Lista de obras - Kasper D Rand - Dominio Público Uruguay

A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene

artículo científico publicado en 2017

A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life

artículo científico publicado en 2017

A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation

artículo científico publicado en 2007

A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry

artículo científico

A post-translational modification of human Norovirus capsid protein attenuates glycan binding

scientific article published on 21 March 2019

A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples

artículo científico publicado en 2016

Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

artículo científico publicado en 2006

An intact C-terminal end of albumin is required for its long half-life in humans

artículo científico publicado en 2020

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

artículo científico publicado en 2011

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

scientific article published on 02 December 2019

Circularized and solubility-enhanced MSPs facilitate simple and high-yield production of stable nanodiscs for studies of membrane proteins in solution

artículo científico publicado en 2019

Conformational Analysis of Proteins in Highly Concentrated Solutions by Dialysis-Coupled Hydrogen/Deuterium Exchange Mass Spectrometry

artículo científico publicado en 2016

Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor

artículo científico publicado en 2015

Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow

artículo científico publicado en 2015

Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry

artículo científico publicado en 2010

Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part.

artículo científico publicado en 2017

Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'.

artículo científico publicado en 2010

Conformational dynamics of the human serotonin transporter during substrate and drug binding

artículo científico publicado en 2019

Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs

artículo científico publicado en 2011

Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

artículo científico publicado en 2017

Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

artículo científico publicado en 2008

Development of a peptide probe for the occurrence of hydrogen (1H/2H) scrambling upon gas-phase fragmentation

scientific article published on 13 October 2007

Direct coupling of a flow-flow electromembrane extraction probe to LC-MS

artículo científico publicado en 2015

Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry

artículo científico publicado en 2014

ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements

artículo científico publicado en 2011

Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens

artículo científico publicado en 2008

Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution

artículo científico publicado en 2008

Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite

artículo científico publicado en 2017

False EX1 signatures caused by sample carryover during HX MS analyses

artículo científico publicado en 2011

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

artículo científico publicado en 2019

Formation of covalent di-tyrosine dimers in recombinant α-synuclein.

artículo científico publicado en 2015

Fully Automated Electro Membrane Extraction Autosampler for LC-MS Systems Allowing Soft Extractions for High-Throughput Applications

artículo científico publicado en 2016

Gas-phase fragmentation of peptides by MALDI in-source decay with limited amide hydrogen (1H/2H) scrambling.

artículo científico publicado en 2008

Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations

artículo científico publicado en 2009

Getting to the core of protein pharmaceuticals--Comprehensive structure analysis by mass spectrometry.

artículo científico publicado en 2015

Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.

artículo científico publicado en 2018

Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry.

artículo científico publicado en 2008

Hydrogen/deuterium exchange mass spectrometry with improved electrochemical reduction enables comprehensive epitope mapping of a therapeutic antibody to the cysteine-knot containing vascular endothelial growth factor

scientific article published on 10 April 2020

Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

scientific article published on 13 August 2019

Installation, validation, and application examples of two instrumental setups for gas-phase HDX-MS analysis of peptides and proteins

scientific article published on 18 May 2018

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb

scientific article published on 14 May 2019

Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS

scientific article published on 16 May 2019

Investigating the Role of Artemin Glycosylation

artículo científico publicado en 2016

Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry

artículo científico publicado en 2014

Investigating the utility of minimized sample preparation and high-resolution mass spectrometry for quantification of monoclonal antibody drugs

scientific article published on 30 July 2018

Loss of Ammonia during Electron-Transfer Dissociation of Deuterated Peptides as an Inherent Gauge of Gas-Phase Hydrogen Scrambling

artículo científico publicado en 2010

Mapping the Interactions of Selective Biochemical Probes of Antibody Conformation by Hydrogen-Deuterium Exchange Mass Spectrometry

artículo científico publicado en 2017

Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling.

artículo científico publicado en 2014

Molecular Basis of the Mechanisms Controlling MASTL

scientific article published on 18 December 2019

Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.

artículo científico publicado en 2006

Molecular architecture of the Jumonji C family histone demethylase KDM5B

artículo científico publicado en 2019

Probing the Binding Interfaces of Protein Complexes Using Gas-Phase H/D Exchange Mass Spectrometry

artículo científico

Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen-Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation.

artículo científico publicado en 2015

Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry

artículo científico publicado en 2018

Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry.

artículo científico publicado en 2009

Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry

artículo científico publicado en 2016

Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors.

artículo científico publicado en 2015

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

scientific article published on 27 June 2019

Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins.

artículo científico publicado en 2016

Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions

artículo científico publicado en 2018

Simple setup for gas-phase H/D exchange mass spectrometry coupled to electron transfer dissociation and ion mobility for analysis of polypeptide structure on a liquid chromatographic time scale

artículo científico publicado en 2014

Site-Specific Analysis of Gas-Phase Hydrogen/Deuterium Exchange of Peptides and Proteins by Electron Transfer Dissociation

artículo científico publicado en 2012

Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry

artículo científico publicado en 2014

Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay

scientific article published on 09 November 2011

Structure and Dynamics of a Promiscuous Xanthan Lyase from Paenibacillus nanensis and the Design of Variants with Increased Stability and Activity

artículo científico publicado en 2018

Substrate- and cofactor-independent inhibition of histone demethylase KDM4C.

artículo científico publicado en 2014

Substrate-induced conformational dynamics of the dopamine transporter.

artículo científico publicado en 2019

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

artículo científico publicado en 2018

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

artículo científico publicado en 2017

The dopamine transporter antiports potassium to increase the uptake of dopamine

artículo científico publicado en 2022

The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications

artículo científico publicado en 2017

The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry.

artículo científico publicado en 2008

Thiol-ene Microfluidic Chip for Performing Hydrogen/Deuterium Exchange of Proteins at Subsecond Time Scales

scientific article published on 21 December 2018

Thiol-ene Monolithic Pepsin Microreactor with a 3D-Printed Interface for Efficient UPLC-MS Peptide Mapping Analyses

artículo científico publicado en 2017

UV Photodissociation Mass Spectrometry Accurately Localize Sites of Backbone Deuteration in Peptides

artículo científico publicado en 2017

Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein (MOMP)-based Fusion Antigen CTH522 into Protein Nanoparticles

artículo científico publicado en 2018

Lista de obras de Kasper D Rand

A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene

A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life

A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation

A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry

A post-translational modification of human Norovirus capsid protein attenuates glycan binding

A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples

Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

An intact C-terminal end of albumin is required for its long half-life in humans

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

Circularized and solubility-enhanced MSPs facilitate simple and high-yield production of stable nanodiscs for studies of membrane proteins in solution

Conformational Analysis of Proteins in Highly Concentrated Solutions by Dialysis-Coupled Hydrogen/Deuterium Exchange Mass Spectrometry

Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor

Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow

Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry

Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part.

Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'.

Conformational dynamics of the human serotonin transporter during substrate and drug binding

Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs

Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

Development of a peptide probe for the occurrence of hydrogen (1H/2H) scrambling upon gas-phase fragmentation

Direct coupling of a flow-flow electromembrane extraction probe to LC-MS

Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry

ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements

Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens

Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution

Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite

False EX1 signatures caused by sample carryover during HX MS analyses

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

Formation of covalent di-tyrosine dimers in recombinant α-synuclein.

Fully Automated Electro Membrane Extraction Autosampler for LC-MS Systems Allowing Soft Extractions for High-Throughput Applications

Gas-phase fragmentation of peptides by MALDI in-source decay with limited amide hydrogen (1H/2H) scrambling.

Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations

Getting to the core of protein pharmaceuticals--Comprehensive structure analysis by mass spectrometry.

Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.

Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry.

Hydrogen/deuterium exchange mass spectrometry with improved electrochemical reduction enables comprehensive epitope mapping of a therapeutic antibody to the cysteine-knot containing vascular endothelial growth factor

Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

Installation, validation, and application examples of two instrumental setups for gas-phase HDX-MS analysis of peptides and proteins

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb

Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS

Investigating the Role of Artemin Glycosylation

Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry

Investigating the utility of minimized sample preparation and high-resolution mass spectrometry for quantification of monoclonal antibody drugs

Loss of Ammonia during Electron-Transfer Dissociation of Deuterated Peptides as an Inherent Gauge of Gas-Phase Hydrogen Scrambling

Mapping the Interactions of Selective Biochemical Probes of Antibody Conformation by Hydrogen-Deuterium Exchange Mass Spectrometry

Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling.

Molecular Basis of the Mechanisms Controlling MASTL

Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.

Molecular architecture of the Jumonji C family histone demethylase KDM5B

Probing the Binding Interfaces of Protein Complexes Using Gas-Phase H/D Exchange Mass Spectrometry

Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen-Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation.

Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry

Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry.

Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry

Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors.

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins.

Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions

Simple setup for gas-phase H/D exchange mass spectrometry coupled to electron transfer dissociation and ion mobility for analysis of polypeptide structure on a liquid chromatographic time scale

Site-Specific Analysis of Gas-Phase Hydrogen/Deuterium Exchange of Peptides and Proteins by Electron Transfer Dissociation

Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry

Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay

Structure and Dynamics of a Promiscuous Xanthan Lyase from Paenibacillus nanensis and the Design of Variants with Increased Stability and Activity

Substrate- and cofactor-independent inhibition of histone demethylase KDM4C.

Substrate-induced conformational dynamics of the dopamine transporter.

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

The dopamine transporter antiports potassium to increase the uptake of dopamine

The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications

The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry.

Thiol-ene Microfluidic Chip for Performing Hydrogen/Deuterium Exchange of Proteins at Subsecond Time Scales

Thiol-ene Monolithic Pepsin Microreactor with a 3D-Printed Interface for Efficient UPLC-MS Peptide Mapping Analyses

UV Photodissociation Mass Spectrometry Accurately Localize Sites of Backbone Deuteration in Peptides

Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein (MOMP)-based Fusion Antigen CTH522 into Protein Nanoparticles