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Lista de obras de Colin Jackson

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

artículo científico publicado en 2014

A 5000-Fold Increase in the Specificity of a Bacterial Phosphotriesterase for Malathion through Combinatorial Active Site Mutagenesis

artículo científico publicado en 2014

A Polymer Surfactant Corona Dynamically Replaces Water in Solvent-Free Protein Liquids and Ensures Macromolecular Flexibility and Activity

scientific article published on 02 August 2012

A revised biosynthetic pathway for the cofactor F in prokaryotes

artículo científico publicado en 2019

Active Site Desolvation and Thermostability Trade-Offs in the Evolution of Catalytically Diverse Triazine Hydrolases

artículo científico publicado en 2016

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

artículo científico publicado en 2020

An integrative analysis of non-coding regulatory DNA variations associated with autism spectrum disorder

artículo científico publicado en 2018

Ancestral Protein Reconstruction Yields Insights into Adaptive Evolution of Binding Specificity in Solute-Binding Proteins

artículo científico publicado en 2016

Ancestral Protein Reconstruction and Circular Permutation for Improving the Stability and Dynamic Range of FRET Sensors.

artículo científico publicado en 2017

Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site

artículo científico publicado en 2006

Author Correction: Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme

artículo científico publicado en 2020

Biochemistry of microbial degradation of hexachlorocyclohexane and prospects for bioremediation

artículo científico publicado en 2010

Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera

artículo científico publicado en 2008

Catalytic improvement and evolution of atrazine chlorohydrolase

artículo científico publicado en 2009

Characterization of the phenylurea hydrolases A and B: founding members of a novel amidohydrolase subgroup

artículo científico publicado en 2009

Classification and substrate head-group specificity of membrane fatty acid desaturases.

artículo científico publicado en 2016

Cloning, expression, purification, crystallization and preliminary X-ray studies of a pyridoxine 5'-phosphate oxidase from Mycobacterium smegmatis

artículo científico publicado en 2008

Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases

artículo científico publicado en 2017

Competing S(N)2 and E2 reaction pathways for hexachlorocyclohexane degradation in the gas phase, solution and enzymes

artículo científico publicado en 2010

Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency

artículo científico publicado en 2016

Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects

artículo científico publicado en 2016

Consensus Mutagenesis and Ancestral Reconstruction Provide Insight into the Substrate Specificity and Evolution of the Front-End Δ6-Desaturase Family

artículo científico publicado en 2020

Constrained evolution of a bispecific enzyme: lessons for biocatalyst design

artículo científico publicado en 2017

Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction

artículo científico publicado en 2015

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

artículo científico publicado en 2019

Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation

artículo científico publicado en 2014

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

scientific article published on 18 September 2019

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

artículo científico publicado en 2012

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain

artículo científico publicado en 2019

Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC

artículo científico publicado en 2015

Engineering a solid-state metalloprotein hydrogen evolution catalyst

scientific article published on 28 February 2020

Enhancement of metallomacrocycle-based oxygen reduction catalysis through immobilization in a tunable silk-protein scaffold

scientific article published on 12 December 2019

Enzyme dynamics and engineering: one step at a time.

artículo científico publicado en 2014

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability

artículo científico publicado en 2016

Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein

artículo científico publicado en 2018

Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron

artículo científico publicado en 2015

Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series

artículo científico publicado en 2010

FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress

scientific article published on 19 December 2018

Genomic and metagenomic surveys of hydrogenase distribution indicate H2 is a widely utilised energy source for microbial growth and survival

artículo científico publicado en 2015

Growth of Escherichia coli coexpressing phosphotriesterase and glycerophosphodiester phosphodiesterase, using paraoxon as the sole phosphorus source

artículo científico publicado en 2004

Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme

scientific article published on 21 October 2019

Hydrophobic Shielding Drives Catalysis of Hydride Transfer in a Family of F420H2-Dependent Enzymes

artículo científico publicado en 2016

Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation

artículo científico publicado en 2010

Improving a natural enzyme activity through incorporation of unnatural amino acids.

artículo científico publicado en 2010

In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase

artículo científico publicado en 2008

Increased expression of a bacterial phosphotriesterase in Escherichia coli through directed evolution

artículo científico publicado en 2005

Intramolecular epistasis and the evolution of a new enzymatic function

artículo científico publicado en 2012

Iron(III) located in the dinuclear metallo-β-lactamase IMP-1 by pseudocontact shifts

artículo científico publicado en 2014

Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers

artículo científico publicado en 2011

Kinetics and efficacy of an organophosphorus hydrolase in a rodent model of methyl-parathion poisoning.

artículo científico publicado en 2010

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

scientific article published on 13 June 2019

Laboratory evolution of protein conformational dynamics.

artículo científico publicado en 2017

Malonate-bound structure of the glycerophosphodiesterase fromEnterobacter aerogenes(GpdQ) and characterization of the native Fe2+metal-ion preference

artículo científico publicado en 2008

Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography

artículo científico publicado en 2016

Method for Developing Optical Sensors Using a Synthetic Dye-Fluorescent Protein FRET Pair and Computational Modeling and Assessment

artículo científico publicado en 2017

Mining electron density for functionally relevant protein polysterism in crystal structures

artículo científico publicado el 29 de diciembre de 2010

Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila

artículo científico publicado en 2017

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

artículo científico publicado en 2018

Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme

artículo científico publicado en 2010

Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism.

artículo científico publicado en 2017

Overcoming insecticide resistance through computational inhibitor design

artículo científico publicado en 2019

Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.

artículo científico publicado en 2016

Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles

artículo científico publicado en 2015

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

artículo científico publicado en 2020

Protein engineering with unnatural amino acids

artículo científico

Protein engineering: the potential of remote mutations

scientific article published on 22 March 2019

Protonation state of F420H2 in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis

artículo científico publicado en 2016

Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling

artículo científico publicado en 2012

Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

artículo científico publicado en 2015

Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosis

artículo científico publicado en 2016

Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase

artículo científico publicado en 2016

Sequence-Structure-Function Classification of a Catalytically Diverse Oxidoreductase Superfamily in Mycobacteria

artículo científico publicado en 2015

Sequential Electrostatic Assembly of a Polymer Surfactant Corona Increases Activity of the Phosphotriesterase arPTE

artículo científico publicado en 2019

Strategies for Increasing Protein Stability

artículo científico publicado en 2020

Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the PII-like Protein, SbtB, from Cyanobium sp. PCC7001

artículo científico publicado en 2019

Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors

artículo científico publicado en 2019

Structural and functional characterization of a putative de novo gene in Drosophila

artículo científico publicado en 2021

Structural reconstruction of protein ancestry

artículo científico publicado en 2017

Structure and function of an insect  -carboxylesterase ( Esterase7) associated with insecticide resistance

artículo científico publicado en 2013

Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge?

artículo científico publicado en 2017

Structure-based rational design of a phosphotriesterase

artículo científico publicado en 2009

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

artículo científico publicado en 2021

Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases

artículo científico publicado en 2021

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes

artículo científico publicado en 2008

Synthesis of a D-Ring Isomer of Galanthamine via a Radical-Based Smiles Rearrangement Reaction

artículo científico publicado en 2014

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

artículo científico publicado en 2017

Testing the evolvability of an insect carboxylesterase for the detoxification of synthetic pyrethroid insecticides

artículo científico publicado en 2012

The Structure and Stability of the Disulfide-Linked γS-Crystallin Dimer Provide Insight into Oxidation Products Associated with Lens Cataract Formation

scientific article published on 13 December 2018

The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase.

artículo científico publicado en 2017

The effects of substrate orientation on the mechanism of a phosphotriesterase

scientific article published on 16 November 2005

The enzymatic basis for pesticide bioremediation.

artículo científico publicado en 2008

The evolution of multiple active site configurations in a designed enzyme

scientific article published in Nature Communications

The evolution of new enzyme function: lessons from xenobiotic metabolizing bacteria versus insecticide-resistant insects

artículo científico publicado en 2011

The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria.

artículo científico publicado en 2016

The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila

artículo científico publicado en 2019

The purification, crystallization and preliminary diffraction of a glycerophosphodiesterase from Enterobacter aerogenes

artículo científico publicado en 2006

The redox cofactor F420 protects mycobacteria from diverse antimicrobial compounds and mediates a reductive detoxification system

artículo científico publicado en 2016

The role of protein dynamics in the evolution of new enzyme function

artículo científico publicado en 2016

The structure and function of a novel glycerophosphodiesterase from Enterobacter aerogenes

artículo científico publicado en 2007

The structure of an enzyme-product complex reveals the critical role of a terminal hydroxide nucleophile in the bacterial phosphotriesterase mechanism

artículo científico publicado en 2005

Total Syntheses of the 3H-Pyrrolo[2,3-c]quinolone-Containing Alkaloids Marinoquinolines A-F, K, and Aplidiopsamine A Using a Palladium-Catalyzed Ullmann Cross-Coupling/Reductive Cyclization Pathway

artículo científico publicado en 2019

Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning

artículo científico publicado en 2014

Use of engineered enzymes to identify organophosphate and pyrethroid-related toxicity in toxicity identification evaluations.

artículo científico publicado en 2009