Lista de obras - Aviad Tsherniak - Dominio Público Uruguay

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

artículo científico publicado en 2017

A first-generation pediatric cancer dependency map

artículo científico publicado en 2021

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

artículo científico publicado en 2012

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

artículo científico publicado en 2019

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

artículo científico publicado en 2021

Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

artículo científico publicado en 2022

Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress

artículo científico publicado en 2019

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

artículo científico publicado en 2017

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

artículo científico publicado en 2017

Cancer vulnerabilities unveiled by genomic loss

artículo científico publicado en 2012

Characterizing genomic alterations in cancer by complementary functional associations

artículo científico publicado en 2016

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

artículo científico publicado en 2017

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

artículo científico publicado en 2017

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

artículo científico publicado en 2017

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

artículo científico

Defining a Cancer Dependency Map.

artículo científico publicado en 2017

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

artículo científico publicado en 2020

Functional Genomic Characterization of Cancer Genomes

artículo científico publicado en 2016

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

artículo científico publicado en 2021

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

artículo científico publicado en 2015

GeNets: a unified web platform for network-based genomic analyses.

artículo científico publicado en 2018

Genetic and transcriptional evolution alters cancer cell line drug response

artículo científico publicado en 2018

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

scientific article published on 21 March 2019

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

scientific article published on 25 July 2018

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

artículo científico publicado en 2018

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

artículo científico publicado en 2016

Global computational alignment of tumor and cell line transcriptional profiles

artículo científico publicado en 2021

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

artículo científico publicado en 2016

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

artículo científico publicado en 2018

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

artículo científico publicado en 2015

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.

artículo científico publicado en 2015

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

scientific article published in Nature Communications

Integrated cross-study datasets of genetic dependencies in cancer

artículo científico publicado en 2021

Integrated genetic and pharmacologic interrogation of rare cancers

artículo científico publicado en 2016

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

artículo científico publicado en 2011

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

article published in 2018

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

artículo científico publicado en 2019

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

artículo científico publicado en 2016

Mitochondrial metabolism promotes adaptation to proteotoxic stress

artículo científico publicado en 2019

Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia

artículo científico publicado en 2017

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

artículo científico publicado en 2020

Mutational processes shape the landscape of TP53 mutations in human cancer.

artículo científico publicado en 2018

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

artículo científico publicado en 2019

Next-generation characterization of the Cancer Cell Line Encyclopedia

artículo científico publicado en 2019

PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF -AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

artículo científico publicado en 2017

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

artículo científico publicado en 2017

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

artículo científico publicado en 2020

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

artículo científico publicado en 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

artículo científico publicado en 2014

Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features

artículo científico publicado en 2011

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

artículo científico publicado en 2012

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer

scientific article published on December 2013

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

artículo científico publicado en 2015

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

article

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.

artículo científico publicado en 2017

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

artículo científico publicado en 2020

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

scientific article published on 01 October 2019

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

artículo científico publicado en 2011

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

artículo científico publicado en 2018

The landscape of cancer cell line metabolism

scientific article published on 08 May 2019

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

scientific article published on 10 April 2019

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

artículo científico publicado en 2012

Lista de obras de Aviad Tsherniak

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

A first-generation pediatric cancer dependency map

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

Cancer vulnerabilities unveiled by genomic loss

Characterizing genomic alterations in cancer by complementary functional associations

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

Defining a Cancer Dependency Map.

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

Functional Genomic Characterization of Cancer Genomes

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

GeNets: a unified web platform for network-based genomic analyses.

Genetic and transcriptional evolution alters cancer cell line drug response

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Global computational alignment of tumor and cell line transcriptional profiles

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

Integrated cross-study datasets of genetic dependencies in cancer

Integrated genetic and pharmacologic interrogation of rare cancers

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Mitochondrial metabolism promotes adaptation to proteotoxic stress

Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

Mutational processes shape the landscape of TP53 mutations in human cancer.

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Next-generation characterization of the Cancer Cell Line Encyclopedia

PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF -AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

The landscape of cancer cell line metabolism

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis