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Lista de obras de John Challiss

"Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology.

artículo científico publicado en 2006

A model for Ca2+ oscillations stimulated by the type 5 metabotropic glutamate receptor: an unusual mechanism based on repetitive, reversible phosphorylation of the receptor

artículo científico publicado en 2011

A problem in the radiochemical assay of glucose-6-phosphatase in muscle

artículo científico publicado el 1 de marzo de 1984

A single point mutation (N514Y) in the human M3 muscarinic acetylcholine receptor reveals differences in the properties of antagonists: evidence for differential inverse agonism.

artículo científico publicado en 2006

Altered M(1) muscarinic acetylcholine receptor (CHRM1)-Galpha(q/11) coupling in a schizophrenia endophenotype

artículo científico publicado en 2009

An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory

artículo científico publicado en 2016

Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle.

artículo científico publicado en 2011

Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells.

artículo científico publicado en 2011

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

artículo científico publicado en 2020

Biosynthetic infochemical communication.

artículo científico

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.

artículo científico publicado en 2003

Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus.

artículo científico publicado en 1998

Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells.

artículo científico publicado en 2009

Characterization of the adenosine receptor modulating insulin action in rat skeletal muscle

artículo científico publicado el 5 de junio de 1992

Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder

artículo científico publicado en 2011

Comparative effects of BRL 38227, nitrendipine and isoprenaline on carbachol- and histamine-stimulated phosphoinositide metabolism in airway smooth muscle

artículo científico publicado el 1 de abril de 1992

Comparison of the effect of isobutylmethylxanthine and phosphodiesterase-selective inhibitors on cAMP levels in SH-SY5Y neuroblastoma cells

artículo científico publicado el 22 de junio de 1993

Conformational analysis of cyclophostin and designed analogs in comparison with the potent IP3 receptor agonist adenophostin A.

artículo científico publicado en 2001

Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor

artículo científico publicado en 2005

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.

artículo científico publicado en 2015

Depolarization and Agonist-Stimulated Changes in Inositol 1,4,5-Trisphosphate and Inositol 1,3,4,5-Tetrakisphosphate Mass Accumulation in Rat Cerebral Cortex

artículo científico publicado el 1 de septiembre de 1991

Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells

artículo científico publicado el 27 de febrero de 1998

Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines

artículo científico publicado el 1 de octubre de 1997

Differential regulation of β2-adrenoceptor and adenosine A2B receptor signalling by GRK and arrestin proteins in arterial smooth muscle

scientific article published on 31 July 2018

Disruption of phosphoinositide signalling by lithium

artículo científico publicado el 1 de mayo de 1992

Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose

artículo científico publicado en 2015

Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons.

artículo científico publicado en 2011

Effect of endurance and sprint exercise on the sensitivity of glucose metabolism to insulin in the epitrochlearis muscle of sedentary and trained rats

artículo científico publicado en 1991

Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor.

artículo científico publicado en 2009

Effects of varying the expression level of recombinant human mGlu1alpha receptors on the pharmacological properties of agonists and antagonists

artículo científico publicado en 1999

Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells

artículo científico publicado en 2002

Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2.

artículo científico publicado en 2009

Enhanced Type 1α Metabotropic Glutamate Receptor-Stimulated Phosphoinositide Signaling after Pertussis Toxin Treatment

artículo científico publicado el 1 de septiembre de 1997

Enhanced inducible mGlu1alpha receptor expression in Chinese hamster ovary cells

artículo científico publicado en 2001

Enhanced purinoceptor-mediated Ca2+ signalling in L-fibroblasts overexpressing type 1 inositol 1,4,5-trisphosphate receptors.

artículo científico publicado en 1999

Evidence for cross‐talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal‐regulated kinase signalling pathways in Chinese hamster ovary cells

artículo científico publicado el 1 de abril de 2003

FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists

artículo científico publicado en 2012

Functional selectivity of muscarinic receptor antagonists for inhibition of M3-mediated phosphoinositide responses in guinea pig urinary bladder and submandibular salivary gland.

artículo científico publicado en 2004

G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists.

artículo científico publicado en 2008

G protein-coupled receptor kinases 3 and 6 use different pathways to desensitize the endogenous M3 muscarinic acetylcholine receptor in human SH-SY5Y cells

artículo científico publicado en 2001

G protein-coupled receptor signalling in astrocytes in health and disease: a focus on metabotropic glutamate receptors

artículo científico publicado en 2012

Group I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to cyclic AMP response element binding protein (CREB) through a common Ca2+ - and protein kinase C-dependent pathway

artículo científico publicado en 2005

Group-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal-regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways

artículo científico publicado en 2002

Growth inhibition by the muscarinic M(3) acetylcholine receptor: evidence for p21(Cip1/Waf1) involvement in G(1) arrest.

artículo científico publicado en 2002

HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4.

artículo científico publicado en 2017

Imaging of muscarinic acetylcholine receptor signaling in hippocampal neurons: evidence for phosphorylation-dependent and -independent regulation by G-protein-coupled receptor kinases.

artículo científico publicado en 2004

Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma

artículo científico publicado en 2011

Inhibitory action of the potassium channel opener BRL 38227 on agonist-stimulated phosphoinositide metabolism in bovine tracheal smooth muscle

artículo científico publicado el 9 de enero de 1992

Insulin sensitivity of rates of glycolysis and glycogen synthesis in soleus, stripped soleus, epitrochlearis, and hemi-diaphragm muscles isolated from sedentary rats

artículo científico publicado el 1 de julio de 1983

Intracellular signalling. Receptor-specific messenger oscillations

artículo científico publicado en 2001

Lack of effect of zaprinast on methacholine-induced contraction and inositol 1,4,5-trisphosphate accumulation in bovine tracheal smooth muscle

artículo científico publicado el 1 de mayo de 1991

Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor.

