranosyl nucleosides

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.