Lista de obras - Craig Lygate - Dominio Público Uruguay

(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism

artículo científico publicado en 2013

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

artículo científico publicado en 2018

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy

scientific journal article

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

scientific journal article

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis

artículo científico publicado en 2013

ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome.

artículo científico publicado en 2016

Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice

artículo científico publicado en 2016

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

scientific journal article

Accelerated cardiac magnetic resonance imaging in the mouse using an eight‐channel array at 9.4 Tesla ⬇️

artículo científico publicado el 1 de enero de 2011

Accelerating cine-MR imaging in mouse hearts using compressed sensing.

artículo científico publicado en 2011

Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling

artículo científico publicado en 2011

Accurate infarct-size measurements from accelerated, compressed sensing reconstructed cine-MRI images in mouse hearts.

artículo científico publicado en 2012

Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans

artículo científico publicado en 2015

Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

scientific article published on 18 March 2019

Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields

artículo científico publicado en 2004

Augmentation of Creatine in the Heart.

artículo científico publicado en 2015

CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system

artículo científico publicado en 2006

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity

artículo científico publicado en 2014

Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background

artículo científico publicado en 2008

Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study

artículo científico publicado en 2008

Changes in creatine transporter function during cardiac maturation in the rat.

artículo científico publicado en 2010

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

artículo científico publicado en 2005

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

artículo científico publicado en 2012

Compressed sensing to accelerate magnetic resonance spectroscopic imaging: evaluation and application to 23Na-imaging of mouse hearts

artículo científico publicado en 2015

Creatine uptake in mouse hearts with genetically altered creatine levels

artículo científico publicado en 2008

Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.

artículo científico publicado en 2017

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.

artículo científico publicado en 2018

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation

artículo científico publicado en 2013

Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system

artículo científico publicado en 2003

Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart

scientific article published on 01 September 2006

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

artículo científico publicado en 2012

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

artículo científico publicado en 2006

High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.

artículo científico publicado en 2010

Highly accelerated cardiac functional MRI in rodent hearts using compressed sensing and parallel imaging at 9.4T.

artículo científico publicado en 2012

How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging.

artículo científico publicado en 2006

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine ⬇️

artículo científico publicado en 2018

Improved method for quantification of regional cardiac function in mice using phase-contrast MRI.

artículo científico publicado en 2011

Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart

scientific journal article

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

artículo científico publicado en 2017

Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart.

artículo científico publicado en 2006

Investigating cardiac energetics in heart failure

artículo científico publicado en 2013

Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats

artículo científico publicado en 2002

Letter to the editor: infarct size measurements are critically important when comparing interventions affecting ventricular remodeling

artículo científico publicado en 2007

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

artículo científico publicado en 2013

Long-term stability of cardiac function in normal and chronically failing mouse hearts in a vertical-bore MR system.

artículo científico publicado en 2004

MLP accumulation and remodelling in the infarcted rat heart

artículo científico publicado en 2005

Mechanisms of creatine depletion in chronically failing rat heart

artículo científico publicado en 2005

Metabolic arithmetic: do two wrongs make a right?

artículo científico publicado en 2017

Metabolic flux as a predictor of heart failure prognosis

artículo científico publicado en 2014

Metabolic remodelling in hypertrophied and failing myocardium: a review.

artículo científico publicado en 2017

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity

artículo científico publicado en 2009

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction

artículo científico publicado en 2012

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart

artículo científico publicado en 2014

Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus

artículo científico publicado en 2013

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion. ⬇️

artículo científico publicado en 2018

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure

scientific article published on 10 January 2020

Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia

artículo científico publicado en 2016

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

artículo científico publicado en 2016

Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice

artículo científico publicado en 2004

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice

artículo científico publicado en 2005

Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo

artículo científico publicado en 2004

Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart

artículo científico publicado en 2009

Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale

artículo científico publicado en 2015

Resolving Fine Cardiac Structures in Rats with High-Resolution Diffusion Tensor Imaging ⬇️

artículo científico publicado en 2016

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.

artículo científico publicado en 2013

Serial high resolution 3D–MRI after aortic banding in mice: band internalization is a source of variability in the hypertrophic response

scientific article published on 01 September 2005

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice

artículo científico publicado en 2005

The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function

artículo científico publicado en 2022

The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction

artículo científico publicado en 2003

The Subcellular Localisation of Neuronal Nitric Oxide Synthase Determines the Downstream Effects of NO on Myocardial Function

artículo científico publicado en 2017

The creatine kinase energy transport system in the failing mouse heart

artículo científico publicado en 2007

The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury

artículo científico publicado en 2018

Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 Tesla

artículo científico publicado en 2008

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.

artículo científico publicado en 2013

Validation of diffusion tensor MRI measurements of cardiac microstructure with structure tensor synchrotron radiation imaging ⬇️

artículo científico publicado en 2017

nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction

artículo científico publicado en 2005

Lista de obras de Craig Lygate

(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis

ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome.

Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

Accelerated cardiac magnetic resonance imaging in the mouse using an eight‐channel array at 9.4 Tesla ⬇️

Accelerating cine-MR imaging in mouse hearts using compressed sensing.

Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling

Accurate infarct-size measurements from accelerated, compressed sensing reconstructed cine-MRI images in mouse hearts.

Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans

Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields

Augmentation of Creatine in the Heart.

CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity

Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background

Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study

Changes in creatine transporter function during cardiac maturation in the rat.

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

Compressed sensing to accelerate magnetic resonance spectroscopic imaging: evaluation and application to 23Na-imaging of mouse hearts

Creatine uptake in mouse hearts with genetically altered creatine levels

Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation

Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system

Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.

Highly accelerated cardiac functional MRI in rodent hearts using compressed sensing and parallel imaging at 9.4T.

How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging.

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine ⬇️

Improved method for quantification of regional cardiac function in mice using phase-contrast MRI.

Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart.

Investigating cardiac energetics in heart failure

Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats

Letter to the editor: infarct size measurements are critically important when comparing interventions affecting ventricular remodeling

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

Long-term stability of cardiac function in normal and chronically failing mouse hearts in a vertical-bore MR system.

MLP accumulation and remodelling in the infarcted rat heart

Mechanisms of creatine depletion in chronically failing rat heart

Metabolic arithmetic: do two wrongs make a right?

Metabolic flux as a predictor of heart failure prognosis

Metabolic remodelling in hypertrophied and failing myocardium: a review.

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart

Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion. ⬇️

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure

Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice

Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo

Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart

Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale

Resolving Fine Cardiac Structures in Rats with High-Resolution Diffusion Tensor Imaging ⬇️

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.

Serial high resolution 3D–MRI after aortic banding in mice: band internalization is a source of variability in the hypertrophic response

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice

The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function

The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction

The Subcellular Localisation of Neuronal Nitric Oxide Synthase Determines the Downstream Effects of NO on Myocardial Function

The creatine kinase energy transport system in the failing mouse heart

The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury

Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 Tesla

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.

Validation of diffusion tensor MRI measurements of cardiac microstructure with structure tensor synchrotron radiation imaging ⬇️

nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction