Lista de obras - Amarnath Natarajan - Dominio Público Uruguay

2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study

artículo científico publicado en 2011

3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition.

artículo científico publicado en 2004

A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.

artículo científico publicado en 2014

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

scientific article published on 18 September 2019

A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ

artículo científico publicado en 2015

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

artículo científico publicado en 2019

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

artículo científico publicado en 2011

Beyond the frog: the evolution of homology models of human IKKβ.

artículo científico publicado en 2011

CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

artículo científico publicado en 2019

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

scientific article published on 26 September 2019

Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.

artículo científico publicado en 2017

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

artículo científico publicado en 2016

Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy.

artículo científico publicado en 2018

Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).

artículo científico publicado en 2017

Computational and experimental studies of the interaction between phospho-peptides and the C-terminal domain of BRCA1.

artículo científico publicado en 2011

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

artículo científico publicado en 2016

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Respo

artículo científico publicado en 2017

Discovery and characterization of small molecule Rac1 inhibitors

artículo científico publicado en 2017

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

artículo científico publicado en 2007

Erratum to: Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option

artículo científico publicado en 2016

Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design

artículo científico publicado en 2011

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase

artículo científico publicado en 2013

Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones.

artículo científico publicado en 2012

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells

artículo científico publicado en 2022

Ferulic acid dimer as a non-opioid therapeutic for acute pain.

artículo científico publicado en 2018

High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity

artículo científico publicado en 2013

High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions

artículo científico publicado en 2010

High-throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of breast cancer gene 1.

artículo científico publicado en 2006

Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

artículo científico publicado en 2016

Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA

artículo científico publicado en 2011

Impact of structurally modifying hyaluronic acid on CD44 interaction.

artículo científico publicado en 2017

Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option

artículo científico publicado en 2012

Irreversible binding of an anticancer compound (BI-94) to plasma proteins

artículo científico publicado en 2015

Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study

artículo científico publicado en 2016

Micellar formulation of indocyanine green for phototherapy of melanoma

artículo científico publicado en 2015

Mouse Pancreatic Tumor Model Independent of Tumor Suppressor Gene Inactivation

artículo científico publicado en 2018

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

artículo científico publicado en 2011

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.

artículo científico publicado en 2004

Novel treatment for mantle cell lymphoma including therapy-resistant tumor by NF-κB and mTOR dual-targeting approach.

artículo científico publicado en 2013

Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain

artículo científico publicado en 2012

Perturbing pro-survival proteins using quinoxaline derivatives: A structure–activity relationship study ⬇️

artículo científico publicado el 16 de febrero de 2012

Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS.

artículo científico publicado en 2013

Poly-L-proline type II peptide mimics as probes of the active site occupancy requirements of cGMP-dependent protein kinase

artículo científico publicado en 2005

Poly-L-proline type II peptide mimics based on the 3-azabicyclo[3.1.0]hexane system

artículo científico publicado en 2001

Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases

artículo científico publicado en 2013

Protein-protein interactions as therapeutic targets in neuropsychopharmacology

artículo científico publicado en 2009

Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames.

artículo científico publicado en 2013

RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment

artículo científico publicado en 2016

Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation Protein

artículo científico publicado en 2017

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

artículo científico publicado en 2019

Selective degradation of CDK6 by a palbociclib based PROTAC

scientific article published on 26 March 2019

Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases

artículo científico publicado en 2014

Structural characterization of BRCT-tetrapeptide binding interactions.

artículo científico publicado en 2010

Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors.

artículo científico publicado en 2017

Structure-activity relationship studies to probe the phosphoprotein binding site on the carboxy terminal domains of the breast cancer susceptibility gene 1.

artículo científico publicado en 2011

Symbiotic Prodrugs (SymProDs) Dual Targeting of NFkappaB and CDK

artículo científico publicado en 2020

Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation.

artículo científico publicado en 2004

Synthesis and evaluation of macrocyclic diarylether heptanoid natural products and their analogs

artículo científico publicado en 2011

Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides

artículo científico publicado en 2007

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

artículo científico publicado en 2018

Synthesis of conformationally constrained lysine analogues

artículo científico publicado en 2006

Synthesis of fluorescein labeled 7-methylguanosinemonophosphate

artículo científico publicado en 2004

Synthesis of unnatural amino acid derivatives via palladium catalyzed 1,4 addition of boronic acids.

artículo científico publicado en 2010

Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy

artículo científico publicado en 2013

The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides

artículo científico publicado en 2013

Thermodynamics of phosphopeptide tethering to BRCT: the structural minima for inhibitor design

scientific article published on 09 August 2007

Lista de obras de Amarnath Natarajan

2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study

3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition.

A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

Beyond the frog: the evolution of homology models of human IKKβ.

CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy.

Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).

Computational and experimental studies of the interaction between phospho-peptides and the C-terminal domain of BRCA1.

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Respo

Discovery and characterization of small molecule Rac1 inhibitors

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

Erratum to: Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option

Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase

Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones.

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells

Ferulic acid dimer as a non-opioid therapeutic for acute pain.

High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity

High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions

High-throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of breast cancer gene 1.

Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA

Impact of structurally modifying hyaluronic acid on CD44 interaction.

Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option

Irreversible binding of an anticancer compound (BI-94) to plasma proteins

Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study

Micellar formulation of indocyanine green for phototherapy of melanoma

Mouse Pancreatic Tumor Model Independent of Tumor Suppressor Gene Inactivation

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.

Novel treatment for mantle cell lymphoma including therapy-resistant tumor by NF-κB and mTOR dual-targeting approach.

Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain

Perturbing pro-survival proteins using quinoxaline derivatives: A structure–activity relationship study ⬇️

Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS.

Poly-L-proline type II peptide mimics as probes of the active site occupancy requirements of cGMP-dependent protein kinase

Poly-L-proline type II peptide mimics based on the 3-azabicyclo[3.1.0]hexane system

Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases

Protein-protein interactions as therapeutic targets in neuropsychopharmacology

Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames.

RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment

Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation Protein

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

Selective degradation of CDK6 by a palbociclib based PROTAC

Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases

Structural characterization of BRCT-tetrapeptide binding interactions.

Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors.

Structure-activity relationship studies to probe the phosphoprotein binding site on the carboxy terminal domains of the breast cancer susceptibility gene 1.

Symbiotic Prodrugs (SymProDs) Dual Targeting of NFkappaB and CDK

Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation.

Synthesis and evaluation of macrocyclic diarylether heptanoid natural products and their analogs

Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

Synthesis of conformationally constrained lysine analogues

Synthesis of fluorescein labeled 7-methylguanosinemonophosphate

Synthesis of unnatural amino acid derivatives via palladium catalyzed 1,4 addition of boronic acids.

Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy

The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides

Thermodynamics of phosphopeptide tethering to BRCT: the structural minima for inhibitor design