Lista de obras - Gordon Roberts - Dominio Público Uruguay

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase†

article

1H NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution

artículo científico publicado en 1989

1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase

artículo científico publicado en 1997

A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation†

article

A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei

scientific article published on 01 July 1989

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

artículo científico publicado en 1997

A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant

artículo científico publicado en 1993

A novel post-translational modification of the peptide antibiotic subtilin: isolation and characterization of a natural variant from Bacillus subtilis A.T.C.C. 6633.

artículo científico publicado en 1993

A variety of roles for versatile zinc in metallo-β-lactamases.

artículo científico

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

artículo científico publicado en 2005

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

artículo científico publicado en 2004

Analysis of the binding of 1,3-diacetylchloramphenicol to chloramphenicol acetyltransferase by isotope-edited proton NMR and site-directed mutagenesis

artículo científico publicado en 1992

Applications of NMR in drug discovery

scientific article published on 01 June 2000

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

artículo científico publicado en 2010

Changes in the structure of bovine phospholipase A2 upon micelle binding

artículo científico publicado en 1995

Complete ¹H, ¹⁵N, and ¹³C resonance assignments of Bacillus cereus metallo-β-lactamase and its complex with the inhibitor R-thiomandelic acid.

artículo científico publicado en 2013

Conformational flexibility and protein specificity.

scientific article published on January 1991

Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis

artículo científico publicado en 2011

Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution

artículo científico publicado en 1999

Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex

artículo científico publicado en 1992

Detection of a Protein Conformational Equilibrium by Electrospray Ionisation-Ion Mobility-Mass Spectrometry

article

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity ⬇️

artículo científico publicado el 1 de mayo de 1998

Determination of the solution structures of domains II and III of protein G from Streptococcus by 1H nuclear magnetic resonance

artículo científico publicado en 1992

Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice

artículo científico publicado en 1995

Dihydrofolate reductase: multiple conformations and alternative modes of substrate binding

artículo científico publicado en 1989

Dihydrofolate reductase; sequential resonance assignments using 2D and 3D NMR and secondary structure determination in solution

artículo científico publicado en 1991

Direct Measurement of the pKaof Aspartic Acid 26 inLactobacillus caseiDihydrofolate Reductase: Implications for the Catalytic Mechanism

artículo científico publicado en 1999

Direct n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase

artículo científico publicado en 1994

Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.

artículo científico publicado en 2009

Domain motions in dihydrofolate reductase: a molecular dynamics study

artículo científico publicado en 1997

Dynamics of mononuclear cadmium beta-lactamase revealed by the combination of NMR and PAC spectroscopy

artículo científico publicado en 2001

Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P-450 BM-3 on substrate binding and catalytic activity

artículo científico publicado en 1995

Effects of single-residue substitutions on negative cooperativity in ligand binding to dihydrofolate reductase

artículo científico publicado en 1997

Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase

artículo científico publicado en 1994

Engineering the substrate specificity of Bacillus megaterium cytochrome P-450 BM3: hydroxylation of alkyl trimethylammonium compounds ⬇️

artículo científico publicado el 15 de octubre de 1997

Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency

artículo científico publicado en 2007

Folding and unfolding for binding: large-scale protein dynamics in protein–protein interactions

article

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

artículo científico publicado en 1996

High resolution 1H-NMR studies of Des-(B26-B30)-insulin; assignment of resonances and properties of aromatic residues

artículo científico publicado en 1989

High-Level Expression and Isotopic Labeling of Lactobacillus casei Dihydrofolate Reductase for Nuclear Magnetic Resonance Spectroscopy

scientific article published on 01 June 1995

Identification of the C2-1H histidine NMR resonances in chloramphenicol acetyltransferase by a 13C-1H heteronuclear multiple quantum coherence method

artículo científico publicado en 1991

Identification of the binding site on S100B protein for the actin capping protein CapZ.

artículo científico publicado en 1997

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

artículo científico publicado en 2006

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide

artículo científico publicado en 2006

In support of the BMRB.

artículo científico publicado en 2012

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

artículo científico publicado en 2007

Interaction of the lantibiotic nisin with mixed lipid bilayers: a 31P and 2H NMR study

article

Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues

artículo científico publicado en 2003

Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4.

artículo científico publicado en 2010

Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.

artículo científico publicado en 2005

Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1

artículo científico publicado en 2000

Mapping the interactions between streptococcal protein G and the Fab fragment of IgG in solution

scientific article published on 01 June 1994

Mechanism of lantibiotic-induced pore-formation.

artículo científico publicado en 1996

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

artículo científico publicado en 1997

Molecular analysis of the regulation of nisin immunity

article

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

artículo científico publicado en 2008

NMR Studies of the Mode of Binding of Corepressors and Inducers to Escherichia coli Trp Repressor

artículo científico publicado en 1996

NMR assignment of the C-terminal actin-binding domain of talin.

artículo científico publicado en 2007

NMR studies of multiple conformations in complexes of Lactobacillus casei dihydrofolate reductase with analogs of pyrimethamine

scientific article published on 01 October 1990

NMR studies of the Escherichia coli trp aporepressor. Sequence-specific assignment of the aromatic proton resonances.

artículo científico publicado en 1989

NMR studies of the activation of the Escherichia coli trp repressor

artículo científico publicado en 1991

Nuclear magnetic resonance assignments and secondary structure of bovine S100β protein

artículo científico publicado en 1995

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

artículo científico publicado en 2004

Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain

artículo científico publicado en 2003

Positively Cooperative Binding of Zinc Ions to Bacillus cereus 569/H/9 β-Lactamase II Suggests that the Binuclear Enzyme Is the Only Relevant Form for Catalysis

scientific article published on 06 August 2009

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

artículo científico publicado en 2013

Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.

artículo científico publicado en 2002

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

artículo científico publicado en 2002

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

artículo científico publicado en 2003

Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity

artículo científico publicado en 2001

Role of transmembrane pH gradient and membrane binding in nisin pore formation.

artículo científico publicado en 1997

Sequence-specific resonance assignment and conformational analysis of subtilin by 2D NMR.

artículo científico publicado en 1992

Sequencing of oligonucleotides using high performance liquid chromatography and electrospray mass spectrometry

article

Sequential 1H NMR assignments and secondary structure of an IgG-binding domain from protein G.

artículo científico publicado en 1991

Site-specific 15N-labelling of oligonucleotides for NMR: the trp operator and its interaction with the trp repressor.

artículo científico publicado en 1995

Solution structures of the Bacillus cereus metallo-β-lactamase BcII and its complex with the broad spectrum inhibitor R -thiomandelic acid

artículo científico publicado en 2013

Steady-state and picosecond-time-resolved fluorescence studies on the recombinant heme domain of Bacillus megaterium cytochrome P-450.

artículo científico publicado en 1997

Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains

artículo científico publicado en 2001

Structural Determinants of Integrin Binding to the Talin Rod

artículo científico publicado en 2009

Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain

artículo científico publicado en 2008

Structural consequences of site-directed mutagenesis in flexible protein domains: NMR characterization of the L(55,56)S mutant of RhoGDI.

artículo científico publicado en 2001

Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI.

artículo científico publicado en 2001

Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin

article

Structure-activity relationships in the peptide antibiotic nisin: role of dehydroalanine 5.

artículo científico publicado en 1996

Synthesis of a Simplified Bryostatin C-Ring Analogue That Binds to the CRD2 of Human PKC-α and Construction of a Novel BC-Analogue by an Unusual Julia Olefination Process

artículo científico publicado en 2003

The 1H-NMR assignments of the aromatic resonances in complexes of Lactobacillus casei dihydrofolate reductase and the origins of their chemical shifts

artículo científico publicado en 1990

The Conformation of Coenzyme A Bound to Chloramphenicol Acetyltransferase Determined by Transferred NOE Experiments

artículo científico publicado en 1996

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

artículo científico publicado en 2009

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

artículo científico publicado en 2010

The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.

artículo científico publicado en 2006

The binding of amide substrate analogues to phospholipase A2. Studies by 13C-nuclear-magnetic-resonance and infrared spectroscopy.

artículo científico publicado en 1992

The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

artículo científico publicado en 1996

The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction

article

The influence of aspartate 26 on the tautomeric forms of folate bound to Lactobacillus casei dihydrofolate reductase

artículo científico publicado en 1997

The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding

artículo científico publicado en 2003

The solution structure of the bovine S100B protein dimer in the calcium-free state

artículo científico publicado en 1996

The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate ⬇️

artículo científico publicado el 20 de marzo de 1998

Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies

artículo científico publicado en 2001

Trp-676 Facilitates Nicotinamide Coenzyme Exchange in the Reductive Half-Reaction of Human Cytochrome P450 Reductase: Properties of the Soluble W676H and W676A Mutant Reductases†

article

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

article

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

artículo científico publicado en 2005

Lista de obras de Gordon Roberts

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase†

1H NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution

1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase

A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation†

A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant

A novel post-translational modification of the peptide antibiotic subtilin: isolation and characterization of a natural variant from Bacillus subtilis A.T.C.C. 6633.