artículo científico publicado en 2018

Lithium-induced disruption of cell signalling in brain: evidence implicating the phosphoinositide cycle

artículo científico publicado el 1 de enero de 1992

Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels.

artículo científico publicado en 2014

M3 muscarinic cholinoceptors are linked to phosphoinositide metabolism in rat cerebellar granule cells

artículo científico publicado el 25 de marzo de 1991

Maximal activities of hexokinase, 6-phosphofructokinase, oxoglutarate dehydrogenase, and carnitine palmitoyltransferase in rat and avian muscles

artículo científico publicado el 1 de diciembre de 1983

Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells

scientific journal article

Modulation of Gq-protein-coupled inositol trisphosphate and Ca2+ signaling by the membrane potential

artículo científico publicado en 2006

Modulation of spasmogen-stimulated Ins(1,4,5)P3 generation and functional responses by selective inhibitors of types 3 and 4 phosphodiesterase in airways smooth muscle

artículo científico publicado en 1998

Muscarinic acetylcholine receptor activation enhances hippocampal neuron excitability and potentiates synaptically evoked Ca(2+) signals via phosphatidylinositol 4,5-bisphosphate depletion

artículo científico publicado en 2005

NMDA-receptor regulation of muscarinic-receptor stimulated inositol 1,4,5-trisphosphate production and protein kinase C activation in single cerebellar granule neurons.

artículo científico publicado en 2004

Neuronal muscarinic receptors and phosphoinositide metabolism

artículo científico publicado el 1 de abril de 1991

Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse

artículo científico publicado en 2008

Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy.

artículo científico publicado en 2013

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.

artículo científico publicado en 2018

No evidence for altered intracellular calcium-handling in airway smooth muscle cells from human subjects with asthma

artículo científico publicado en 2015

Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation

artículo científico publicado en 2013

Pharmacological assessment of m1 muscarinic acetylcholine receptor-gq/11 protein coupling in membranes prepared from postmortem human brain tissue

artículo científico publicado en 2008

Pharmacological characterization of type 1alpha metabotropic glutamate receptor-stimulated [35S]-GTPgammaS binding.

artículo científico publicado en 1997

Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.

artículo científico publicado en 2011

Quantitation of the lithium-sensitive component of the muscarinic receptor-stimulated inositol 1,3,4,5-tetrakisphosphate response in rat cerebral cortex

artículo científico publicado el 1 de mayo de 1992

Reassessment of the Ca2+ sensing property of a type I metabotropic glutamate receptor by simultaneous measurement of inositol 1,4,5-trisphosphate and Ca2+ in single cells.

artículo científico publicado en 2001

Receptors: GPCR-G protein preassembly?

artículo científico publicado en 2011

Regulation of brain capillary endothelial cells by P2Y receptors coupled to Ca2+, phospholipase C and mitogen‐activated protein kinase

artículo científico publicado el 1 de noviembre de 1997

Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells

artículo científico publicado en 2007

Regulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscle

artículo científico publicado en 2009

Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I‐ and II‐ selective metabotropic glutamate receptor agonists

artículo científico publicado el 1 de febrero de 1998

Role of Ca2+ feedback on single cell inositol 1,4,5-trisphosphate oscillations mediated by G-protein-coupled receptors.

artículo científico publicado en 2003

Role of protein kinase C in the regulation of histamine and bradykinin stimulated inositol polyphosphate turnover in adrenal chromaffin cells

artículo científico publicado el 1 de diciembre de 1992

Roles of phosphorylation-dependent and -independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons.

artículo científico publicado en 2005

Selective regulation of H1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells.

artículo científico publicado en 2008

Single cell analysis and temporal profiling of agonist-mediated inositol 1,4,5-trisphosphate, Ca2+, diacylglycerol, and protein kinase C signaling using fluorescent biosensors.

artículo científico publicado en 2005

Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions

artículo científico publicado en 2018

Specificity of g protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell m3 muscarinic acetylcholine receptor signaling

artículo científico publicado en 2003

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

artículo científico publicado en 2015

Structural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation

artículo científico publicado en 2011

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

artículo científico publicado en 2001

Sugar transport asymmetry in human erythrocytes--the effect of bulk haemoglobin removal and the addition of methylxanthines

artículo científico publicado en 1980

Synaptic activity augments muscarinic acetylcholine receptor-stimulated inositol 1,4,5-trisphosphate production to facilitate Ca2+ release in hippocampal neurons

artículo científico publicado en 2004

Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons.

artículo científico publicado en 2008

The Use of Translocating Fluorescent Biosensors for Real-Time Monitoring of GPCR-Mediated Signaling Events

artículo científico publicado el 1 de enero de 2011

The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats

artículo científico publicado el 1 de junio de 1997

The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons

scientific journal article

Treatment of experimental NADH ubiquinone reductase deficiency with menadione

artículo científico publicado el 1 de agosto de 1992

Visualizing the temporal effects of vasoconstrictors on PKC translocation and Ca2+ signaling in single resistance arterial smooth muscle cells

artículo científico publicado en 2008

[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma

artículo científico publicado en 2014