Lista de obras - Karen J Gregory - Dominio Público Uruguay

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

artículo científico publicado en 2013

Allosteric modulation of metabotropic glutamate receptors

artículo científico publicado en 2011

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5

article

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

artículo científico publicado en 2014

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

artículo científico publicado en 2015

Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2.

artículo científico publicado en 2005

Commentary on "Morphine-induced respiratory depression is independent of β-arrestin2 signalling"

artículo científico publicado en 2020

Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound

artículo científico publicado en 2012

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

artículo científico publicado en 2010

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin

artículo científico publicado en 2013

Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.

artículo científico publicado en 2016

Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7

artículo científico publicado en 2014

Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site

scientific article published on 26 February 2014

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships

artículo científico publicado en 2012

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

artículo científico publicado en 2013

NeuroChat with Dr. Karen Gregory

artículo científico publicado en 2020

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover

artículo científico publicado en 2012

Overview of Receptor Allosterism

artículo científico publicado en 2010

Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders

artículo científico

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

artículo científico publicado en 2016

Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology

artículo científico publicado en 2013

Quantification of adenosine A(1) receptor biased agonism: Implications for drug discovery

artículo científico publicado en 2015

Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.

artículo científico publicado en 2016

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS

artículo científico publicado en 2014

Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor

artículo científico publicado en 2012

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator

artículo científico publicado en 2014

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

artículo científico publicado en 2016

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity

artículo científico publicado en 2012

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

artículo científico publicado en 2015

Lista de obras de Karen J Gregory

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

Allosteric modulation of metabotropic glutamate receptors

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2.

Commentary on "Morphine-induced respiratory depression is independent of β-arrestin2 signalling"

Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin

Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.

Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7

Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

NeuroChat with Dr. Karen Gregory

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover

Overview of Receptor Allosterism

Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology

Quantification of adenosine A(1) receptor biased agonism: Implications for drug discovery

Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS

Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy