Lista de obras - Josune Orbe - Dominio Público Uruguay

A comparison between percutaneous and surgical transplantation of autologous skeletal myoblasts in a swine model of chronic myocardial infarction☆

article

Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury

artículo científico publicado en 2015

Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity.

artículo científico publicado en 2012

Altered atherosclerotic-related gene expression signature in circulating mononuclear leukocytes from hypercholesterolemic patients with low HDL cholesterol levels.

artículo científico publicado en 2014

Analysis of monocitary subpopulations in relation to cardiovascular risk factors

artículo científico publicado en 2019

Antioxidant vitamins increase the collagen content and reduce MMP-1 in a porcine model of atherosclerosis: implications for plaque stabilization

artículo científico publicado en 2003

Arterial thrombosis and genetic polymorphisms: too many actors, complex scenario

artículo científico publicado en 2005

Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease

scientific article published on 01 December 2008

Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis.

artículo científico publicado en 2011

Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury.

artículo científico publicado en 2014

Association of age, inflammatory markers and subclinical atherosclerosis in subjects free from cardiovascular disease

artículo científico publicado en 2008

Association of sepsis-related mortality with early increase of TIMP-1/MMP-9 ratio.

artículo científico publicado en 2014

Aterosclerosis en las enfermedades inflamatorias

scientific article published on 01 May 2007

C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis.

artículo científico publicado en 2006

CCL20 is increased in hypercholesterolemic subjects and is upregulated by LDL in vascular smooth muscle cells: role of NF-κB.

artículo científico publicado en 2011

CM352 Reduces Brain Damage and Improves Functional Recovery in a Rat Model of Intracerebral Hemorrhage.

artículo científico publicado en 2017

Changes in the fibrinolytic components of cultured human umbilical vein endothelial cells induced by endotoxin, tumor necrosis factor-alpha and interleukin-1alpha

artículo científico publicado en 1999

Circulating TIMP-1 is associated with hematoma volume in patients with spontaneous intracranial hemorrhage

artículo científico publicado en 2020

Combined sustained release of BMP2 and MMP10 accelerates bone formation and mineralization of calvaria critical size defect in mice

artículo científico publicado en 2018

Cyclooxygenase-2: a new therapeutic target in atherosclerosis?

artículo científico publicado en 2006

Design, Synthesis, and Biological Evaluation of Novel Matrix Metalloproteinase Inhibitors As Potent Antihemorrhagic Agents: From Hit Identification to an Optimized Lead

scientific article published on 25 February 2015

Different expression of MMPs/TIMP-1 in human atherosclerotic lesions. Relation to plaque features and vascular bed

artículo científico publicado en 2003

Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage

artículo científico publicado en 2015

Effect of the administration of recombinant hirudin and/or tissue-plasminogen activator (t-PA) on endotoxin-induced disseminated intravascular coagulation model in rabbits

artículo científico publicado en 1999

Effect of the administration of recombinant hirudin and/or tissue-plasminogen activator (t-PA) on endotoxin-induced disseminated intravascular coagulation model in rabbits

artículo científico publicado en 1999

Effects of low molecular weight heparin, alone or combined with antithrombin III, on mortality, fibrin deposits and hemostatic parameters in endotoxin-induced disseminated intravascular coagulation in rabbits.

artículo científico publicado en 1999

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis

artículo científico publicado en 2016

Evidence that Heparin but Not Hirudin Reduces PAI-1 Expression in Cultured Human Endothelial Cells

article

Fibrinógeno. Vieja proteína hemostática con nueva función: marcador no invasivo de aterosclerosis subclínica

artículo científico publicado en 2005

Folic acid and B vitamins improve hyperhomocysteinemia-induced cardiovascular risk profile in renal transplant recipients

artículo científico publicado en 2007

Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia.

artículo científico publicado en 2014

Functional and transcriptomic analysis of extracellular vesicles identifies calprotectin as a new prognostic marker in peripheral arterial disease (PAD)

artículo científico publicado en 2020

High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients

scientific article published on 18 July 2019

High triglyceride-low HDL cholesterol lipid profile is associated with a dysregulated gene expression in mononuclear leukocyte from hypercholesterolemic patients

scientific article published on 22 October 2014

Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test.

artículo científico publicado en 2008

Independent association of fibrinogen with carotid intima-media thickness in asymptomatic subjects.

artículo científico publicado en 2003

Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis

artículo científico publicado en 2006

Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects

artículo científico publicado en 2005

Influence of the 4G/5G PAI-1 genotype on angiotensin II-stimulated human endothelial cells and in patients with hypertension.

artículo científico publicado en 2004

Integrating soluble biomarkers and imaging technologies in the identification of vulnerable atherosclerotic patients.

