Lista de obras - Karl Kuchler - Dominio Público Uruguay

A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species

artículo científico publicado en 2019

A genetic screen identifies mutations in the yeast WAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation

scientific article published on 17 May 2007

A histone deacetylase adjusts transcription kinetics at coding sequences during Candida albicans morphogenesis

artículo científico publicado en 2012

A histone deacetylase complex mediates biofilm dispersal and drug resistance in Candida albicans.

artículo científico publicado en 2014

A sensitive and inexpensive yeast bioassay for the mycotoxin zearalenone and other compounds with estrogenic activity.

artículo científico publicado en 2003

ABC proteins in yeast and fungal pathogens.

artículo científico publicado en 2011

ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae.

artículo científico publicado en 2009

ATAC-Seq Identifies Chromatin Landscapes Linked to the Regulation of Oxidative Stress in the Human Fungal Pathogen Candida albicans

scientific article published on 21 September 2020

Activin A and follicle-stimulating hormone control tight junctions in avian granulosa cells by regulating occludin expression

artículo científico publicado en 2004

Activin a signaling induces Smad2, but not Smad3, requiring protein kinase a activity in granulosa cells from the avian ovary

artículo científico publicado en 2003

Activin and follicle-stimulating hormone signaling are required for long-term culture of functionally differentiated primary granulosa cells from the chicken ovary

artículo científico publicado en 2003

An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells

artículo científico publicado en 2012

Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus-binding molecule

artículo científico publicado en 2011

Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance.

artículo científico publicado en 2008

Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors

artículo científico publicado en 2008

Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy.

artículo científico publicado en 2009

Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate

artículo científico publicado en 2015

Cdr2p contributes to fluconazole resistance in Candida dubliniensis clinical isolates

artículo científico publicado en 2011

Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression pattern

artículo científico publicado en 1995

Construction and characterization of single-transcript tricistronic retroviral vectors using two internal ribosome entry sites

artículo científico publicado en 1998

Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling

artículo científico publicado en 2011

DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

artículo científico publicado en 2014

Dectin-1 is required for miR155 upregulation in murine macrophages in response to Candida albicans.

artículo científico publicado en 2016

Dedicated transporters for peptide export and intercompartmental traffic in the yeast Saccharomyces cerevisiae

artículo científico publicado en 1992

Diazaborine resistance in the yeast Saccharomyces cerevisiae reveals a link between YAP1 and the pleiotropic drug resistance genes PDR1 and PDR3.

artículo científico publicado en 1997

Efg1 Controls Caspofungin-Induced Cell Aggregation of Candida albicans through the Adhesin Als1 ⬇️

artículo científico publicado el 28 de octubre de 2011

Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae.

artículo científico publicado en 1995

Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.

artículo científico publicado en 1998

Estradiol impairs the Th17 immune response against Candida albicans

article

Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase

artículo científico publicado en 2004

Flagging Drugs That Inhibit the Bile Salt Export Pump

artículo científico publicado en 2015

Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae

artículo científico publicado en 1992

Functional genomics of drug-induced ion homeostasis identifies a novel regulatory crosstalk of iron and zinc regulons in yeast.

artículo científico publicado en 2010

Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification.

artículo científico publicado en 2001

Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?

artículo científico publicado en 2016

Fungal attacks on mammalian hosts: pathogen elimination requires sensing and tasting.

artículo científico publicado en 2010

Fungal pathogens-a sweet and sour treat for toll-like receptors

artículo científico publicado en 2012

Genetic Transformation of Candida glabrata by Electroporation

artículo científico publicado en 2015

Genetic Transformation of Candida glabrata by Heat Shock.

artículo científico publicado en 2015

Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.

artículo científico publicado en 1998

Global Phenotypic Analysis and Transcriptional Profiling Defines the Weak Acid Stress Response Regulon in Saccharomyces cerevisiae ⬇️

artículo científico publicado el 14 de noviembre de 2003

Global gene deletion analysis exploring yeast filamentous growth

artículo científico publicado en 2012

High Pdr12 levels in spoilage yeast (Saccharomyces cerevisiae) correlate directly with sorbic acid levels in the culture medium but are not sufficient to provide cells with acquired resistance to the food preservative

artículo científico publicado en 2006

Human Dermo-1 has attributes similar to twist in early bone development

artículo científico publicado en 2000

Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages

artículo científico publicado en 2014

Identification of mouse histone deacetylase 1 as a growth factor-inducible gene

scientific journal article

Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages

artículo científico publicado en 2013

Immunological Identification of Fungal Species.

artículo científico publicado en 2017

In vitro systems for studying the interaction of fungal pathogens with primary cells from the mammalian innate immune system

artículo científico publicado en 2009

Inhibition of CBLB protects from lethal Candida albicans sepsis

artículo científico publicado en 2016

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense

scientific journal article

Klebsiella pneumoniae prevents spore germination and hyphal development of Aspergillus species

artículo científico publicado en 2019

Large-scale Phenotypic Profiling of Gene Deletion Mutants in Candida glabrata.

artículo científico publicado en 2015

Loss of Cmk1 Ca(2+)-calmodulin-dependent protein kinase in yeast results in constitutive weak organic acid resistance, associated with a post-transcriptional activation of the Pdr12 ATP-binding cassette transporter

artículo científico publicado en 2000

Loss of peroxisome function triggers necrosis.

artículo científico publicado en 2008

MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators.

artículo científico publicado en 2013

Membrane translocation of proteins without hydrophobic signal peptides.

artículo científico publicado en 1990

Methionine is required for cAMP-PKA mediated morphogenesis and virulence of Candida albicans.

artículo científico publicado en 2018

Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant

artículo científico publicado en 2014

Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP-binding cassette transporter.

artículo científico publicado en 2003

Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance.

artículo científico publicado en 1994

Morphological and molecular genetic analysis of epigenetic switching of the human fungal pathogen Candida albicans.

artículo científico publicado en 2011

Mutations in the nucleotide-binding domain of putative sterol importers Aus1 and Pdr11 selectively affect utilization of exogenous sterol species in yeast

scientific article published on 23 December 2019

Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts

artículo científico publicado en 2015

Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata.

artículo científico publicado en 2011

Pathogenetic Impact of Bacterial-Fungal Interactions

scientific article published on 16 October 2019

Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3

artículo científico publicado en 1997

Positions and numbers of FKS mutations in Candida albicans selectively influence in vitro and in vivo susceptibilities to echinocandin treatment.

artículo científico publicado en 2014

Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis

artículo científico publicado en 2000

Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response

artículo científico publicado en 2018

Retinol in avian oogenesis: molecular properties of the carrier protein

artículo científico publicado en 1995

Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast

artículo científico publicado en 2003

Screening the yeast deletant mutant collection for hypersensitivity and hyper-resistance to sorbate, a weak organic acid food preservative.

artículo científico publicado en 2004

Secretion of peptides and proteins lacking hydrophobic signal sequences: the role of adenosine triphosphate-driven membrane translocators

artículo científico publicado el 1 de agosto de 1992

Subcellular and submitochondrial localization of phospholipid-synthesizing enzymes in Saccharomyces cerevisiae.

artículo científico publicado en 1986

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).

artículo científico publicado en 2016

Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes

artículo científico publicado en 2014

Targeting chromatin in fungal pathogens as a novel therapeutic strategy: histone modification gets infectious.

artículo científico publicado en 2011

The ABC of ABCs: multidrug resistance and genetic diseases ⬇️

artículo científico publicado el 1 de agosto de 2011

The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

artículo científico publicado en 2019

The ATP-binding cassette (ABC) transporter Bpt1p mediates vacuolar sequestration of glutathione conjugates in yeast.

artículo científico publicado en 2002

The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3

artículo científico publicado en 1996

The CRG1 gene required for resistance to the singlet oxygen-generating cercosporin toxin in Cercospora nicotianae encodes a putative fungal transcription factor.

artículo científico publicado en 2003

The Candida albicans Cdr2p ATP-binding cassette (ABC) transporter confers resistance to caspofungin.

artículo científico publicado en 2003

The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals

artículo científico publicado en 2017

The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways

artículo científico publicado en 2015

The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways

scientific article published on 01 July 2019

The Paralogous Histone Deacetylases Rpd3 and Rpd31 Play Opposing Roles in Regulating the White-Opaque Switch in the Fungal Pathogen Candida albicans.

artículo científico publicado en 2016

The Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism

artículo científico publicado en 1999

The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicans

artículo científico publicado en 2010

The Two-Component Response Regulator Ssk1 and the Mitogen-Activated Protein Kinase Hog1 Control Antifungal Drug Resistance and Cell Wall Architecture of Candida auris

artículo científico publicado en 2020

The a-factor transporter (STE6 gene product) and cell polarity in the yeast Saccharomyces cerevisiae ⬇️

artículo científico publicado el 1 de marzo de 1993

The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation

artículo científico publicado en 2011

The histone acetyltransferase Hat1 facilitates DNA damage repair and morphogenesis in Candida albicans

artículo científico publicado en 2012

The hydrophilic and acidic N-terminus of the integral membrane enzyme phosphatidylserine synthase is required for efficient membrane insertion

artículo científico publicado en 1990

The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome

artículo científico publicado en 2014

The nuclear actin-related protein Act3p/Arp4p of Saccharomyces cerevisiae is involved in transcription regulation of stress genes.

artículo científico publicado en 2003

The pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast

artículo científico publicado en 1998

The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study

artículo científico publicado en 2011

The sensitivities of yeast strains deficient in PDR ABC transporters, to quinoline-ring antimalarial drugs.

artículo científico publicado en 2004

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

artículo científico publicado en 2017

The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility

artículo científico publicado en 2000

The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection

scientific journal article

The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators ⬇️

artículo científico publicado el 1 de diciembre de 1997

The yeast Pdr15p ATP-binding cassette (ABC) protein is a general stress response factor implicated in cellular detoxification.

artículo científico publicado en 2003

The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole

scientific article published on 01 January 1996

The yeast zinc finger regulators Pdr1p and Pdr3p control pleiotropic drug resistance (PDR) as homo- and heterodimers in vivo

artículo científico publicado en 2002

Transcription factor Efg1 shows a haploinsufficiency phenotype in modulating the cell wall architecture and immunogenicity of Candida albicans.

artículo científico publicado en 2011

Transcriptional loops meet chromatin: a dual-layer network controls white-opaque switching in Candida albicans

artículo científico publicado en 2009

Two precursors of thyrotropin-releasing hormone from skin of Xenopus laevis. Each contains seven copies of the end product ⬇️

artículo científico publicado el 15 de julio de 1990

Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections

artículo científico publicado en 2012

Unusual routes of protein secretion: the easy way out

artículo científico publicado en 1993

Upregulation of chicken p15INK4b at senescence and in the developing brain.

artículo científico publicado en 2006

War1p, a novel transcription factor controlling weak acid stress response in yeast.

artículo científico publicado en 2003

Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants

artículo científico publicado en 2003

Weak organic acid stress triggers hyperphosphorylation of the yeast zinc-finger transcription factor War1 and dampens stress adaptation.

artículo científico publicado en 2010

Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation.

artículo científico publicado en 2008

Yeast ABC transporters-- a tale of sex, stress, drugs and aging.

artículo científico publicado en 2005

Yeast ATP-binding cassette transporters: cellular cleaning pumps.

artículo científico publicado en 2005

Lista de obras de Karl Kuchler

A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species

A genetic screen identifies mutations in the yeast WAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation

A histone deacetylase adjusts transcription kinetics at coding sequences during Candida albicans morphogenesis

A histone deacetylase complex mediates biofilm dispersal and drug resistance in Candida albicans.

A sensitive and inexpensive yeast bioassay for the mycotoxin zearalenone and other compounds with estrogenic activity.

ABC proteins in yeast and fungal pathogens.

ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae.

ATAC-Seq Identifies Chromatin Landscapes Linked to the Regulation of Oxidative Stress in the Human Fungal Pathogen Candida albicans

Activin A and follicle-stimulating hormone control tight junctions in avian granulosa cells by regulating occludin expression

Activin a signaling induces Smad2, but not Smad3, requiring protein kinase a activity in granulosa cells from the avian ovary

Activin and follicle-stimulating hormone signaling are required for long-term culture of functionally differentiated primary granulosa cells from the chicken ovary

An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells

Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus-binding molecule

Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance.

Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors

Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy.

Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate

Cdr2p contributes to fluconazole resistance in Candida dubliniensis clinical isolates

Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression pattern

Construction and characterization of single-transcript tricistronic retroviral vectors using two internal ribosome entry sites

Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling

DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

Dectin-1 is required for miR155 upregulation in murine macrophages in response to Candida albicans.

Dedicated transporters for peptide export and intercompartmental traffic in the yeast Saccharomyces cerevisiae

Diazaborine resistance in the yeast Saccharomyces cerevisiae reveals a link between YAP1 and the pleiotropic drug resistance genes PDR1 and PDR3.

Efg1 Controls Caspofungin-Induced Cell Aggregation of Candida albicans through the Adhesin Als1 ⬇️

Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae.

Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.

Estradiol impairs the Th17 immune response against Candida albicans

Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase

Flagging Drugs That Inhibit the Bile Salt Export Pump

Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae

Functional genomics of drug-induced ion homeostasis identifies a novel regulatory crosstalk of iron and zinc regulons in yeast.

Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification.

Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?

Fungal attacks on mammalian hosts: pathogen elimination requires sensing and tasting.

Fungal pathogens-a sweet and sour treat for toll-like receptors

Genetic Transformation of Candida glabrata by Electroporation

Genetic Transformation of Candida glabrata by Heat Shock.

Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.

Global Phenotypic Analysis and Transcriptional Profiling Defines the Weak Acid Stress Response Regulon in Saccharomyces cerevisiae ⬇️

Global gene deletion analysis exploring yeast filamentous growth

High Pdr12 levels in spoilage yeast (Saccharomyces cerevisiae) correlate directly with sorbic acid levels in the culture medium but are not sufficient to provide cells with acquired resistance to the food preservative

Human Dermo-1 has attributes similar to twist in early bone development

Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages

Identification of mouse histone deacetylase 1 as a growth factor-inducible gene

Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages

Immunological Identification of Fungal Species.

In vitro systems for studying the interaction of fungal pathogens with primary cells from the mammalian innate immune system

Inhibition of CBLB protects from lethal Candida albicans sepsis

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense

Klebsiella pneumoniae prevents spore germination and hyphal development of Aspergillus species

Large-scale Phenotypic Profiling of Gene Deletion Mutants in Candida glabrata.

Loss of Cmk1 Ca(2+)-calmodulin-dependent protein kinase in yeast results in constitutive weak organic acid resistance, associated with a post-transcriptional activation of the Pdr12 ATP-binding cassette transporter

Loss of peroxisome function triggers necrosis.

MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators.

Membrane translocation of proteins without hydrophobic signal peptides.

Methionine is required for cAMP-PKA mediated morphogenesis and virulence of Candida albicans.

Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant

Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP-binding cassette transporter.

Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance.

Morphological and molecular genetic analysis of epigenetic switching of the human fungal pathogen Candida albicans.

Mutations in the nucleotide-binding domain of putative sterol importers Aus1 and Pdr11 selectively affect utilization of exogenous sterol species in yeast

Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts

Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata.

Pathogenetic Impact of Bacterial-Fungal Interactions

Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3

Positions and numbers of FKS mutations in Candida albicans selectively influence in vitro and in vivo susceptibilities to echinocandin treatment.

Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis

Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response

Retinol in avian oogenesis: molecular properties of the carrier protein

Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast

Screening the yeast deletant mutant collection for hypersensitivity and hyper-resistance to sorbate, a weak organic acid food preservative.

Secretion of peptides and proteins lacking hydrophobic signal sequences: the role of adenosine triphosphate-driven membrane translocators

Subcellular and submitochondrial localization of phospholipid-synthesizing enzymes in Saccharomyces cerevisiae.

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).

Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes

Targeting chromatin in fungal pathogens as a novel therapeutic strategy: histone modification gets infectious.

The ABC of ABCs: multidrug resistance and genetic diseases ⬇️