Lista de obras - Douglas Palmer - Dominio Público Uruguay

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

artículo científico publicado en 2005

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

artículo científico publicado en 2008

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

artículo científico publicado en 2009

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

artículo científico publicado en 2014

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

artículo científico publicado en 2016

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

artículo científico publicado en 2004

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

artículo científico publicado en 2006

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

artículo científico publicado en 2005

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

artículo científico publicado en 2015

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

artículo científico publicado en 2013

Cross-priming utilizes antigen not available to the direct presentation pathway.

artículo científico publicado en 2006

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

artículo científico publicado en 2011

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

artículo científico publicado en 2008

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

artículo científico publicado en 2015

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.

artículo científico publicado en 2018

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

artículo científico publicado en 2007

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

artículo científico publicado en 2005

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

artículo científico publicado en 2010

IFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cells

artículo científico publicado en 2010

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

artículo científico publicado en 2004

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

artículo científico publicado en 2008

Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing

artículo científico publicado en 2014

Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen

artículo científico publicado en 2008

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

artículo científico publicado en 2010

Inflammatory mediator production in swine following endotoxin challenge with or without co-administration of dexamethasone.

artículo científico publicado en 2003

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

scientific article published on 16 September 2013

Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy.

artículo científico publicado en 2012

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

artículo científico publicado en 2016

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

artículo científico publicado en 2015

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

artículo científico publicado en 2015

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

artículo científico publicado en 2013

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

artículo científico publicado en 2007

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

artículo científico publicado en 2015

Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma

artículo científico publicado en 2009

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

artículo científico publicado en 2016

Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.

artículo científico publicado en 2009

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

artículo científico publicado en 2005

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

scientific article published on 02 September 2013

Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases.

artículo científico publicado en 2006

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.

artículo científico publicado en 2005

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

artículo científico publicado en 2009

T cell stemness and dysfunction in tumors are triggered by a common mechanism

artículo científico publicado en 2019

T-cell receptor gene therapy of established tumors in a murine melanoma model

artículo científico publicado en 2008

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

scientific journal article

Th17 cells are long lived and retain a stem cell-like molecular signature

artículo científico publicado en 2011

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells.

artículo científico publicado en 2018

The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.

artículo científico publicado en 2006

The transcription factor BACH2 promotes tumor immunosuppression.

artículo científico publicado en 2016

Toll-like receptors in tumor immunotherapy

artículo científico publicado en 2007

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity ⬇️

artículo científico publicado el 15 de noviembre de 2010

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

artículo científico publicado en 2003

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

artículo científico publicado en 2010

Tumor-specific Th17-polarized cells eradicate large established melanoma

artículo científico publicado en 2008

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

artículo científico publicado en 2014

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells

artículo científico publicado en 2009

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

artículo científico publicado en 2009

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.

artículo científico publicado en 2014

Lista de obras de Douglas Palmer

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

Cross-priming utilizes antigen not available to the direct presentation pathway.

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

IFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cells

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing

Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

Inflammatory mediator production in swine following endotoxin challenge with or without co-administration of dexamethasone.

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy.

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases.

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

T cell stemness and dysfunction in tumors are triggered by a common mechanism

T-cell receptor gene therapy of established tumors in a murine melanoma model

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

Th17 cells are long lived and retain a stem cell-like molecular signature

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells.

The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.

The transcription factor BACH2 promotes tumor immunosuppression.

Toll-like receptors in tumor immunotherapy

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity ⬇️

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

Tumor-specific Th17-polarized cells eradicate large established melanoma

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.