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Lista de obras de Fred van Leeuwen

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

artículo científico publicado en 2013

A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover

artículo científico publicado en 2011

A genetic interaction map centered on cohesin reveals auxiliary factors in sister chromatid cohesion

artículo científico publicado en 2020

A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast

artículo científico publicado en 2012

A modified epigenetics toolbox to study histone modifications on the nucleosome core.

artículo científico publicado en 2010

A network model of the molecular organization of chromatin in Drosophila

artículo científico publicado en 2013

A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma

artículo científico publicado en 2019

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

artículo científico publicado en 2012

Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells

scientific article published on 31 March 2020

CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

scientific article published on 04 December 2019

CD8– dendritic cells preferentially cross-presentSaccharomyces cerevisiae antigens

artículo científico publicado en 2008

Chemical biology approaches to probe the proteome.

artículo científico publicado en 2008

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma

scientific article published on 17 June 2019

Crosstalk between aging and the epigenome

artículo científico publicado en 2012

Decoding the chromatin proteome of a single genomic locus by DNA sequencing

artículo científico publicado en 2018

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

artículo científico publicado en 2016

Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.

artículo científico publicado en 2011

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

artículo científico publicado en 2015

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

scientific article published on 01 November 2018

Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine.

artículo científico publicado en 2017

Epi-ID: Systematic and Direct Screening for Chromatin Regulators in Yeast by Barcode-ChIP-Seq

artículo científico publicado en 2019

Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo

artículo científico publicado en 2014

Heterologous expression reveals distinct enzymatic activities of two DOT1 histone methyltransferases of Trypanosoma brucei

artículo científico publicado en 2010

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

artículo científico publicado en 2021

Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes

scientific article published on 18 March 2020

Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila

artículo científico publicado en 2007

Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae

artículo científico publicado en 2009

Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes.

artículo científico publicado en 2009

N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging

artículo científico publicado en 2014

News about old histones: A role for histone age in controlling the epigenome

artículo científico publicado en 2012

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

artículo científico publicado en 2008

Patterns and mechanisms of ancestral histone protein inheritance in budding yeast.

artículo científico publicado en 2011

Progressive methylation of ageing histones by Dot1 functions as a timer.

artículo científico

Recombination-induced tag exchange (RITE) cassette series to monitor protein dynamics in Saccharomyces cerevisiae

artículo científico publicado en 2013

Recombination-induced tag exchange to track old and new proteins

artículo científico publicado en 2009

Spatiotemporal analysis of organelle and macromolecular complex inheritance

artículo científico publicado en 2012

The emerging roles of DOT1L in leukemia and normal development

artículo científico

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

artículo científico publicado en 2020

The modified DNA base beta-D-glucosylhydroxymethyluracil confers resistance to micrococcal nuclease and is incompletely recovered by 32P-postlabeling

artículo científico publicado en 1998

The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans

artículo científico publicado en 1999

Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

artículo científico publicado en 2014