artículo científico publicado en 2007

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors.

artículo científico publicado en 2002

Lack of TAFI increases brain damage and microparticle generation after thrombolytic therapy in ischemic stroke.

artículo científico publicado en 2015

MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade

scientific article published on 08 January 2020

MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy.

artículo científico publicado en 2014

MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes

scientific article published on 27 July 2018

Matrix Metalloproteinases in Diabetic Kidney Disease

scientific article published on 08 February 2020

Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C-X-C chemokine receptor 4 axis

artículo científico publicado en 2015

Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease

scientific article published on 23 October 2014

Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification

artículo científico publicado en 2018

Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism.

artículo científico publicado en 2011

Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair

artículo científico publicado en 2013

Matrix metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation

artículo científico publicado en 2009

Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis.

scientific article published on 02 October 2009

Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli.

artículo científico publicado en 2008

Metaloproteasas, remodelado vascular y syndromes aterotrombóticos

artículo científico publicado en 2007

Monocyte cyclooxygenase-2 activity: a new therapeutic target for atherosclerosis?

artículo científico publicado en 2005

Monocyte cyclooxygenase-2 overactivity: a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors?

artículo científico publicado en 2004

NADPH Oxidase Overactivity Underlies Telomere Shortening in Human Atherosclerosis

artículo científico publicado en 2020

New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator

artículo científico publicado en 2017

Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients

artículo científico publicado en 2019

Phagocytic NADPH Oxidase-Dependent Superoxide Production Stimulates Matrix Metalloproteinase-9

artículo científico publicado en 2006

Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents

scientific article published on 16 April 2018

Polimorfismo 4G/5G del PAI-1 en el síndrome metabólico

artículo científico publicado en 2006

Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension

artículo científico publicado en 2003

Prevalence of FVR506Q and prothrombin 20210A mutations in the Navarrese population

artículo científico publicado en 1998

Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors.

artículo científico publicado en 2006

Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease

artículo científico publicado en 2004

Recent progress in translational research on neurovascular and neurodegenerative disorders

artículo científico publicado en 2017

Reduced high-density lipoprotein cholesterol: A valuable, independent prognostic marker in peripheral arterial disease

artículo científico publicado en 2017

Selective increase of cardiomyocyte derived extracellular vesicles after experimental myocardial infarction and functional effects on the endothelium

artículo científico publicado en 2018

Serum levels of matrix metalloproteinase-10 are associated with the severity of atherosclerosis in patients with chronic kidney disease

artículo científico publicado en 2010

Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction

artículo científico publicado en 2015

Signature of subclinical femoral artery atherosclerosis in peripheral blood mononuclear cells

artículo científico publicado en 2014

Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo.

artículo científico publicado en 2012

Targeting γ-secretases protect against angiotensin II-induced cardiac hypertrophy

artículo científico publicado en 2015

The 372 T/C genetic polymorphism of TIMP-1 is associated with serum levels of TIMP-1 and survival in patients with severe sepsis.

artículo científico publicado en 2013

The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin.

artículo científico publicado en 2006

The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives.

artículo científico publicado en 2003

The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis.

artículo científico publicado en 2009

The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activity

artículo científico publicado en 2014

Tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients.

artículo científico publicado en 2013

Tissue-specific PAI-1 gene expression and glycosylation pattern in insulin-resistant old rats.

artículo científico publicado en 2009

Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease

artículo científico publicado en 2019

Vitamins C and E attenuate plasminogen activator inhibitor-1 (PAI-1) expression in a hypercholesterolemic porcine model of angioplasty

artículo científico publicado en 2001

Vulnerable plaque versus vulnerable patient: emerging blood biomarkers for risk stratification.

artículo científico publicado en 2007

[Atheroma plaque stabilization: a new concept based on the dynamic biology of atherosclerosis].

artículo científico publicado en 2003

[Functional characterization of a monoclonal antibody which interferes with the binding of t-PA to fibrin]

scientific article published on 01 August 1994

proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke.

artículo científico publicado en 2013

“Tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients.” Reply to a comment by Geddings and Mackman

artículo científico publicado en 2013

Lista de obras de Josune Orbe

A comparison between percutaneous and surgical transplantation of autologous skeletal myoblasts in a swine model of chronic myocardial infarction☆

Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury

Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity.

Altered atherosclerotic-related gene expression signature in circulating mononuclear leukocytes from hypercholesterolemic patients with low HDL cholesterol levels.

Analysis of monocitary subpopulations in relation to cardiovascular risk factors

Antioxidant vitamins increase the collagen content and reduce MMP-1 in a porcine model of atherosclerosis: implications for plaque stabilization

Arterial thrombosis and genetic polymorphisms: too many actors, complex scenario

Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease

Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis.

Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury.

Association of age, inflammatory markers and subclinical atherosclerosis in subjects free from cardiovascular disease

Association of sepsis-related mortality with early increase of TIMP-1/MMP-9 ratio.

Aterosclerosis en las enfermedades inflamatorias

C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis.

CCL20 is increased in hypercholesterolemic subjects and is upregulated by LDL in vascular smooth muscle cells: role of NF-κB.

CM352 Reduces Brain Damage and Improves Functional Recovery in a Rat Model of Intracerebral Hemorrhage.

Changes in the fibrinolytic components of cultured human umbilical vein endothelial cells induced by endotoxin, tumor necrosis factor-alpha and interleukin-1alpha

Circulating TIMP-1 is associated with hematoma volume in patients with spontaneous intracranial hemorrhage

Combined sustained release of BMP2 and MMP10 accelerates bone formation and mineralization of calvaria critical size defect in mice

Cyclooxygenase-2: a new therapeutic target in atherosclerosis?

Design, Synthesis, and Biological Evaluation of Novel Matrix Metalloproteinase Inhibitors As Potent Antihemorrhagic Agents: From Hit Identification to an Optimized Lead

Different expression of MMPs/TIMP-1 in human atherosclerotic lesions. Relation to plaque features and vascular bed

Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage

Effect of the administration of recombinant hirudin and/or tissue-plasminogen activator (t-PA) on endotoxin-induced disseminated intravascular coagulation model in rabbits

Effect of the administration of recombinant hirudin and/or tissue-plasminogen activator (t-PA) on endotoxin-induced disseminated intravascular coagulation model in rabbits

Effects of low molecular weight heparin, alone or combined with antithrombin III, on mortality, fibrin deposits and hemostatic parameters in endotoxin-induced disseminated intravascular coagulation in rabbits.

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis

Evidence that Heparin but Not Hirudin Reduces PAI-1 Expression in Cultured Human Endothelial Cells

Fibrinógeno. Vieja proteína hemostática con nueva función: marcador no invasivo de aterosclerosis subclínica

Folic acid and B vitamins improve hyperhomocysteinemia-induced cardiovascular risk profile in renal transplant recipients

Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia.

Functional and transcriptomic analysis of extracellular vesicles identifies calprotectin as a new prognostic marker in peripheral arterial disease (PAD)

High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients

High triglyceride-low HDL cholesterol lipid profile is associated with a dysregulated gene expression in mononuclear leukocyte from hypercholesterolemic patients

Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test.

Independent association of fibrinogen with carotid intima-media thickness in asymptomatic subjects.

Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis

Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects

Influence of the 4G/5G PAI-1 genotype on angiotensin II-stimulated human endothelial cells and in patients with hypertension.

Integrating soluble biomarkers and imaging technologies in the identification of vulnerable atherosclerotic patients.

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors.

Lack of TAFI increases brain damage and microparticle generation after thrombolytic therapy in ischemic stroke.

MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade

MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy.

MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes

Matrix Metalloproteinases in Diabetic Kidney Disease

Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C-X-C chemokine receptor 4 axis

Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease

Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification

Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism.

Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair

Matrix metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation

Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis.

Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli.

Metaloproteasas, remodelado vascular y syndromes aterotrombóticos

Monocyte cyclooxygenase-2 activity: a new therapeutic target for atherosclerosis?

Monocyte cyclooxygenase-2 overactivity: a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors?

NADPH Oxidase Overactivity Underlies Telomere Shortening in Human Atherosclerosis

New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator

Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients

Phagocytic NADPH Oxidase-Dependent Superoxide Production Stimulates Matrix Metalloproteinase-9

Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents

Polimorfismo 4G/5G del PAI-1 en el síndrome metabólico

Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension

Prevalence of FVR506Q and prothrombin 20210A mutations in the Navarrese population

Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors.

Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease

Recent progress in translational research on neurovascular and neurodegenerative disorders

Reduced high-density lipoprotein cholesterol: A valuable, independent prognostic marker in peripheral arterial disease

Selective increase of cardiomyocyte derived extracellular vesicles after experimental myocardial infarction and functional effects on the endothelium

Serum levels of matrix metalloproteinase-10 are associated with the severity of atherosclerosis in patients with chronic kidney disease

Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction

Signature of subclinical femoral artery atherosclerosis in peripheral blood mononuclear cells

Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo.

Targeting γ-secretases protect against angiotensin II-induced cardiac hypertrophy

The 372 T/C genetic polymorphism of TIMP-1 is associated with serum levels of TIMP-1 and survival in patients with severe sepsis.

The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin.

The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives.

The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis.