Lista de obras - Tomas Simunek - Dominio Público Uruguay

Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?

artículo científico publicado en 2016

Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.

artículo científico publicado en 2016

Cardiac troponin T as an indicator of reduced left ventricular contractility in experimental anthracycline-induced cardiomyopathy

artículo científico publicado en 2003

Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane

artículo científico publicado en 2015

Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

artículo científico publicado en 2016

Cardioprotective potential of iron chelators and prochelators

artículo científico publicado en 2017

Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells

artículo científico publicado en 2013

Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.

artículo científico publicado en 2016

Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways.

artículo científico publicado en 2012

Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits.

artículo científico publicado en 2002

Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury.

artículo científico publicado en 2010

Comparison of protective effects of two iron chelating compounds – deferiprone and dexrazoxane – against chronic anthracycline cardiotoxicity

Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.

artículo científico publicado en 2014

Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.

artículo científico publicado en 2011

Corrigendum to: "Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model" [Exp. Cell Res. 339 2 (2015) 174-186].

artículo científico publicado en 2016

DNA topoisomerase IIβ: a player in regulation of gene expression and cell differentiation

artículo científico publicado en 2012

Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo.

artículo científico publicado en 2008

Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium

artículo científico publicado en 2012

Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death

artículo científico publicado en 2009

Direct administration of rutin does not protect against catecholamine cardiotoxicity.

artículo científico publicado en 2008

Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic anthracycline cardiotoxicity in rabbits.

artículo científico publicado en 2013

Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships

artículo científico publicado en 2014

Far-red-absorbing cationic phthalocyanine photosensitizers: synthesis and evaluation of the photodynamic anticancer activity and the mode of cell death induction

artículo científico publicado en 2015

Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase

artículo científico publicado en 2007

Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles

artículo científico publicado en 2015

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

artículo científico publicado en 2015

In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

artículo científico publicado en 2007

In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity ⬇️

artículo científico publicado el 3 de noviembre de 2010

Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress.

artículo científico publicado en 2016

Investigation of structure-activity relationships of dexrazoxane analogues reveals topoisomerase IIβ interaction as a prerequisite for effective protection against anthracycline cardiotoxicity

scientific article published on 06 April 2020

Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity.

artículo científico publicado en 2010

Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH)

artículo científico publicado en 2007

Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.

artículo científico publicado en 2006

LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)

artículo científico publicado en 2014

Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: novel iron chelators with selective antiproliferative action.

artículo científico publicado en 2012

Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up.

artículo científico publicado en 2014

Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits.

artículo científico publicado en 2005

Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection.

artículo científico publicado en 2012

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

artículo científico publicado en 2015

Proteomic insights into chronic anthracycline cardiotoxicity.

artículo científico publicado en 2011

Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model.

artículo científico publicado en 2015

Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs as protectants against anthracycline-induced cardiotoxicity

artículo científico publicado en 2008

Quantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugs

artículo científico publicado en 2014

SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.

artículo científico publicado en 2005

Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats

artículo científico publicado en 2013

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

artículo científico publicado en 2014

Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits.

artículo científico publicado en 2005

Synthesis and Initial in Vitro Evaluations of Novel Antioxidant Aroylhydrazone Iron Chelators with Increased Stability against Plasma Hydrolysis ⬇️

artículo científico publicado el 7 de enero de 2011

Tetra(3,4-pyrido)porphyrazines Caught in the Cationic Cage: Toward Nanomolar Active Photosensitizers.

artículo científico publicado en 2016

Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy.

artículo científico publicado en 2013

Lista de obras de Tomas Simunek

Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?

Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.

Cardiac troponin T as an indicator of reduced left ventricular contractility in experimental anthracycline-induced cardiomyopathy

Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane

Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

Cardioprotective potential of iron chelators and prochelators

Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells

Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.

Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways.

Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits.

Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury.

Comparison of protective effects of two iron chelating compounds – deferiprone and dexrazoxane – against chronic anthracycline cardiotoxicity

Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.

Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.

Corrigendum to: "Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model" [Exp. Cell Res. 339 2 (2015) 174-186].

DNA topoisomerase IIβ: a player in regulation of gene expression and cell differentiation

Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo.

Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium

Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death

Direct administration of rutin does not protect against catecholamine cardiotoxicity.

Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic anthracycline cardiotoxicity in rabbits.

Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships

Far-red-absorbing cationic phthalocyanine photosensitizers: synthesis and evaluation of the photodynamic anticancer activity and the mode of cell death induction

Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase

Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity ⬇️

Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress.

Investigation of structure-activity relationships of dexrazoxane analogues reveals topoisomerase IIβ interaction as a prerequisite for effective protection against anthracycline cardiotoxicity

Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity.

Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH)

Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.

LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)

Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: novel iron chelators with selective antiproliferative action.

Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up.

Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits.

Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection.

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

Proteomic insights into chronic anthracycline cardiotoxicity.

Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model.

Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs as protectants against anthracycline-induced cardiotoxicity

Quantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugs

SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.

Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits.

Synthesis and Initial in Vitro Evaluations of Novel Antioxidant Aroylhydrazone Iron Chelators with Increased Stability against Plasma Hydrolysis ⬇️

Tetra(3,4-pyrido)porphyrazines Caught in the Cationic Cage: Toward Nanomolar Active Photosensitizers.

Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy.