Lista de obras - J. Evan Sadler - Dominio Público Uruguay

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1

artículo científico publicado en 2009

A covalent oxidoreductase intermediate in propeptide-dependent von Willebrand factor multimerization

artículo científico publicado en 2004

A new name in thrombosis, ADAMTS13.

artículo científico publicado en 2002

A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury

artículo científico publicado en 2004

ADAMTS13 and TTP

artículo científico publicado en 2002

Accelerated clearance alone explains ultra-large multimers in von Willebrand disease Vicenza

artículo científico publicado en 2010

Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C ⬇️

artículo científico publicado el 15 de mayo de 1998

Activation of recombinant proenteropeptidase by duodenase

artículo científico publicado en 2000

Adjuvant low-dose rituximab and plasma exchange for acquired TTP

scientific article published on 22 July 2019

Allosteric activation of ADAMTS13 by von Willebrand factor.

artículo científico publicado en 2014

An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura

artículo científico publicado en 2013

Aortic Stenosis, von Willebrand Factor, and Bleeding ⬇️

artículo científico publicado el 30 de octubre de 2003

Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.

artículo científico publicado en 1999

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor

artículo científico publicado en 2008

Atypical HUS may become a diagnosis of inclusion.

artículo científico publicado en 2015

BIOMEDICINE: Contact-How Platelets Touch von Willebrand Factor

scientific article published in Science

Binding of ADAMTS13 to von Willebrand factor

artículo científico publicado en 2005

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

artículo científico publicado en 2004

Biochemistry and genetics of von Willebrand factor ⬇️

artículo científico publicado el 1 de enero de 1998

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

artículo científico publicado en 1997

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

artículo científico publicado en 2002

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

artículo científico publicado en 2003

Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow

artículo científico publicado en 2005

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

artículo científico publicado en 1985

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide

artículo científico publicado en 1999

Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins

artículo científico publicado en 2003

Effect of ST2, a Fragment of ADAMTS13, on Cleavage of Von Willebrand Factor

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

artículo científico publicado en 2004

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains

artículo científico publicado en 1994

Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

artículo científico publicado en 2006

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

scientific article published on 28 January 2019

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

artículo científico publicado en 2008

Functional architecture of Weibel-Palade bodies

artículo científico publicado en 2011

Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor

artículo científico publicado en 2005

Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

artículo científico publicado en 2008

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

artículo científico publicado en 1998

Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress

artículo científico publicado en 2008

Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)

scientific article published in Journal of Biological Chemistry

Isolation and Characterization of Glycosyl Transferases

artículo científico publicado en 1977

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor

artículo científico publicado en 2000

Medicine: K is for koagulation

artículo científico publicado en 2004

Molecular mapping of the heparin-binding exosite of thrombin

artículo científico publicado en 1994

Multi-step binding of ADAMTS-13 to von Willebrand factor.

artículo científico publicado en 2009

Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency

artículo científico publicado en 2002

New concepts in von Willebrand disease

artículo científico publicado en 2005

Pathogenesis of thrombotic microangiopathies

artículo científico publicado en 2008

Pathophysiology of thrombotic thrombocytopenic purpura

artículo científico publicado en 2017

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

scientific article published on 30 January 2019

Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor.

artículo científico publicado en 2011

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin

artículo científico publicado en 2000

Provisional criteria for the diagnosis of VWD type 1: on behalf of the ISTH SSC Subcommittee on von Willebrand Factor

artículo científico publicado en 2005

Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases

artículo científico publicado en 2012

Redeeming ristocetin

artículo científico publicado en 2010

Refractory Immune Hemolytic Anemia With A High Thermal Amplitude, Low Affinity IgG Anti-PraCold Autoantibody

artículo científico publicado en 1992

Ring ‘flipping’ in bis(cyclo-octatetraene)titanium(II); an organometallic intramolecular redox reaction which involves only the geometrical deformation of organic ligands

scholarly article by Jeffrey Schwartz & J. Evan Sadler published 1973 in Journal of the Chemical Society. Chemical communications

