Lista de obras - Raffaele De Francesco - Dominio Público Uruguay

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

artículo científico publicado en 2006

A POU-A related region dictates DNA binding specificity of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer ⬇️

artículo científico publicado el 1 de noviembre de 1992

A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease

artículo científico publicado en 1996

A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates

artículo científico publicado en 1996

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

artículo científico publicado en 2002

A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand

artículo científico publicado en 2005

A high-throughput radiometric assay for hepatitis C virus NS3 protease

artículo científico publicado en 1999

A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody

artículo científico publicado en 1999

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR (EMBO reports, February 2003) (Erratum)

article

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR.

artículo científico publicado en 2003

A scintillation proximity active site binding assay for the hepatitis C virus serine protease

artículo científico publicado en 2002

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies

artículo científico publicado en 2006

A zinc binding site in viral serine proteinases

artículo científico publicado en 1996

Activity of purified hepatitis C virus protease NS3 on peptide substrates

artículo científico publicado en 1996

Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease ⬇️

artículo científico publicado el 1 de mayo de 1997

An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A

artículo científico publicado en 1995

Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees

artículo científico publicado en 2022

Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study

artículo científico publicado en 2021

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

artículo científico publicado en 2003

Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines.

artículo científico publicado en 2000

Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence

artículo científico publicado en 2000

Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires ⬇️

artículo científico publicado el 1 de octubre de 1997

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

artículo científico publicado en 2003

Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

artículo científico publicado en 2004

Circular dichroism study on the conformational stability of the dimerization domain of transcription factor LFB1

artículo científico publicado en 1991

Cirrhosis and Rapid Virological Response to Peginterferon Plus Ribavirin Determine Treatment Outcome in HCV-1 IL28B rs12979860 CC Patients ⬇️

artículo científico publicado el 9 de julio de 2013

Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide

artículo científico publicado en 1997

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

artículo científico publicado en 1998

Corrigendum: Genome-Wide Analysis of DNA Methylation, Copy Number Variation, and Gene Expression in Monozygotic Twins Discordant for Primary Biliary Cirrhosis

artículo científico publicado en 2014

Crystallization and preliminary X-ray diffraction studies of the transcriptional regulator TraR bound to its cofactor and to a specific DNA sequence

artículo científico publicado en 2002

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.

artículo científico publicado en 2015

Daclatasvir: a team player rather than a prima donna in the treatment of hepatitis C.

artículo científico publicado en 2014

Design of selective eglin inhibitors of HCV NS3 proteinase

artículo científico publicado en 1998

Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance

article

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

artículo científico publicado en 2011

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase

artículo científico publicado en 2004

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.

artículo científico publicado en 2011

Enzymatic properties of hepatitis C virus NS3-associated helicase

artículo científico publicado en 2000

Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.

artículo científico publicado en 2007

Flavodoxin-cytochrome c interactions: circular dichroism and nuclear magnetic resonance studies.

artículo científico publicado en 1987

Genetic variation in the interleukin -28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection

article

Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis

artículo científico publicado en 2014

HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis

artículo científico publicado en 2004

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.

artículo científico publicado en 2015

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors

artículo científico publicado en 2006

Hepatitis C virus-specific directly acting antiviral drugs

artículo científico

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

artículo científico publicado en 2013

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming

artículo científico publicado en 2016

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.

artículo científico publicado en 2012

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors

artículo científico publicado en 2009

Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis

artículo científico publicado en 2012

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

artículo científico publicado en 2003

In vitro antibiofilm activity of bioactive glass S53P4.

artículo científico publicado en 2014

Influence of 8.alpha.-imidazole substitution of the FMN cofactor on the rate of electron transfer from the neutral semiquinones of two flavodoxins to cytochrome c

scientific article published on 01 August 1987

Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

artículo científico publicado en 2003

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.

artículo científico publicado en 2014

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

artículo científico publicado en 2005

Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients

artículo científico publicado en 2014

Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.

artículo científico publicado en 2012

Kinetic Studies on the Electron-Transfer Reaction between Cytochrome c3 and Flavodoxin from Desulfovibrio vulgaris Strain Hildenborough

artículo científico publicado en 1994

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

artículo científico publicado en 2014

LFB1/HNF1 acts as a repressor of its own transcription

scientific journal article

Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells

artículo científico publicado en 2009

Measurement of homonuclear three-bond J(H(N)Halpha) coupling constants in unlabeled peptides complexed with labeled proteins: application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatitis C virus (HCV).

artículo científico publicado en 2001

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

artículo científico publicado en 2003

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity

artículo científico publicado en 2012

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

scientific article published on February 1994

Molecular virology of the hepatitis C virus.

artículo científico publicado en 1999

Multiple determinants influence complex formation of the hepatitis C virus NS3 protease domain with its NS4A cofactor peptide.

artículo científico publicado en 1999

Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus

artículo científico publicado en 1998

Mutational analysis of hepatitis C virus NS3-associated helicase

artículo científico publicado en 2000

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

artículo científico publicado en 2016

NS3 is a serine protease required for processing of hepatitis C virus polyprotein

artículo científico publicado en 1993

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes

artículo científico publicado en 2014

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.

artículo científico publicado en 2017

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment

artículo científico publicado en 2020

New horizons in hepatitis C antiviral therapy with direct-acting antivirals.