A variety of roles for versatile zinc in metallo-β-lactamases.

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

Analysis of the binding of 1,3-diacetylchloramphenicol to chloramphenicol acetyltransferase by isotope-edited proton NMR and site-directed mutagenesis

Applications of NMR in drug discovery

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

Changes in the structure of bovine phospholipase A2 upon micelle binding

Complete ¹H, ¹⁵N, and ¹³C resonance assignments of Bacillus cereus metallo-β-lactamase and its complex with the inhibitor R-thiomandelic acid.

Conformational flexibility and protein specificity.

Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis

Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution

Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex

Detection of a Protein Conformational Equilibrium by Electrospray Ionisation-Ion Mobility-Mass Spectrometry

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity ⬇️

Determination of the solution structures of domains II and III of protein G from Streptococcus by 1H nuclear magnetic resonance

Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice

Dihydrofolate reductase: multiple conformations and alternative modes of substrate binding

Dihydrofolate reductase; sequential resonance assignments using 2D and 3D NMR and secondary structure determination in solution

Direct Measurement of the pKaof Aspartic Acid 26 inLactobacillus caseiDihydrofolate Reductase: Implications for the Catalytic Mechanism

Direct n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase

Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.

Domain motions in dihydrofolate reductase: a molecular dynamics study

Dynamics of mononuclear cadmium beta-lactamase revealed by the combination of NMR and PAC spectroscopy

Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P-450 BM-3 on substrate binding and catalytic activity

Effects of single-residue substitutions on negative cooperativity in ligand binding to dihydrofolate reductase

Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase

Engineering the substrate specificity of Bacillus megaterium cytochrome P-450 BM3: hydroxylation of alkyl trimethylammonium compounds ⬇️

Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency

Folding and unfolding for binding: large-scale protein dynamics in protein–protein interactions

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

High resolution 1H-NMR studies of Des-(B26-B30)-insulin; assignment of resonances and properties of aromatic residues

High-Level Expression and Isotopic Labeling of Lactobacillus casei Dihydrofolate Reductase for Nuclear Magnetic Resonance Spectroscopy

Identification of the C2-1H histidine NMR resonances in chloramphenicol acetyltransferase by a 13C-1H heteronuclear multiple quantum coherence method

Identification of the binding site on S100B protein for the actin capping protein CapZ.

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide

In support of the BMRB.

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

Interaction of the lantibiotic nisin with mixed lipid bilayers: a 31P and 2H NMR study

Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues

Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4.

Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.

Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1

Mapping the interactions between streptococcal protein G and the Fab fragment of IgG in solution

Mechanism of lantibiotic-induced pore-formation.

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

Molecular analysis of the regulation of nisin immunity

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

NMR Studies of the Mode of Binding of Corepressors and Inducers to Escherichia coli Trp Repressor

NMR assignment of the C-terminal actin-binding domain of talin.

NMR studies of multiple conformations in complexes of Lactobacillus casei dihydrofolate reductase with analogs of pyrimethamine

NMR studies of the Escherichia coli trp aporepressor. Sequence-specific assignment of the aromatic proton resonances.

NMR studies of the activation of the Escherichia coli trp repressor

Nuclear magnetic resonance assignments and secondary structure of bovine S100β protein

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain

Positively Cooperative Binding of Zinc Ions to Bacillus cereus 569/H/9 β-Lactamase II Suggests that the Binuclear Enzyme Is the Only Relevant Form for Catalysis

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity

Role of transmembrane pH gradient and membrane binding in nisin pore formation.

Sequence-specific resonance assignment and conformational analysis of subtilin by 2D NMR.

Sequencing of oligonucleotides using high performance liquid chromatography and electrospray mass spectrometry

Sequential 1H NMR assignments and secondary structure of an IgG-binding domain from protein G.

Site-specific 15N-labelling of oligonucleotides for NMR: the trp operator and its interaction with the trp repressor.

Solution structures of the Bacillus cereus metallo-β-lactamase BcII and its complex with the broad spectrum inhibitor R -thiomandelic acid

Steady-state and picosecond-time-resolved fluorescence studies on the recombinant heme domain of Bacillus megaterium cytochrome P-450.

Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains

Structural Determinants of Integrin Binding to the Talin Rod