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Lista de obras de Luiz A. Basso

2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

artículo científico publicado en 2016

A structural model for chorismate synthase from Mycobacterium tuberculosis in complex with coenzyme and substrate.

artículo científico publicado en 2006

Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection

artículo científico publicado en 2012

Analysis of select members of the E26 (ETS) transcription factors family in colorectal cancer.

artículo científico publicado en 2011

Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain

artículo científico publicado en 2011

Biochemical characterization of recombinant nucleoside hydrolase from Mycobacterium tuberculosis H37Rv

artículo científico publicado en 2013

Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis

artículo científico publicado en 2013

Capillary bioreactors based on human purine nucleoside phosphorylase: A new approach for ligands identification and characterization

scientific article published on 28 October 2011

Chorismate synthase: an attractive target for drug development against orphan diseases.

artículo científico publicado en 2007

Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum

artículo científico publicado en 2013

Cloning and expression of functional shikimate dehydrogenase (EC 1.1.1.25) from Mycobacterium tuberculosis H37Rv

artículo científico publicado en 2002

Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase

artículo científico publicado en 2003

Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis H37Rv

artículo científico publicado en 2011

Cooperativity between trimers of the hexameric glutamate dehydrogenase from Clostridium symbiosum

scientific article published on 01 February 1998

Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir.

artículo científico publicado en 2011

Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products.

artículo científico publicado en 2011

Crystal structure of human PNP complexed with hypoxanthine and sulfate ion.

artículo científico publicado en 2005

Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution

artículo científico publicado en 2003

Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir

artículo científico publicado en 2003

Crystallization and preliminary X-ray crystallographic analysis of chorismate synthase from Mycobacterium tuberculosis

artículo científico publicado en 2004

Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis

artículo científico publicado en 2006

Crystallographic structure of PNP from Mycobacterium tuberculosis at 1.9A resolution

artículo científico publicado en 2004

Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis

artículo científico publicado en 2007

DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme

scientific journal article

Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer

artículo científico publicado en 2019

Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity

artículo científico publicado en 2013

Determining the structural basis for specificity of ligands using crystallographic screening.

artículo científico publicado en 2006

Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach.

artículo científico publicado en 2013

Dynamics of glyphosate-induced conformational changes of Mycobacterium tuberculosis 5-enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) determined by hydrogen-deuterium exchange and electrospray mass spectrometry

artículo científico publicado en 2008

Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase fromMycobacterium tuberculosis

artículo científico publicado en 2007

Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs

artículo científico publicado en 2005

Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents.

artículo científico publicado en 2007

Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex.

artículo científico publicado en 2011

Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification

scientific journal article

Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization.

artículo científico publicado en 2005

Gene replacement and quantitative mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth.

artículo científico publicado en 2015

Homogeneous recombinant Mycobacterium tuberculosis shikimate dehydrogenase production: an essential step towards target-based drug design.

artículo científico publicado en 2009

Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization.

artículo científico publicado en 2008

Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis

artículo científico publicado en 2014

Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization

scientific journal article

IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages

artículo científico publicado en 2013

Identification of Rv3852 as a nucleoid-associated protein in Mycobacterium tuberculosis

artículo científico publicado en 2009

Initial formation of a non-covalent enzyme-reagent complex during the inactivation of clostridial glutamate dehydrogenase by Ellman's reagent: determination of the enzyme's dissociation constant for the binary complex with NAD+ from protection studi

scientific article published on 01 December 1994

Interaction of shikimic acid with shikimate kinase.

artículo científico publicado en 2004

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

artículo científico publicado en 2003

Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.

artículo científico publicado en 2011

Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis

artículo científico publicado en 2006

Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase

artículo científico publicado en 2013

Kinetic mechanism determination and analysis of metal requirement of dehydroquinate synthase from Mycobacterium tuberculosis H37Rv: an essential step in the function-based rational design of anti-TB drugs

scientific journal article

Kinetic studies on the binding of 1,N6-etheno-NAD+ to glutamate dehydrogenase from Clostridium symbiosum

artículo científico publicado en 1997

Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine

artículo científico publicado en 2005

Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection.

artículo científico publicado en 2016

Molecular Models of Tryptophan Synthase From Mycobacterium tuberculosis Complexed With Inhibitors

scientific article published on 01 January 2006

Molecular cloning and transgenic expression of a synthetic human erythropoietin gene in tobacco.

artículo científico publicado en 2011

Molecular cloning, expression in Escherichia coli and production of bioactive homogeneous recombinant human granulocyte and macrophage colony stimulating factor

artículo científico publicado en 2009

Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities

artículo científico publicado en 2005

Molecular model of shikimate kinase from Mycobacterium tuberculosis

artículo científico publicado en 2002

Molecular modeling and dynamics simulations of PNP from Streptococcus agalactiae.

artículo científico publicado en 2008

Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.

artículo científico publicado en 2008

Molecular modeling and dynamics studies of purine nucleoside phosphorylase from Bacteroides fragilis.

artículo científico publicado en 2009

Molecular modeling, dynamics and docking studies of purine nucleoside phosphorylase from Streptococcus pyogenes.

artículo científico publicado en 2009

Molecular models for shikimate pathway enzymes of Xylella fastidiosa

artículo científico publicado en 2004

Molecular models of protein targets from Mycobacterium tuberculosis.

artículo científico publicado en 2005

Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase

artículo científico publicado en 2011

Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23)

artículo científico publicado en 2011

Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding

artículo científico publicado en 2007

New Sensitive Fluorophores for Selective DNA Detection

scientific article published on 05 September 2007

New catalytic mechanism for human purine nucleoside phosphorylase

artículo científico publicado en 2005

Observed crowding effects on Mycobacterium tuberculosis 2-trans-enoyl-ACP (CoA) reductase enzyme activity are not due to excluded volume only

artículo científico publicado en 2017

On the selective detection of duplex deoxyribonucleic acids by 2,1,3-benzothiadiazole fluorophores

artículo científico publicado en 2010

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

artículo científico publicado en 2003

Phosphate closes the solution structure of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from Mycobacterium tuberculosis

artículo científico publicado en 2006

Piperazine derivatives: synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies

artículo científico publicado en 2014

Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis

artículo científico publicado en 2018

Production of recombinant human annexin V by fed-batch cultivation

artículo científico publicado en 2014

Protective Effects of Resveratrol on Hepatotoxicity Induced by Isoniazid and Rifampicin via SIRT1 Modulation

artículo científico publicado en 2014

Purine Salvage Pathway in Mycobacterium tuberculosis.

scientific article published on January 2011

Purine nucleoside phosphorylase activity and expression are upregulated in sites affected by periodontal disease.

artículo científico publicado en 2010

Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts

artículo científico publicado en 2001

Real time PCR quantification of viable Mycobacterium tuberculosis from sputum samples treated with propidium monoazide.

artículo científico publicado en 2014

Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme–ligand binary complex formation

artículo científico publicado en 2011

Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)

artículo científico publicado en 2012

Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes

artículo científico publicado en 2004

Shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development.

artículo científico publicado en 2011

Shikimate kinase: a potential target for development of novel antitubercular agents.

artículo científico publicado en 2007

Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex.

artículo científico publicado en 2006

Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase

artículo científico publicado en 2010

Structural bioinformatics study of EPSP synthase from Mycobacterium tuberculosis.

artículo científico publicado en 2003

Structural bioinformatics study of PNP from Listeria monocytogenes

artículo científico publicado en 2008

Structural bioinformatics study of PNP from Schistosoma mansoni

artículo científico publicado en 2004

Structural studies of PNP from Toxoplasma gondii.

artículo científico publicado en 2009

Structural studies of human purine nucleoside phosphorylase: towards a new specific empirical scoring function

artículo científico publicado en 2008

Structural studies of prephenate dehydratase from Mycobacterium tuberculosis H37Rv by SAXS, ultracentrifugation, and computational analysis.

artículo científico publicado en 2008

Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis

artículo científico publicado en 2008

Structure of chorismate synthase from Mycobacterium tuberculosis.

artículo científico publicado en 2006

Structure of human PNP complexed with ligands.

artículo científico publicado en 2005

Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid

scientific journal article

Structures of human purine nucleoside phosphorylase complexed with inosine and ddI

artículo científico publicado en 2004

Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces

artículo científico publicado en 2001

Targeting the histidine pathway in Mycobacterium tuberculosis.

artículo científico

The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP

scientific journal article

The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials.

artículo científico publicado en 2007

The kinetic mechanism of Human Thymidine Phosphorylase - a molecular target for cancer drug development

artículo científico publicado en 2014

The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy

artículo científico publicado en 2010

The mechanism of substrate and coenzyme binding to clostridial glutamate dehydrogenase during oxidative deamination

artículo científico publicado en 1993

The mechanism of substrate and coenzyme binding to clostridial glutamate dehydrogenase during reductive amination

artículo científico publicado en 1995

The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses

artículo científico publicado en 2013

The transition state analog inhibitor of Purine Nucleoside Phosphorylase (PNP) Immucillin-H arrests bone loss in rat periodontal disease models

UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation

scientific journal article

Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS?

artículo científico publicado en 2012

[Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy

artículo científico publicado en 2014