Lista de obras - Christian Speck - Dominio Público Uruguay

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

artículo científico publicado en 2009

A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase.

artículo científico publicado en 2015

A top-down view on DNA replication and recombination from 9,000 feet above sea level

artículo científico publicado en 2011

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA

artículo científico publicado en 2014

ATP- and ADP-dnaA protein, a molecular switch in gene regulation.

artículo científico publicado en 1999

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

artículo científico publicado en 2005

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

artículo científico publicado en 2013

An integrated workflow for crosslinking mass spectrometry

Bacterial replication initiator DnaA. Rules for DnaA binding and roles of DnaA in origin unwinding and helicase loading

artículo científico publicado en 2001

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.

artículo científico publicado en 2015

Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy

artículo científico publicado en 2012

Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.

artículo científico publicado en 2017

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

artículo científico publicado en 2013

Evolution of DNA replication origin specification and gene silencing mechanisms

artículo científico publicado en 2020

Exceeding the limits - Cdc45 overexpression turns bad.

artículo científico publicado en 2016

From footprint to toeprint: a close-up of the DnaA box, the binding site for the bacterial initiator protein DnaA.

artículo científico publicado en 1997

From structure to mechanism-understanding initiation of DNA replication.

artículo científico publicado en 2017

Functional domains of DnaA proteins.

artículo científico publicado en 1999

Genetic organization of the Vibrio harveyi DnaA gene region and analysis of the function of the V. harveyi DnaA protein in Escherichia coli

artículo científico publicado en 2002

Helicase loading: how to build a MCM2-7 double-hexamer.

artículo científico

Identification of the chromosomal replication origin from Thermus thermophilus and its interaction with the replication initiator DnaA.

artículo científico publicado en 2000

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

artículo científico publicado en 2013

Opening the gate to DNA replication

artículo científico publicado en 2015

Recognition of DNA by omega protein from the broad-host range Streptococcus pyogenes plasmid pSM19035: analysis of binding to operator DNA with one to four heptad repeats

artículo científico publicado en 2004

Replicating repetitive DNA

artículo científico publicado en 2016

Seeing is believing: the MCM2-7 helicase trapped in complex with its DNA loader

artículo científico publicado en 2013

Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function

artículo científico publicado en 2014

Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.

artículo científico publicado en 2017

Structural elements of the Streptomyces oriC region and their interactions with the DnaA protein

artículo científico publicado en 1998

Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6

artículo científico publicado en 2020

Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated

artículo científico publicado en 2014

The Escherichia coli SeqA protein binds specifically and co-operatively to two sites in hemimethylated and fully methylated oriC

artículo científico publicado en 2000

The GTP-dependent restriction enzyme McrBC from Escherichia coli forms high-molecular mass complexes with DNA and produces a cleavage pattern with a characteristic 10-base pair repeat.

artículo científico publicado en 2002

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

artículo científico publicado en 2013

The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading

artículo científico publicado en 2013

The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae

artículo científico publicado en 2008

The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression.

artículo científico publicado en 2014

Lista de obras de Christian Speck

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase.

A top-down view on DNA replication and recombination from 9,000 feet above sea level

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA

ATP- and ADP-dnaA protein, a molecular switch in gene regulation.

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

An integrated workflow for crosslinking mass spectrometry

Bacterial replication initiator DnaA. Rules for DnaA binding and roles of DnaA in origin unwinding and helicase loading

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.

Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy

Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

Evolution of DNA replication origin specification and gene silencing mechanisms

Exceeding the limits - Cdc45 overexpression turns bad.

From footprint to toeprint: a close-up of the DnaA box, the binding site for the bacterial initiator protein DnaA.

From structure to mechanism-understanding initiation of DNA replication.

Functional domains of DnaA proteins.

Genetic organization of the Vibrio harveyi DnaA gene region and analysis of the function of the V. harveyi DnaA protein in Escherichia coli

Helicase loading: how to build a MCM2-7 double-hexamer.

Identification of the chromosomal replication origin from Thermus thermophilus and its interaction with the replication initiator DnaA.

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

Opening the gate to DNA replication

Recognition of DNA by omega protein from the broad-host range Streptococcus pyogenes plasmid pSM19035: analysis of binding to operator DNA with one to four heptad repeats

Replicating repetitive DNA

Seeing is believing: the MCM2-7 helicase trapped in complex with its DNA loader

Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function

Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.

Structural elements of the Streptomyces oriC region and their interactions with the DnaA protein

Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6

Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated

The Escherichia coli SeqA protein binds specifically and co-operatively to two sites in hemimethylated and fully methylated oriC

The GTP-dependent restriction enzyme McrBC from Escherichia coli forms high-molecular mass complexes with DNA and produces a cleavage pattern with a characteristic 10-base pair repeat.

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading

The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae

The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression.