Lista de obras - John Petrini - Dominio Público Uruguay

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

artículo científico publicado en 2016

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

artículo científico publicado en 2014

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability

artículo científico publicado en 2008

Association of Mre11p with double-strand break sites during yeast meiosis

artículo científico publicado en 2004

At the end, remodeling leads to eviction

artículo científico publicado en 2005

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice

artículo científico publicado en 2002

Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression

artículo científico publicado en 2012

Cell signaling. A touching response to damage.

artículo científico publicado en 2007

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

scientific journal article

Checkpoint response to DNA damage.

artículo científico publicado en 2009

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells

artículo científico publicado en 2012

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage

scientific journal article

Cohesin association to replication sites depends on rad50 and promotes fork restart

artículo científico publicado en 2012

DNA replication reaches the breaking point.

artículo científico publicado en 2009

DNA replication-dependent nuclear dynamics of the Mre11 complex.

artículo científico publicado en 2003

Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model

artículo científico publicado en 2015

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS

artículo científico publicado en 2009

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

artículo científico publicado en 2004

Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex.

artículo científico publicado en 2009

Double strand break metabolism and cancer susceptibility: lessons from the mre11 complex

artículo científico publicado en 2004

Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage ⬇️

artículo científico publicado el 29 de agosto de 2011

Functional interactions between Sae2 and the Mre11 complex.

artículo científico publicado en 2008

Functions of the MRE11 complex in the development and maintenance of oocytes

artículo científico publicado en 2015

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

artículo científico publicado en 2016

Interdependence of the rad50 hook and globular domain functions

artículo científico publicado en 2015

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway

artículo científico publicado en 2009

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas

artículo científico publicado en 2010

Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization

artículo científico publicado en 2009

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression

artículo científico publicado en 2015

Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism.

artículo científico publicado en 2006

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis

scientific article published on 18 March 2020

Modeling disease in the mouse: lessons from DNA damage response and cell cycle control genes

artículo científico publicado en 2006

Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication

artículo científico publicado en 2007

NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.

artículo científico publicado en 2009

Rad50 is dispensable for the maintenance and viability of postmitotic tissues

scientific journal article

Rad50S alleles of the Mre11 complex: questions answered and questions raised

artículo científico publicado en 2006

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

artículo científico publicado en 2009

Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation

artículo científico publicado en 2005

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy

artículo científico publicado en 2014

TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding

artículo científico publicado en 2015

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

artículo científico publicado en 2005

The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks

artículo científico publicado en 2013

The MRE11 complex: starting from the ends.

scientific article published on February 2011

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis

scientific journal article

The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis.

artículo científico publicado en 2013

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

artículo científico publicado en 2011

The Rad50 hook domain is a critical determinant of Mre11 complex functions

artículo científico publicado en 2005

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

artículo científico publicado en 2014

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

artículo científico publicado en 2002

The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

artículo científico publicado en 2005

The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.

artículo científico publicado en 2007

The mre11 complex and the response to dysfunctional telomeres

scientific article published on 10 August 2009

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

artículo científico publicado en 2004

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

artículo científico publicado en 2017

Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression.

artículo científico publicado en 2008

ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over

scientific journal article

Lista de obras de John Petrini

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability

Association of Mre11p with double-strand break sites during yeast meiosis

At the end, remodeling leads to eviction

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice

Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression

Cell signaling. A touching response to damage.

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

Checkpoint response to DNA damage.

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage

Cohesin association to replication sites depends on rad50 and promotes fork restart

DNA replication reaches the breaking point.

DNA replication-dependent nuclear dynamics of the Mre11 complex.

Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex.

Double strand break metabolism and cancer susceptibility: lessons from the mre11 complex

Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage ⬇️

Functional interactions between Sae2 and the Mre11 complex.

Functions of the MRE11 complex in the development and maintenance of oocytes

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

Interdependence of the rad50 hook and globular domain functions

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas

Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression

Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism.

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis

Modeling disease in the mouse: lessons from DNA damage response and cell cycle control genes

Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication

NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.

Rad50 is dispensable for the maintenance and viability of postmitotic tissues

Rad50S alleles of the Mre11 complex: questions answered and questions raised

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy

TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks

The MRE11 complex: starting from the ends.

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis

The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis.

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

The Rad50 hook domain is a critical determinant of Mre11 complex functions

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.

The mre11 complex and the response to dysfunctional telomeres

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression.

ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over