STRUCTURAL BIOLOGY: A Menage a Trois in Two Configurations

artículo científico publicado en 2003

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

artículo científico publicado en 2011

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

artículo científico publicado en 2010

Should all adult patients with diarrhoea-associated HUS receive plasma exchange?

artículo científico publicado en 2012

Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings

artículo científico publicado en 2014

Slippery criteria for von Willebrand disease type 1

artículo científico publicado en 2004

Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity

artículo científico publicado en 2000

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

artículo científico publicado en 2001

The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner

artículo científico publicado en 2012

Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis

artículo científico publicado en 2013

Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

artículo científico publicado en 2007

Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project

artículo científico publicado en 2007

Unfolding the A2 domain of von Willebrand factor with the optical trap

artículo científico publicado en 2010

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

artículo científico publicado en 2006

Von Willebrand disease type 1: a diagnosis in search of a disease

artículo científico publicado en 2002

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

artículo científico publicado en 2008

Zinc and calcium ions cooperatively modulate ADAMTS13 activity

artículo científico publicado en 2005

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA).

scientific article published on March 2008

von Willebrand factor assembly and secretion

artículo científico publicado en 2009

von Willebrand factor in its native environment

artículo científico publicado en 2013

von Willebrand factor: two sides of a coin

artículo científico publicado en 2005

Lista de obras de J. Evan Sadler

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1

A covalent oxidoreductase intermediate in propeptide-dependent von Willebrand factor multimerization

A new name in thrombosis, ADAMTS13.

A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury

ADAMTS13 and TTP

Accelerated clearance alone explains ultra-large multimers in von Willebrand disease Vicenza

Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C ⬇️

Activation of recombinant proenteropeptidase by duodenase

Adjuvant low-dose rituximab and plasma exchange for acquired TTP

Allosteric activation of ADAMTS13 by von Willebrand factor.

An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura

Aortic Stenosis, von Willebrand Factor, and Bleeding ⬇️

Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor

Atypical HUS may become a diagnosis of inclusion.

BIOMEDICINE: Contact-How Platelets Touch von Willebrand Factor

Binding of ADAMTS13 to von Willebrand factor

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

Biochemistry and genetics of von Willebrand factor ⬇️

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide

Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins

Effect of ST2, a Fragment of ADAMTS13, on Cleavage of Von Willebrand Factor

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains

Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

Functional architecture of Weibel-Palade bodies

Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor

Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress

Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)

Isolation and Characterization of Glycosyl Transferases

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor

Medicine: K is for koagulation

Molecular mapping of the heparin-binding exosite of thrombin

Multi-step binding of ADAMTS-13 to von Willebrand factor.

Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency

New concepts in von Willebrand disease

Pathogenesis of thrombotic microangiopathies

Pathophysiology of thrombotic thrombocytopenic purpura

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor.

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin

Provisional criteria for the diagnosis of VWD type 1: on behalf of the ISTH SSC Subcommittee on von Willebrand Factor

Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases

Redeeming ristocetin

Refractory Immune Hemolytic Anemia With A High Thermal Amplitude, Low Affinity IgG Anti-PraCold Autoantibody

Ring ‘flipping’ in bis(cyclo-octatetraene)titanium(II); an organometallic intramolecular redox reaction which involves only the geometrical deformation of organic ligands

STRUCTURAL BIOLOGY: A Menage a Trois in Two Configurations

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

Should all adult patients with diarrhoea-associated HUS receive plasma exchange?

Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings

Slippery criteria for von Willebrand disease type 1

Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner

Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis

Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project

Unfolding the A2 domain of von Willebrand factor with the optical trap

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

Von Willebrand disease type 1: a diagnosis in search of a disease

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

Zinc and calcium ions cooperatively modulate ADAMTS13 activity

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA).

von Willebrand factor assembly and secretion

von Willebrand factor in its native environment

von Willebrand factor: two sides of a coin