Lista de obras - Paul H. Weinreb - Dominio Público Uruguay

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

artículo científico publicado en 2020

Aggregated SOD1 causes selective death of cultured human motor neurons

artículo científico publicado en 2018

Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

artículo científico publicado en 2007

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis

artículo científico publicado en 2016

Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism

artículo científico publicado en 2008

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

artículo científico publicado en 2010

Blockade of Nogo receptor ligands promotes functional regeneration of sensory axons after dorsal root crush.

artículo científico publicado en 2009

Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases

artículo científico publicado en 1998

Characterization of integrin beta6 and thrombospondin-1 double-null mice

scientific journal article

Characterization of trisulfide modification in antibodies

artículo científico publicado en 2010

Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice

artículo científico publicado en 2015

Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment

artículo científico publicado en 2003

Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.

artículo científico publicado en 2006

Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma.

artículo científico publicado en 2011

Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.

artículo científico publicado en 2012

Effect of wound type on Smad 2 and 4 translocation

artículo científico publicado en 2005

Enhanced potency of human Sonic hedgehog by hydrophobic modification.

artículo científico publicado en 2001

Fibronectin-guided migration of carcinoma collectives

artículo científico publicado en 2017

Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes

artículo científico publicado en 2004

Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice.

artículo científico publicado en 2010

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

article

High expression of integrin β6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers.

artículo científico publicado en 2016

Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin

scientific journal article

Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice.

artículo científico publicado en 2016

Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation

artículo científico publicado en 2014

Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis

artículo científico publicado en 2007

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis

artículo científico publicado en 2014

Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

artículo científico publicado en 2017

Integrin alphavbeta6 and mediators of extracellular matrix deposition are up-regulated in experimental biliary atresia.

artículo científico publicado en 2008

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.

scientific article published on 08 October 2015

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.

artículo científico publicado en 2008

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

artículo científico publicado en 2020

Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β

artículo científico publicado en 2012

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

artículo científico publicado en 2009

Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

artículo científico publicado en 2009

Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo

scientific article published on 01 May 2003

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice.

artículo científico publicado en 2009

Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival

scientific article published on 01 July 2007

Overexpression of the alphavbeta6 integrin in endometrial cancer

scientific article published on 01 December 2008

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation

scientific article published on 04 October 2007

Post-translational modification of polyketide and nonribosomal peptide synthases ⬇️

artículo científico publicado el 1 de octubre de 1997

Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy.

artículo científico publicado en 2007

Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression

artículo científico publicado en 2016

Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering ⬇️

artículo científico publicado el 1 de septiembre de 2010

Role of ITGAE in the development of autoimmune diabetes in non-obese diabetic mice

artículo científico publicado en 2014

Stoichiometry and Specificity of In Vitro Phosphopantetheinylation and Aminoacylation of the Valine-Activating Module of Surfactin Synthetase ⬇️

artículo científico publicado el 10 de febrero de 1998

Stromal features are predictive of disease mortality in oral cancer patients

artículo científico publicado en 2011

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.

artículo científico publicado en 2018

Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.

artículo científico publicado en 2014

Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1.

artículo científico publicado en 2015

The alpha(v)beta6 integrin receptor for Foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle.

artículo científico publicado en 2005

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

artículo científico publicado en 2016

The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.

artículo científico publicado en 2010

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

artículo científico publicado en 1995

Therapeutic targeting of integrin αvβ6 in breast cancer

artículo científico publicado en 2014

Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models.

artículo científico publicado en 2017

Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis

artículo científico publicado en 2017

α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.

artículo científico publicado en 2012

αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor

artículo científico publicado en 2016

αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease

artículo científico publicado en 2015

Lista de obras de Paul H. Weinreb

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Aggregated SOD1 causes selective death of cultured human motor neurons

Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis

Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

Blockade of Nogo receptor ligands promotes functional regeneration of sensory axons after dorsal root crush.

Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases

Characterization of integrin beta6 and thrombospondin-1 double-null mice

Characterization of trisulfide modification in antibodies

Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice

Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment

Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.

Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma.

Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.

Effect of wound type on Smad 2 and 4 translocation

Enhanced potency of human Sonic hedgehog by hydrophobic modification.

Fibronectin-guided migration of carcinoma collectives

Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes

Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice.

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

High expression of integrin β6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers.

Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin

Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice.

Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation

Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis

Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

Integrin alphavbeta6 and mediators of extracellular matrix deposition are up-regulated in experimental biliary atresia.

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice.

Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival

Overexpression of the alphavbeta6 integrin in endometrial cancer

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation

Post-translational modification of polyketide and nonribosomal peptide synthases ⬇️

Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy.

Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression

Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering ⬇️

Role of ITGAE in the development of autoimmune diabetes in non-obese diabetic mice

Stoichiometry and Specificity of In Vitro Phosphopantetheinylation and Aminoacylation of the Valine-Activating Module of Surfactin Synthetase ⬇️

Stromal features are predictive of disease mortality in oral cancer patients

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.

Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.

Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1.

The alpha(v)beta6 integrin receptor for Foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle.

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

Therapeutic targeting of integrin αvβ6 in breast cancer

Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models.

Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis

α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.

αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor

αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease