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Lista de obras de Power DM

A PTH/PTHrP receptor antagonist blocks the hypercalcemic response to estradiol-17β

article

A gene-based radiation hybrid map of the gilthead sea bream Sparus aurata refines and exploits conserved synteny with Tetraodon nigroviridis

artículo científico publicado en 2007

A genetic linkage map of the hermaphrodite teleost fish Sparus aurata L.

artículo científico publicado en 2006

A novel gastrin-processing pathway in mammalian antrum ⬇️

artículo científico publicado el 18 de mayo de 1988

A thyroid hormone regulated asymmetric responsive centre is correlated with eye migration during flatfish metamorphosis

artículo científico publicado en 2018

A yeast assay based on the gilthead sea bream (teleost fish) estrogen receptor beta for monitoring estrogen mimics.

artículo científico publicado en 2009

AVT is involved in the regulation of ion transport in the intestine of the sea bream (Sparus aurata).

artículo científico publicado en 2013

Acidification effects on biofouling communities: winners and losers

artículo científico publicado en 2015

Adaptation to different salinities exposes functional specialization in the intestine of the sea bream (Sparus aurata L.)

artículo científico publicado en 2012

Advances in European sea bass genomics and future perspectives.

artículo científico publicado en 2014

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact

artículo científico publicado en 2011

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. II--Genetic factors related to animal performance and advances in methodology.

artículo científico publicado en 2011

Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function.

artículo científico publicado en 2015

Analysis of the transthyretin-like (TTL) gene family in Ostertagia ostertagi--comparison with other strongylid nematodes and Caenorhabditis elegans

artículo científico publicado en 2008

Antioxidant capacity and immunomodulatory effects of a chrysolaminarin-enriched extract in Senegalese sole

artículo científico publicado en 2018

Application of comparative genomics in fish endocrinology

artículo científico publicado en 2002

CRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary gland

artículo científico publicado en 2010

Ca(2+)-Calmodulin regulation of testicular androgen production in Mozambique tilapia (Oreochromis mossambicus).

artículo científico publicado en 2009

Calcitonin receptor family evolution and fishing for function using in silico promoter analysis

article

Calcitonin: characterisation and expression in a teleost fish, Fugu rubripes

artículo científico publicado en 2002

Calcium balance in sea bream (Sparus aurata): the effect of oestradiol-17beta

artículo científico publicado en 2002

Calcium mobilization from fish scales is mediated by parathyroid hormone related protein via the parathyroid hormone type 1 receptor.

artículo científico publicado en 2005

Cartilage Acidic Protein 2 a hyperthermostable, high affinity calcium-binding protein

artículo científico publicado en 2012

Cells to shells: The genomics of mollusc exoskeletons

scientific article published on 10 May 2016

Cellular morphology and markers of cartilage and bone in the marine teleost Sparus auratus.

artículo científico publicado en 2011

Characterization of a sea bream (Sparus aurata) thyroid hormone receptor-beta clone expressed during embryonic and larval development.

artículo científico publicado en 2001

Characterization of the peripheral thyroid system of gilthead seabream acclimated to different ambient salinities.

artículo científico publicado en 2016

Cloning and Expression of an Elongation Factor-1alpha in Sea Bream (Sparus aurata) Larvae and Adult Tissue.

artículo científico publicado en 2000

Cloning and sequencing of a full-length sea bream (Sparus aurata) beta-actin cDNA.

artículo científico publicado en 1997

Cloning of the cDNA for sea bream (Sparus aurata) parathyroid hormone-related protein

artículo científico publicado en 2000

Cloning of the cDNA for the putative calcium-sensing receptor and its tissue distribution in sea bream (Sparus aurata).

artículo científico publicado en 2002

Cloning, characterization, and tissue distribution of prolactin receptor in the sea bream (Sparus aurata).

artículo científico publicado en 2001

Cloning, expression, and tissue localisation of prolactin in adult sea bream (Sparus aurata).

artículo científico publicado en 1999

Comparative analysis and characterization of expressed sequence tags in gilthead sea bream (Sparus aurata) liver and embryos

article

Comparative analysis of a teleost skeleton transcriptome provides insight into its regulation.

artículo científico publicado en 2013

Comparative study of family 2 GPCRs in Fugu rubripes

artículo científico publicado en 2005

Comparative thyroid endocrinology

artículo científico publicado en 2007

Comparison of the transcriptional responses of skeletal muscle and bone to a flooding dose of leucine in the gilthead sea bream (Sparus aurata).

artículo científico publicado en 2016

Coordination of deiodinase and thyroid hormone receptor expression during the larval to juvenile transition in sea bream (Sparus aurata, Linnaeus).

artículo científico

Cortisol and parathyroid hormone-related peptide are reciprocally modulated by negative feedback

artículo científico publicado en 2006

DAX1 regulatory networks unveil conserved and potentially new functions.

artículo científico

Degradation of endogenous heptadecapeptide gastrin by endopeptidase 24.11 in the pig

artículo científico publicado en 1987

Determination of tissue and plasma concentrations of PTHrP in fish: development and validation of a radioimmunoassay using a teleost 1-34 N-terminal peptide.

artículo científico publicado en 2003

Developmental expression of DAX1 in the European sea bass, Dicentrarchus labrax: lack of evidence for sexual dimorphism during sex differentiation

artículo científico publicado en 2007

Developmental ontogeny of prolactin and its receptor in fish

artículo científico publicado en 2004

Developmental ontogeny of prolactin and prolactin receptor in the sea bream (Sparus aurata).

artículo científico

Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish.

artículo científico

Dietary keto-acid feed-back on pituitary activity in gilthead sea bream: effects of oral doses of AKG. A proteomic approach

artículo científico publicado en 2010

Disruption of the thyroid system by diethylstilbestrol and ioxynil in the sea bream (Sparus aurata).

artículo científico publicado en 2009

Disruption of thyroid hormone binding to sea bream recombinant transthyretin by ioxinyl and polybrominated diphenyl ethers

artículo científico publicado en 2007

Divergence of duplicate POMC genes in gilthead sea bream Sparus auratus.

artículo científico publicado en 2010

Divergent responsiveness of the dentary and vertebral bone to a selective estrogen-receptor modulator (SERM) in the teleost Sparus auratus

artículo científico publicado en 2012

Duplicated receptors for VIP and PACAP (VPAC1R and PAC1R) in a teleost fish, Fugu rubripes.

artículo científico publicado en 2004

Dynamics of scale regeneration in seawater- and brackish water-acclimated sea bass, Dicentrarchus labrax

artículo científico publicado en 2012

Effect of maternal under-nutrition in late gestation on muscle and bone development in fetal sheep

article

Effects of estrogens and estrogenic disrupting compounds on fish mineralized tissues.

artículo científico publicado en 2014

Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish

artículo científico publicado en 2006

Endocrine regulation of carbonate precipitate formation in marine fish intestine by stanniocalcin and PTHrP

artículo científico publicado en 2014

Estradiol and genistein effects on the sea bass (Dicentrarchus labrax) scales: Transcriptome dataset

artículo científico publicado en 2019

European sea bass genome and its variation provide insights into adaptation to euryhalinity and speciation

artículo científico publicado en 2014

Evolution and diversity of alpha-carbonic anhydrases in the mantle of the Mediterranean mussel (Mytilus galloprovincialis)

scientific article published on 18 July 2019

Evolution of secretin family GPCR members in the metazoa.

artículo científico publicado en 2006

Evolution of the thyroid hormone-binding protein, transthyretin

artículo científico publicado en 2000

Experimental infection of European flat oyster Ostrea edulis with ostreid herpesvirus 1 microvar (OsHV-1μvar): Mortality, viral load and detection of viral transcripts by in situ hybridization.

artículo científico publicado en 2016

Expression of pituitary prolactin, growth hormone and somatolactin is modified in response to different stressors (salinity, crowding and food-deprivation) in gilthead sea bream Sparus auratus

artículo científico publicado en 2009

Expression of skeletal myosin light chain 2 in gilthead sea bream (Sparus aurata, L): regulation and correlation to growth markers

Expression of the myosin light chains 1, 2 and 3 in the muscle of blackspot seabream (Pagellus bogaraveo, Brunnich), during development

artículo científico publicado en 2010

Feeding and the rhodopsin family g-protein coupled receptors in nematodes and arthropods

artículo científico publicado en 2012

Fish genomes provide novel insights into the evolution of vertebrate secretin receptors and their ligand.

artículo científico publicado en 2014

Five gonadotrophin-releasing hormone receptors in a teleost fish: isolation, tissue distribution and phylogenetic relationships.

artículo científico publicado en 2005

Flatfish metamorphosis: a hypothalamic independent process?

artículo científico publicado en 2015

Four stanniocalcin genes in teleost fish: structure, phylogenetic analysis, tissue distribution and expression during hypercalcemic challenge.

artículo científico publicado en 2011

Fresh-blood-free diet for rearing malaria mosquito vectors

scientific article published in Scientific Reports

Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken.

artículo científico publicado en 2012

Functional modifications associated with gastrointestinal tract organogenesis during metamorphosis in Atlantic halibut (Hippoglossus hippoglossus).

artículo científico publicado en 2014

Gene expression profiling of gilthead sea bream during early development and detection of stress-related genes by the application of cDNA microarray technology

artículo científico publicado en 2005

Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken

artículo científico publicado en 2010

Genomic analysis of reveals the evolutionary dynamics of sex-biased genes in a sequential hermaphrodite fish

article

Genomic characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripes

artículo científico publicado en 2003

Genomic structure and expression of parathyroid hormone-related protein gene (PTHrP) in a teleost, Fugu rubripes

artículo científico publicado en 2000

Gill transcriptome response to changes in environmental calcium in the green spotted puffer fish.

artículo científico publicado en 2010

Growth hormone and insulin-like growth factors in fish: where we are and where to go.

artículo científico publicado en 2005

Heterogeneity of ubiquitin immunoreactivity in neurofibrillary tangles of Alzheimer's disease

artículo científico publicado en 1989

High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.

artículo científico publicado en 2004

Hormone affinity and fibril formation of piscine transthyretin: the role of the N-terminal.

artículo científico publicado en 2008

ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis.

artículo científico publicado en 2006

Identification and analysis of teleost slow muscle troponin T (sTnT) and intronless TnT genes

artículo científico publicado en 2005

Identification of androgen receptor variants in testis from humans and other vertebrates.

artículo científico publicado en 2012

Identification of estrogen-responsive genes in the testis of sea bream (Sparus auratus) using suppression subtractive hybridization

artículo científico publicado en 2006

Identification of molecular and physiological responses to chronic environmental challenge in an invasive species: the Pacific oyster, Crassostrea gigas ⬇️

artículo científico publicado en 2013

Immunochemical Detection of Parathyroid Hormone-Related Protein in the Saccus Vasculosus of a Teleost Fish

artículo científico publicado en 1996

Immunocytochemical identification of growth hormone, prolactin, and gonadotropin cells in the pituitary of male plaice (Pleuronectes platessa) during gonadal maturation

artículo científico publicado el 1 de marzo de 1992

Immunocytochemistry of somatotrophs, gonadotrophs, prolactin and adrenocorticotropin cells in larval sea bream (Sparus auratus) pituitaries

artículo científico publicado en 1992

Insights into shell deposition in the Antarctic bivalve Laternula elliptica: gene discovery in the mantle transcriptome using 454 pyrosequencing.

artículo científico publicado en 2010

Integument structure and function in juvenile Xenopus laevis with disrupted thyroid balance.

artículo científico publicado en 2011

Intra-adrenal interactions in fish: catecholamine stimulated cortisol release in sea bass (Dicentrarchus labrax L.).

artículo científico publicado en 2006

Involvement of growth hormone-insulin-like growth factor I system in cranial remodeling during halibut metamorphosis as indicated by tissue- and stage-specific receptor gene expression and the presence of growth hormone receptor protein.

artículo científico publicado en 2008

Is salmon smoltification an example of vertebrate metamorphosis? Lessons learnt from work on flatfish larval development

article

Isolation and Characterisation of the Corticotropin Releasing Factor Receptor 1 (CRFR1) Gene in a Teleost Fish, Fugu rubripes ⬇️

artículo científico publicado el 1 de junio de 2003

Isolation and characterization of piscine osteonectin and downregulation of its expression by PTH-related protein

artículo científico publicado en 2004

Isolation of Atlantic halibut pituitary hormones by continuous-elution electrophoresis followed by fingerprint identification, and assessment of growth hormone content during larval development

artículo científico publicado en 2006

Isolation of a novel aquaglyceroporin from a marine teleost (Sparus auratus): function and tissue distribution

artículo científico publicado en 2004

Ligand binding and signalling pathways of PTH receptors in sea bream (Sparus auratus) enterocytes.

artículo científico publicado en 2005

MARINE-EXPRESS: taking advantage of high throughput cloning and expression strategies for the post-genomic analysis of marine organisms

artículo científico publicado en 2010

Marine fish egg hydration is aquaporin-mediated

artículo científico publicado en 2005

Maternal thyroid hormones are essential for neural development in zebrafish

artículo científico publicado en 2014

Measurement of PTHrP, PTHR1, and CaSR expression levels in tissues of sea bream (Sparus aurata) using quantitative PCR.

artículo científico publicado en 2005

Molecular and cellular changes in skin and muscle during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus) are accompanied by changes in deiodinases expression.

artículo científico publicado en 2012

Molecular characterization and transcriptional regulation of the Na +/K+ ATPase α subunit isoforms during development and salinity challenge in a teleost fish, the Senegalese sole (Solea senegalensis).

artículo científico publicado en 2014

Molecular cloning and sequence of Sparus aurata skeletal myosin light chains expressed in white muscle: developmental expression and thyroid regulation.

artículo científico publicado en 2001

Molecular cloning and sequence of gilthead sea bream (Sparus aurata) alpha-skeletal actin: tissue and developmental expression

artículo científico publicado en 2001

Molecular, cellular and histological changes in skin from a larval to an adult phenotype during bony fish metamorphosis

artículo científico publicado en 2006

Nematode and arthropod genomes provide new insights into the evolution of class 2 B1 GPCRs

artículo científico publicado en 2014

Neuroendocrine control of appetite in Atlantic halibut (Hippoglossus hippoglossus): changes during metamorphosis and effects of feeding.

artículo científico publicado en 2015

Novel bioactive parathyroid hormone and related peptides in teleost fish

artículo científico publicado en 2005

Occurrence of ghrelin-producing cells, the ghrelin receptor and Na+,K + -ATPase in tissues of Atlantic halibut (Hippoglossus hippoglossus) during early development

artículo científico publicado en 2011

Ocean acidification affects the expression of neuroplasticity and neuromodulation markers in seabream

artículo científico publicado en 2022

Ontogeny of osteonectin expression in embryos and larvae of sea bream (Sparus auratus).

artículo científico

Orchestrating change: The thyroid hormones and GI-tract development in flatfish metamorphosis.

artículo científico

PACAP system evolution and its role in melanophore function in teleost fish skin

artículo científico publicado en 2015

PACAP, VIP and their receptors in the metazoa: insights about the origin and evolution of the ligand-receptor pair.

artículo científico publicado en 2007

PARATHYROID HORMONE-RELATED PROTEIN IN LOWER VERTEBRATES

article

PRL and GH synthesis and release from the sea bream (Sparus auratus L.) pituitary gland in vitro in response to osmotic challenge

artículo científico publicado en 2010

PTHrP regulates water absorption and aquaporin expression in the intestine of the marine sea bream (Sparus aurata, L.).

artículo científico publicado en 2015

PTHrP-induced modifications of the sea bream (Sparus auratus) vertebral bone proteome

artículo científico publicado en 2013

Parathyroid Hormone-Related Protein Is a Factor in Normal Fish Pituitary

scientific article published on 01 November 1993

Parathyroid hormone-related protein regulates intestinal calcium transport in sea bream (Sparus auratus)

artículo científico publicado en 2006

Parathyroid hormone-related protein-stanniocalcin antagonism in regulation of bicarbonate secretion and calcium precipitation in a marine fish intestine

artículo científico publicado en 2010

Persistence of duplicated PAC1 receptors in the teleost, Sparus auratus

artículo científico publicado en 2007

Persistence of the ABCC6 genes and the emergence of the bony skeleton in vertebrates.

artículo científico publicado en 2018

Piscine PTHrP regulation of calcium and phosphate transport in winter flounder renal proximal tubule primary cultures.

artículo científico publicado en 2010

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al

artículo científico publicado en 2013

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al

article

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

artículo científico publicado en 2013

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

artículo científico publicado en 2013

Production and characterisation of gilthead sea bream (Sparus auratus) recombinant parathyroid hormone related protein

artículo científico publicado en 2005

Prolactin regulates luminal bicarbonate secretion in the intestine of the sea bream (Sparus aurata L.)

artículo científico publicado en 2012

Proteomic approach to skin regeneration in a marine teleost: modulation by oestradiol-17β.

artículo científico

Quantification of prolactin (PRL) and PRL receptor messenger RNA in gilthead seabream (Sparus aurata) after treatment with estradiol-17beta.

artículo científico publicado en 2003

Quantifying dominant bacterial genera detected in metagenomic data from fish eggs and larvae using genus‐specific primers

artículo científico publicado en 2022

Regulation of calcium balance in the sturgeon Acipenser naccarii: a role for PTHrP.

artículo científico publicado en 2007

Regulation of transthyretin by thyroid hormones in fish

artículo científico publicado en 2006

Regulation of troponin T expression during muscle development in sea bream Sparus auratus Linnaeus: the potential role of thyroid hormones

artículo científico publicado en 2006

Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

artículo científico publicado en 2013

Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al.

artículo científico publicado en 2013

Revealing higher than expected meiofaunal diversity in Antarctic sediments: a metabarcoding approach

artículo científico publicado en 2017

STC1 and PTHrP Modify Carbohydrate and Lipid Metabolism in Liver of a Teleost Fish

artículo científico publicado en 2019

Sea Bream (Sparus auratus) Estrogen Receptors: Phylogeny and Tissue Distribution

artículo científico publicado en 2005

Second generation genetic linkage map for the gilthead sea bream Sparus aurata L.

artículo científico publicado en 2014

Second-generation environmental sequencing unmasks marine metazoan biodiversity

artículo científico publicado en 2010

Separation of rainbow trout (Salmo gairdneri) growth hormone by gel electrophoresis

artículo científico publicado en 1990

Skin healing and scale regeneration in fed and unfed sea bream, Sparus auratus.

artículo científico publicado en 2011

Somatotropin release-inhibiting factor and galanin innervation in the hypothalamus and pituitary of seabream (Sparus aurata).

artículo científico publicado en 1996

Stage-Specific Transcriptomes of the Mussel Mytilus coruscus Reveals the Developmental Program for the Planktonic to Benthic Transition

scientific article published in 2023

Staging of Atlantic halibut (Hippoglossus hippoglossus L.) from first feeding through metamorphosis, including cranial ossification independent of eye migration

article by Ø. Sæle et al published September 2004 in Aquaculture

Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish

artículo científico publicado en 2015

Stimulation of cortisol release by the N terminus of teleost parathyroid hormone-related protein in interrenal cells in vitro.

artículo científico publicado en 2004

Stress response of Listeria monocytogenes isolated from cheese and other foods.

artículo científico publicado en 2003

Structure, tissue distribution and estrogen regulation of splice variants of the sea bream estrogen receptor α gene.

artículo científico publicado en 2012

Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach

artículo científico publicado en 2018

The International Conference on Comparative Endocrinology and Physiology.

artículo científico publicado en 2014

The effect of food deprivation and refeeding on the liver, thyroid hormones and transthyretin in sea bream

artículo científico publicado en 2000

The first radiation hybrid map of a perch-like fish: The gilthead seabream (Sparus aurata L)

article

The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry

artículo científico publicado en 2016

The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish.

artículo científico publicado en 2006

The regulatory action of estrogen and vasoactive intestinal peptide on prolactin secretion in sea bream (Sparus aurata, L.).

artículo científico publicado en 2003

The role of prolactin in the regulation of brood care in the cooperatively breeding fish Neolamprologus pulcher

artículo científico publicado en 2008

The secretin G-protein-coupled receptor family: teleost receptors

artículo científico publicado en 2005

The serendipitous origin of chordate secretin peptide family members

artículo científico publicado en 2010

The transcriptome of metamorphosing flatfish.

artículo científico publicado en 2016

Thermal imprinting modifies bone homeostasis in cold challenged sea bream (Sparus aurata, L.).

artículo científico

Thyroid and pituitary gland development from hatching through metamorphosis of a teleost flatfish, the Atlantic halibut.

artículo científico

Thyroid disruption in the lizard Podarcis bocagei exposed to a mixture of herbicides: a field study.

artículo científico publicado en 2012

Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus).

artículo científico publicado en 2007

Thyroid hormones in growth and development of fish.

artículo científico publicado en 2001

Tissue responsiveness to estradiol and genistein in the sea bass liver and scale.

artículo científico publicado en 2015

Transcriptome of the Atlantic halibut (Hippoglossus hippoglossus).

artículo científico publicado en 2014

Transcriptomics provides insight into Mytilus galloprovincialis (Mollusca: Bivalvia) mantle function and its role in biomineralisation.

artículo científico publicado en 2016

Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis.

artículo científico publicado en 2017

Transient up- and down-regulation of expression of myosin light chain 2 and myostatin mRNA mark the changes from stratified hyperplasia to muscle fiber hypertrophy in larvae of gilthead sea bream (Sparus aurata L.)

artículo científico publicado en 2015

Transthyretin in fish: state of the art.

artículo científico publicado en 2002

Troponin T isoform expression is modulated during Atlantic halibut metamorphosis

artículo científico publicado en 2007

Two estrogen receptors expressed in the teleost fish, Sparus aurata: cDNA cloning, characterization and tissue distribution

artículo científico publicado en 2000

Ubiquitin deposits in anterior horn cells in motor neurone disease.

artículo científico publicado en 1988

Ultrasequencing of the meiofaunal biosphere: practice, pitfalls and promises.

artículo científico publicado en 2010

Understanding pseudo-albinism in sole (Solea senegalensis): a transcriptomics and metagenomics approach

artículo científico publicado en 2019

Unravelling the Evolution of the Allatostatin-Type A, KISS and Galanin Peptide-Receptor Gene Families in Bilaterians: Insights from Anopheles Mosquitoes

artículo científico publicado en 2015

Water absorption and bicarbonate secretion in the intestine of the sea bream are regulated by transmembrane and soluble adenylyl cyclase stimulation

artículo científico publicado en 2012

Water calcium concentration modifies whole-body calcium uptake in sea bream larvae during short-term adaptation to altered salinities

artículo científico publicado en 2004

Waterborne exposure of zebrafish embryos to micromole concentrations of ioxynil and diethylstilbestrol disrupts thyrocyte development.

artículo científico publicado en 2013

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