artículo científico

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

scientific article published on 08 February 2014

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling

artículo científico publicado en 2003

Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?

artículo científico publicado en 2007

Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material.

artículo científico publicado en 2014

Potent Peptide Inhibitors of Human Hepatitis C Virus NS3 Protease Are Obtained by Optimizing the Cleavage Products ⬇️

artículo científico publicado el 23 de junio de 1998

Probing the active site of the hepatitis C virus serine protease by fluorescence resonance energy transfer

artículo científico publicado en 2000

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

artículo científico publicado en 2008

Product Inhibition of the Hepatitis C Virus NS3 Protease ⬇️

artículo científico publicado el 23 de junio de 1998

RNA-dependent RNA polymerase of hepatitis C virus.

artículo científico publicado en 1996

Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

artículo científico publicado en 2019

Rational design and functional expression of a constitutively active single-chain NS4A-NS3 proteinase

artículo científico publicado en 1998

Redesigning the substrate specificity of the hepatitis C virus NS3 protease.

artículo científico publicado en 1996

Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerase

artículo científico publicado en 2002

Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric sindbis viruses

artículo científico publicado en 1999

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

artículo científico publicado en 2002

Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

artículo científico publicado en 2009

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

artículo científico publicado en 2008

Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors

artículo científico publicado en 2009

Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies

artículo científico publicado en 1999

Structure and function of the hepatitis C virus NS3-NS4A serine proteinase.

artículo científico publicado en 2000

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

artículo científico publicado en 2007

Substrate specificity of the hepatitis C virus serine protease NS3.

artículo científico publicado en 1997

Synthetic depsipeptide substrates for the assay of human hepatitis C virus protease

artículo científico publicado en 1996

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?

artículo científico publicado en 2017

The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent

artículo científico publicado en 2014

The dimerization domain of LFB1/HNF1 related transcription factors: a hidden four helix bundle?

artículo científico publicado el 1 de diciembre de 1992

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.

artículo científico publicado en 2015

The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.

artículo científico publicado en 1998

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase

artículo científico publicado en 2004

The nonstructural proteins of the hepatitis C virus: structure and functions.

artículo científico publicado en 1997

The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

artículo científico publicado en 1999

The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain.

artículo científico publicado en 1993

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.

artículo científico publicado en 2016

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients

artículo científico publicado en 2015

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

artículo científico publicado en 2016

Why is it so difficult to develop a hepatitis C virus preventive vaccine?

artículo científico publicado en 2013

pKa values of the 8α-imidazole substituents in selected flavoenzymes containing 8α-histidylflavins

artículo científico publicado en 1988

Lista de obras de Raffaele De Francesco

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

A POU-A related region dictates DNA binding specificity of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer ⬇️

A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease

A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand

A high-throughput radiometric assay for hepatitis C virus NS3 protease

A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR (EMBO reports, February 2003) (Erratum)

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR.

A scintillation proximity active site binding assay for the hepatitis C virus serine protease

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies

A zinc binding site in viral serine proteinases

Activity of purified hepatitis C virus protease NS3 on peptide substrates

Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease ⬇️

An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A

Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees

Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines.

Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence

Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires ⬇️

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

Circular dichroism study on the conformational stability of the dimerization domain of transcription factor LFB1

Cirrhosis and Rapid Virological Response to Peginterferon Plus Ribavirin Determine Treatment Outcome in HCV-1 IL28B rs12979860 CC Patients ⬇️

Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

Corrigendum: Genome-Wide Analysis of DNA Methylation, Copy Number Variation, and Gene Expression in Monozygotic Twins Discordant for Primary Biliary Cirrhosis

Crystallization and preliminary X-ray diffraction studies of the transcriptional regulator TraR bound to its cofactor and to a specific DNA sequence

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.

Daclatasvir: a team player rather than a prima donna in the treatment of hepatitis C.

Design of selective eglin inhibitors of HCV NS3 proteinase

Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.

Enzymatic properties of hepatitis C virus NS3-associated helicase

Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.

Flavodoxin-cytochrome c interactions: circular dichroism and nuclear magnetic resonance studies.

Genetic variation in the interleukin -28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection

Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis

HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors

Hepatitis C virus-specific directly acting antiviral drugs

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors

Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

In vitro antibiofilm activity of bioactive glass S53P4.

Influence of 8.alpha.-imidazole substitution of the FMN cofactor on the rate of electron transfer from the neutral semiquinones of two flavodoxins to cytochrome c

Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients

Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.

Kinetic Studies on the Electron-Transfer Reaction between Cytochrome c3 and Flavodoxin from Desulfovibrio vulgaris Strain Hildenborough

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

LFB1/HNF1 acts as a repressor of its own transcription

Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells

Measurement of homonuclear three-bond J(H(N)Halpha) coupling constants in unlabeled peptides complexed with labeled proteins: application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatitis C virus (HCV).

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

Molecular virology of the hepatitis C virus.

Multiple determinants influence complex formation of the hepatitis C virus NS3 protease domain with its NS4A cofactor peptide.

Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus

Mutational analysis of hepatitis C virus NS3-associated helicase

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

NS3 is a serine protease required for processing of hepatitis C virus polyprotein

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment

New horizons in hepatitis C antiviral therapy with direct-acting antivirals.

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling